ライフサイエンスコーパス: antiviral effect

1 on-alpha, which was essential for the innate antiviral effect.

2 agy promoted viral replication dampening the antiviral effect.

3 nation with pIFN-alpha, it has a synergistic antiviral effect.

4 oblasts indicated that host YB-1 mediates an antiviral effect.

5 , suggesting host species specificity of the antiviral effect.

6 ng HCV replication and mediating IFN-induced antiviral effect.

7 ugmented both IFN-dependent and -independent antiviral effect.

8 anscription and translation machinery in the antiviral effect.

9 ntributed, albeit to a lesser extent, to the antiviral effect.

10 nterferon secretion is not necessary for the antiviral effect.

11 ector molecules that ultimately mediate this antiviral effect.

12 a and anti-TNF Abs significantly blocked the antiviral effect.

13 antagonizes the GTPase activity and thus the antiviral effect.

14 osbuvir and ribavirin results in an additive antiviral effect.

15 GTPase activity, which was critical for its antiviral effect.

16 ith these lipoproteins further increased the antiviral effect.

17 ect) and reduced NK cell-mediated (indirect) antiviral effects.

18 wnstream of TNFR1 and -2 with known pro- and antiviral effects.

19 and impaired promoter activity and displayed antiviral effects.

20 properties, but nothing is known about their antiviral effects.

21 ny of which have been investigated for their antiviral effects.

22 cts of TNF must be considered along with its antiviral effects.

23 es have developed strategies to overcome its antiviral effects.

24 ferons (IFNalpha/beta), which mediate potent antiviral effects.

25 is an interferon-stimulated gene that exerts antiviral effects.

26 ron stimulated genes (ISGs) that have direct antiviral effects.

27 IFN-alpha and increases the efficacy of its antiviral effects.

28 virus infection, as it has both proviral and antiviral effects.

29 used in the treatment of HIV-1, exert their antiviral effects.

30 host defenses, including mucus and paracrine antiviral effects.

31 ducible genes and generation of IFN-mediated antiviral effects.

32 icating that the drug is not exerting direct antiviral effects.

33 ns, and different stimuli can activate these antiviral effects.

34 e of T-cell immunity in mediating protective antiviral effects.

35 ly identified form of cell death with potent antiviral effects.

36 amma) are produced by immune cells to elicit antiviral effects.

37 iR-122 and a DAA had additive or synergistic antiviral effects.

38 tion of type I interferons with the expected antiviral effects.

39 HCV-specific CD8 T cells and the downstream antiviral effects.

40 biogenesis pathway to subvert miRNA-induced antiviral effects.

41 This conveys antiviral effects, activates other immune cells (NK cell

42 f pigs' innate immune defenses allows potent antiviral effects after Ad5-poIF7/3(5D) administration.

43 Overall, PCZ showed a previously unknown antiviral effect against DENV infection, and D2R may pla

44 r activity against PI4KB as well as profound antiviral effect against hepatitis C virus, human rhinov

45 the mechanism behind the type I IFN-mediated antiviral effect against HEV remains unclear.

46 Oseltamivir produced a dose-dependent antiviral effect against VN1203/04 in vivo (P<.01).

47 FITM2 and IFITM3 have been described to have antiviral effects against a broad range of RNA viruses.

48 IL-12-polarized Th1 cells, displayed potent antiviral effects against a variety of viruses.

49 s, suggesting that such reagents may possess antiviral effects against both viral assembly and uncoat

50 2 (also known as Viperin)) that mediated the antiviral effects against different neurotropic viruses.

51 Cyclosporine, but not tacrolimus, has potent antiviral effects against HCV replication in cell cultur

52 evealing a network of host factors mediating antiviral effects against HCV, we identified EFTUD2 as a

53 stimulated genes (ISGs) and determined their antiviral effects against HCV.

54 Silymarin had antiviral effects against hepatitis C virus cell culture

55 (AuNP-PT) exhibit substantially more potent antiviral effects against HIV-1 than corresponding pepti

56 Lambda interferon (IFN-lambda) has potent antiviral effects against multiple enteric viral pathoge

57 se, and we show that miR-342-5p exerts broad antiviral effects against multiple, unrelated pathogenic

58 IFN-gamma and TNF-alpha also exerted antiviral effects against vesicular stomatitis virus inf

59 antiviral activity against VV by (1) direct antiviral effects against VV; and (2) stimulating the ex

60 n for all genotypes and showed the strongest antiviral effect among the retinoids tested.

61 contrast, miR-122 antagonism shows extensive antiviral effects among all HCV genotypes and a high bar

62 lower level, the loss of interferon-induced antiviral effect and an increased availability of target

63 The combination exerted an additive antiviral effect and reduced heart pathology.

64 In addition to a direct antiviral effect and synergism with IFN, the SOCS antago

65 ding potential protective mechanisms such as antiviral effects and enhanced steroid responsiveness.

66 ingle treatments had additive or synergistic antiviral effects and helped to efficiently suppress HCV

67 esent studies, we investigated the nature of antiviral effects and identity of antiviral effectors pr

68 Both direct antiviral effects and indirect immune-mediated effects,

69 n vivo treatment with histones did not yield antiviral effects and instead exacerbated lung pathology

70 Thus, gal-1 may have direct antiviral effects and may also augment the innate immune

71 determinants for the observed differences in antiviral effects and other biological functions.

72 jects were monitored for 58 days for safety, antiviral effects, and PRO 140 serum concentrations.

73 jects were monitored for 58 days for safety, antiviral effects, and serum concentrations of PRO 140.

74 that Silymarin exerts anti-inflammatory and antiviral effects, and suggest that complementary and al

75 In the present study, we investigated the antiviral effect as well as the potential immunomodulato

76 This antiviral effect, as well as the protective effect again

77 eta, which may play a role in the antagonist antiviral effect at the cellular level.

78 IFN-gamma mimetic to exert a multiplicative antiviral effect at the level of transcription, the cell

79 P activity is associated with maintenance of antiviral effects but diminished tissue damage may be si

80 AZA, 6-mercaptopurine, still possessed this antiviral effect, but a metabolite further downstream, 6

81 into assembling virions, where it exerts its antiviral effect by deaminating viral cDNA cytosines dur

82 but significant reversal of the PIC-mediated antiviral effect by IDO RNA interference and/or tryptoph

83 C/C genotype at IL28B rs12979860 exerts its antiviral effect by increasing the infected hepatocyte d

84 that as an RNase, MCPIP1 has broad-spectrum antiviral effects by targeting viral RNA.

85 ations indicate that the TRIM5alpha-mediated antiviral effects can be orchestrated by the conventiona

86 Thus, in addition to their direct antiviral effect, CD4-mimetic compounds dramatically enh

87 mbination of both antibodies had no additive antiviral effect compared to a single dose of PGT121, po

88 ng drugs may achieve synergistic or additive antiviral effects compared with single drug therapy.

89 imen may be required for the most beneficial antiviral effect.CONCLUSIONS.

90 wo is more important than finger one for the antiviral effect, demonstrating a correlation between de

91 ock NS5A dimerization, suggesting that their antiviral effects do not involve the disruption of NS5A-

92 ng in an increase in the type I IFN-mediated antiviral effect during HEV replication.

93 69 muM against NS5B polymerase and selective antiviral effect (EC50 = 3.03 muM) coupled with the abse

94 IC50 of 7.9 muM against NS5B polymerase and antiviral effect (EC50 = 8.1 muM; EC90 = 23.3 muM) coupl

95 in IDO-expressing cells, indicating that the antiviral effect elicited by IDO is mediated by tryptoph

96 ms produce ROS that provide vital protective antiviral effects for the host.

97 precise cellular pathway that mediates this antiviral effect has not been identified.

98 owever, the mechanisms underlying the direct antiviral effect have not been determined.

99 potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a

100 tic benefit over Tamiflu and has an additive antiviral effect in combination with Tamiflu.

101 f SOCS-1, pJAK2(1001-1013), that had both an antiviral effect in keratinocytes against HSV-1 as well

102 ce, although TNF-alpha did not have a direct antiviral effect in primary neuron cultures.

103 challenge assay (IVCA) that measures the net antiviral effect in whole peripheral blood mononuclear c

104 In this issue of Blood, Tebas et al report antiviral effects in a clinical trial of multiple infusi

105 ukemia protein (PML) since interferon has no antiviral effects in PML(-/-) cells.

106 e data suggest that IFN-gamma production has antiviral effects in rabies, largely due to the inductio

107 elminth infection can have remote protective antiviral effects in the lung through induction of a mic

108 and FK778, have been reported to exert broad antiviral effects, in addition to their immunosuppressiv

109 a cell culture system, we found TNF to have antiviral effects independently of, as well as in combin

110 he blood-brain barrier to achieve its direct antiviral effect, intrathecal administration of IFN is w

111 ents with IFN-gamma, the establishment of an antiviral effect is demonstrated to occur within the fir

112 ike membrane-binding photosensitizers: their antiviral effect is dependent on light and the generatio

113 FN-gamma induced the type I IFN pathway, its antiviral effect is likely to be partially induced via c

114 Recent data suggest that the antiviral effect is mediated by inhibition of cyclophili

115 Although significant, clemizole's antiviral effect is moderate (50% effective concentratio

116 l(s) upon which IFN-lambda acts to exert its antiviral effects is unclear.

117 enium status or selenium supplementation has antiviral effects, is essential for successful male and

118 iated with the production of IFN-gamma, with antiviral effects likely mediated through the enhanced e

119 These results suggest that Ifit2 exerts its antiviral effect mainly at the level of viral replicatio

120 on (IFN-gamma) secretion likely mediated the antiviral effect needed to control virus infectivity in

121 However, the strong antiviral effect observed suggests that with further dev

122 fety and tolerability, pharmacokinetics, and antiviral effect of a single dose of RG-101, a hepatocyt

123 It is not clear whether this antiviral effect of ADAR1 is a common mechanism in respo

124 A modest antiviral effect of alisporivir against contemporary (Ma

125 mmunomodulatory properties which augment the antiviral effect of antiviral agents and offer the poten

126 to investigate this previously unanticipated antiviral effect of AZA on HCV in the posttransplant set

127 The antiviral effect of CD40L required activation of c-Jun N

128 e EGFR inhibitor, erlotinib, potentiates the antiviral effect of each compound in a highly synergisti

129 efective Huh7.5.1 cells, indicating that the antiviral effect of EFTUD2 is dependent on RIG-I.

130 nor knockdown of STAT1 diminished the early antiviral effect of exogenous IL-6.

131 the Ebola glycoprotein (GP) antagonized the antiviral effect of human and murine tetherin and facili

132 The antiviral effect of IDO, the enzyme that catalyzes the f

133 other viruses, much less is known about the antiviral effect of IFITM3 on alphaviruses.

134 at Janus kinase activity is required for the antiviral effect of IFN against HBV, but that phosphatid

135 the parental virus was more resistant to the antiviral effect of IFN than the mutant viruses.

136 The synergistic antiviral effect of IFN-alpha and RBV combination treatm

137 In this study we investigated the potential antiviral effect of IFN-beta-induced Sp100.

138 s an important role in the inhibition of the antiviral effect of IFN-gamma in keratinocytes infected

139 ally induced genes that are required for the antiviral effect of IFNalpha.

140 -7 or IL-15 but suggest that the NK-mediated antiviral effect of IL-15 may be superior.

141 d to in vivo studies to explore the possible antiviral effect of immunostimulation with ZOL in this c

142 cal study suggested that NTZ can augment the antiviral effect of interferon (IFN), although the molec

143 The antiviral effect of LMP-1 is associated with the ability

144 However, the antiviral effect of MAb treatment during acute HIV-1 inf

145 hese observations could explain the clinical antiviral effect of NTZ.

146 ion to being relatively insusceptible to the antiviral effect of oseltamivir, might confer an additio

147 and mutational analyses established that the antiviral effect of P56 was mediated by its direct inter

148 The translation inhibition and antiviral effect of PARP12L appear to be mediated by mor

149 eater sensitivity of mG versus wt RSV to the antiviral effect of passively transferred RSV antibodies

150 abeled drug binding studies showing that the antiviral effect of pleconaril against HRV16 is greater

151 (FRG) mouse model was used to determine the antiviral effect of PLK1 inhibitor BI-2536 on HBV infect

152 The antiviral effect of PLSCR1 correlated with increased exp

153 We examined the antiviral effect of ribavirin in a cohort of nine AGMs b

154 agy promoted viral replication, reducing the antiviral effect of RNase L.

155 and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib (in addition

156 B8R protein in WISH cells did not block the antiviral effect of the mimetics against encephalomyocar

157 of chronic WHV carriers that counteracts the antiviral effect of the treatment.

158 and this occurrence correlated with a modest antiviral effect of TNF-alpha on primary macrophages but

159 Thus, viruses subvert the known antiviral effect of type I IFN through STAT2-specific si

160 xpress IFN-stimulated genes, and mediate the antiviral effect of type I IFNs against La Crosse virus

161 verse transcription and as a mediator to the antiviral effect of virion-incorporated Apobec3G, a cyti

162 The antiviral effect of WJ379 was also synergistic with osel

163 virus type 1 (HTLV-1) were resistant to the antiviral effects of all three lectins.

164 pox virus (FWPV), is highly resistant to the antiviral effects of avian IFN.

165 The antiviral effects of bat IFNs appeared not to correlate

166 dentified several that were resistant to the antiviral effects of BMS-806 and #155.

167 B-MLV was resistant to the antiviral effects of both human and rhesus monkey TRIM5a

168 A clear understanding of the antiviral effects of CD8(+) T cells in the context of ch

169 Taken together, the observed antiviral effects of CDots on noroviruses were mainly th

170 nhibit IKKe was much more susceptible to the antiviral effects of double-stranded RNA than the wild-t

171 CV replication assays were used to study the antiviral effects of drug combinations that included cle

172 n decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes.

173 The antiviral effects of hepatitis C virus (HCV)-specific CD

174 Inhibition of the antiviral effects of IFN by the capsid appears to occur

175 of the cells to IFN-alpha and to compare the antiviral effects of IFN-alpha and IFN-lambda.

176 vIRF-1 is inadequate to subvert many of the antiviral effects of IFN-alpha so that IFN-alpha can eff

177 ntify the cellular proteins that mediate the antiviral effects of IFN-alpha, we created a HEK293-base

178 in mouse cells, as assessed by assays of the antiviral effects of IFN-alpha/beta and the IFN-alpha/be

179 dendritic cells, and are dispensable for the antiviral effects of IFN-alpha/beta that block MNV repli

180 a cell-type-dependent ability to resist the antiviral effects of IFN-alpha/beta.

181 ls, suggests that PML acts as an effector of antiviral effects of IFN-beta.

182 Due to the antiviral effects of IFN-gamma, we examined whether IL-1

183 rategies used by flavivirus NS5 to evade the antiviral effects of IFN-I and how this information can

184 re often targeted by viruses to suppress the antiviral effects of IFN-I.

185 fected fibroblasts but instead modulated the antiviral effects of IFN-induced proteins with tetratric

186 antagonize STAT1 signaling to counteract the antiviral effects of IFN.

187 of potentiating and recapitulating important antiviral effects of IFN.

188 ses, was found to be highly sensitive to the antiviral effects of IFN.

189 PTP1B inhibitors robustly augmented the antiviral effects of IFN1 against vesicular stomatitis a

190 ntiviral miRNAs with anti-miRNAs reduces the antiviral effects of IFNbeta against HCV.

191 these IFNbeta-induced miRNAs reproduces the antiviral effects of IFNbeta on HCV replication and infe

192 olved multiple tricks to avoid the immediate antiviral effects of IFNs and, in turn, hosts have adapt

193 Although the antiviral effects of IFNs are well characterized, their

194 ed with TNF before infection, the subsequent antiviral effects of IFNs were increased.

195 e JAK/STAT pathway that is necessary for the antiviral effects of IFNs.

196 ssion and to the protection of EEEV from the antiviral effects of IFNs.

197 ce determinant that allows EBOV to evade the antiviral effects of IFNs.

198 green fluorescent protein (NDV-GFP) from the antiviral effects of interferon (IFN).

199 ls, SAMe increased induction of ISGs and the antiviral effects of interferon by increasing STAT1 meth

200 havior can be explained by incorporating the antiviral effects of interferon into the model.

201 4 promoted viral replication and blocked the antiviral effects of interferon-gamma (IFNgamma) by indu

202 however, the mechanisms responsible for the antiviral effects of IRF-1 are still poorly understood.

203 echanism that is likely to contribute to the antiviral effects of IRF-1 in other virus systems.

204 n primary macrophages and contributed to the antiviral effects of IRF-1.

205 upport a role for protein conjugation in the antiviral effects of ISG15.

206 To analyze immunomodulatory and antiviral effects of liver-specific IFN-gamma expression

207 s apparently evolved to partially resist the antiviral effects of mA3 and to totally resist the abili

208 Potent antiviral effects of MPA at clinically relevant concentr

209 The antiviral effects of NDGA resulted in reduced HCV replic

210 Control monocytes increased the antiviral effects of NK cells from patients with chronic

211 in mice seems to be resistant to any direct antiviral effects of NK cells.

212 s, in this contribution we have analyzed the antiviral effects of peptides derived from the membrane-

213 interact with cell cycle proteins; thus, the antiviral effects of Rosco on VZV growth were evaluated.

214 servations, taken together, suggest that the antiviral effects of SCH-C and AD101 involve stabilizati

215 This study aimed to evaluate the antiviral effects of sorbifolin (1) and pedalitin (2), t

216 Unexpectedly, we found that the antiviral effects of statins are counteracted by type I

217 type I interferon signaling counteracts the antiviral effects of statins.

218 In contrast to the direct antiviral effects of Tetherin, which are dependent on ce

219 es have evolved mechanisms to antagonize the antiviral effects of the autophagy pathway, others subve

220 evolved a remarkable strategy to thwart the antiviral effects of the cellular cytidine deaminase APO

221 Antiviral effects of the extract were attributable in pa

222 ated the role of type I IFN induction in the antiviral effects of the miR-34 family and confirmed tha

223 Antiviral effects of the type III IFN family have previo

224 The potent antiviral effects of these cells make them important com

225 Here, we describe the antiviral effects of two molecules that alter polyamine

226 pe 5 E1B 55-kDa protein protects against the antiviral effects of type 1 interferon (IFN), we examine

227 ts required to induce ISGs and the potential antiviral effects of type I IFN on JCV replication in hu

228 N-inducible HIV-1 attachment factor, offsets antiviral effects of type I IFN.

229 and CD4(+) T cells in trans and thus offset antiviral effects of type I IFN.

230 and its replication space is limited by the antiviral effects of type I interferon in the chronicall

231 avian cells, DTMUV was more sensitive to the antiviral effects of type I interferon than other known

232 UN) exhibited an enhanced sensitivity to the antiviral effects of type I interferon.

233 FN receptor and IRF-1 expression potentiated antiviral effects of type II IFN to restrict gammaherpes

234 In contrast, the antiviral effects of Xrn2 were limited to JFH1 and H77D

235 immunomodulatory role and can have a direct antiviral effect on a wide spectrum of virus families.

236 ta suggest that castanospermine has a strong antiviral effect on dengue virus infection and warrants

237 component of human lipid metabolism with an antiviral effect on HCV.

238 PA for Flaviviridae and may exert a specific antiviral effect on HCV.

239 e components of the ATR pathway may exert an antiviral effect on infection.

240 hemes were used that allow estimation of the antiviral effect on infectiousness from individual studi

241 ntiviral efficacy for pathogenicity, and the antiviral effect on infectiousness.

242 shutoff, neither PKR nor RNase L exerted an antiviral effect on reovirus growth.

243 hat the human cathelicidin LL-37 mediates an antiviral effect on RSV by inducing direct damage to the

244 egulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection.

245 rall, we identified 34 ISGs that elicited an antiviral effect on the replication of either one or bot

246 The designed siRNAs exerted a potent antiviral effect on these HIV-1 strains.

247 f hepatitis C virus inhibitors had different antiviral effects on genotypes 4a vs 1b.

248 n enzymatic activity, can also have profound antiviral effects on HCV-infected subjects.

249 sing group of drugs that could have profound antiviral effects on herpesviruses.

250 que immune stimulation by poly(I:C) with its antiviral effects on imDCs marked by the expression of I

251 ique ISGs that have either broad or specific antiviral effects on these viruses.

252 with other anti-HCV agents can increase the antiviral effect over that achieved with each drug alone

253 showed ER-stress-dependent and -independent antiviral effects, preventing virus release in human LCL

254 dent protein kinase, PKR, exerted some early antiviral effects prior to IFN-alpha/beta signaling; how

255 expression of pairs of ISGs showed additive antiviral effects similar to those of moderate type I in

256 y complex internalization could result in an antiviral effect, since it may interfere with virus part

257 ntify and interrogate other host factors for antiviral effect starting from chemical matter of unknow

258 ry indicates that factors beyond tenofovir's antiviral effect substantially influence PrEP efficacy.

259 ells, combined with its previously described antiviral effect, suggests a possible mechanism of actio

260 self-complementary AAV vector showed better antiviral effects than single shRNA both in vitro and in

261 n of alisporivir and telbivudine had greater antiviral effects than those of telbivudine or alisporiv

262 The pretreatment study demonstrated an antiviral effect that lasted 100 days after a single int

263 In addition to its direct antiviral effect, the mimetic also possessed adjuvant ef

264 tors that rely on SUMOylation to exert their antiviral effects, the enzymes that mediate these SUMOyl

265 ly inhibit PKR and several of its downstream antiviral effects, thereby enhancing virus survival.

266 Interferons alpha and beta exert their antiviral effects through the induction of hundreds of i

267 ha/beta interferon (IFN-alpha/beta) produces antiviral effects through upregulation of many interfero

268 Analysis of the antiviral effects, toxicities, and pharmacodynamics of d

269 Therapeutic anti-Env Abs can also exert antiviral effects via Fc-mediated effector mechanisms or

270 acteristic of the PKR/RNase L/Mx-independent antiviral effect was a blockage of viral protein accumul

271 However, no antiviral effect was achieved and, instead, an enhanceme

272 The antiviral effect was dependent on the continued presence

273 No antiviral effect was detected by measuring the secreted

274 al analyses of HPV16 PsV determined that the antiviral effect was exerted at the level of endosomal p

275 Clemizole's antiviral effect was highly synergistic with the HCV pro

276 egression analysis showed that the ALN-RSV01 antiviral effect was independent of other factors, inclu

277 Interestingly, the EFTUD2-induced antiviral effect was independent of the classical IFN-in

278 A(H7N9) harboring HA2-Asp19Gly, although the antiviral effect was lessened.

279 The antiviral effect was mediated at the RNA level (as obser

280 velopment of these functional attributes, no antiviral effect was observed early during infection, ev

281 Conclusion: A synergistic antiviral effect was observed when R1626 was combined wi

282 s experimentally infected with RSV, a potent antiviral effect was observed with a mean 4.2 log10 redu

283 was measured in a biochemical assay, but no antiviral effect was observed.

284 This antiviral effect was predominantly mediated by tumor nec

285 their combination was synergistic, and their antiviral effect was reversed by either AAK1 or GAK over

286 o M Rosco prevented VZV replication, and the antiviral effect was reversible for at least up to 24 h

287 fic CD8 T-cell activation with cytolytic and antiviral effects was blunted by PD-L1 expression on HCV

288 The enhanced antiviral effects were abrogated in the presence of a po

289 d with pulmonary surfactant protein D, their antiviral effects were additive.

290 In contrast, cooperative antiviral effects were noted in some instances when rela

291 the ribavirin treatment, moderately reversed antiviral effects were observed, suggesting that the rib

292 Nevertheless, for some compounds antiviral effects were specific to a block of ion channe

293 Antiviral effects were studied during analytic treatment

294 RBV and IFN alfa were highly synergistic for antiviral effect when administered as combination therap

295 TLR7 and TLR8 were identified as eliciting antiviral effects when stimulated by viral ssRNA.

296 ption and translation completely abolish the antiviral effect, which also appears to require cellular

297 These data suggest that LMP-1 has antiviral effect, which may be an intrinsic part of EBV

298 o peak viral synthesis and exerted sustained antiviral effects while present in culture medium.

299 esults suggest that signaling through IP has antiviral effects while protecting against RSV-induced i

300 of S1P-dependent GPC cleavage, the additive antiviral effect with ribavirin, and the low probability