ライフサイエンスコーパス: anxiogenic

1 However, OT can also be anxiogenic.

2 The anxiogenic action of mecamylamine (30 and 100 ng) was mo

3 els of social investigation, thus indicating anxiogenic actions in the social interaction test.

4 signaling within the BNST and the CeA in the anxiogenic actions of cocaine.

5 ial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently em

6 environments paired with the drug's delayed/anxiogenic actions.

7 ot exhibit the convulsant, proconvulsant, or anxiogenic activity associated with nonselective GABA(A)

8 Intravenous administration of the anxiogenic agent sodium lactate elicited robust increase

9 of CRF2 receptor knock-out mice suggest both anxiogenic and anxiolytic effects of CRF2 receptor activ

10 gnition-enhancing effects in animals but are anxiogenic and can precipitate convulsions.

11 treatment of cognitive disorders because of anxiogenic and convulsant side effects.

12 testing in adult mice revealed a persistent anxiogenic and despair-like phenotype.

13 CUS for 3 wk in adult mice induced anxiogenic and helpless-like behavior and decreased memo

14 The anxiogenic and panicogenic effects of peripheral adminis

15 fied the mechanism by which PACAP exerts its anxiogenic and pro-depressant effects, via the recruitme

16 imbic neuronal circuit, RGS6 exerts powerful anxiogenic and prodepressant actions.

17 R, but its acute hypolocomotor, hypothermic, anxiogenic, and antinociceptive effects are not.

18 selective activation of GR within the CeA is anxiogenic, and peripheral administration of an ERbeta a

19 reas CCK administration into mPFC mimics the anxiogenic- and depressant-like effects of social stress

20 hippocampal activity in mice exposed to two anxiogenic arenas.

21 e general syndrome, by altering reactions to anxiogenic, aversive, and nociceptive stimuli as well.

22 However, there were no changes in anxiogenic behavior using the elevated plus maze (p>0.05

23 in the BLA, but not CeA, has been implicated anxiogenic behaviors and anxiety disorders.

24 , infusions of mCPP into the CeA produced no anxiogenic behaviors suggesting that 5-HT(2C) receptors

25 mice (39,XO), and found that they exhibited anxiogenic behaviour relative to normal females (40,XX).

26 atergic projections resulted in aversive and anxiogenic behavioural phenotypes.

27 The anxiogenic benzodiazepine inverse agonist FG7142 increas

28 The anxiogenic beta-carboline, FG 7142 (20 mg/kg) significan

29 ine system by mild stress can be mimicked by anxiogenic beta-carbolines such as FG7142.

30 and planning and to target depressogenic and anxiogenic cognitions that undermine effective self-mana

31 These findings indicate that anxiogenic compounds produce an effect similar to physic

32 eful assay for detecting both anxiolytic and anxiogenic compounds, and suggests that the high affinit

33 Consistent with data demonstrating the anxiogenic consequences of 5-HT(2C)R activation in human

34 duced hyperthermia, and a challenge with the anxiogenic drug metachlorophenylpiperazine (mCPP).

35 system to pharmacological challenge with the anxiogenic drug, N-methyl-beta-carboline-3-carboxamide (

36 Moreover, intra-BLA injection of anxiogenic drugs is sufficient to bias rats towards the

37 ve or habit learning, intra-BLA infusions of anxiogenic drugs result in a behavioral profile indicati

38 phosphodiesterase inhibitor antagonized the anxiogenic effect of 15% N2O and enhanced the anxiolytic

39 Evidence that the anxiogenic effect of 8-OH-DPAT (50 ng) was due to activa

40 ffect basal anxiety, but fully prevented the anxiogenic effect of acute stress.

41 However, 1.4 g/kg ethanol blocked the anxiogenic effect of caffeine.

42 n of corticoamygdala projections blocked the anxiogenic effect of CCK, although no effect was observe

43 al anxiolytic response, opposing the general anxiogenic effect of Crh mediated by Crhr1.

44 alteration in 5-HT systems, we examined the anxiogenic effect of mCPP in exercising and nonexercisin

45 This suggests that tolerance to the anxiogenic effect of nicotine administered into the dors

46 ediating the development of tolerance to the anxiogenic effect of nicotine in the social interaction

47 In the social interaction test, the anxiogenic effect of pirenzepine (30-100 ng) provided ev

48 ely, vehicle injection failed to prevent the anxiogenic effect of stress in bilaterally adrenalectomi

49 enalectomized rats by injection, the delayed anxiogenic effect of stress was once again blocked.

50 However, this anxiogenic effect was blunted in exercising mice.

51 n in vehicle pre-treated rats, indicating an anxiogenic effect, but tolerance to this effect was seen

52 e; a higher dose of 5 micrograms produced an anxiogenic effect.

53 on of idazoxan did not reproduce yohimbine's anxiogenic effects and anxiety was not reduced by periph

54 l hippocampus, nicotine (0.1-8.0 microg) had anxiogenic effects in conditions of moderate anxiety; me

55 e plus-maze pirenzepine and mecamylamine had anxiogenic effects in the dose range of 30-300 ng; galla

56 sal hippocampus is one area that can mediate anxiogenic effects in the social interaction test, but t

57 th panic disorder were more sensitive to the anxiogenic effects of CO2 than were normal subjects, and

58 ratory physiology by several mechanisms: the anxiogenic effects of hyperventilation, the catastrophic

59 leus of the stria terminalis (BNST) mediates anxiogenic effects of OT.

60 ral malaise contributes to the stressful and anxiogenic effects of systemic YO and that YO recruits b

61 the mouse brain, dramatically reduced acute anxiogenic effects of the glucocorticoid hormone cortico

62 Male mice were more vulnerable to the anxiogenic effects of the high fat diet, and obese male

63 or and olfactory function, as well as on the anxiogenic effects of this amine.

64 selective antagonist antalarmin, blocked the anxiogenic effects of urocortin 2.

65 Conversely, the anxiogenic effects of withdrawal after long-term ethanol

66 In contrast, MTIP dose-dependently reversed anxiogenic effects of withdrawal from a 3 g/kg alcohol d

67 cted exposure to a cat produces long-lasting anxiogenic effects on behavior which are NMDA receptor-d

68 well studied, the mechanisms underlying its anxiogenic effects remain unclear.

69 that Asn (60 pmoles) was able to reverse the anxiogenic effects seen during acute administration of U

70 scape, the elevated plus maze for anxiolytic/anxiogenic effects, place preference conditioning for re

71 olateral nucleus of the amygdala may produce anxiogenic effects, while agonist activation of BDZ rece

72 lation of carbon dioxide (CO2) may blunt its anxiogenic effects.

73 and high doses (0.5 and 1.0 mg/kg i.p.) had anxiogenic effects.

74 o produce both initial rewarding and delayed anxiogenic effects.

75 ectopic G9a overexpression leads to lasting anxiogenic effects.

76 als in the dBNST reduces anxiety in a highly anxiogenic environment.

77 s into the dBNST increases anxiety in a less anxiogenic environment.

78 t has been proposed to regulate responses to anxiogenic environments in humans and rodents.

79 al BNST neurons that differentiated safe and anxiogenic environments.

80 line, and this correlation increased in both anxiogenic environments.

81 macological activation of the 5-HT system is anxiogenic in animal models and also in humans.

82 nts were anxiolytic in proestrus females but anxiogenic in males as determined by time spent in the o

83 ehavioural phenotype with beta-carboline, an anxiogenic inverse benzodiazepine receptor agonist, norm

84 mice also exhibit a significant increase in anxiogenic-like behavior as assessed by the elevated plu

85 The increased anorectic and anxiogenic-like behavior most likely is caused by increa

86 deficits to obtain less palatable food, and anxiogenic-like behavior.

87 sible inhibitor of the SERCA pump, exhibited anxiogenic-like behaviors and increased Ih, similar to t

88 ressful situations, provoking depressive and anxiogenic-like behaviors, even more intense than the av

89 However, only short-term activation induces anxiogenic-like behaviors.

90 ncy to emerge into the light compartment, an anxiogenic-like effect.

91 Overall, d-amphetamine (5 and 10mg/L) evokes anxiogenic-like effects in zebrafish acutely, but not 7

92 t not in nondependent, rats and reversed the anxiogenic-like effects of ethanol abstinence using an a

93 lock the potentiation of nicotine CPP or the anxiogenic-like effects of kappa-receptor activation.

94 ance and sucrose preference deficits but not anxiogenic-like effects.

95 havioral models, the NPY KO mice may have an anxiogenic-like phenotype, and appear to be hypoalgesic

96 administration (30 and 50 mg/L) produces an anxiogenic-like reduction of top swimming, paralleled wi

97 enetic models, mice over-expressing CRF show anxiogenic-like responses compared to wild-type mice, an

98 f activity, overly aggressive treatment with anxiogenic medications, and more prolonged and frequent

99 hypercapnia or hyperventilation, the use of anxiogenic medications, and the stress of coping with ch

100 anxiety and is a key site of action for the anxiogenic neuromodulator, corticotropin releasing facto

101 corticotropin-releasing hormone (CRH) is an anxiogenic neuropeptide that may mediate the stressor-li

102 An anxiogenic odor potentiated their abnormal repetitive le

103 d that enhances cognition in animals without anxiogenic or convulsant effects.

104 sed on GABAergic interneurons containing the anxiogenic peptide cholecystokinin (CCK), we also examin

105 icotropin releasing factor (CRF), a putative anxiogenic peptide, inhibit maternal defense behavior.

106 that central infusion of urocortin 1 and 3, anxiogenic peptides that bind to CRF receptors, reduce m

107 pecifically into the mPFC displayed the same anxiogenic phenotype as the CSDS mice, whereas overexpre

108 We conclude that the anxiogenic phenotype in female LXRbeta(-/-) mice is caus

109 FKBP51(mut) BLA-overexpression, reduced the anxiogenic phenotype.

110 striatum alone was sufficient to produce an anxiogenic phenotype.

111 GABAA current, a possible mechanism for its anxiogenic, proconvulsant sequelae.

112 xhibited novelty-induced hyperlocomotion, an anxiogenic profile in the elevated plus-maze and open fi

113 27 rats and Sprague-Dawley rats reversed the anxiogenic profile of the TGR (mREN2)27 rat on the eleva

114 maze the TGR (mREN2)27 rat showed a greater 'anxiogenic' profile (fewer open arm entries) than the co

115 than the control Sprague-Dawley rats, this 'anxiogenic' profile increased further during a second ex

116 iod of fluid-deprivation (3 h) reversed the 'anxiogenic' profile of the TGR (mREN2)27 on the elevated

117 ch conditioned effects may be related to the anxiogenic properties of cocaine.

118 Consistent with its anxiogenic properties, mCPP produced a dose-dependent in

119 s of these events that are depressogenic and anxiogenic remain uncertain.

120 (BLA) in male Wistar rats would result in an anxiogenic response as measured in the social interactio

121 he AMY, but not into the HIPP, abolished the anxiogenic response elicited by acute stress.

122 tive PPARgamma antagonist, elicited a marked anxiogenic response in PPARgamma wild-type (WT), but not

123 inforcing effects effects of ethanol and the anxiogenic response to ethanol withdrawal.

124 ol consumption and plays a major role in the anxiogenic response to ethanol withdrawal.

125 we found that Rcan1 KO mice lacked the early anxiogenic response to the selective serotonin reuptake

126 haplotype AC/C/G exhibited a dose-dependent, anxiogenic response, individuals homozygous for the low

127 de or genetic deletion of PPARgamma enhanced anxiogenic responses and increased vulnerability to stre

128 orticotropin-releasing factor (CRF) mediates anxiogenic responses by activating CRF type 1 (CRF1) rec

129 Furthermore, Asn has no effect on anxiogenic responses due to sodium lactate infusions in

130 Our data also reveal an unanticipated anxiogenic role for this particular DOR subpopulation, w

131 al responses, DORs exert dual anxiolytic and anxiogenic roles, both of which may have implications in

132 neously as a dominant behavioral strategy in anxiogenic situations.

133 ateral septum attenuates active avoidance of anxiogenic stimuli (i.e., decreased burying behavior), b

134 and was specific to both the presence of the anxiogenic stimulus and the familiar social partner.

135 s to reflect an unconditioned response to an anxiogenic stimulus, whereas fear-potentiated startle re

136 ety-like behaviors induced by an ethological anxiogenic stimulus.

137 in the maze, regardless of the nature of the anxiogenic stimulus.

138 We used a clinically substantiated anxiogenic treatment to induce sustained anxiety in rats

139 an-20-one (3alpha, 5alpha-THP) that produces anxiogenic withdrawal symptoms.

140 wo opposing circuits, one anxiolytic and one anxiogenic, within the BNST, the relative strength of wh