ライフサイエンスコーパス: aortic regurgitation

1 valve positioning and reduction of residual aortic regurgitation.

2 alve during the index procedure for residual aortic regurgitation.

3 gradient, with no worsening of paravalvular aortic regurgitation.

4 ondiscriminatory in relation to post-TAVR PV aortic regurgitation.

5 Hg, and 95% of patients had </=+1 degree of aortic regurgitation.

6 mm Hg and 40+/-14 mm Hg, whereas 50% had >2+ aortic regurgitation.

7 eries, dilatation of the neoaortic root, and aortic regurgitation.

8 6 pigs, one being excluded because of severe aortic regurgitation.

9 not involve prosthetic heart valves or acute aortic regurgitation.

10 vascular complications and less paravalvular aortic regurgitation.

11 mination who had no more than mild mitral or aortic regurgitation.

12 lmonary stenosis, pulmonary hypertension, or aortic regurgitation.

13 tion and 43 patients (86%) had at least mild aortic regurgitation.

14 erienced no change in severity of mitral and aortic regurgitation.

15 in a significantly higher incidence of mild aortic regurgitation.

16 >6 months and predominantly results in mild aortic regurgitation.

17 not occur in the 26 patients with persistent aortic regurgitation.

18 ay be heterogeneous in patients with chronic aortic regurgitation.

19 gnosed cardiac-valve disorders, particularly aortic regurgitation.

20 quals mitral inflow volume in the absence of aortic regurgitation.

21 gitation, ventricular septal defect flow and aortic regurgitation.

22 cally in eight sheep with surgically induced aortic regurgitation.

23 onary (n = 3) leaflet was excised to produce aortic regurgitation.

24 forward stroke volume remained unchanged in aortic regurgitation.

25 rofile method for evaluating the severity of aortic regurgitation.

26 afterload mismatch dominates the response in aortic regurgitation.

27 ration in asymptomatic patients with chronic aortic regurgitation.

28 thod can be used to evaluate the severity of aortic regurgitation.

29 strokes, and incidence of moderate or severe aortic regurgitation.

30 rwent additional balloon dilation to correct aortic regurgitation.

31 of CT-ADP in order to identify patients with aortic regurgitation.

32 ost pronounced in patients without post-TAVI aortic regurgitation.

33 nd low New York Heart Association class with aortic regurgitation.

34 +/-8 and 53+/-17 mm Hg, whereas 28% had >II+ aortic regurgitation.

35 There was no residual moderate or severe aortic regurgitation.

36 predictors of valve surgery in asymptomatic aortic regurgitation.

37 e subset of patients with no post-procedural aortic regurgitation.

38 es across the aortic valve and the degree of aortic regurgitation.

39 lower prosthesis-patient mismatch, and more aortic regurgitation.

40 rease in MVA than did those with trace or no aortic regurgitation (0.19 vs. 0.086 cm2/year, p < 0.05)

41 HMW multimers normalized in patients without aortic regurgitation (137 patients).

42 gher rate of moderate or severe paravalvular aortic regurgitation (15.3%) than in-range (6.5%) or abo

43 ere was a higher prevalence of any degree of aortic regurgitation (17.0 percent vs. 11.8 percent, P=0

44 ; 95% CI, 1.02-2.29), and moderate to severe aortic regurgitation (22.4% vs 14.7%; HR, 2.05; 95% CI,

45 ears), including 46 normal subjects, 52 with aortic regurgitation, 253 with mitral regurgitation and

46 y lower frequency of residual more-than-mild aortic regurgitation (4.1% vs 18.3%; RR, 0.23; 95% CI, 0

47 ) tracts, 50 normal volunteers without MR or aortic regurgitation (44+/-5 years, 31 male) were studie

48 , 1179 with tricuspid regurgitation, 817 had aortic regurgitation, 471 with aortic stenosis, and 193

49 ave aortic root dilatation (92% versus 84%), aortic regurgitation (55% versus 36%), and to have under

50 ation had significantly more mild or greater aortic regurgitation (60% vs. 4%, p < 0.0001), moderate

51 on, with a significantly higher frequency of aortic regurgitation (622 [33.1%] vs 57 [24.1%], P < .00

52 Aortic regurgitation (a previously unreported problem) w

53 vasodilator therapy in patients with chronic aortic regurgitation, a reduction in left ventricular vo

54 ently associated with the presence of severe aortic regurgitation, abscess, embolization before surgi

55 ho had at least mild mitral regurgitation or aortic regurgitation after exposure to fenfluramines on

56 aphy resulted in lower rates of paravalvular aortic regurgitation after self-expanding transcatheter

57 ADP, were each predictive of the presence of aortic regurgitation after TAVR and were associated with

58 4; p < 0.001; presence of moderate or severe aortic regurgitation after TAVR, HR: 2.79, 95% CI: 1.82

59 Patients with aortic regurgitation after the initial implantation, as

60 mensional (2D) TEE as methods for predicting aortic regurgitation after transcatheter aortic valve re

61 late-onset ND abnormalities are common; 10) aortic regurgitation and aortic root dilation are well t

62 in one patient and ventricular dysfunction, aortic regurgitation and atrioventricular valve regurgit

63 cular arrhythmia, mitral or aortic stenosis, aortic regurgitation and chronic obstructive pulmonary d

64 alve were significantly associated with mild aortic regurgitation and elevated peak velocities across

65 In patients with severe aortic regurgitation and LV dysfunction, older age and h

66 s, whereas TAVR had higher rates of residual aortic regurgitation and need for pacemaker implantation

67 No changes in residual aortic regurgitation and no cases of structural valve fa

68 diography for diagnosis of acute significant aortic regurgitation and pericardial tamponade was 100%.

69 e) with isolated moderately severe to severe aortic regurgitation and preserved left ventricular (LV)

70 enosis in combination with at least moderate aortic regurgitation and preserved left ventricular func

71 Classic physical findings such as aortic regurgitation and pulse deficit were noted in onl

72 Greater than or equal to III+ aortic regurgitation and severe aortic stenosis were see

73 Aortic valve stenosis (with or without aortic regurgitation and without associated mitral steno

74 ic aortic valves (with or without associated aortic regurgitation and without associated mitral valve

75 aortic stenosis (with or without associated aortic regurgitation) and without associated mitral sten

76 ired normal left ventricular function, </=2+ aortic regurgitation, and >/=2 echocardiograms performed

77 .29; 95% confidence interval, 2.46-11.4) for aortic regurgitation, and 19.4% versus 9.6% (odds ratio,

78 In 18 sheep (4 normal, 6 with aortic regurgitation, and 8 with old myocardial infarcti

79 ction <30%), the presence of moderate/severe aortic regurgitation, and chronic obstructive pulmonary

80 ortic stenosis populations, in patients with aortic regurgitation, and in patients with bicuspid aort

81 ociety of Thoracic Surgeons score, degree of aortic regurgitation, and right ventricular systolic pre

82 , hypertension, hyperlipidemia, medications, aortic regurgitation, and right ventricular systolic pre

83 Inherited aortopathies, moderate to severe aortic regurgitation, and severe aortic stenosis were se

84 d management of the valve disease, including aortic regurgitation, aortic root dilation, hypertension

85 trol patients with matched valvular lesions (aortic regurgitation, aortic stenosis, or mixed lesions)

86 Aortic regurgitation (AR) after transcatheter aortic val

87 gitation (MR) is common in those with severe aortic regurgitation (AR) and can predispose to atrial f

88 ve replacement (AVR) in patients with severe aortic regurgitation (AR) and left ventricular (LV) dysf

89 CMR) imaging allow quantification of chronic aortic regurgitation (AR) and mitral regurgitation (MR).

90 ptomatic/minimally symptomatic patients with aortic regurgitation (AR) and normal left ventricular (L

91 (S3-THV) incorporates new features to reduce aortic regurgitation (AR) and vascular complications in

92 patients with mitral regurgitation (MR) and aortic regurgitation (AR) continues to elicit uncertaint

93 ient reduction was 54+/-26%, and significant aortic regurgitation (AR) developed in 15% of patients.

94 ons for surgery in patients with significant aortic regurgitation (AR) focus on symptoms and left ven

95 Residual aortic regurgitation (AR) following transcatheter aortic

96 Post-implantation aortic regurgitation (AR) grade >/= 2 occurred in 28.4%

97 (MAVD) and isolated aortic stenosis (AS) or aortic regurgitation (AR) has not been performed, making

98 Chronic severe aortic regurgitation (AR) imposes significant volume and

99 o determine the prevalence and correlates of aortic regurgitation (AR) in a population-based sample g

100 rdiography (TEE) to define the mechanisms of aortic regurgitation (AR) in acute type A aortic dissect

101 -sectional area to determine the severity of aortic regurgitation (AR) in an animal model.

102 (3D) method for determining the severity of aortic regurgitation (AR) in an experimental animal mode

103 ography, angiography, and measurement of the aortic regurgitation (AR) index, which is calculated as

104 Significant postprocedural aortic regurgitation (AR) is observed in 10% to 20% of c

105 Neo-aortic root dilation (ARD) and neo-aortic regurgitation (AR) may be progressive after arter

106 valve (MV) enlargement occurring in chronic aortic regurgitation (AR) prevents functional mitral reg

107 The causes of aortic regurgitation (AR) severe enough to warrant aorti

108 lor flow vena contracta (VC) measurements of aortic regurgitation (AR) severity by comparing them to

109 s), elevated transaortic flow velocities and aortic regurgitation (AR) was determined.

110 undergoing aortic valve surgery for chronic aortic regurgitation (AR), we sought to: 1) compare surv

111 function-either aortic stenosis (AS) or pure aortic regurgitation (AR)-something not previously under

112 ranscatheter aortic valve replacement (TAVR) aortic regurgitation (AR).

113 to 2D-TEE for the prediction of paravalvular aortic regurgitation (AR).

114 therapy on survival in patients with severe aortic regurgitation (AR).

115 for neo-aortic root size and severity of neo-aortic regurgitation (AR).

116 fibrosis is common in patients with chronic aortic regurgitation (AR).

117 ve replacement (AVR) in patients with severe aortic regurgitation (AR).

118 g, but this method has not been validated in aortic regurgitation (AR).

119 lacement (TAVR) in patients with pure native aortic regurgitation (AR).

120 on of effective regurgitant orifice (ERO) of aortic regurgitation (AR).

121 oms on survival after surgical correction of aortic regurgitation (AR).

122 gic stresses and energetic adaptation during aortic regurgitation (AR).

123 nappreciated cause of both acute and chronic aortic regurgitation (AR).

124 Using FDA criteria (aortic regurgitation [AR] > or =mild and/or mitral regur

125 Although more severe degrees of aortic regurgitation are associated with aortic dilatati

126 Residual gradient and residual aortic regurgitation are major predictors of midterm and

127 troke, nonfemoral access, and postprocedural aortic regurgitation are predictors of adverse outcome,

128 ogression of discrete subaortic stenosis and aortic regurgitation, as well as reoperation.

129 Paravalvular aortic regurgitation at 30 days was moderate or higher i

130 with BAV had more frequently moderate/severe aortic regurgitation at first presentation compared with

131 ation at any level of >20% or more than mild aortic regurgitation at up to 4 years of follow-up.

132 1) undergoing operation for severe isolated aortic regurgitation between 1980 and 1989 were compared

133 and 198 men undergoing surgery for isolated aortic regurgitation between 1980 and 1989.

134 The VCW is a reliable measure of mitral and aortic regurgitation, but its value in measuring TR is u

135 for the quantification of aortic stenosis or aortic regurgitation by application of Doppler technique

136 Aortic regurgitation can be difficult to diagnose and qu

137 Chronic aortic regurgitation can lead to significant morbidity a

138 the outcome of aortic valve replacement for aortic regurgitation complicated by extreme left ventric

139 The outcome of aortic regurgitation conservatively followed in clinical

140 optimal timing of surgical repair in chronic aortic regurgitation continues to be a topic of interest

141 r aortic valve implantation patients without aortic regurgitation (correction) and transcatheter aort

142 wer rates of moderate or severe paravalvular aortic regurgitation: DAR </=10%, 17.6%; DAR 10% to 15%,

143 This study, using quantified aortic regurgitation, demonstrates that the flow converg

144 46 patients with severe or moderately severe aortic regurgitation diagnosed by color Doppler echocard

145 days, the incidence of moderate paravalvular aortic regurgitation did not increase, and no associatio

146 sment of hemostasis could be used to monitor aortic regurgitation during TAVR.

147 points included the presence of paravalvular aortic regurgitation evaluated by an independent echocar

148 o 27.2, 95% CI 1.2 to 619.6, p = 0.0386) and aortic regurgitation (GEE risk ratio 2.4, 95% CI 1.3 to

149 Aortic regurgitation grade > or = 3 (RR 4.27, p = 0.04)

150 (p = 0.02), and post-implant periprosthetic aortic regurgitation grade >/=2 of 4 (p < 0.001).

151 Post-procedure aortic regurgitation grade I or lower was present in 34

152 ent (10.0+/-3.4 vs 9.7+/-4.1 mm Hg; P=0.58), aortic regurgitation >/=2 of 4 (19.0% vs 14.9%; P=0.54),

153 Aortic regurgitation >/=mild after TAVR was associated w

154 Preimplantation aortic regurgitation >/=mild was associated with reduced

155 Patients with associated aortic regurgitation had a higher rate of decrease in MV

156 Doppler assessment of the progression of aortic regurgitation has been shown in larger studies th

157 than a century, numerous eponymous signs of aortic regurgitation have been described in textbooks an

158 Indications for surgical correction of aortic regurgitation have been established mostly in men

159 ft ventricular dilation and symptom onset in aortic regurgitation have been performed, with the data

160 asive methods for evaluating the severity of aortic regurgitation have not been accepted widely nor c

161 score (hazard ratio, 1.35), higher grades of aortic regurgitation (hazard ratio, 1.29), and higher ri

162 fidence interval [CI], 1.006-1.13; P = .03), aortic regurgitation (HR, 10.2; 95% CI, 3.2-32.2; P < .0

163 e subset of patients with no post-procedural aortic regurgitation (HR: 1.88; p = 0.02).

164 rative to precisely quantify the severity of aortic regurgitation immediately after valve implantatio

165 ast one grade in 17 patients (P = 0.001) and aortic regurgitation improved by at least one grade in 1

166 50 mm Hg in 65% of neonates and significant aortic regurgitation in 14%.

167 cardiography results demonstrated mild or no aortic regurgitation in 99% (73 of 74) with a mean gradi

168 Patients diagnosed with severe aortic regurgitation in clinical practice incur excess m

169 ence was primarily due to more frequent mild aortic regurgitation in dexfenfluramine patients (6.3% v

170 The indication for TV-in-TV was significant aortic regurgitation in most patients, often due not onl

171 OA, decreased ejection fraction, and greater aortic regurgitation in TAVR patients; and smaller left

172 ith pulmonary atresia and moderate or severe aortic regurgitation in univariate analyses, but no inde

173 Aortic regurgitation increased from trivial (none to mil

174 with aortic stenosis and nearly 5 years with aortic regurgitation; independent correlates included sm

175 Development of transcatheter approaches for aortic regurgitation is challenging, owing to the absenc

176 Moderate or severe aortic regurgitation is common after TAVR and an adverse

177 low tract gradient slowly increases and mild aortic regurgitation is common, although generally nonpr

178 tors, although stroke risk is equivalent and aortic regurgitation is less.

179 t textbook support of the eponymous signs of aortic regurgitation is not matched by the literature.

180 Extreme left ventricular dilation due to aortic regurgitation is observed in male patients and is

181 Similarly, moderate or severe aortic regurgitation is uncommon.

182 of surgery in asymptomatic mild to moderate aortic regurgitation may be predicted by indices of left

183 Forty-five patients with chronic aortic regurgitation (mean age 50+/-14 years) were studi

184 rupt onset of chest or back pain) and signs (aortic regurgitation murmur or pulse deficits) of dissec

185 aortic stenosis (n=14), dilated root without aortic regurgitation (n=15), and dilated root with aorti

186 regurgitation (n=15), and dilated root with aortic regurgitation (n=20).

187 ts with residual high shear or with residual aortic regurgitation, no recovery of HMW multimers was o

188 Among the 46 patients with aortic regurgitation, normalization occurred in 20 patie

189 Aortic regurgitation occurred in 10% of a sample group o

190 Moderate or severe aortic regurgitation occurred in 40 (14%) of 280 patient

191 Aortic regurgitation occurred more often in the last 20

192 Postprocedural aortic regurgitation occurs in 10 to 20% of patients und

193 annular sizing approach resulted in less PV aortic regurgitation of grade worse than mild after TAVR

194 eria of the Food and Drug Administration for aortic regurgitation of mild or greater severity and mit

195 djusted odds ratio compared with controls of aortic regurgitation of mild or greater severity increas

196 These analyses showed that aortic regurgitation of mild or greater severity occurre

197 Aortic regurgitation of mild or greater severity, mitral

198 Aortic regurgitation (of any degree) was present in 13.8

199 FDA-grade regurgitation (at least mild aortic regurgitation or at least moderate mitral regurgi

200 eter aortic valve implantation patients with aortic regurgitation or balloon valvuloplasty patients (

201 sion was more often associated with moderate aortic regurgitation or greater (odds ratio 2.4, 95% con

202 c regurgitation vs 56.6% for those with mild aortic regurgitation or less; p=0.003).

203 Drug Administration criteria (at least mild aortic regurgitation or moderate mitral regurgitation).

204 No patient had significant aortic regurgitation or other valvular disease.

205 type A IMH were less likely to present with aortic regurgitation or pulse deficits and were more lik

206 nd 1999 with ejection fraction > or =50% and aortic regurgitation or stenosis, absent or mild.

207 tenosis, severe mitral regurgitation, severe aortic regurgitation, or subaortic stenosis.

208 rgical criteria defined for aortic stenosis, aortic regurgitation, or the aorta are reached.

209 (p = 0.019), and more total and paravalvular aortic regurgitation (p < 0.0001).

210 Older patients more often had post-dilation aortic regurgitation (p < 0.001).

211 05) and there was a higher incidence of mild aortic regurgitation (p < 0.05).

212 in both dexfenfluramine groups had decreased aortic regurgitation (P = 0.003 for the dexfenfluramine

213 at aortic diameters increased with worsening aortic regurgitation (P:<0.001) and advancing age (P:<0.

214 imensions for the prediction of paravalvular aortic regurgitation (PAR) following transcatheter aorti

215 Paravalvular aortic regurgitation (PAR) negatively affects the progno

216 point-of-care assessment of peri-prosthetic aortic regurgitation (periAR) during transcatheter aorti

217 was a predictor for progression to moderate aortic regurgitation postoperatively.

218 Echocardiographic evidence suggests that aortic regurgitation regresses in some previously treate

219 y of requiring 2 valves and leaving residual aortic regurgitation remain important considerations.

220 echocardiography in the surgical timing for aortic regurgitation remains a matter of debate because

221 In asymptomatic aortic regurgitation, resting LV strain, resting RV stra

222 between the popliteal-brachial gradient and aortic regurgitation severity.

223 lity, suggesting that surgical correction of aortic regurgitation should be considered at an earlier

224 f mortality, strokes, and moderate or severe aortic regurgitation, TAVR was both non-inferior (pooled

225 tic valve dysfunction, men had more frequent aortic regurgitation than women (33.8% versus 22.2%, P<0

226 had baseline bicuspid aortic valve and mild aortic regurgitation that progressed to moderate regurgi

227 an important study in patients with chronic aortic regurgitation, the optimal timing of surgery in a

228 er of the aortic root; the rate of change in aortic regurgitation; the time to aortic dissection, aor

229 r adaptation occurs in patients with chronic aortic regurgitation to maintain left ventricular (LV) p

230 There were six cases of aortic regurgitation, two cases of mitral regurgitation,

231 chronic animal model with surgically created aortic regurgitation using a new semiautomated color Dop

232 the TAVR group (72.4% for moderate or severe aortic regurgitation vs 56.6% for those with mild aortic

233 as 8.5 +/- 5.6 mm Hg, and moderate or severe aortic regurgitation was 1.9% at discharge.

234 The prevalence of moderate or severe aortic regurgitation was 3.5% (95% confidence interval,

235 as 4.1%, and the incidence of periprosthetic aortic regurgitation was 64.5%.

236 Aortic regurgitation was assessed by color flow Doppler

237 For each steady state, the severity of aortic regurgitation was assessed by measurement of the

238 ultiple CT annular measures for post-TAVR PV aortic regurgitation was compared with 2D echocardiograp

239 itral regurgitation jet length>/=2 cm or any aortic regurgitation was considered best suited to be FC

240 At the end of the follow-up, trivial or no aortic regurgitation was demonstrated in 33.3%, mild in

241 nd Drug Administration criteria, significant aortic regurgitation was detected in 15 subjects (6.6%)

242 0.001), although moderate or severe residual aortic regurgitation was higher in TAVR patients (6.8% v

243 cedural months (19% versus 12%; P=0.01); but aortic regurgitation was less (34% versus 52% mild and 8

244 h severe aortic stenosis and complex anatomy aortic regurgitation was less than moderate in 99% of pa

245 frequency of moderate or severe paravalvular aortic regurgitation was lower 12 months after self-expa

246 Rate of mild aortic regurgitation was lower with the repositionable a

247 decrease, 35 mm Hg), and acute post-dilation aortic regurgitation was moderate or greater in 70 patie

248 spite relief of the obstruction, progressive aortic regurgitation was noted at follow-up after 14 pro

249 Mild aortic regurgitation was present in 68% but generally di

250 Mild or greater aortic regurgitation was present in 8.8% of treated pati

251 Aortic regurgitation was quantified using standard crite

252 Eight to 20 weeks after aortic regurgitation was surgically induced in six sheep

253 but progressive valve disease (predominantly aortic regurgitation) was identified in 17% of adult and

254 Nonfemoral access and postprocedural aortic regurgitation were also significant predictors of

255 AS gradient and lower grade of post-dilation aortic regurgitation were associated with longer freedom

256 ary artery disease, or greater than moderate aortic regurgitation were excluded.

257 Echocardiographic changes in aortic regurgitation were observed in 8 controls (7 [1.7

258 d to FDA-grade regurgitation or any grade of aortic regurgitation were older age, higher diastolic bl

259 es mellitus, and moderate to severe residual aortic regurgitation were significantly associated with

260 an gradient and incidence of moderate/severe aortic regurgitation were similar in both groups at 1 ye

261 Mean gradient, valve area, and residual aortic regurgitation were stable during follow-up.

262 ic valve replacement has been recommended in aortic regurgitation with extreme left ventricular dilat

263 f 92.3%, 92.4%, and 98.6%, respectively, for aortic regurgitation, with similar results in the valida

264 ement or repair, and 31 patients with native aortic regurgitation without coexisting aortic stenosis.