ライフサイエンスコーパス: aortic root

1 c plaques in both the carotid artery and the aortic root.

2 atherosclerotic lesions on cross sections of aortic root.

3 e tendon-bone attachments (entheses) and the aortic root.

4 ct rotation, which resulted in a dextroposed aortic root.

5 racic aorta was much less than that in mouse aortic root.

6 arteries via a catheter positioned into the aortic root.

7 m an ultrasonic flow probe placed around the aortic root.

8 e morphological/functional parameters of the aortic root.

9 lly reduced atherosclerosis in the aorta and aortic root.

10 times smaller atherosclerotic lesions in the aortic roots.

11 ice showed increased lesion size in both the aortic root (1.2-fold) and the aorta (1.6-fold), despite

12 of the thoracic aorta most pronounced at the aortic root (3.2+/-2.0 versus 9.1+/-4.7x10(-3) mm Hg(-1)

13 endocarditis/iatrogenic injury involving the aortic root (6.4% [n=5] versus 7.1% [n=9]; P=1.0).

14 n increased prevalence of BAV, their risk of aortic root abnormalities is unknown.

15 thetic valve endocarditis, complicated by an aortic root abscess.

16 h(+/+)/Ldlr(-/-) mice in the cross-sectional aortic root analysis.

17 of valvular calcification and distortion of aortic root anatomy in many patients.

18 ed significantly more atherosclerosis in the aortic root and abdominal aorta at all time points compa

19 ce had larger atherosclerotic lesions in the aortic root and aorta than did mice that had received co

20 ntly accelerated atherosclerosis at both the aortic root and aortic arch.

21 dentified by computed tomography such as the aortic root and arch and correlated with magnetic resona

22 6.7%, P<0.001) and diffuse dilatation of the aortic root and ascending aorta (16.2% versus 7.3%, P<0.

23 ls accumulated in the aorta, principally the aortic root and ascending aorta, of 10-wk-old ApoE(-/-)

24 bular junction, or diffuse dilatation of the aortic root and ascending aorta.

25 LA volumes correlated negatively with aortic root and ascending aortic distensibility and posi

26 are marked histological abnormalities in the aortic root and ascending aortic wall of patients with T

27 erotic plaques and neointimal lesions at the aortic root and descending aorta were markedly decreased

28 elation between functional parameters of the aortic root and expression of aortopathy in patients und

29 Macrophage content at the aortic root and in the aorta was reduced, as determined

30 Atherosclerotic lesions at the aortic root and plasma lipid levels of 234 female F2 mic

31 he assessment of peripheral vasculature, the aortic root and the annulus and optimal fluoroscopic pos

32 on of the atherosclerotic plaque size at the aortic root and the aorta for high-fat diet animals as c

33 In patients with dilated aortic root and trileaflet aortic valve, a ratio of aort

34 n, inflammation also develops in vivo at the aortic root and valve, which are structurally similar to

35 ination during ablation) were located in the aortic root and/or anteroseptal left ventricular endocar

36 es recommend prophylactic replacement of the aortic root and/or ascending aorta once the aortic diame

37 sectional atherosclerotic lesion area at the aortic root, and a genome scan was carried out with 192

38 tole (50%-60%) for the left coronary artery, aortic root, and ascending aorta.

39 soft tissue structures of the outflow tract, aortic root, and noncalcified valve cusps.

40 ry for aneurysm; surgical techniques for the aortic root; and surgical and endovascular management of

41 joint destruction, mutant mice also develop aortic root aneurism and aorto-mitral valve disease that

42 more, haploinsufficient Tgfb2(+/-) mice have aortic root aneurysm and biochemical evidence of increas

43 treatment of choice for young patients with aortic root aneurysm and normal or near-normal aortic cu

44 are an excellent option for patients with an aortic root aneurysm and normal/minimally diseased aorti

45 atients with Marfan syndrome operated on for aortic root aneurysm from 1988 through 2012 were followe

46 me the preferred surgical procedure to treat aortic root aneurysm in patients with Marfan syndrome, b

47 lticenter registry of patients who underwent aortic root aneurysm repair.

48 He later had an aortic root aneurysm that required surgical correction.

49 In 71%, an aortic root aneurysm was found.

50 for the most life-threatening manifestation, aortic root aneurysm, has led to a nearly normal lifespa

51 ssue disorder notable for the development of aortic root aneurysms and the subsequent life-threatenin

52 Young adults with aortic root aneurysms associated with genetic syndromes

53 ons for the timing of surgical repair of the aortic root aneurysms may be overly aggressive.

54 lve graft (CVG) procedures for patients with aortic root aneurysms, comparative long-term outcomes ar

55 generated from images of a C-arm rotational aortic root angiogram during breath-hold, rapid ventricu

56 nificantly larger atherosclerotic lesions in aortic roots, aortic arches, and abdominal aortas.

57 This was broadly observed in aortic root, arch, and total aorta of male mice, whereas

58 ow with oscillation in branch points and the aortic root are athero-prone, in part, because of the di

59 A ratio of aortic root area over height was calculated (cm(2)/m) on

60 root and trileaflet aortic valve, a ratio of aortic root area to height provides independent and impr

61 e atherosclerotic lesions in whole aorta and aortic root area, with markedly increased SRA expression

62 For longer-term mortality, the addition of aortic root area/height ratio >/=10 cm(2)/m to a clinica

63 tivariable Cox proportional hazard analysis, aortic root area/height ratio (hazard ratio, 4.04; 95% c

64 Aortic root area/height ratio was >/=10 cm(2)/m in 24%.

65 between 4.5 and 5.5 cm, 44% had an abnormal aortic root area/height ratio, of which 78% died.

66 mpared with controls, patients had increased aortic root areas (602.6+/-240.5 versus 356.8+/-113.4 mm

67 ensibility, and beta-stiffness index) at the aortic root, ascending aorta, and descending aorta.

68 mice accumulated even more monocytes in the aortic root, ascending aorta, and thoracic aorta after b

69 percent of patients initially presented with aortic root, ascending aortic or arch lesions, whereas 8

70 Measured circumference of the aortic root at the sinotubular junction and at the ascen

71 -deficient ApoE(-/-)Rag2(-/-) mice augmented aortic root atherosclerosis by approximately 75% that wa

72 nti-CD4 depletion has no additive effects on aortic root atherosclerosis.

73 ) and MKP-1(-/-) mice had significantly less aortic root atherosclerotic lesion formation than MKP-1(

74 On both diets, en face and aortic root atherosclerotic lesions in sIgM.Ldlr(-/-) mi

75 ck-out mice (Ldlr(-/-)), they develop larger aortic root atherosclerotic lesions than Ldlr(-/-) contr

76 Aortic root autograft plus arterial switch procedure is

77 1 years (median age 7 months) have undergone aortic root autograft translocation plus arterial switch

78 herosclerotic plaques in the aortic arch and aortic roots, but showed little difference in plaque bur

79 G2A deficiency increased lesion size in the aortic root by 50%.

80 e in pulse pressure was related to a smaller aortic root (by 0.19 mm in men and 0.08 mm in women) aft

81 body mass index was associated with a larger aortic root (by 0.78 mm in men and 0.51 mm in women) aft

82 increase in age was associated with a larger aortic root (by 0.89 mm in men and 0.68 mm in women) aft

83 e stress, atherosclerotic lesion size in the aortic roots, cell proliferation, and adhesion molecule

84 Aortic root circumference to left ventricular index and

85 reductions in lesion formation in aortas and aortic roots compared with controls.

86 l, 2.67-26.33; P<0.001) were associated with aortic root contained/noncontained rupture.

87 by Oil Red O staining of en face aortas and aortic root cross-sections, and changed plaque compositi

88 ts with repaired tetralogy of Fallot have an aortic root diameter >/=40 mm, the prevalence of a dilat

89 root diameter were associated with childhood aortic root diameter (difference per additional average

90 Genetic risk scores based on SNPs for aortic root diameter and pulse pressure in adults are as

91 hletes have a small but significantly larger aortic root diameter at the sinuses of Valsalva and aort

92 Of the 327 patients with aortic root diameter between 4.5 and 5.5 cm, 44% had an

93 The maximal aortic root diameter in the cohort was 42 mm.

94 Aortic root diameter increased with age in both men and

95 On meta-regression, the weighted mean aortic root diameter measured at the sinuses of Valsalva

96 pants of the Framingham Heart Study to track aortic root diameter over 16 years in mid to late adulth

97 Additionally, aortic root diameter prior to or at the time of type A a

98 Weighted and unweighted risk scores for aortic root diameter were associated with childhood aort

99 as calculated as change in echocardiographic aortic root diameter z score per year.

100 icular end-diastolic diameter and 5 SNPs for aortic root diameter) and blood pressure outcomes (29 SN

101 tterns and function; left atrial volume; and aortic root diameter.

102 608766 in GOSR2, and rs17696696 in CFDP1 for aortic root diameter; and rs12440869 in IQCH for Doppler

103 therapy by comparing the rates of change in aortic-root diameter before and after the initiation of

104 The mean (+/-SD) rate of change in aortic-root diameter decreased significantly from 3.54+/

105 less than zero, indicating a decrease in the aortic-root diameter relative to body-surface area with

106 ment, expressed as the change in the maximum aortic-root-diameter z score indexed to body-surface are

107 ved between circulating TGF-beta1 levels and aortic root diameters in Fbn1(C1039G/+) and wild-type mi

108 Aortic root diameters reached a plateau at the uppermost

109 Maximum end-diastolic aortic root diameters were measured in the parasternal l

110 males were more likely than females to have aortic root dilatation (92% versus 84%), aortic regurgit

111 Reduced aortic bioelasticity and aortic root dilatation are present in transposition of t

112 o determine the prevalence and predictors of aortic root dilatation in adults with repaired tetralogy

113 evaluating athletes should know that marked aortic root dilatation likely represents a pathological

114 Overall, losartan significantly reduced aortic root dilatation rate (no losartan, 1.3+/-1.5 mm/3

115 onsive to losartan therapy for inhibition of aortic root dilatation rate compared with dominant negat

116 However, losartan reduced only aortic root dilatation rate in haploinsufficient patient

117 phenotypic features, including prevalence of aortic root dilatation.

118 are an important causative factor leading to aortic root dilatation.

119 gesting a causative mechanism for subsequent aortic root dilatation.

120 und no significant difference in the rate of aortic-root dilatation between the two treatment groups

121 rocedure owing to severe neo-AI (n = 7), neo-aortic root dilation (n = 1), and neo-aortic pseudoaneur

122 onger follow-up time was associated with neo-aortic root dilation (p < 0.0001).

123 spectrum of severity and are associated with aortic root dilation across age groups.

124 ac manifestations of Marfan syndrome include aortic root dilation and mitral valve prolapse (MVP).

125 lve abnormalities and their association with aortic root dilation are not available.

126 ies are common; 10) aortic regurgitation and aortic root dilation are well tolerated; and 11) the agi

127 ellae in the ascending aorta and progressive aortic root dilation as assessed by echocardiography tha

128 Rate of aortic root dilation before cardiac MRI was calculated a

129 cal armamentarium for treating patients with aortic root dilation caused by a variety of disorders.

130 , and ascending aorta in the BAV group, with aortic root dilation in 25% of subjects with BAV versus

131 her rates of surgical aortic replacement and aortic root dilation in children and young adults with C

132 MRI, surgical root replacement, and rates of aortic root dilation in children and young adults with C

133 ssion accelerates atherosclerosis and causes aortic root dilation in fat-fed Ldlr(-/-) mice (as we pr

134 dysfunction, mitral regurgitation (MR), and aortic root dilation occur early after diagnosis; their

135 nce remained significant in subjects without aortic root dilation or hypertension (p = 0.002 and p =

136 d atherosclerotic plaque growth and promoted aortic root dilation through Plg-dependent pathways.

137 The prevalence of aortic root dilation was 32% in FDRs and 53% in BAV pati

138 Neo-aortic root dilation was not associated with neo-AI or r

139 nosis, MR was present in 27% of subjects and aortic root dilation was present in 8%; each was associa

140 ocedures, which preserve the aortic cusps in aortic root dilation with aortic insufficiency.

141 ionships among early LV dysfunction, MR, and aortic root dilation with coronary artery dilation and l

142 lve disease, including aortic regurgitation, aortic root dilation, hypertension, coronary artery dise

143 uals with abnormal valvular structure and/or aortic root dilation.

144 P=0.02) was associated with a higher rate of aortic root dilation.

145 There was no progression of aortic root dilation.

146 significantly slowed the rate of progressive aortic-root dilation.

147 The prevalence of an observed-to-expected aortic root dimension ratio >1.5 was 6.6% (95% confidenc

148 The aortic root dimension was >/=40 mm in 28.9% (95% confide

149 e of the aortic arch was not associated with aortic root dimension.

150 these studies met our criteria by reporting aortic root dimensions at the aortic valve annulus or si

151 mine whethere athletes demonstrate increased aortic root dimensions compared with nonathlete controls

152 We identified 71 studies reporting aortic root dimensions in 8564 unique athletes, but only

153 Aortic root dimensions in healthy elite athletes are wit

154 Aortic root dimensions were measured by MRI at baseline

155 re aortic root replacement in the absence of aortic root disease are associated with poorer outcomes.

156 Proximal aortic root disease seems to protect against arterioscle

157 Mice underwent euthanasia and aortic root dissection.

158 Aortic-root dissection is the leading cause of death in

159 rsus 41.1+/-6.0; P<0.01) and correlated with aortic root distensibility (P=0.004).

160 developed early fatty streak lesions in the aortic root, elevated plasma levels of cholesterol and l

161 Surgical aortic root enlargement (ARE) during aortic valve replac

162 estations: a prolapsed mitral valve, myopia, aortic root enlargement, and skeletal and skin manifesta

163 The deviation of aortic-root enlargement from normal, as expressed by the

164 use models of Marfan's syndrome suggest that aortic-root enlargement is caused by excessive signaling

165 The primary outcome was the rate of aortic-root enlargement, expressed as the change in the

166 Studies suggest that with regard to slowing aortic-root enlargement, losartan may be more effective

167 tients with Marfan's syndrome who had severe aortic-root enlargement.

168 al therapy had failed to prevent progressive aortic-root enlargement.

169 bjective three-dimensional assessment of the aortic root, evaluation of the iliofemoral access route,

170 on of the aortic valve and remodeling of the aortic root) expanded the surgical armamentarium for tre

171 Atherosclerotic lesions in the aortic root, fasting plasma glucose, and body weight wer

172 al angiographic reconstructions (3DA) of the aortic root for prediction of the optimal deployment ang

173 Automated quantitative 3D modeling of the aortic root from 3D TEE or CT data is technically feasib

174 nal (3D) algorithm to model and quantify the aortic root from 3D transesophageal echocardiography (TE

175 studied consecutive patients with a dilated aortic root (>/=4 cm) that underwent echocardiography an

176 In the aortic root, HF-fed vitamin D-deficient mice had increas

177 Contained rupture of the aortic root in balloon-expandable TAVI is associated wit

178 potential cause of contained rupture of the aortic root in balloon-expandable transcatheter aortic v

179 dilation and abnormal elastic properties of aortic root in first-degree relatives (FDRs) of bicuspid

180 ogenic damage of different structures of the aortic root, in the region of the so-called "device land

181 ustained skin-specific inflammation promotes aortic root inflammation and thrombosis and suggest that

182 el of psoriasiform skin disease, spontaneous aortic root inflammation was observed in 33% of KC-Tie2

183 Dilatation of the aortic root is a known feature in tetralogy of Fallot (T

184 The aortic root is functionally abnormal and dilation is com

185 Progressive enlargement of the aortic root, leading to dissection, is the main cause of

186 etween the left ventricular outflow axis and aortic root (left ventricle/aorta angle) in both groups

187 ransgenic mice resulted in a 73% increase in aortic root lesion area compared with recipients of NKT

188 oOS in lesional macrophages, correlates with aortic root lesion development.

189 had significantly decreased cross-sectional aortic root lesion fraction area and reduced lesion comp

190 inated skin inflammation and the presence of aortic root lesion in 1-year-old KC-Tie2 animals.

191 The greater aortic root lesion size in C1qa-/-/Ldlr-/- mice occurred

192 A significant QTL for aortic root lesion size was on chromosome 9 (61 Mb, LOD=

193 , and this led to a significant reduction in aortic root lesional area.

194 flammation markers, including macrophages in aortic root lesions and chemokine expression in aortic t

195 uced both en face aortic lesion coverage and aortic root lesions compared with recipients of bone mar

196 Aortic root lesions from the pioglitazone-treated mice s

197 lesions: at 20 weeks of age, the size of the aortic root lesions in Thbs4(-/-)/ApoE(-/-) mice was dec

198 Increased apoptosis was observed in aortic root lesions of both sIgM.Ldlr(-/-) and C1qa.Ldlr

199 sed lipid burden and neointimal thickness in aortic root lesions of hyperglycemic ApoE(-/-) mice; als

200 undant staining for nitrated proteins in the aortic root lesions of LA-apoA-I(-/-) as compared with t

201 Aortic root lesions were threefold larger in C1qa-/-/Ldl

202 and increased smooth muscle cell content in aortic root lesions.

203 a, with markedly increased SRA expression in aortic root lesions.

204 r in males than in females (P<0.0001) at all aortic root levels.

205 Aortic root magnetic resonance imaging was performed aft

206 and diminishes the macrophage content in the aortic root of ApoE(-/-) mice.

207 RI revealed high uptake of (89)Zr-DNP in the aortic root of apolipoprotein E knock out (ApoE(-/-)) mi

208 Histological analyses of the aortic root of both groups revealed similar plaque size

209 or saline revealed signal enhancement in the aortic root of mice receiving VINP-28 (P<0.05).

210 librated aortic flow probe placed around the aortic root on a beat-to-beat basis in seven anesthetize

211 Dilatation of the aortic root only (type 1) or involving the entire AAo an

212 eneral, most effectively approached from the aortic root or anteroseptal left ventricular endocardium

213 Failure to extend the primary surgery to aortic root or arch repair leads to a highly complex cli

214 with regard to the recommended threshold of aortic root or ascending aortic dilatation that would ju

215 nnulus can be treated with remodeling of the aortic root or with reimplantation of the aortic valve.

216 able correlation patterns between functional aortic root parameters and expression of aortopathy are

217 Although aortic root pathology has been described in patients wit

218 nd Marfan syndrome, initial valve-preserving aortic root reconstruction, and need for a concomitant p

219 surgery, the replacement of multiple valves, aortic root reconstruction, or reconstruction of the asc

220 decreased atherosclerotic lesion size at the aortic root region, the entire aorta, and the innominate

221 Aortic root remodeling in adulthood is known to be assoc

222 longitudinal community-based data show that aortic root remodeling occurs over mid to late adulthood

223 nal data defining the clinical correlates of aortic root remodeling over the adult life course.

224 Freedom from need for aortic root reoperation in patients who underwent primar

225 sus 36%), and to have undergone prophylactic aortic root replacement (47% versus 24%), all P<0.001.

226 fore compared these outcomes after autograft aortic root replacement (Ross procedure) versus homograf

227 Prophylactic aortic root replacement and mitral valve surgery were ra

228 ts with Marfan syndrome who undergo elective aortic root replacement have MVP, only 20% have concomit

229 ve required replacement in 21 cases (38) and aortic root replacement in 21 (38), with ascending aorti

230 eplacement (Ross procedure) versus homograft aortic root replacement in adults.

231 ratio to receive an autograft or a homograft aortic root replacement in one centre in the UK.

232 Prosthetic heart valves (PHVs) that require aortic root replacement in the absence of aortic root di

233 m survival after stentless porcine xenograft aortic root replacement is equivalent to that after a me

234 Aortic root replacement or repair is highly recommended

235 ly a composite valved graft or valve-sparing aortic root replacement procedure was 95+/-3%, 88+/-5%,

236 in patients with Marfan syndrome undergoing aortic root replacement.

237 ially in men and after previous prophylactic aortic root replacement.

238 rongly associated with previous prophylactic aortic root replacement.

239 igned to receive an autograft or a homograft aortic root replacement.

240 to undergo homograft versus freestyle total aortic root replacement.

241 lcification is an important limitation after aortic root replacement.

242 (P=0.01) were independently associated with aortic root replacement.

243 t 16 of 83 (19%) patients underwent surgical aortic root replacement.

244 ary ascending replacement, 15% valve-sparing aortic root replacement; 12% total arch replacement; 3%

245 In both groups, histological analyses of the aortic root revealed similar plaque size and macrophage

246 We sought to identify predictors of aortic root rupture during balloon-expandable TAVR by us

247 ing are associated with an increased risk of aortic root rupture during TAVR with balloon-expandable

248 Aortic root rupture is a major concern with balloon-expa

249 ets were available in 65 patients; contained aortic root rupture was diagnosed in 3 patients.

250 Aortic root rupture was identified in 20 patients and pe

251 Atherosclerosis development was assessed in aortic root sections after 4 weeks of high-fat diet, whe

252 Histology of the aortic root showed progression of lesions to the fibroat

253 or mean aortic gradient and independently of aortic root size (all P<0.05).

254 es than in the nonathletic controls, whereas aortic root size at the aortic valve annulus was 1.6 mm

255 Aortic root size had little association with inflammator

256 , for English-language studies reporting the aortic root size in elite athletes.

257 term follow-up after the Ross procedure, neo-aortic root size increases significantly out of proporti

258 rsely, in patients without previous surgery, aortic root size was greater in patients with subsequent

259 Aortic root size was measured by echocardiography.

260 erum uric acid levels, mean platelet volume, aortic root size, and heart failure.

261 ith variation in LV diastolic dimensions and aortic root size, but such findings explained a very sma

262 q23, 12p12, 12q14, and 17p13 associated with aortic root size, explaining 1%-3% of trait variance).

263 was to describe the relationship between neo-aortic root size, neo-aortic insufficiency (AI), and rei

264 with LV mass and wall thickness, and 8 with aortic root size.

265 Aortic root specimens were collected for biochemical and

266 In multivariable analysis, lower aortic root strain (P=0.05) and higher vertebral tortuos

267 d without aortic stenosis underwent elective aortic root surgery (AVS, n = 253; CVG with a bioprosthe

268 ome, in an immunocompetent patient following aortic root surgery.

269 The 3-year rates of aortic-root surgery, aortic dissection, death, and a com

270 egurgitation; the time to aortic dissection, aortic-root surgery, or death; somatic growth; and the i

271 the long-term results of alternatives to the aortic root technique for implantation (i.e., subcoronar

272 neutral lipid and CD68+ infiltration in the aortic root than LDLr(-/-) mice.

273 In the aortic root, the mean MPO-Gd CNRs after agent injection

274 te of change in the absolute diameter of the aortic root; the rate of change in aortic regurgitation;

275 d (2) incremental prognostic use of indexing aortic root to patient height.

276 e incremental prognostic utility of indexing aortic root to patient height.

277 ion of homografts versus Medtronic freestyle aortic roots to determine the functional consequences an

278 to report our intermediate-term results with aortic root translocation plus arterial switch for d-tra

279 type 1, dilation of the ascending aorta and aortic root; type 2, isolated dilation of the ascending

280 There is limited information regarding the aortic root upper physiological limits in all planes in

281 ic and electrophysiologic characteristics of aortic root ventricular arrhythmias (VAs).

282 ce compared with Ldlr-/- mice (3.72 +/- 1.0% aortic root versus 1.1 +/- 0.4%; mean +/- SEM, P < 0.001

283 The native aortic root was excised from the right ventricle infundi

284 Lesion area at the aortic root was increased by STZ treatment alone but was

285 The aortic root was measured in a parasternal long-axis view

286 e was performed in 121 and remodeling of the aortic root was performed in 25 patients.

287 In 1447 patients (69%), the aortic root was preserved and supracoronary replacement

288 Collagen content in plaques in the aortic root was reduced, suggesting an alteration of smo

289 Atherosclerotic lesion size at the aortic root was similar between all groups.

290 -) mice, AdvSca1 cells normally found at the aortic root were either absent or greatly diminished in

291 Serial sections from the aortic root were examined for fatty streak formation.

292 meters of advanced plaque progression in the aortic root were quantified.

293 and the development of lipid streaks in the aortic roots when fed a regular diet and at normal plasm

294 ameter >/=40 mm, the prevalence of a dilated aortic root, when defined by an indexed ratio of observe

295 ncreased numbers of apoptotic cells in their aortic roots, which correlated with altered lipid profil

296 Freedom from neo-aortic root z-score >4 was only 3% and from moderate or

297 -adjusted rate of change in the mean (+/-SE) aortic-root z score did not differ significantly between

298 6.2 years in the losartan group), who had an aortic-root z score greater than 3.0.

299 ore indexed to body-surface area (hereafter, aortic-root z score) over a 3-year period.

300 was disproportionate enlargement of the neo-aortic root (z-score increase of 0.75/year [p < 0.0001])