ライフサイエンスコーパス: aortic stiffness

1 carotid and femoral arteries as a measure of aortic stiffness.

2 ident stroke independently of CV factors and aortic stiffness.

3 stroke risk prediction beyond Framingham and aortic stiffness.

4 n is predominantly correlated with increased aortic stiffness.

5 se wave velocity (aPWV), a robust measure of aortic stiffness.

6 this effect correlates with the decrease in aortic stiffness.

7 s likely account for the greater increase in aortic stiffness.

8 cancer therapy adversely increases thoracic aortic stiffness, a known independent predictor of adver

9 thesized that anthracycline use may increase aortic stiffness, a known predictor of CV events.

10 Increased aortic stiffness, a major mechanical factor predicting C

11 content and improved its solubility, reduced aortic stiffness, ameliorated diabetic nephrosclerosis,

12 Rationale: Increased aortic stiffness, an important feature of many vascular

13 The association between aortic stiffness and all-cause mortality in kidney trans

14 es a measure of systemic arterial stiffness, aortic stiffness and central arterial pressure.

15 (PMAP), peripheral vascular resistance, AIx, aortic stiffness and central pulse pressure, but only an

16 ur results suggest that associations between aortic stiffness and CVD events are mediated by pathways

17 analyses, 8% to 13% of the relation between aortic stiffness and CVD events was mediated by hyperemi

18 WD feeding resulted in aortic stiffness and endothelial dysfunction as determin

19 onsistent with the hypothesis that increased aortic stiffness and excessive flow pulsatility damage t

20 ysis showed that 34% of the relation between aortic stiffness and GFR was mediated by pulsatility ind

21 for pulsatility index, the relation between aortic stiffness and GFR was no longer significant (P=0.

22 However, the relationship between aortic stiffness and HCM has not been studied previously

23 Our findings indicate that abnormal aortic stiffness and increased pressure pulsatility are

24 Both training modes reduced aortic stiffness and increased whole body insulin sensit

25 and determine their relationship to central aortic stiffness and left ventricular (LV) remodeling.

26 ions of total arterial and proximal thoracic aortic stiffness and LV mass.

27 Adult OHF animals showed increased aortic stiffness and reduced endothelium-dependent relax

28 Aortic stiffness and small-artery structure and function

29 arable with EDS patients, they had decreased aortic stiffness and tensile strength and hyperextensibl

30 Inter-relations of aortic stiffness and vasodilator function with incident

31 ators of vascular phenotype severity such as aortic stiffness and vertebral tortuosity index have bee

32 ining reversed the reduction in E/A, reduced aortic stiffness, and eliminated impairment of coronary

33 yocardial inflammation, myocardial fibrosis, aortic stiffness, and pericardial fat volume.

34 ntral pulse pressure (PP), PP amplification, aortic stiffness, and wave reflections.

35 prevalence and correlates of abnormally high aortic stiffness are incompletely understood.

36 nd without myocardial fibrosis, have altered aortic stiffness as assessed by magnetic resonance imagi

37 d whether this association is independent of aortic stiffness as estimated by carotid-femoral pulse w

38 Increased aortic stiffness, as indicated by increased PWV, is evid

39 Aortic stiffness, as represented by the pressure strain

40 Higher aortic stiffness assessed by PWV is associated with incr

41 creased filling pressures were correlated to aortic stiffness (augmentation pressure and index, P<0.0

42 terial tonometry, we evaluated 3 measures of aortic stiffness: brachial pulse pressure; carotid-femor

43 We assessed the relation between aortic stiffness by cardiac MRI, surgical root replaceme

44 P amplification, mainly related to increased aortic stiffness, contributes to the significant increas

45 In addition, increased aortic stiffness correlates with myocardial fibrosis, an

46 al pulse wave velocity, a measure of central aortic stiffness, decreased after cranberry juice (8.3 +

47 Because aortic stiffness depends on the prevailing blood pressur

48 inear relationship of PMAP with both AIx and aortic stiffness did not differ significantly between dr

49 In this cohort, higher aortic stiffness, FWA, and augmentation index were assoc

50 ansplant recipients (KTRs) is uncertain, and aortic stiffness has not yet been incorporated into risk

51 Abnormal aortic stiffness implies an unfavorable prognosis and ha

52 of microvascular structure and function, and aortic stiffness in 2045 participants (1107 women, mean

53 aortic arch is related to increased proximal aortic stiffness in individuals without cardiovascular d

54 elationship between telomere length (TL) and aortic stiffness in well-characterized, younger and olde

55 PWV was higher (i.e., increased aortic stiffness) in HCM patients with myocardial fibros

56 nt for age, important correlates of abnormal aortic stiffness included higher mean arterial pressure,

57 n the participants receiving anthracyclines, aortic stiffness increased markedly (relative to baselin

58 eys (Macaca fascicularis) (n=7/group), where aortic stiffness increases by 200% in vivo.

59 The prevalence of abnormal aortic stiffness increases steeply with advancing age in

60 Aortic stiffness increases with age and vascular risk fa

61 Increased pulse pressure, a reflection of aortic stiffness, increases cardiac load and may increas

62 - 1.6 x 10(-3) mm Hg, p < 0.001) and greater aortic stiffness index (26.7 +/- 25.8 and 55.9 +/- 76.8

63 Thus, whereas aortic stiffness is a known independent predictor of mor

64 Higher aortic stiffness is associated with higher rates of surg

65 Increased aortic stiffness is associated with numerous common dise

66 t that the burden of disease attributable to aortic stiffness is likely to increase considerably over

67 atrilat compared with enalapril suggest that aortic stiffness is maintained by specific, partially re

68 The resultant increase in aortic stiffness likely further worsens systolic hyperte

69 ese analyses provide the first evidence that aortic stiffness may contribute to lower GFR by transfer

70 dation of the role this novel locus plays in aortic stiffness may facilitate development of therapeut

71 ch as renal dysfunction and enhanced central aortic stiffness may play an important role in the devel

72 Aortic stiffness, measured by pulse wave velocity, was a

73 ng adults with a CTD was performed to derive aortic stiffness measures (strain, distensibility, and b

74 We evaluated 2 aortic stiffness measures, carotid-femoral pulse wave ve

75 erations in left ventricular function and in aortic stiffness occur during the early phase of aneurys

76 CONCLUSION A significant increase in aortic stiffness occurs within 4 months of exposure to a

77 id profile, adipose tissue inflammation, and aortic stiffness of LCR rats.

78 individuals (<50 years), whereas changes in aortic stiffness per se are more marked in older individ

79 These changes in aortic stiffness persisted after accounting for age, sex

80 in left ventricular stroke volume (LVSV) and aortic stiffness predict future pulmonary edema.

81 E/A), myocardial performance index (MPI) and aortic stiffness (pulse wave velocity; PWV) were evaluat

82 n IVRT, a 64% decrease in E/A, and increased aortic stiffness (PWV: 6.36 +/- 0.47 vs.4.89 +/- 0.41, O

83 ral hemodynamic parameters involve increased aortic stiffness, reduced wave reflections, and increase

84 sis factor-alpha therapy and correlates with aortic stiffness reduction.

85 cognitive impairment in the presence of high aortic stiffness remain unclear.

86 Results At the 4-month follow-up visit, aortic stiffness remained similar to baseline in the con

87 te this, the role of FFAs in obesity-related aortic stiffness remains unclear.

88 were independently associated with increased aortic stiffness, renal injury, and incident cardiovascu

89 lying clinical conditions known to influence aortic stiffness, such as hypertension or diabetes (P <

90 st, however, after additional adjustment for aortic stiffness, suggesting a shared causal pathway.

91 Aortic stiffness tended to decrease, but FMD was not cha

92 Increased aortic stiffness that decreases LVSV during adrenergic s

93 h IFG to prevent LV hypertrophy and abnormal aortic stiffness that is observed in middle-aged and old

94 e velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increa

95 ected five highly significant QTLs affecting aortic stiffness: two interacting QTLs (AS-m1 on chromos

96 The WD-induced aortic stiffness was associated with enhanced endothelia

97 Higher aortic stiffness was associated with higher LV mass, ind

98 cardiovascular disease risk factors, higher aortic stiffness was associated with increased LV mass (

99 Higher aortic stiffness was associated with older age, higher s

100 for mean arterial pressure, each measure of aortic stiffness was associated with reduced hyperemic f

101 Aortic stiffness was evaluated as the product of Young's

102 Assessment of aortic stiffness was evaluated by measuring pulse wave v

103 modify arterial stiffness, proximal thoracic aortic stiffness was not increased in those with IFG com

104 ted for age, sex, heart rate, and body size, aortic stiffness was related to GFR (Slope of regression

105 pulse wave velocity, which reflects central aortic stiffness, was statistically significantly lower

106 in which factors known to influence thoracic aortic stiffness were included as covariates in the mode

107 Correlates of aortic stiffness were similar if we used age-specific ra

108 trophy, diastolic dysfunction, and increased aortic stiffness, which are independent predictors of ca

109 rmal (9.2 +/- 2.2 m/s), indicating increased aortic stiffness, which strongly correlated with NT-proB

110 H patients have increased apparent ascending aortic stiffness, which was strongly associated with the

111 anges in vascular properties responsible for aortic stiffness with aging would be greater in old male

112 Proximal aortic stiffness (Z(c)) is greater in women than men, an