ライフサイエンスコーパス: apex

1 direct injection (d-DIHEN) and desolvation (APEX).

2 es using an engineered ascorbate peroxidase (APEX).

3 ia-targeted proximity labeling enzyme (cilia-APEX).

4 ost common site of reactivation disease (the apex).

5 ated by engineered ascorbic acid peroxidase (APEX).

6 mixing with cold seawater at the tufa-column-apex.

7 es PIN3, promoting auxin accumulation in the apex.

8 was a complete triangle reaching the orbital apex.

9 t base and the pattern reversed at the crypt apex.

10 resulting from an intricate heat flow at the apex.

11 s driven by lateral inhibitions at the shoot apex.

12 develop a mass of callus tissue at the shoot apex.

13 ferating and endocycling domains of the root apex.

14 onsistent with newly synthesized wall at the apex.

15 at decreased blood flow is restricted to the apex.

16 in extensive infection patches at the nodule apex.

17 cell division plane orientation at the shoot apex.

18 gulator of stem cell activation at the shoot apex.

19 gen species-activated cation currents in the apex.

20 e; and 4) BT 5 and 10 mm apical to the tooth apex.

21 unogens that elicit antibodies to the trimer apex.

22 ng control cell differentiation at the shoot apex.

23 tress with cell differentiation at the shoot apex.

24 ces a permanent dipole oriented from base to apex.

25 domain-general networks with the LFPC at the apex.

26 pecifically from epidermal cells of the root apex.

27 n the left ventricle, most frequently at the apex.

28 recognizes the trimer at its membrane-distal apex.

29 lower levels in nuclei further away from the apex.

30 fic cell populations within the primary root apex.

31 immunopathology and transmission at the lung apex.

32 bsolutely conserved cysteine residues at its apex.

33 olar localization of proteins at the growing apex.

34 in a wave from the chamber base towards its apex.

35 ry structure-dependent epitope at the trimer apex.

36 the cortical actin fringe at the pollen tube apex.

37 ling times for MTs after reaching the hyphal apex.

38 trate both exocytosis and endocytosis at the apex.

39 h nanoscale tips are insulated except at the apex.

40 , which ultimately focuses exocytosis at the apex.

41 after physical contact with the pollen tube apex.

42 time" of the electron gas temperature at the apex.

43 ed by V1V2 loops that interact at the trimer apex.

44 hallus shape given growth suppression at the apex.

45 s from the level of the prostate base to the apex.

46 rriers by slowing down plasmons at the taper apex.

47 ilization of the distal region of the trimer apex.

48 ndergo binary collisions beneath the surface apexes.

49 cally lower H(+)-ATPase activity in the root apex, (2) greater salt-induced membrane depolarization,

50 ) and regionally: they were decreased in the apex (-8.5% versus -17.1%; P<0.0001) and mid segments (-

51 res that would be somehow limited by the tip apex, a statement well accepted for the past 2 decades.

52 helium formation is completely absent in the apex and all three cristae of the semicircular canal amp

53 crotubule plus ends extend toward the cell's apex and base with a region of antiparallel microtubule

54 ea varies substantially between the cochlear apex and base.

55 port primary wall synthesis occurring at the apex and discrete distal regions of the tip.

56 with an empowered, highly capable WHO at its apex and enduring, equitable national health systems at

57 from xylem, allowing the toxic ion to reach apex and flowers.

58 re assessed for PAPVR or TAPVR, PDA, cardiac apex and heart chambers, interatrial or interventricular

59 nces arise when the relative position of tip apex and molecule changes by a fraction of the molecule

60 CM, LVH was frequently (36%) confined to the apex and only 15 individuals (14%) exhibited mild concen

61 the severe alterations observed in the shoot apex and reproductive organs under salinity conditions.

62 y and clinically, are lesions around implant apex and sinus tract.

63 ghly sequence diverse, is located at the Env apex and stabilizes the trimeric gp120 spike on the viri

64 highest levels in the nucleus closest to the apex and successively lower levels in nuclei further awa

65 escribed a bnAb lineage targeting the Env V2 apex and the Ab-Env co-evolution that led to development

66 nces between the epicardial border of the LV apex and the midpoint of a line connecting the origins o

67 preferentially involved the left ventricular apex and the midwall.

68 s, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide

69 ween the Q/R editing site near the pore loop apex and the transmembrane M3 helix of kainate receptor

70 e expression and cell mechanics at the shoot apex and, by extension, in the epidermis of any thick ti

71 (mAbs) indicated major contacts with the V2 apex, and 3D electron microscopy reconstructions of Fab-

72 ther to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at sequentially lower

73 t-Golgi carriers undergoing transport to the apex, and hypA encodes Trs120.

74 n the right atrium, at the right ventricular apex, and in a coronary vein.

75 detail the functional role of the hypocotyl apex, and the regions surrounding it, in establishing ph

76 The Dirac cone apex appears at different binding energies and exhibits

77 e show that salinity application to the root apex arrests root growth in a highly tissue- and treatme

78 s: (i) identification of the HIV envelope V2 apex as a new in vivo protective epitope, (ii) a novel c

79 l, Mick and colleagues (2015) describe cilia-APEX as an approach to provide dynamic "snapshots" of th

80 ng approach therefore excludes the hypocotyl apex as the site for light perception for phototropism a

81 recombination events, an alternative mode of apex binding has been sought.

82 lineage thus identifies a solution for V1V2-apex binding that provides a more conventional B cell pa

83 y while improving the presentation of trimer apex bNAb epitopes.

84 could serve as an immunogen to initiate a V2-apex bnAb response.

85 tion of immunization strategies to induce V2 apex bnAb responses.

86 oscopy, we solved the atomic structure of an apex bnAb, PGT145, in complex with Env.

87 G9, CH01, PGT145, and CAP256.VRC26.09) of V2 apex bnAbs and showed that all recognized a core epitope

88 V2-apex bNAbs are derived from rare precursors with long an

89 The evolution of apex bnAbs from one donor (CAP256) has been studied in d

90 Apex broadly neutralizing HIV antibodies (bnAbs) recogni

91 (out of 25 detected) amino acids in the root apex but not in the mature zone and changed the organic

92 s rule works well in the central part of the apex, but fails to account for cell division planes in t

93 ent and emergent leaf primordia at the shoot apex, but not in the vegetative meristem or stem.

94 tion of F-actin unleashes SVs focused at the apex by myosin-5 to microtubule-dependent motors, we est

95 We evaluated the isotopic niche of an apex carnivore, the cougar (Puma concolor), over broad s

96 dscapes can provide sufficient resources for apex carnivores, they do not necessarily preserve their

97 c thin section of the approximately 3,465 Ma Apex chert of northwestern Western Australia, prepared f

98 The 3.46-Ga Apex chert provides a test bed for claims of biogenicity

99 ) uptake was about 4-fold higher in the root apex compared with the mature zone, mature root cells ac

100 ontains loops with variable regions at their apexes conferring capsid surface topologies different fr

101 On average, a damaged apex cost each ramet 5015 seeds.

102 ratio statistical variable selection and the apex detection algorithms in order to perform prioritiza

103 ay microanalysis at two positions behind the apex determined the cell-specific elemental concentratio

104 The link between delayed shoot apex development and the induction of cold tolerance was

105 from the outpatient department (OPD) of the apex diabetic healthcare hospital of the country under t

106 Here, we isolated a lineage of Env apex-directed neutralizing antibodies, N90-VRC38.01-11,

107 With applying magnetic field along the base-apex direction, the hole wave function shrinks in the ba

108 Considering left ventricular base-to-apex distribution, MF was 31.9%, 43%, and 46.2% at basal

109 ) and high-dose (HD) groups (</= or > median apex dose 84.35 Gy).

110 sses, including quaternary-dependent, trimer-apex (e.g., PGT145) and gp120/gp41 interface (e.g., PGT1

111 iRNA and miRNA-target levels were reduced in apex-enriched samples of rcf3 mutants, but not in other

112 Upon activation, the APEX enzyme catalyzes the biotinylation of neighboring e

113 eneration procedure was developed from shoot apex explants and used to downregulate expression of 3 m

114 itivity precludes applications requiring low APEX expression, we used yeast-display evolution to impr

115 e of the largest and the most widely ranging apex felid predators with a strictly carnivorous diet, c

116 rosophila muscle to demonstrate the power of APEX for characterizing subcellular proteomes in live ce

117 brane receptor potential fluctuations in the apex for precise phase-locking to sound signals.

118 compositions confirm the biogenicity of the Apex fossils and validate their morphology-based taxonom

119 Integrating this apex geometry with a widening slope, analogous to cactus

120 APEX has been used to capture entire organelle proteomes

121 vant to vaccine design involving its dynamic apex.IMPORTANCE The Env trimer is the only viral protein

122 ormal choriocapillaris confined to the tumor apex in 17 (58%).

123 After resection of the left ventricular apex in 2-day-old neonatal mice, sympathetic nerve struc

124 tely 40 A from their positions at the trimer apex in closed Env to the sides of the trimer in positio

125 with that elastically scattered from the tip apex in the near field is responsible for this control o

126 Other wall components increased behind the apex including cellulose and the alpha-Fuc-(1,2)-beta-Ga

127 ) carriers travel to, and accumulate at, the apex, indicating that fusion is rate limiting for exocyt

128 n the trimer while apparently leaving the V2 apex intact.

129 c model of primordia initiation at the shoot apex, integrating locality and stochasticity in the patt

130 orm a triangle of tissue back to the orbital apex, intraconal spread apparently being prevented by th

131 APEX is an engineered peroxidase that functions as an el

132 We hypothesized that vasoconstriction at the apex is essential for rupture.

133 They show that while the pool of FlbB at the apex is required for triggering asexual development, the

134 nopodial apices, implying that once a cotton apex is SP-determined, it cannot be reset by florigen.

135 emonstrate that a chemically inert tip whose apex is terminated by a xenon atom cannot induce the rea

136 Auxin produced by an active primary shoot apex is transported down the main stem and inhibits the

137 taxa are lower than those of bulk samples of Apex kerogen (-27 per thousand), those of SIMS-measured

138 We demonstrate that APEX labeling functions effectively in multiple fly tiss

139 Altogether, APEX labeling in live Drosophila tissues provides an opp

140 om distant failure rates were 96% and 95% in apex LD and HD groups at 5 years and 77% and 95% at 10 y

141 Apex LD and HD groups did not differ for time to death o

142 isual acuity outcomes did not differ between apex LD and HD groups.

143 dom from local failure rates were 90% in the apex LD group vs 89% in the HD group at 5 and 10 years (

144 nd optic neuropathy rates were higher in the apex LD than HD group.

145 These new phases contain sheets or chains of apex-linked V(3+)O4 squares stacked with SrH layers/chai

146 Eyes were divided into apex low-dose (LD) and high-dose (HD) groups (</= or > m

147 Standard right ventricular apex+LV and LV-only pacing enhanced systolic function an

148 n comparison with the AAI, right ventricular apex+LV and LV-only pacing resulted in improved stroke v

149 d: standard biventricular (right ventricular apex+LV), LV-only, HIS, simultaneous HIS and LV (HIS+LV)

150 ration sequencing, autozygosity mapping, and apex microarray, were tried to reach a diagnosis; all pa

151 Ventricular apex myocytes isolated from ST3Gal4(-/-) mice demonstrat

152 Near the root apex, Na declined across the cortex in roots from the ae

153 ate- differentiating neurons of the cochlear apex never form.

154 risk of autotoxicity, as necrosis killed the apex of 37% of the ungalled ramets.

155 dicate that CDCP1 cleavage, occurring at the apex of a beta1 integrin/FAK/PI3K/Akt signaling cascade,

156 These AML LSCs were shown to reside at the apex of a cellular hierarchy that initiates and maintain

157 t hematopoietic stem cells (HSCs) sit at the apex of a developmental hierarchy in which HSCs undergo

158 SCs) are conventionally thought to be at the apex of a hierarchy that produces all mature cells of th

159 inear frequency conversion efficiency at the apex of a nanometre conical tip.

160 erein light is confined and amplified at the apex of a nanoscale plasmonic probe, meets these criteri

161 less than 50 nanometres that resides at the apex of a sharp pipette: it provides scanning cryogenic

162 sted nitrogen-vacancy centre attached to the apex of a silicon thermal tip as a local temperature sen

163 PIF transcription factors positioned at the apex of a transcriptional network that regulates a diver

164 Therefore SVs arrive at the apex of A. nidulans by anterograde transport involving c

165 wall glucans indicated wall synthesis at the apex of both Gh tip types and in distal zones.

166 how to maximize vapour diffusion fluxat the apex of convex millimetric bumps by optimizing the radiu

167 It comprises central elements (the apex of d10, d11 and the following polypyrimidine tract)

168 to the ATM and ATR kinases which are at the apex of DNA damage signaling pathways.

169 The apex of Gh hemisphere tips was enriched in homogalacturo

170 erimentally estimate the aspect ratio of the apex of gold coated AFM probe using only optical forces.

171 zing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine

172 is activated by the cleavage of PBS1 at the apex of its activation loop.

173 asculature of developing nodules, and at the apex of mature nodules.

174 A dense glycan shield at the apex of pre-fusion hMPV F suggests that antibodies again

175 These findings identify SIK2 at the apex of the adipocyte-induced signaling cascades in canc

176 density for a bound sugar is observed at the apex of the almost occluded cavity in the middle of the

177 network of electrostatic interactions at the apex of the AMPAR ligand-binding domain (LBD) is essenti

178 ersity in the structures of the loops at the apex of the C2 domain implicated in membrane recognition

179 rength of the stimulus and originated in the apex of the cell, spreading as a fast Ca(2+) wave.

180 ification is greater in the base than in the apex of the cochlea.

181 ath, revealed that many sensory cells at the apex of the cochlear spiral were missing.

182 complex (RPEDC, the axial distance from the apex of the drusen and RPE layer to Bruch's membrane) an

183 mation, the gp120 V1V2 loops interact at the apex of the Env trimer.

184 lts demonstrate that vasoconstriction at the apex of the follicle is essential for ovulation.

185 s diatoms (Bacillariophyta), confined to the apex of the frond structure, which were low light acclim

186 ls are minimally differentiated cells at the apex of the hierarchical system of memory T lymphocytes.

187 At the apex of the hierarchy, hematopoietic stem cells undergo

188 erent connections positioned mid LPFC as the apex of the hierarchy.

189 lizing antibodies (bnAbs) directed to the V2 apex of the HIV envelope (Env) trimer isolated from indi

190 tibodies that recognize the V2 region at the apex of the HIV envelope trimer are among the most commo

191 Neutralizing antibodies that target the V1V2 apex of the HIV-1 envelope (Env) trimer feature unusuall

192 ibodies targeting quaternary epitopes on the apex of the HIV-1 envelope spike are an attractive vacci

193 established that FlbB localizes to both the apex of the hypha, where it interacts with and is anchor

194 longitudinal direction from the base to the apex of the left ventricle, there was a trend of decreas

195 Focused ion beam (FIB) cutting of the apex of the ME was used to expose an electroactive BDD d

196 -J gp85 on chNHE1 is probably located on the apex of the molecule; the receptor-binding mode might be

197 , the position of young nectophores near the apex of the nectosome allows them to dominate torque pro

198 equation only depends on two parameters: The apex of the peak (A) and the mean drift time value (mu).

199 FP) expression was targeted to the hypocotyl apex of the phot-deficient mutant using the promoters of

200 cifically recognizes antigenic site O at the apex of the pre-F protein trimer.

201 e that forms at the subunit interface at the apex of the receptor.

202 ocardiography showed a filling defect at the apex of the right ventricle (RV).

203 ecular precision by functionalization of the apex of the scanning probe tip with a single atom or mol

204 Quaternary epitopes at the apex of the spike are recognized by some of the most pot

205 b, a specimen was collected from the conical apex of the storage tube where a pellet was formed.

206 ent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env) trimer.

207 , bind asymmetrically as a single Fab to the apex of the symmetric Env trimer using a protruding CDRH

208 tween the tip of the helical hairpin and the apex of the transmembrane cavity.

209 nfined phase is first seen to form along the apex of the wedge and then grows out of the pocket openi

210 The E1 enzyme functions at the apex of this pathway and plays a critical role in activa

211 The 2424 epitope is focused on the very apex of V3, away from nearby glycans, facilitating antib

212 play similar hierarchal organization, at the apex of which are "stem-like cells" that drive tumor gro

213 ants occupying more exposed positions at the apexes of the beta-barrel structure are most in-line wit

214 d the apical region (much poorer in the root apex) of the root.

215 ng and localization to the outer surface, or apex, of the follicle.

216 from the cementoenamel junction to the root apex, on radiographs).

217 Gh tapered tips ruptured either at the apex or distantly.

218 of pulse trains on single electrodes at the apex or middle of long electrode arrays.

219 either tightly packed at the membrane-distal apex or rotated into a receptor-accessible conformation.

220 hollow Au24 nanoparticle either through the apex or side entry, while shuttling a metal atom out of

221 rsors of bNAbs that target either the trimer apex or the CD4-binding site.

222 leads were placed into the right ventricular apex/outflow tract through a subclavian vein puncture wi

223 Live-cell proximity labeling using APEX peroxidase followed by anti-biotin enrichment and m

224 ht glycan-dependent bNAbs targeting the V1V2 apex (PG9, PG16, and PGT145), the V3 loop (2G12, PGT121,

225 n-1 with myosin-5 and can move away from the apex powered by dynein.

226 y structure to the same extent as loss of an apex predator and even to a greater extent than loss of

227 We contend that trophic cascades induced by apex predator extirpation may be an overlooked driver of

228 changes on hapuku (Polyprion oxygeneios), an apex predator found in continental slope habitats (>200

229 Daspletosaurus was an important apex predator in the late Campanian dinosaur faunas of L

230 ral rabbit populations and in two endangered apex predator populations: the Iberian lynx (Lynx pardin

231 vides evidence linking the suppression of an apex predator to the historic encroachment of shrubs.

232 demographic and ecological data for a marine apex predator, the broadnose sevengill shark Notorynchus

233 hting the fences used to contain fish as the apex predator; a cutthroat trout from the experiment, th

234 y exposing them to predation risk from avian apex predators (cormorants, Phalacrocorax carbo).

235 Late Cretaceous) have been characterized as apex predators [2-5], whereas members of the distantly r

236 ous" felids are recognized for their role as apex predators and hence as key elements in food webs an

237 tioned from small-bodied hunters to gigantic apex predators but from which no diagnostic specimens ar

238 pture (CR) modeling techniques used to study apex predators has also limited robust temporal and cros

239 ng Tyrannosaurus and Albertosaurus--were the apex predators in continental ecosystems in Asia and Nor

240 Tunas are apex predators in marine food webs that can accumulate m

241 Apex predators initiate trophic cascades which can influ

242 Extirpation of apex predators is linked inextricably to pastoralism, bu

243 than their iconic representation as gigantic apex predators of Mesozoic marine ecosystems suggests.

244 on of which is prevalent in the Arctic where apex predators such as polar bears (Ursus maritimus) can

245 Polar bears (Ursus maritimus) are apex predators that primarily consume benthic and pelagi

246 (LMH), while much less studied than those of apex predators, are increasingly recognized to exert pow

247 y large-bodied vertebrates, especially large apex predators, maintain their associated ecosystems thr

248 As long-lived apex predators, predatory birds represent a sentinel spe

249 uatic ecosystems and declining abundances of apex predators.

250 The Sargassum apex presents characteristics of a self-organising syste

251 P contributes to the rise in GA at the shoot apex, promoting rapid induction of flowering.

252 que, termed the absolute protein expression (APEX) proteomics tool.

253 25 plaque brachytherapy (67.5-81 Gy at tumor apex) provides safe and effective tumor control for juxt

254 gher dose of radiation delivered to prostate apex, radiation delivered per treatment, and prior trans

255 Mean thickness of bone at 5 mm from apex ranged from 11.94 to 10.47 mm (SD = 2.96 for tooth

256 whereas mean thickness of bone at 10 mm from apex ranged from 13.75 to 11.08 mm (SD = 2.79 for tooth

257 A Carboniferous root apex reiterates the importance of the fossil record and

258 demonstrated in fish and newborn mice after apex resection or cardiac infarctions.

259 neonatal mouse hearts failed to repair after apex resection, whereas adult mouse cardiomyocytes with

260 aptic ribbons in regions 5.5 and 6.5 mm from apex, respectively, elevations in 4-, 8- and 20 kHz tona

261 e demonstrate that, using a single protocol, APEX-RIP can isolate RNAs from a variety of subcellular

262 Since APEX-RIP is simple, versatile, and does not require spec

263 Here, we develop such a method, termed APEX-RIP, which combines peroxidase-catalyzed, spatially

264 ivered from the epicardial right ventricular apex, RV outflow tract, and LV free wall, as well as pre

265 rdiac function relative to right ventricular apex (RVA) pacing in animals.

266 ain threshold, the singular structure at its apex sharpens abruptly.

267 s's Alzheimer's Prevention through Exercise (APEX) Study.

268 Here, we used enhanced ascorbate peroxidase (APEX)-tagged PB2 proteins and electron microscopy to stu

269 described for another donor who developed V2-apex targeting bnAbs.

270 The SIMS data for the two highest delta(13)C Apex taxa are consistent with those of extant phototroph

271 Here, we combine APEX technology with a SILAC-based ratiometric tagging s

272 trate-parallel contractile actin belt at the apex that governs anaphase cell flattening.

273 rythrocyte membrane, with a structure at the apex that likely represents the adhesion site.

274 centrated endocytosis just behind the hyphal apex (the "endocytic collar"); and small, rapidly moving

275 finement for hole wave function from base to apex, the center of effective mass moves up during shrin

276 progenitor populations in the rodent incisor apex, the dental pulp, the alveolar bone, the periodonta

277 unique transcripts were identified in shoot apex tissue between fast- and slow-developing RILs, 13 o

278 regulate the actin cytoskeleton at the tube apex to drive tip growth.

279 Chest HRCTs from the lung apex to the base were performed using a 16-slice multi-d

280 ters of the cross sections increase from the apex to the base.

281 we applied engineered ascorbate peroxidase (APEX) to map the proteome at EMCs in live HEK293 cells.

282 At the biventricular level, we reduced the apex-to-base and transmural gradients of action potentia

283 selected manually and matched in number and apex-to-base distribution.

284 Inner hair cells are transduced in an apex-to-base gradient, with transduction reaching 96% in

285 We assessed the overall amount, apex-to-base, circumferential, epicardial-endocardial di

286 opulation was assessed in this retrospective APEX trial substudy (Acute Medically Ill Venous Thromboe

287 es identifying known ciliary proteins, cilia-APEX uncovered several ciliary signaling molecules.

288 e and Gb tips ruptured preferentially at the apex upon treatment with wall degrading enzymes, consist

289 ion of the stray field surrounding the probe apex using electron holography convincingly demonstrates

290 nal difference in the base compared with the apex was significantly greater for SSc than for controls

291 APEX was targeted to the outer mitochondrial membrane, a

292 The Fe flux to the DGT resin at the root apexes was 3-fold higher than the anaerobic bulk soil an

293 e nearly twice as conducting as those at the apex, was almost absent.

294 Using this technique, termed "GPCR-APEX," we track activation and internalization of the an

295 responding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.

296 divisions occurring in the Arabidopsis shoot apex, which contains domains with anisotropic curvature

297 p, generating plasmons that propagate to the apex while undergoing asymptotic compression and amplifi

298 loops form a narrow constriction near their apex with a wide vestibule toward the cytoplasm and an a

299 by demonstrating an impressive lesion at RV apex with the typical 3-layer appearance and thrombus fo

300 :P1-GFP was clearly visible at the hypocotyl apex, with weaker expression in the cotyledons, whereas