ライフサイエンスコーパス: apical

1 ic circulation (basolateral) and the retina (apical).

2 ormigenes culture conditioned medium (CM) on apical (14)C-oxalate uptake by human intestinal Caco-2-B

3 cells requires growth and reorganization of apical actin and membrane structures.

4 microtubule configuration, aligned with the apical actin cable and adherens-junctions within chick a

5 in A/C-mediated formation of the perinuclear apical actin cables protects the nuclear structural inte

6 Here, we characterize an apoptotic extrusion apical actin ring (EAAR) that is assembled within the ap

7 n of hair cells is essential for stabilizing apical actin structures like the hair bundle and ensurin

8 In the first phase, an apical actomyosin network is formed.

9 nscriptome profiles of gametes, zygotes, and apical and basal daughter cells.

10 We examined synaptic interactions between apical and basal dendrites of CA1 pyramidal neurons in m

11 the male gametocyte and locates both at the apical and basal ends of ookinete and sporozoite stages.

12 are formed by contact and self-fusion of the apical and basal plasma membranes.

13 wed a cleft in the outer retina, creating an apical and basal separation of retinal layers.

14 n of the cell surface by cell junctions into apical and basolateral domains.

15 is showed that the size and concentration of apical and basolateral exosomes remained relatively stab

16 and LEPROT) revealed distinct effects on the apical and basolateral recycling and transcytotic pathwa

17 +/- 3.2 years, 3 of the 93 patients with LV apical aneurysms (3%) died suddenly or of heart failure,

18 HCM patients with LV apical aneurysms are at high risk for arrhythmic sudden

19 is of a large cohort of HCM patients with LV apical aneurysms over long-term follow-up.

20 extending from the left lower lobe up to the apical (apicoposterior) segment of the left upper lobe.

21 al cells, we found that basolateral, but not apical, application of SMase leads to a redistribution o

22 th elongation occurring predominantly in the apical approximately 4 cm of the stem.

23 Cells must significantly expand their apical area and transition from a polygonal to circular

24 When Rab35 function is disrupted, apical area oscillations still occur and contractile ste

25 shown that restriction of microvilli to the apical aspect of epithelial cells requires the localized

26 The Kir7.1 channel is localized to the apical aspects of retinal pigment epithelium (RPE) cells

27 Apical ATP release was attenuated in Calhm1 knockout cul

28 The role of protein localization along the apical-basal axis of polarized cells is difficult to inv

29 ng prevail and cells divide along their long apical-basal axis.

30 that localize to defined positions along the apical-basal axis.

31 in which cells exchange neighbors along the apical-basal axis.

32 of afadin in vivo leads to misorientation of apical-basal cell division in nephron tubules.

33 mponents initiate the planar polarization of apical-basal determinants, ensuring asymmetric division

34 he basal cytonemes and formed characteristic apical-basal distributions in the anterior compartment c

35 zzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3).

36 In epithelia, apical-basal polarity often coexists, and sometimes inte

37 tions, the cytoskeleton and the formation of apical-basal polarity.

38 n, jagn-deficient embryos display defects in apical-basal spindle orientation in delaminated embryoni

39 ented relative to two axes: longitudinal and apical-basal.

40 e purinergic signalling regions exist at the apical border of differentiated surface cells.

41 the accumulation of AJCs to the basolateral-apical boundary.

42 o proximal tubule epithelial cells along the apical but not the basolateral membrane.

43 also found a strong dependence on PARD6B for apical, but not basolateral, recycling, implicating this

44 ained open in 13.9% cases (types I), whereas apical calcification bridge formed in 47.2% (type II) an

45 n, excluding actomyosin and forming a mature apical cap.

46 is no connection between phyllotaxis and the apical cell division pattern indicating a position-depen

47 otaxis (137.5 degrees angle) and an unlinked apical cell division pattern.

48 Loss of crumbs function disrupts the apical cell junction belt and crumbs overexpression expa

49 cell adhesion molecules, thus regulating the apical cell membrane remodeling and cytoskeletal dynamic

50 is integral to the tight junction (TJ), the apical cell-cell adhesion and a key regulator of the epi

51 pment and each module develops from a single apical cell.

52 reeping body (the thallus), which grows from apical cells in an invaginated "notch." The genetic mech

53 contraction participate in concert to drive apical centrosome migration.

54 CFTR) chloride channel, leading to defective apical chloride transport.

55 mpaired cardiac deformation indices (reduced apical circumferential strain, -16+/-1.0 versus -23+/-1.

56 eral Na(+) -HCO3(-) cotransporter (NBC1) and apical Cl(-) /HCO3(-) exchanger (solute carrier family 2

57 easing the basolateral K(+) permeability and apical Cl(-) and HCO3(-) permeabilities (CFTR), and redu

58 ication bridge formed in 47.2% (type II) and apical closure (type III) in 38.9% cases.

59 commonly used in the dental clinic to obtain apical closure of immature permanent teeth with thin den

60 y in promoting root lengthening, widening or apical closure.

61 oembolic events (1.1%/year), whereas 13 with apical clots and anticoagulation did not incur embolic e

62 ough the formation and fusion of a large pre-apical compartment (PAC) to the apical surface.

63 Concurrent chondrogenic induction in the apical compartment enabled the maintenance of functional

64 erentiated on culture inserts, separated the apical compartment that simulates the intestinal lumen,

65 xan parasites such as Toxoplasma gondii, the apical complex includes a spiral cap of tubulin-rich fib

66 The apical complex of the vitelliform lesion eventually dege

67 The apical complex of Toxoplasma gondii and some other apico

68 Their defining characteristic is the apical complex-membranous and cytoskeletal elements at t

69 ellular events such as convergent extension, apical constriction and interkinetic nuclear migration,

70 A major driver of apical constriction and junctional disassembly are perio

71 -polarized dynamic actomyosin networks drive apical constriction and the anisotropic loss of cell con

72 myosin-driven anisotropic junction loss and apical constriction are the main drivers of this process

73 Apical constriction depends on a Rho GTPase signaling pa

74 Apical constriction is a widely utilized cell shape chan

75 When apical constriction is disrupted, compressing force gene

76 It remains unclear how apical constriction is regulated spatiotemporally during

77 e that neither loss of spatially coordinated apical constriction nor its complete blockage prevent in

78 omplex genes that regulate cell adhesion and apical constriction.

79 esumptive mesoderm cells exhibit coordinated apical constrictions that mediate invagination [5, 6].

80 Our data argue that apical contractility gradients are important for tissue

81 VL to assemble the actin cytoskeleton in the apical cortex and in protruding lamellipodia.

82 directed Myosin flow clears Myosin from the apical cortex.

83 atially distinct cellular domain, the medial apical cortex.

84 of MIST1 in PCs caused them to expand their apical cytoplasm, rearrange mitochondrial/lysosome traff

85 ap junctions distributed uniformly along the apical dendrite and, on average, proximally with respect

86 Our findings indicate apical dendrite degeneration as a novel cellular patholo

87 Alzheimer's disease (AD), and found profound apical dendrite degeneration of Betz cells in both fALS

88 develops into a DGC, consisting of a single apical dendrite with further branches, remains largely u

89 granule cells (DGCs) have a single, complex, apical dendrite.

90 ominantly within their soma, rather than the apical dendrite.

91 e enhanced dendritic arborization within the apical dendrites of hippocampal cornu ammonis 1 and gran

92 clustered loss of dendritic spines along the apical dendrites of layer (L) 5 pyramidal neurons (PNs)

93 , S-SDS increases arborization and spines of apical dendrites of these neurons in a D1 receptor-depen

94 matergic terminals, and postsynaptically, at apical dendrites, without inhibiting the soma.

95 eral and temporoammonic inputs at the distal apical dendrites.

96 feliforms) exhibiting bifurcating, V-shaped apical dendrites.

97 number and function of spine synapses in the apical dendritic tuft of layer V pyramidal neurons in th

98 tuning the endocytosis and activity of this apical determinant.

99 lonic enterocytes which are characterized by apical dislocation of claudins are CPE-susceptible.

100 No evidence for apical dispersion was obtained.

101 GroEL binds to the Het-s fibrils via its apical domain located at the top of the large open ring.

102 rsion of ARF6 into the GDP-bound form in the apical domain of hair cells is essential for stabilizing

103 e, in which the Par complex localises to the apical domain, excluding actomyosin and forming a mature

104 ifferences stem from the orientations of the apical domain.

105 st growth factor 8 (Fgf8) is produced by the apical ectodermal ridge (AER) at the distal tip of the l

106 at the blood-testis barrier (BTB) and at the apical ectoplasmic specialization.

107 Finally, basolateral but not apical EHV1 infection of EREC was dependent on cellular

108 -membranous and cytoskeletal elements at the apical end of the cell that participate in host-cell inv

109 A variety of biological systems affect apical end points used in regulatory risk assessments, a

110 PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioact

111 arity gene in assembly or maintenance of the apical endosomal system.

112 phology, (2) invasion of bacteria across the apical epithelial barrier, (3) nuclear factor-kappaB act

113 whole-embryo dynamics of the actomyosin-rich apical epithelial surface.

114 le knockdown (dKD) of ZO-1/ZO-2 elevates the apical epithelial tension and effective viscosity.

115 gated spermatid interface, which is known as apical ES and possibly the Sertoli-Sertoli cell interfac

116 rticular, spermatid adhesion (i.e., inducing apical ES degeneration) and BTB function (i.e., basal ES

117 pendent mechanism and is capable of inducing apical ES degeneration, which leads to germ cell exfolia

118 dulate cell junction dynamics at the BTB and apical ES.

119 (lenti-Munc18c-shRNA-treated) exhibit normal apical exocytosis of zymogen granules (ZGs) in response

120 is pathway and leads to the inability of the apical exosomal cargo protein GPRC5B to enter the ILV/ex

121 g inflammation; however, a rationale for its apical expression has been lacking.

122 thoracic echocardiography was used to obtain apical four-chamber images to construct -volume relation

123 trabeculation was measured with the maximal apical fractal dimension (FD), which is a marker of endo

124 nes ethylene and auxin play key roles during apical hook development by controlling differential grow

125 sis CTL1, which controls seedling growth and apical hook development by regulating intracellular traf

126 whereas BIG ARF-GEFs act at a later stage of apical hook development.

127 vascular system, and the concave side of the apical hook.

128 edling emerges from soil by the formation of apical hook.

129 Restriction of infection via apical inoculation was overcome by disruption of interce

130 ic phenotypic deviations of tip swelling and apical invaginations.

131 n Lpa1(-/-) mice further suggested defective apical junction integrity in these mice.

132 l barrier in the intestine via regulation of apical junction integrity.

133 olfactory neuroepithelium, especially at the apical junctional belt of the sustentacular cells.

134 ctrin betaV was invariably detected near the apical junctional complex and above the cuticular plate,

135 alyses revealed that Notch signaling induces apical junctional complex genes that regulate cell adhes

136 ane trafficking, which were present near the apical junctional complex in the hair cells of mammalian

137 ndependently, App also recruits Dachs to the apical junctional region through protein-protein associa

138 nal modification and recruiting Dachs to the apical junctional region, thereby promoting tissue growt

139 mulation of the atypical myosin Dachs at the apical junctional region, which in turn promotes growth

140 that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylor

141 P2(S227E) reestablished both proteins at the apical junctions.

142 ding enlarged mandibles and greatly enlarged apical labial palpomeres with dense specialized sensory

143 ch has a functional counterpart of transient apical left ventricular ballooning.

144 We demonstrate that forced apical localization of Par3, which is normally restricte

145 odium channel (ENaC) and ROMK expression and apical localization.

146 the HIV exon splicing silencer 3 (ESS3) 7-nt apical loop.

147 ane surrounding the apicosome is enriched in apical markers and displays microvilli and a primary cil

148 els of beta-hydroxybutyrate (beta-HB) in the apical medium following ingestion of OS by human fetal R

149 A2B purinergic P1 receptors induced V-ATPase apical membrane accumulation in medullary A-ICs but not

150 the Plasmodium falciparum vaccine candidate apical membrane Ag-1 (AMA1) in HIV-infected and uninfect

151 orts, and that changes in antibody levels to Apical Membrane Antigen 1 suggested a decrease in transm

152 ntration and transmit the information to the apical membrane are not clear.

153 otease-activated receptor 2 activates airway apical membrane chloride permeability and increases cili

154 low-level nitric oxide production, increases apical membrane Cl(-) permeability approximately 3-5-fol

155 s like the hair bundle and ensuring that the apical membrane forms appropriately around the stereocil

156 d to tight junctions, is sufficient to alter apical membrane identity through its interactions with p

157 initially developed normally, but the cell's apical membrane lifted away from the cuticular plate, an

158 he role of AP-2 in the maintenance of proper apical membrane lipid and cell wall composition is furth

159 ize in unique and overlapping domains at the apical membrane of ciliated surface cells.

160 tood, nonheme iron is transported across the apical membrane of the intestinal enterocyte by divalent

161 n belt and crumbs overexpression expands the apical membrane size.

162 ppeared more dispersed, and the intensity of apical membrane staining for AQP2 was reduced significan

163 AQP2-S256E, which fits well with its role in apical membrane targeting.

164 sporter and collectrin, which is involved in apical membrane vesicle trafficking.

165 arity by recruiting polarity proteins to the apical membrane, but how a change in protein localizatio

166 also known as Mpp5), a core component of the apical membrane-determining CRB complex in the nephron.

167 ) transport by altering ENaC activity in the apical membrane.

168 2 translocation from storage vesicles to the apical membrane.

169 imulates the NKCC1 co-transporter at the CPE apical membrane.

170 ecting sequestration of GUCY2C to intestinal apical membranes and segregation of mucosal and systemic

171 H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation vi

172 rtures are formed by fusion of the basal and apical membranes into a tunnel that spans the height of

173 iltered by the kidney, binds to SGLT2 in the apical membranes of the early proximal tubule, and is su

174 re, we scrutinized the elastic properties of apical membranes separated from living cells and attache

175 Both receptors are located in A-IC apical membranes, and adenosine injection increased urin

176 e the body arises through the activity of an apical meristem (a niche of cells or a single cell).

177 leaves, initiate at the flanks of the shoot apical meristem (SAM) following auxin maxima signals; ho

178 Enlargement and doming of the shoot apical meristem (SAM) is a hallmark of the transition fr

179 Different with model plants, the shoot apical meristem (SAM) of Moso is composed of six layers

180 ically through the phloem to reach the shoot apical meristem (SAM).

181 opment correlated with rounding of the shoot apical meristem and induction of TGSQA expression, a tul

182 hat regulates stem cell numbers of the shoot apical meristem has exclusively been studied in Arabidop

183 During early seedling development, the shoot apical meristem is protected from damage as the seedling

184 ly dividing fields of cells within the shoot apical meristem of Arabidopsis show dynamic regulation o

185 ure (RSA), reduces primary root growth, root apical meristem size, and meristematic activity in Arabi

186 Within the root apical meristem, a group of slowly dividing quiescent ce

187 ore morphological changes occur in the shoot apical meristem, the expression of floral repressors in

188 ype due to reduced cell division in the root apical meristem.

189 ranscriptional profiling in developing shoot apical meristems of vrs3 suggested that VRS3 acts as a t

190 stribution and is enriched in shoot and root apical meristems, lateral root primordia, the vascular s

191 In mammals, peropsin is present in the apical microvilli of retinal pigment epithelial (RPE) ce

192 RL-TGR is expressed in zebrafish in both i) apical microvilli of the chemosensory cells of taste bud

193 ave now been described, all sharing a unique apical morphology that provides clues to their ability t

194 ach) and body wall-associated muscles (e.g., apical muscle) and appendages (e.g., tube feet and papul

195 ity of tube feet or the body wall-associated apical muscle, contrasting with the relaxing effect of A

196 riches Rok and Protein Kinase N (Pkn) on the apical neuroblast cortex.

197 llowing: (i) entorhinal cortex (ERC) and CA1 apical neuropil layer [CA1-stratum radiatum lacunosum mo

198 nerated by the coordinated activities of the apical notches.

199 expansion took several hours and occurred in apical nucleation centers, either close to or in associa

200 20 metabolites in the medium from either the apical or basal side.

201 EVs were isolated from media bathing either apical or basolateral RPE surfaces, and two subpopulatio

202 cells derived from human dental pulp (DPSC), apical papilla (SCAP) and follicle (DFSC) during this st

203 oned stem cells, including stem cells of the apical papilla (SCAP), into the root canal system.

204 The larva has groups of neurons in its apical papillae, epidermal neurons in the rostral and ap

205 Here we examine the apical patterning of the brown alga, Sargassum muticum,

206 ifferences between exosomes derived from the apical plasma membrane and basolateral plasma membrane o

207 ardiolipin, among other phospholipids in the apical plasma membrane compared to the basolateral plasm

208 SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required

209 PIN1 phosphorylation at the basal and apical plasma membrane was differentially sensitive to B

210 ck protein 90, were identified in samples of apical plasma membrane-derived exosomes, but not in baso

211 ense F-actin meshwork located underneath the apical plasma membrane.

212 uire control of physical properties of their apical plasma membranes for normal development and funct

213 sh mpp5b(ponli) (ponli) and crumbs2b (crb2b) apical polarity genes' restrictive transcription in the

214 Our findings reveal Moesin as a novel apical polarity protein that drives cortical remodeling

215 These findings support a link between apical polarity proteins and renal diseases, especially

216 Here, using live imaging of apical polarity proteins in Nematostella embryos, we dem

217 val from the basolateral membrane to achieve apical polarity, that Stx3 plays a role in the recruitme

218 r clustered hPSCs to initiate self-organized apical polarization and lumenogenesis.

219 Here, we show that apical polarization begins on the interior of single hPS

220 orces to push the centrosome toward the cell apical pole.

221 ), were associated with a statistically more apical position of the bone compared with baseline.

222 adial glia (aRG) that selectively lose their apical processes.

223 In the third ventricle floor, apical profiles with only primary cilia define an additi

224 Here, we localize 11 previously undescribed apical proteins in T. gondii and identify an essential c

225 We conclude that FATP2 is a major apical proximal tubule NEFA transporter that regulates l

226 e basal progenitors derived from ventricular apical radial glia (aRG) that selectively lose their api

227 mic and cortical, but restricted to the cell apical region) in cochlear inner hair cells.

228 LD transit from basal to apical regions was slow (0-2 mum/min) and frequently int

229 ar coupling between myosin and junctions and apical relaxation of neighboring cells.

230 ewborn mammals regenerate their hearts after apical resection by cardiomyocyte proliferation.

231 Our data show that apical resection rather transiently accelerates centroso

232 sible links between endocrine mechanisms and apical responses when those end points are not measured

233 Thus, apical revascularization facilitates tooth-root developm

234 Following apical revascularization with 6- to 66-month recalls, ro

235 Apical revascularization, adopted by the American Dental

236 esent study is to perform a meta-analysis on apical revascularization.

237 e derived from dioxygenation of pyrene at an apical ring, 2H-naphtho[2,1,8-def]chromen-2-one (NCO), w

238 Our data suggest that apical Rok first increases phospho-Myosin, followed by P

239 External apical root resorption during orthodontic treatment impl

240 of (1) clastic cell adhesion in the external apical root resorption process and the specific role of

241 LV twist and apical rotation were not altered from baseline or differ

242 ring beta1 -adrenergic receptor blockade, LV apical rotation, twist and untwisting velocity were redu

243 and altered the proteomic profiles of airway apical secretions compared to cigarette-exposed HBECs.

244 =5; 5.2%), papillary muscle (n=3; 3.1%), and apical-septal bundle (n=1; 1.0%), as well as imaging pla

245 and transition from a polygonal to circular apical shape to achieve robust mitotic rounding in epith

246 C glucose, is preferentially exported to the apical side and is taken up by the retina.

247 ated genes encoding proteins enriched at the apical side of cholangiocytes, including CFTR and SLC5A1

248 ls, GRASP clusters in close proximity to the apical side of lipid droplets (LDs).

249 Tight junctions (TJs) form a barrier on the apical side of neighboring epithelial cells in the bronc

250 e SGLT1 is exposed to luminal glucose at the apical side of the cell, suggesting that the two types o

251 that nearly 100 mitochondria cluster at the apical side of the inner segment, directly below the out

252 ze and export metabolic intermediates to the apical side to nourish the outer retina.

253 ng precisely regulated divisions at its most apical side, the ventricular lining (VL).

254 ike peptide 1, and the BA transport systems, apical sodium-dependent bile acid transporter and Na(+)

255 nd TGR5, and transporters, such as the ileal apical sodium-dependent bile acid transporter, appear to

256 bed in the renal tubule by the action of the apical sodium-dependent phosphate transporters, NaPi-IIa

257 w demonstrated increased uptake and basal-to-apical solute transport, which could be substantially re

258 kes and transition from glumes to florets in apical spikelets.

259 h BasA (sphingolipid biosynthesis) and StoA (apical sterol-rich membrane domains), and its essentiali

260 Thus, the apicosome is a unique preassembled apical structure that can be rapidly used in single or c

261 ells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental e

262 raphy of kidney showed F-Dapa binding to the apical surface of early proximal tubules.

263 in and localize to cell junction area at the apical surface of epithelia.

264 s associated with myosin accumulation at the apical surface of epithelial cells, as seen in the verte

265 t the second ion channel is expressed at the apical surface of hair cells and that it contains the Pi

266 as immature stereocilia and kinocilia on the apical surface of hair cells.

267 cretory duct begins as buds of chitin at the apical surface of individual secretory cells.

268 of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictat

269 al expression of biglycan and decorin on the apical surface of MEE, combined with the evidence that t

270 children and has a selective tropism for the apical surface of well-differentiated human airway epith

271 oximal tubules, with greater uptake from the apical surface than from the basolateral surface.

272 s DLG-1 within adherens junctions and at the apical surface, thereby generating arcade cell polarity.

273 bly is primed by centrosome migration to the apical surface, yet surprisingly little is known about t

274 relocalize proteins from the cytosol to the apical surface.

275 a large pre-apical compartment (PAC) to the apical surface.

276 e primary cilium at the abneural edge of the apical surface.

277 , either close to or in association with the apical surface.

278 chondroitin sulfate proteoglycans (CSPGs) on apical surfaces of palatal medial edge epithelial (MEE)

279 ells express neurog1 inside the placode, and apical symmetric divisions amplify the specified pool.

280 high and when the needle tip is close to the apical terminus.

281 ese findings demonstrate that the absence of apical TGF-beta signaling in normal epithelia is primari

282 organelles that deploy their contents at the apical tip of apicomplexan parasites in a regulated mann

283 -actin organization to allow formation of an apical TJ network only in the uppermost viable layer.

284 A switch from apical to lateral reproductive organ development is prop

285 %-22% 2D RL and the 26%-28% 3D RSA bone loss apical to the cemento-enamel junction corresponded to a

286 Such apical-to-basal neighbor exchanges were observed more fr

287 on, branching, hydration, and mobility in an apical-to-basal pattern, while the cellulose content inc

288 sing by DCT cells and couples this signal to apical transport processes.

289 nd the decreased expression of the bile acid apical transporter gene Slc10A2, as an effect of the Apc

290 The abundance of apical transporters and Na(+) delivery are the main dete

291 rom the urinary fluid is mediated by various apical transporters, whereas basolateral chloride exit i

292 pillae, epidermal neurons in the rostral and apical trunk, caudal neurons in the dorsal and ventral e

293 nd NMDA-receptor-dependent calcium spikes in apical tuft dendrites.

294 dient, with transduction reaching 96% in the apical turn.

295 tions at four locations distributed over the apical two turns of the guinea pig cochlea.

296 Ca(2+) imaging and direct patch-clamping of apical vacuolar membranes revealed that ML1 mediates a P

297 A intercalated cells (A-ICs) is regulated by apical vesicle recycling and stimulated by cAMP.

298 regions of the pollen tube plasma membrane, apical vesicle-rich inverted cone region, nucleus, and c

299 worse LV longitudinal strain, radial strain (apical view), and longitudinal synchrony (multivariable-

300 with global longitudinal and radial strain (apical view, P<0.0001), whereas no such association was