ライフサイエンスコーパス: apical constriction

1 omplex genes that regulate cell adhesion and apical constriction.

2 the neural plate driven largely by cellular apical constriction.

3 e and non-muscle myosin II, which coordinate apical constriction.

4 t not dynamic, microtubules are required for apical constriction.

5 hat actomyosin contractility is required for apical constriction.

6 and unpredicted role for microtubules during apical constriction.

7 pithelial markers and do not undergo ectopic apical constriction.

8 as found to be expressed in cells engaged in apical constriction.

9 with the polarization that establishes this apical constriction.

10 enriches junctional components to facilitate apical constriction.

11 contractility during Drosophila melanogaster apical constriction.

12 bly and thus dynamics also play key roles in apical constriction.

13 nitor proliferation, neural tube closure and apical constriction.

14 portant to generate contractile force during apical constriction.

15 active force generation required other than apical constriction.

16 undergo continuous, rather than incremental, apical constriction.

17 in Shot, and disruption of Shot also impairs apical constriction.

18 proceeded stepwise and were correlated with apical constriction.

19 s in the contractile cytoskeleton underlying apical constriction.

20 ell shape changes driven by myosin-dependent apical constriction.

21 e different morphogenetic movement, mesoderm apical constriction.

22 d elevated DE-cadherin is thought to promote apical constriction.

23 tchet-like stabilization of cell shape drive apical constriction.

24 ocytosis nor GTP-shifted Dyn2 mutants induce apical constriction.

25 tes polarization of epiblast cells and their apical constriction, a prerequisite for lumenogenesis.

26 Coordinated apical constriction (AC) in epithelial sheets drives tis

27 Apical constriction (AC) is a widely utilized mechanism

28 To test whether the physical forces from apical constriction alone are sufficient to drive the fo

29 IM is required for neural fold elevation and apical constriction along with cell polarization and elo

30 ered apical junctions, with perturbations in apical constriction and actin accumulation.

31 in vivo 4D microscopy, I show that, besides apical constriction and apoptosis, the LECs undergo exte

32 nhibiting actomyosin contractility prevented apical constriction and blocked branch initiation.

33 o signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagin

34 activated actomyosin contraction that drives apical constriction and ingression.

35 loss of both together leads to a failure of apical constriction and ingression.

36 ellular events such as convergent extension, apical constriction and interkinetic nuclear migration,

37 , we show that disruption of Rho1 suppresses apical constriction and invagination in APC null cells.

38 We find that apical constriction and invagination of APC null tissue

39 A major driver of apical constriction and junctional disassembly are perio

40 he airway epithelium and used it to simulate apical constriction and proliferation in the primary bro

41 oduces balanced activities of RhoA-generated apical constriction and Rac1-dependent cell elongation t

42 l-autonomous Ras-MAPK signal is required for apical constriction and Rock2a localization.

43 activating the actomyosin network to promote apical constriction and rosette formation in the pLLp.

44 ntracellular Ras-MAPK, which is required for apical constriction and rosette formation in the pLLp.

45 -polarized dynamic actomyosin networks drive apical constriction and the anisotropic loss of cell con

46 Affected cells also undergo progressive apical constriction and, frequently, delamination.

47 mediating events as diverse as cytokinesis, apical constriction, and cell migration.

48 ts of the contractile complexes required for apical constriction, and for the apical localization of

49 APC loss leads to segregation, apical constriction, and invagination that result from t

50 sential roles in both endogenous and ectopic apical constriction, and might be involved in Vangl2 tra

51 Thus, apical constriction appears to be triggered not by a cha

52 ell biological processes that together drive apical constriction are coordinated.

53 myosin-driven anisotropic junction loss and apical constriction are the main drivers of this process

54 invasive basal ends rather than depending on apical constriction as do the corresponding "bottle cell

55 elial cells, Apxl and KIAA1202 do not induce apical constriction as Shroom does, but have the capacit

56 tance, involves apicobasal cell heightening, apical constriction at hingepoints, convergent extension

57 molecular bases of such cell behaviors (e.g. apical constriction, basal nuclear migration) are poorly

58 nvagination are thought to be facilitated by apical constriction, but the mechanism by which changes

59 he Galpha12/13 pathway coordinate collective apical constriction, but the mechanism of coordination i

60 al force-producing actomyosin networks drive apical constriction by contracting while connected to ce

61 ression of the fog signaling protein induces apical constriction by interacting with a receptor whose

62 We conclude that apical constriction can function to position blastomeres

63 Apical constriction changes cell shapes, driving critica

64 Epithelial folding mediated by apical constriction converts flat epithelial sheets into

65 Apical constriction depends on a Rho GTPase signaling pa

66 sistent with a role for Shroom in organizing apical constriction, disrupting Shroom function resulted

67 larization of Rab11 is essential for ectopic apical constriction driven by the actin-binding protein

68 Apical constriction drives tissue folding or cell extrus

69 uggest that Vangl2 affects Rab11 to regulate apical constriction during blastopore formation.

70 disassembly, or pulses, are associated with apical constriction during Drosophila melanogaster gastr

71 the airway epithelium is driven primarily by apical constriction during monopodial branching of the a

72 room3, a molecule previously associated with apical constriction during morphogenesis of the neural p

73 ate that Shroom is an essential regulator of apical constriction during neurulation.

74 between Wnt5a and Lgl that is essential for apical constriction during vertebrate gastrulation.

75 e a role for PCP signaling in the process of apical constriction during Xenopus gastrulation.

76 cluding remodeling of the basement membrane, apical constriction, epithelial de-adhesion, directed mo

77 Apical constriction facilitates epithelial sheet bending

78 myosin mutants with in vivo measurements of apical constriction for the same mutants, we show that i

79 Work on apical constriction from multiple systems including Dros

80 constrict isotropically, which suggests that apical constriction generates anisotropic epithelial ten

81 Most studies of tissue folding, including apical constriction, have focused on how RhoA is activat

82 ve posterior endoderm, which still undergoes apical constriction in acellular embryos as in wildtype.

83 iscent of similar requirements of Cap during apical constriction in Drosophila development, suggestin

84 nts, that there is no role for columnar cell apical constriction in FC morphogenesis, and that squamo

85 microtubule cytoskeleton leads to failure of apical constriction in placodal cells fated to invaginat

86 lations by formation of smooth boundaries or apical constriction in small groups of cells.

87 that there are two crucial preconditions for apical constriction in the ventral furrow: myosin stabil

88 pression of Shroom is sufficient to organize apical constriction in transcriptionally quiescent, naiv

89 Our results suggest a new model for apical constriction in which a cortical actin-myosin cyt

90 networks previously shown to underlie pulsed apical constrictions in the amnioserosa are apparently a

91 pectrin and integrins as novel regulators of apical constriction-independent cell elongation, as alph

92 mechanism involving volume conservation and apical constriction-induced basal movement of cytoplasm

93 Apical constriction is a cell shape change that promotes

94 Apical constriction is a cell shape change that promotes

95 Apical constriction is a change in cell shape that drive

96 Apical constriction is a widely utilized cell shape chan

97 Apical constriction is conventionally thought to be driv

98 When apical constriction is disrupted, compressing force gene

99 Although it has been well documented that apical constriction is necessary for VF formation, the m

100 It remains unclear how apical constriction is regulated spatiotemporally during

101 t, consistent with the experimental results, apical constriction is sufficient to drive the early sta

102 Apical constriction is thought to be triggered by contra

103 We propose that apical constriction leading to endoderm invagination is

104 both the common themes and the variations in apical constriction mechanisms promises to provide insig

105 s is topologically analogous to well-studied apical constriction mechanisms, but very different from

106 pressing cells flanking the boundary undergo apical constriction, move inwards and adopt a bottle mor

107 e that neither loss of spatially coordinated apical constriction nor its complete blockage prevent in

108 tial and temporal differences in the rate of apical constriction of AS cells.

109 1 and Rho-associated kinase (Rock), regulate apical constriction of bottle cells at the blastopore an

110 Xenopus laevis gastrulation is marked by the apical constriction of bottle cells in the dorsal margin

111 Shroom regulates this process by causing apical constriction of epithelial cells via a pathway in

112 osophila ventral furrow and other epithelia, apical constriction of hundreds of epithelial cells fold

113 precursor cells in a process that depends on apical constriction of ingressing cells.

114 We show that the apical constriction of lens epithelial cells that accomp

115 Apical constriction of mesodermal cells initiates but is

116 We suggest that apical constriction of the actin cytoskeleton may provid

117 ow that monopodial branching is initiated by apical constriction of the airway epithelium, and not by

118 ile behavior in wild-type embryos drives the apical constriction of the cells.

119 n, DE-cadherin and Armadillo associated with apical constriction of the centripetal FC.

120 on of beta(H) by the karst mutation prevents apical constriction of the follicle cells during mid-oog

121 ession of individual cells, but is driven by apical constriction of the kind that promotes migration

122 nalysis of Drosophila gastrulation, that the apical constriction of ventral furrow cells is pulsed.

123 by a columnar-to-conical cell shape change (apical constriction or AC) and is known to be dependent

124 contacts induces cell shape changes, such as apical constriction or polarized junction remodeling, dr

125 al constriction, the diversity of roles that apical constriction plays in development, and the common

126 Strikingly, apical constriction produces similar flow patterns in mu

127 The requirement of Cap1 for a cellular apical constriction step is reminiscent of similar requi

128 ws that Wnt signaling directly regulates the apical constriction that drives gastrulation movements i

129 losure and appears pivotal in regulating the apical constrictions that drive epithelial foldings in v

130 esumptive mesoderm cells exhibit coordinated apical constrictions that mediate invagination [5, 6].

131 rt to explore the diversity of mechanisms of apical constriction, the diversity of roles that apical

132 n of the PAR-3 protein complex, then undergo apical constriction to form a cylindrical cyst.

133 by actomyosin cortical networks, which drive apical constriction to position the first inner cells of

134 l cells change shape, undergoing synchronous apical constriction, to create the ventral furrow (VF).

135 ary for VF formation, the mechanism by which apical constriction transmits forces throughout the bulk

136 Shroom-induced apical constriction was associated with enrichment of ap

137 Surprisingly, apical constriction was inhibited in the presence of noc

138 nerate invagination as a passive response to apical constriction when it is combined with region-spec

139 ical and molecular changes characteristic of apical constriction, whereas depletion of their function

140 ty and adhesion in unique ways, resulting in apical constriction with varying dynamics and subcellula

141 in the shape of the neural plate as well as apical constriction within the neural plate are perturbe

142 non-GTP state, by contrast, causes dramatic apical constriction without disrupting polarity.