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1 2 translocation from storage vesicles to the apical membrane.
2 g at AREs and carrier vesicle docking at the apical membrane.
3 tween intracellular storage vesicles and the apical membrane.
4 riggers a reduction in CFTR abundance at the apical membrane.
5 recruitment of Yrt restricts the size of the apical membrane.
6 gulates the levels and asymmetry of D at the apical membrane.
7 e small GTPase Rab11a before arriving at the apical membrane.
8 al and CF donor lungs, CTSB localized to the apical membrane.
9 teins that would normally be targeted to the apical membrane.
10 , as well as physically anchoring Dia to the apical membrane.
11 basal to apical, forming the midbody at the apical membrane.
12 lular distribution of the channel toward the apical membrane.
13 umber, shape and positioning relative to the apical membrane.
14 of vesicles from their storage areas to the apical membrane.
15 cient and distinct restriction of Dia to the apical membrane.
16 zrin to continually bias its function to the apical membrane.
17 e migrating centrosome onto the lateral then apical membrane.
18 he rate at which ENaC was retrieved from the apical membrane.
19 ial for bile acid-dependent bile flow at the apical membrane.
20 ed JAM-A moved to the brain endothelial cell apical membrane.
21 was required to restrict its function to the apical membrane.
22 PDZK1 in the stabilization of NaPi-2c in the apical membrane.
23 GPR91 was expressed in RPE but only in the apical membrane.
24 alization using a specific marker of the RPE apical membrane.
25 ferential regulation and/or stability in the apical membrane.
26 rols, despite its normal localization to the apical membrane.
27 imulates the NKCC1 co-transporter at the CPE apical membrane.
28 storage pool than the lipid entering via the apical membrane.
29 l cyclase, colocalized with CFTR in the cell apical membrane.
30 rting or in maintaining the stability of the apical membrane.
31 thus recruiting the accumulated ENaC to the apical membrane.
32 possibly internalization of NaPi-2a from the apical membrane.
33 QP2), and increased abundance of AQP2 on the apical membrane.
34 the basolateral side and secrete them at the apical membrane.
35 icking pathways, including polar delivery to apical membrane.
36 xpressed at the basolateral membrane and the apical membrane.
37 KC/Cdc42 polarity complex to localize to the apical membrane.
38 cells and MTOC function is reassigned to the apical membrane.
39 ) transport by altering ENaC activity in the apical membrane.
40 ses the basolateral membrane en route to the apical membrane.
41 tabolism and normal GLUT5 trafficking to the apical membrane.
42 ches develop bubble-like cysts with enlarged apical membranes.
43 cell retained tight junctions and segregated apical membranes.
44 lateral membranes and the basolateral to the apical membranes.
45 trols anion secretion across epithelial cell apical membranes.
46 ional claudin molecules such as claudin-4 at apical membranes.
47 stability and confinement of the channel to apical membranes.
49 tion is part of a process that controls AQP2 apical membrane abundance in a vasopressin-dependent man
50 A2B purinergic P1 receptors induced V-ATPase apical membrane accumulation in medullary A-ICs but not
51 pididymal clear cells, cAMP induces V-ATPase apical membrane accumulation, which is linked to proton
54 nogenicity of vaccines against P. falciparum apical membrane Ag 1 in rhesus macaques (Macaca mulatta)
56 the Plasmodium falciparum vaccine candidate apical membrane Ag-1 (AMA1) in HIV-infected and uninfect
58 cation of the proton pump, HK-ATPase, to the apical membrane along with activation of apical chloride
59 tionally, Moe mutant cells lost Crb from the apical membrane and accumulated excess Crb at the MZ, su
60 s open in response to ATP stimulation at the apical membrane and allow K(+) flux to the airway surfac
61 of the sub-cellular components including the apical membrane and cytoplasm of the cell at the tissue
63 e stiffness of the intact, living urothelial apical membrane and found it to be highly deformable, ev
66 sms leading to myosin II accumulation at the apical membrane and its exclusion from other membranes a
67 rotein Ve-cadherin disrupts formation of the apical membrane and lumen in a cell-autonomous manner.
69 acidified resorption compartment between the apical membrane and the bone surface to solubilize hydro
70 nslocation to the renal proximal tubule cell apical membrane and the internalization of Na(+)-H(+) ex
71 that Cad99C serves as a link between the SG apical membrane and the secreted apical ECM component(s)
72 ecting sequestration of GUCY2C to intestinal apical membranes and segregation of mucosal and systemic
73 The active form of mDia1 localized to the apical membrane, and introduction of an active form of m
74 and displaced from M025alpha and NCC at the apical membrane, and redistributes to dense punctate str
75 he expression of FLVCR was restricted to the apical membrane, and the expression of BCRP and PCFT was
78 centrosomes and nuclei move near the future apical membranes, and the postmitotic centrosomes lose a
80 host outer membrane and serve as ligands for apical membrane antigen (AMA) family surface proteins di
82 iparum vaccine candidate antigens, including apical membrane antigen 1 (AMA-1), circumsporozoite prot
83 e that is based on the 3D7 clone sequence of apical membrane antigen 1 (AMA1) and formulated in Adjuv
84 A), a blood-stage candidate vaccine based on apical membrane antigen 1 (AMA1) from the 3D7 strain of
89 at includes a type I membrane protein called apical membrane antigen 1 (AMA1) to invade host cells.
90 ), erythrocyte binding antigen 175 (EBA175), apical membrane antigen 1 (AMA1), and parasite lysate.
91 rotein 2 (RON2) to the hydrophobic groove of apical membrane antigen 1 (AMA1), triggering junction fo
94 orts, and that changes in antibody levels to Apical Membrane Antigen 1 suggested a decrease in transm
96 e antigens from the P. falciparum 3D7 clone (apical membrane antigen 1, AMA1-3D7; merozoite surface p
99 umsporozoite protein, liver-stage antigen-1, apical membrane antigen-1, and merozoite surface protein
101 umsporozoite protein, liver-stage antigen 1, apical-membrane antigen 1 (AMA-1), and merozoite surface
103 Steady-state surface NKCC2 levels in the apical membrane are maintained by a balance between exoc
105 initial vascular cords of endothelial cells, apical membranes are established and become cleared of c
106 Drosophila ovarian follicle cell epithelium, apical membranes are specified by Crumbs (Crb), Stardust
108 DZK1 can both enhance the scaffolding at the apical membrane as well as augment EBP50's role in micro
109 s on trafficking to, and insertion into, the apical membrane, as well as on phosphorylation of conser
110 ppo kinase cascade, in turn, is regulated by apical membrane-associated proteins such as the FERM dom
111 Cad99C or SAS causes a dramatic increase in apical membrane at the expense of other membrane domains
112 ivation increased renal proximal tubule cell apical membrane AT2R protein (P<0.001) without changing
114 arity by recruiting polarity proteins to the apical membrane, but how a change in protein localizatio
115 tightly packed arrays of microvilli in their apical membrane, but the fate of these microvilli is rel
121 4 revealed the presence of subdomains on the apical membrane characterized by extensive exocytosis.
122 otease-activated receptor 2 activates airway apical membrane chloride permeability and increases cili
123 low-level nitric oxide production, increases apical membrane Cl(-) permeability approximately 3-5-fol
124 t the HAT-7 cells were polarized with a high apical membrane CO2 permeability and vigorous basolatera
125 arized acini lipids were more ordered at the apical membranes compared to basal membranes, and that a
126 nal crypt enterocytes PDK1 distributes to an apical membrane compartment comprising plasma membrane a
127 ila protein Crumbs (Crb), which nucleates an apical membrane complex that functionally interacts with
128 controlling the distribution and function of apical membrane complexes, regulating the small GTPase R
129 ns and decreased protein and activity on the apical membrane, confirming that GPI-anchored Hyal2 is e
130 ll as repressing Yki by recruiting Ex to the apical membrane, Crb promotes phosphorylation-dependent
131 iet showed elevated levels of both total and apical membrane Ctr1 protein in response to transient di
132 mental studies, however, have focused on the apical membrane, despite the fact that ion transport acr
133 also known as Mpp5), a core component of the apical membrane-determining CRB complex in the nephron.
134 n the renal outer medullary K(+) channel, an apical membrane distal nephron K(+) channel that is inte
136 1(+) vesicles containing PCP proteins to the apical membrane during the initiation of planar cell pol
139 NaC expression 2.5-fold but did not increase apical membrane ENaC or amiloride-sensitive Na current (
142 also degrades old cuticle at molts, promotes apical membrane expansion in larval tracheae, and promot
143 b, a selective EGFR inhibitor, enhanced AQP2 apical membrane expression in collecting duct principal
144 hydrolase virulence factor that reduces the apical membrane expression of ABC transporters such as t
147 oteins are important in epithelial polarity, apical membrane formation, and tight junction (TJ) assem
148 s like the hair bundle and ensuring that the apical membrane forms appropriately around the stereocil
149 increase or decrease ENaC expression at the apical membrane; forskolin increased the association of
150 multaneously targeting PI3K and Tiam1 to the apical membrane has a synergistic effect on membrane rem
151 or (FcRn) located at the brush border of the apical membrane has been implicated as the "receptor" me
152 Crumbs (Crb) is a conserved determinant of apical membrane identity that regulates epithelial morph
153 d to tight junctions, is sufficient to alter apical membrane identity through its interactions with p
155 al recycling endosomes (ARE) and reaches the apical membrane in a microtubule- and Rab11-dependent ma
156 pressed at the ATP release site, such as the apical membrane in airway epithelial cells; (3) the phar
157 ssigned to non-centrosomal sites such as the apical membrane in epithelial cells, the nuclear envelop
158 y, we demonstrate that Ctr1 localizes to the apical membrane in intestinal epithelial cells of the mo
164 H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation vi
165 ectively, in maturation and targeting to the apical membrane, in polarized Madin-Darby Canine Kidney
166 in the RPE with specific localization to the apical membrane, indicating that succinate in the subret
168 eting of apical endosomes to the midbody and apical membrane initiation site (AMIS) during lumenogene
169 urface and initiating its transcytosis to an apical membrane initiation site for lumen formation.
171 rtures are formed by fusion of the basal and apical membranes into a tunnel that spans the height of
172 ent of MTOC function from centrosomes to the apical membrane is associated with a physical hand-off o
176 initially developed normally, but the cell's apical membrane lifted away from the cuticular plate, an
177 he role of AP-2 in the maintenance of proper apical membrane lipid and cell wall composition is furth
179 Furthermore, knockdown of PHLPP altered the apical membrane localization of aPKCs and reduced the fo
180 ly reduced colocalization of KCNN4c with the apical membrane marker wheat germ agglutinin in T84WT ce
181 n caused by defective anion transport at the apical membrane may contribute to the excessive and pers
182 osomal microtubules, and its delivery to the apical membrane mediated by the small GTPase rab11a.
183 cking component mislocalizes the same set of apical membrane molecules basolaterally, including the p
185 a a cyclic AMP-independent process involving apical membrane Na-H, SCFA-HCO(3), and Cl-SCFA exchanges
187 oteins are more effectively processed to the apical membrane of airway epithelia than human DeltaF508
189 dings of excised inside-out patches from the apical membrane of aldosterone-stimulated A6 collecting
190 cretory sorting of the auxin carrier PIN2 to apical membrane of Arabidopsis root epithelial cells.
192 es bile secretion and other functions at the apical membrane of biliary epithelial cells (i.e., chola
195 ast to wild-type Ncc, which localized to the apical membrane of distal convoluted tubule cells, T58M
197 topic transmembrane protein localized at the apical membrane of enterocytes and the canalicular membr
202 DUOX2), a hydrogen-peroxide generator at the apical membrane of gastrointestinal epithelia, is up-reg
205 egulation by GPCRs that are expressed at the apical membrane of intestinal and airway epithelia.
207 ated by the NaDC1 transporter located on the apical membrane of kidney proximal tubule and small inte
208 Unlike in the DCT, OSR1 remains at the TAL apical membrane of KO mice where it is accompanied by an
210 imary cilia, which are positioned within the apical membrane of neuroepithelial progenitors, we hypot
211 ssociated with a multiprotein complex at the apical membrane of normal mouse cholangiocytes, with pro
212 response to acid stimuli, is enriched in the apical membrane of PKD2L1-expressing taste cells and is
217 al disease by binding ganglioside GM1 on the apical membrane of polarized intestinal epithelial cells
218 nase A (PKA)-activated Cl(-) channels in the apical membrane of principal cells from the cortical col
219 a significant redistribution of AQP2 to the apical membrane of principal cells in cortical collectin
220 creased expression of NaPi-2a protein in the apical membrane of proximal tubules but impaired up-regu
221 with clathrin, but not with caveolin, at the apical membrane of PTECs, which determines clathrin-medi
223 omolecular complex within lipid rafts at the apical membrane of surface and glandular airway epitheli
224 arrier to CO(2) resides in the umbrella cell apical membrane of the bladder with its dense array of u
225 increased the ROMK channel intensity in the apical membrane of the collecting tubule in Romk1(+/+),
226 c lines showed that Cftr is localized to the apical membrane of the epithelial cells in KV during lum
227 tood, nonheme iron is transported across the apical membrane of the intestinal enterocyte by divalent
228 ely activate type 2 chloride channels in the apical membrane of the intestinal epithelial cells leadi
229 ) is the major salt transport pathway of the apical membrane of the mammalian thick ascending limb of
230 unctional SGLT2 transporters detected in the apical membrane of the proximal tubule but not detected
232 P) 2B1 (OATP-B; SLCO2B1) is expressed in the apical membrane of the small intestine and the hepatocyt
233 regulatory molecule, Cab39/MO25alpha, at the apical membrane of the thick ascending limb (TAL) and di
234 stry, aquaporin 2 was concentrated along the apical membrane of tubular cells with ET but not PA, and
235 kidney tissue showed expression of 24p3R in apical membranes of distal tubules and collecting ducts,
236 y normal localization, PIN2 is depleted from apical membranes of epidermal cells and shows basal to a
237 g assembly before they are inserted into the apical membranes of epithelial cells, and maximal activi
239 f PC2 channel function from a preparation of apical membranes of human syncytiotrophoblast (PC2hst) r
242 2 is expressed in several tissues, including apical membranes of small intestinal epithelial cells.
243 in is reduced 23%, NHE2 remains localized to apical membranes of surface epithelium, and NHE1 protein
245 iltered by the kidney, binds to SGLT2 in the apical membranes of the early proximal tubule, and is su
246 d cellular mechanism to create and model the apical membranes of the two fundamental types of photore
248 ing Cdc42 clustering, by tethering it to the apical membrane or lowering its diffusion, restores norm
249 e cell surface, but fails to localize at the apical membrane patch specialized for fusion and fails t
250 ss of the shell generated by adhesion of the apical membrane patches to the pore rim and the apparent
251 in the facilitated iodide efflux across the apical membrane (PDS), the organification of iodide with
252 ndings, we propose a trafficking pathway for apical membrane polarity and lumen morphogenesis that im
253 daptor protein 1 (AP-1)-dependent intestinal apical membrane polarity and polarity-dependent localiza
255 , this network regulates lateral mobility of apical membrane probes such as integrins or epidermal gr
256 ested this model using the Toxoplasma gondii apical membrane protein 1 (TgAMA1), which binds to aldol
257 th and modulate the activity of a variety of apical membrane proteins, including the renal outer medu
259 of the endothelium through the formation of apical membrane protrusions that embrace adherent leukoc
262 ficial mistargeting of endogenous LGN to the apical membrane results in a near 90 degrees rotation of
263 ll-attached patch recording on the hair-cell apical membrane revealed, after BAPTA treatment or durin
264 ngly, patch clamp studies on cortical tubule apical membranes revealed that mTOR inhibition markedly
266 re, we scrutinized the elastic properties of apical membranes separated from living cells and attache
267 bacterial adherence, from basolateral to the apical membrane sides in a microtubule- and Stim1-depend
269 Loss of this regulation results in increased apical membrane size with scattered apical recycling end
272 'bare zone', a microvilli-free sub-region of apical membrane specified by the Insc-LGN-Galphai protei
273 del intestinal epithelium, the conversion of apical membrane sphingomyelin to ceramide by exogenous b
274 ppeared more dispersed, and the intensity of apical membrane staining for AQP2 was reduced significan
275 letal polarization to control the developing apical membrane surface during blood vessel tubulogenesi
277 nge factor that is recruited by ezrin to the apical membrane, that is enriched at a marginal zone api
278 s TRPV4 trafficking and translocation to the apical membrane, the PKC-dependent pathway increases the
279 nating abscission with delamination from the apical membrane; timing of neurogenesis and its indirect
280 have evolved unique structures to expand the apical membrane to accommodate the phototransduction mac
281 in concert with a Cl:HCO3- exchanger in the apical membrane to affect transcellular HCO3- transport.
285 n of syntaxin 2 and 5' nucleotidase from the apical membrane to subapical puncta, whereas multidrug r
286 orphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytos
287 initiation, but rather the inability of the apical membrane to transform and elaborate into a rhabdo
288 caused localization of intestinal SR-B1 from apical membranes to intracellular organelles and reduced
290 helial cyst cultures, Myo5B was required for apical membrane trafficking and de novo lumen formation,
294 e (KHK), as well as GLUT5 trafficking to the apical membrane via the Ras-related protein-in-brain 11
295 he apical and basolateral membranes, but the apical membrane was more active in endocytosing and degr
296 r Cl(-) /HCO3(-) exchange via SLC26A6 at the apical membrane were able to support a HCO3(-) -rich sec
297 than threefold brighter than the surrounding apical membrane when the densities of fluorescently labe
298 of KCNE2 to be markedly enriched in the CPe apical membrane, where we also discovered expression of
299 ts in dividing cells become localized to the apical membrane, which becomes highly enriched in microt
300 roscopy examination revealed that hepatocyte apical membrane with microvilli substantially extended i
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