ライフサイエンスコーパス: apical-basal

1 ented relative to two axes: longitudinal and apical-basal.

2 he ubiquitous epithelial polarization in the Apical-Basal (A/B) axis, many epithelia (and associated

3 ens junctions, tight junctions and by intact apical-basal (A/B) polarity.

4 rate epithelia and is perpendicular to their apical/basal (A/B) polarity axis.

5 ression of a small number of genes along the apical-basal and dorsal-ventral axes in the globular emb

6 encoding components of the highly conserved apical-basal and planar cell polarity pathways, suggesti

7 t did disrupt spatial patterning in both the apical-basal and planar dimensions of the retinal epithe

8 ophyte develops morphogenetic defects in the apical-basal and radial axes.

9 lecular marker for the establishment of both apical-basal and radial patterns during plant embryogene

10 ased on HD-ZIP III repression, mediates both apical-basal and radial polarity in the embryo and later

11 consequence, increases are observed in both apical-basal and right-left ventricular gradients of rep

12 ouples cytokinesis with the establishment of apical, basal, and lateral membrane domains that are sep

13 e, for example, changes in relative sizes of apical, basal, and lateral membranes, is a key mechanism

14 Depending on the relative tension of the apical, basal, and lateral sides of the cells, tissue th

15 prostate glands with marked staining of the apical, basal, and lateral surfaces.

16 anar cell polarity (PCP) orthogonal to their apical-basal axes.

17 thin the plane of a tissue orthogonal to the apical basal axis.

18 sis and is required for establishment of the apical-basal axis and bilateral symmetry.

19 thelial cells, which are polarized along the apical-basal axis and divide symmetrically along the pla

20 und that both the cell lengthening along the apical-basal axis and the movement of the nucleus to the

21 ristems show a functional zonation along the apical-basal axis and the radial axis.

22 Blood vessel polarization in the apical-basal axis is important for directed secretion of

23 and Rac1-dependent pathway markers over the apical-basal axis of lens pit cells showed that in RhoA

24 The role of protein localization along the apical-basal axis of polarized cells is difficult to inv

25 control cell-type patterning throughout the apical-basal axis of the Arabidopsis seedling.

26 cell surface affect changes along the entire apical-basal axis of the cell remains elusive.

27 ic site of localization of the RNA along the apical-basal axis of the cell.

28 Comparison of material along the apical-basal axis of the frond demonstrates that structu

29 the patterning of spatial domains along the apical-basal axis of the gynoecium.

30 coordinated cell polarization and subsequent apical-basal axis orientation during embryogenesis and,

31 In some species it is graded along the apical-basal axis with a maximum in the basal tissue of

32 eir spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem c

33 ize asymmetry, spindle orientation along the apical-basal axis, basal Numb localization, and requirem

34 larity (PCP) in epithelia, orthogonal to the apical-basal axis, is essential for numerous development

35 ay asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (

36 e cytoskeleton, and helps define each cell's apical-basal axis.

37 ll populations occurs at opposite ends of an apical-basal axis.

38 r that epithelial cells elongate along their apical-basal axis.

39 of seed plant embryos is polarized along the apical-basal axis.

40 ll division is oriented perpendicular to the apical-basal axis.

41 y along an axis orthogonal to the epithelial apical-basal axis.

42 f proteins and junctional complexes along an apical-basal axis.

43 ng prevail and cells divide along their long apical-basal axis.

44 is of elongation, and orthogonal to the cell apical-basal axis.

45 ial polarity axis but jointly to pattern the apical-basal axis.

46 auxin response that specifies the embryonic apical-basal axis.

47 ical complex that orients spindles along the apical-basal axis.

48 that localize to defined positions along the apical-basal axis.

49 in which cells exchange neighbors along the apical-basal axis.

50 nesis initiates with the establishment of an apical-basal axis; however, the molecular mechanisms acc

51 Establishment and maintenance of apical basal cell polarity are essential for epithelial

52 of afadin in vivo leads to misorientation of apical-basal cell division in nephron tubules.

53 Defects in apical-basal cell polarity and abnormal expression of ce

54 s involving genes encoding components of the apical-basal cell polarity complexes.

55 Establishment of apical-basal cell polarity has emerged as an important p

56 The establishment and maintenance of apical-basal cell polarity is critical for assembling ep

57 Only in outer cells, the apical-basal cell polarity is established, and Hippo sig

58 in a conserved molecular pathway that links apical-basal cell polarity to Notch signaling and cell f

59 ikely due to abnormalities in development of apical-basal cell polarity, as well as in laminin-511 an

60 , Discs large (dlg) plays a critical role in apical-basal cell polarity, cell adhesion and cell proli

61 ired for the establishment or maintenance of apical-basal cell polarity, suggesting different functio

62 yers in the establishment and maintenance of apical-basal cell polarity.

63 requirement for Cdc42 in establishing proper apical/basal cell polarity and cell-cell adhesions.

64 sophila Abl (dAbl) causes loss of epithelial apical/basal cell polarity and secretion of matrix metal

65 tant imaginal disc epithelia have defects in apical/basal cell polarity and tissue morphology.

66 at Moesin1 contributes to the maintenance of apical/basal cell polarity of the ISVs as defined by adh

67 in different aspects of the formation of the apical-basal cellular architecture.

68 blasts undergo asymmetric division along the apical-basal cellular axis.

69 ar cell polarity core protein Vangl2 and the apical-basal complex component aPKC.

70 ent manner then lead to rapid and pronounced apical-basal contractions of the neuroepithelium.

71 tors are correctly specified and show normal apical-basal cortical polarity, they can dedifferentiate

72 ila neuroblasts align their spindle along an apical/basal cortical polarity axis to self-renew an api

73 nal modifications including acetylation, and apical-basal cytoskeletal polarization to control the de

74 In Drosophila, abnormal expression of apical-basal determinants can cause neoplastic phenotype

75 mponents initiate the planar polarization of apical-basal determinants, ensuring asymmetric division

76 We conclude that the ratio of apical/basal determinants specifies neuroblast/GMC ident

77 road hypothesis that integrins contribute to apical-basal differences in dendrites and that the integ

78 r these effects was supported by the lack of apical/basal directionality of the dilution potentials,

79 sophila embryos, microtubules oriented along apical-basal directions support saltatory vesicle moveme

80 he basal cytonemes and formed characteristic apical-basal distributions in the anterior compartment c

81 betagamma signaling in progenitors regulates apical-basal division and asymmetric cell-fate decisions

82 s causes a shift in spindle orientation from apical-basal divisions to planar divisions.

83 Formation of the apical-basal embryonic pattern in P. abies proceeds thro

84 Whereas Crumbs is implicated in apical-basal epithelial polarity and photoreceptor morph

85 lkb1 mutant clones also disrupt apical-basal epithelial polarity, suggesting a general r

86 ane protein Crumbs, a conserved regulator of apical-basal epithelial polarity.

87 ens, due to an inability to establish normal apical/basal epithelial polarity, as well as proper cell

88 A model is proposed suggesting an apical-basal gradient of auxin during gynoecium developm

89 In addition, we report both an apical-basal gradient of these clusters in individual ha

90 thelial polarity and are expected to perform apical-basal interkinetic nuclear migration (INM)--a hal

91 l resistance (TEER), and strongly polarised (apical:basal) localisation of transporters and receptors

92 ally, we show that TJ-mediated separation of apical-basal membrane domains is established prior to eq

93 where they are required for the formation of apical-basal microtubule arrays.

94 neural plate and for the formation of stable apical-basal microtubule arrays.

95 analyze interkinetic nuclear migration, the apical-basal movement of nuclei in phase with the cell c

96 uit fly Drosophila have a well-characterized apical-basal orientation (the Rabl configuration [4]).

97 RPE monolayers also retained proper apical-basal orientation and secreted multiple factors i

98 sis, Inscuteable is required for the correct apical-basal orientation of the mitotic spindle and for

99 slp embryos exhibit a normal apical-basal pattern and radial tissue organization, but

100 s in stamen number and anther formation, and apical-basal patterning defects in the gynoecium.

101 suggest that auxin acts in the formation of apical basal patterns in F. distichus embryo development

102 We also found that, within their specific apical-basal plane, most nascent transcript foci could o

103 which act antagonistically to mediate their apical-basal polar delivery.

104 d associated with the requirement for normal apical basal polarity and adherens junctions for the acc

105 by redundant mechanisms, whereas it disrupts apical basal polarity and inhibits apoptosis using Tyr 1

106 scs large (dlg) act together to maintain the apical basal polarity of epithelial cells in the Drosoph

107 a complex with Crb/Sdt, is not essential for apical basal polarity or for the stability of the Crb/Sd

108 A key component of apical-basal polarity (A-BP) signaling, aPKC, also inhib

109 ominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton,

110 pe observed for all three genes is a loss of apical-basal polarity and accumulation of follicular epi

111 1 (annotated as TRIM62) in the regulation of apical-basal polarity and acinar morphogenesis as well a

112 abl depletion disrupted apical-basal polarity and adherens junction organization

113 The transitional cells exhibit a similar apical-basal polarity and antigenic phenotype as the ova

114 exact in vivo function of Patj in regulating apical-basal polarity and development remains to be eluc

115 ssembly of the AJ, and finally, to a loss of apical-basal polarity and disruption of the tissue.

116 ice and differentiation are coordinated with apical-basal polarity and epithelial morphogenesis.

117 wn in low calcium, although these cells lack apical-basal polarity and exhibit loss of plasma membran

118 ane microdomains, but fail to develop normal apical-basal polarity and generate a continuous lumen.

119 tumor-suppressor gene scribble (scrib) lose apical-basal polarity and have the potential to form lar

120 f Nck signaling included loss of endothelial apical-basal polarity and impaired lumenization.

121 ty Alix plays a role in the establishment of apical-basal polarity and in the maintenance of the epit

122 Drosophila Crumbs (Crb) is required for apical-basal polarity and is an apical determinant in em

123 membrane microdomains, thereby establishing apical-basal polarity and lumen formation/elongation dur

124 building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled compl

125 hich targets RhoA for degradation to control apical-basal polarity and tight junction dissolution.

126 ulation and provide a molecular link between apical-basal polarity and tissue growth.

127 licle-cell differentiation and follicle cell apical-basal polarity are unaffected in the lanA mutant

128 cal cell membrane, although other aspects of apical-basal polarity are unaffected.

129 y, but not sufficient, for the disruption of apical-basal polarity associated with loss of lethal gia

130 ovel, redundant activity in establishing the apical-basal polarity axis of the gynoecium, indicating

131 In contrast, PAR-1 directly modulates apical-basal polarity between border cells and epithelia

132 t, in contrast, plays a more limited role in apical-basal polarity but is essential for the proper lo

133 emonstrate that activation of ErbB2 disrupts apical-basal polarity by associating with Par6-aPKC, com

134 Conversely, ULT1 and KAN1 together establish apical-basal polarity by promoting basal cell fate in th

135 In neuroblasts, establishment of apical-basal polarity by the protein Inscuteable is cruc

136 Atypical protein kinase C (aPKC) is a key apical-basal polarity determinant and Par complex compon

137 However, the pathways through which apical-basal polarity determinants affect growth are poo

138 model, we found that distinct alterations in apical-basal polarity dictate airway epithelial differen

139 n of Arabidopsis, which is known to maintain apical-basal polarity during embryogenesis.

140 s complex is also required for disruption of apical-basal polarity during the oncogene ErbB2-induced

141 zzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3).

142 Lethal giant larvae (Lgl) is an apical-basal polarity gene identified in Drosophila, whe

143 in Crumbs (Crb), a determinant of epithelial apical-basal polarity in Drosophila embryos, as an upstr

144 as not per se crucial for the maintenance of apical-basal polarity in Drosophila melanogaster epithel

145 Lethal (2) giant larvae (Lgl) regulates the apical-basal polarity in epithelia and asymmetric cell d

146 etric cell division, or the establishment of apical-basal polarity in epithelia, this review will foc

147 e uncover the role of retromer in regulating apical-basal polarity in epithelial cells and identify r

148 role in the establishment and maintenance of apical-basal polarity in epithelial cells in various org

149 ite for the establishment and maintenance of apical-basal polarity in epithelial cells.

150 role in the establishment and maintenance of apical-basal polarity in forming epithelia, the Cdc42-Pa

151 Cdc42 does not prevent the establishment of apical-basal polarity in individual cells but rather dis

152 Apical adherens junctions also establish the apical-basal polarity in neural progenitors, which in tu

153 erly specified and appear to display correct apical-basal polarity in sax-7(eq1);hmr-1(RNAi) embryos.

154 which form an epithelium in WT embryos, lose apical-basal polarity in sec61al1(c163) mutants.

155 As cells acquire apical-basal polarity in the blastula the protein become

156 s the establishment of endothelial cell (EC) apical-basal polarity in three-dimensional (3D) extracel

157 In the absence of Baz, the apical-basal polarity is compromised in early pupal phot

158 irect regulation of Rbl2 and Cdkn1a, whereas apical-basal polarity is controlled by regulation of Tia

159 nstrate that the EGFR-mediated regulation of apical-basal polarity is essential for the segregation o

160 Disruption of apical-basal polarity is implicated in developmental dis

161 Establishing apical-basal polarity is instrumental in the functional

162 We conclude that PAR-1-dependent apical-basal polarity is required for proper detachment

163 The development of apical-basal polarity is the earliest visible difference

164 PTEN, although proliferation, patterning and apical-basal polarity markers are normal in the mutants.

165 Disruption of epithelial cell apical-basal polarity occurs in early cancer development

166 rity characteristic of cell migration to the apical-basal polarity of an epithelium.

167 r, ectopically expressed PON responds to the apical-basal polarity of epithelial cells and is suffici

168 The signaling pathway that establishes this apical-basal polarity of NE is not completely understood

169 n of ciliary Arl13b led to a reversal of the apical-basal polarity of radial progenitors and aberrant

170 42 has an essential role in establishing the apical-basal polarity of the telencephalic NE, which is

171 hat both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells.

172 In epithelia, apical-basal polarity often coexists, and sometimes inte

173 In addition to the apical-basal polarity pathway operating in epithelial ce

174 ponents of both the planar cell polarity and apical-basal polarity pathways, but their roles are not

175 during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for th

176 clusters requires a rapid reorganization of apical-basal polarity that depends on Lulu/Epb4.1l5.

177 uroepithelium (NE) of mammalian brain has an apical-basal polarity that is marked by the positioning

178 two distinct processes: the establishment of apical-basal polarity that requires Bazooka (Baz), and t

179 tially polarized state of the FSC, establish apical-basal polarity throughout the lineage, and promot

180 ndent mechanism that links the regulation of apical-basal polarity to tissue morphogenesis.

181 However, apical-basal polarity was not compromised, transmembrane

182 The establishment of apical-basal polarity within a single cell and throughou

183 orting and non-essential roles in regulating apical-basal polarity, although such a supporting role m

184 lial de-adhesion, directed motility, loss of apical-basal polarity, and acquisition of mesenchymal ad

185 tip cells, following stalk cells exhibiting apical-basal polarity, and lumens and branches connectin

186 Epithelial cells display apical-basal polarity, and the apical surface is segrega

187 terior-posterior polarity, while maintaining apical-basal polarity, but how this is achieved at the m

188 lycan null mutant follicle cells have normal apical-basal polarity, but lose the planar polarity of t

189 sepithelial barrier but is not necessary for apical-basal polarity, epithelial integrity, or cytoskel

190 ly active atypical PKC results in defects in apical-basal polarity, increased Cyclin E protein expres

191 cinar cells changed phenotypes, establishing apical-basal polarity, increasing the size of zymogen gr

192 Cells loose their apical-basal polarity, mislocalize DE-cadherin, and dela

193 icient acinar cells in mice do not establish apical-basal polarity, properly position zymogen granule

194 Markers of apical-basal polarity, such as ZO-1, were mislocalized a

195 ntation during mitosis, the establishment of apical-basal polarity, the formation of apical cell-cell

196 attachment and a resultant disruption in MC apical-basal polarity, which culminated in retinal dyspl

197 ells resemble a columnar epithelium and have apical-basal polarity, with microvilli along the apical

198 es and degraded, causing a disruption of the apical-basal polarity.

199 roliferation and differentiation, as well as apical-basal polarity.

200 Arg kinase leads to a striking inversion of apical-basal polarity.

201 tions, the cytoskeleton and the formation of apical-basal polarity.

202 including proliferation, differentiation and apical-basal polarity.

203 iary proteins TCF2/HNF1beta nor with loss of apical-basal polarity.

204 d paracellular barrier function, but not for apical-basal polarity.

205 sional plane lying orthogonal to the axis of apical-basal polarity.

206 ells and has been reported to play a role in apical-basal polarity.

207 ic three-dimensional acini without affecting apical-basal polarity.

208 d basal plasma membranes and preservation of apical-basal polarity.

209 tions to promote cortical actin assembly and apical-basal polarity.

210 participate in the progressive emergence of apical-basal polarity.

211 s and seedlings express molecular markers of apical-basal polarity.

212 ivation of Hippo signaling and disruption of apical-basal polarity.

213 gh its regulation of cellular metabolism and apical-basal polarity.

214 tions controlled by modulation of epithelial apical-basal polarity.

215 ls1 or Mpp5 in mammalian cells) to establish apical-basal polarity.

216 We find that spindle alignment orthogonal to apical/basal polarity always segregates apical determina

217 s (neuroblasts) align their spindle along an apical/basal polarity axis to generate a self-renewed ap

218 d Moesin1 function to establish and maintain apical/basal polarity during multicellular lumen formati

219 se results indicate that cells need not lose apical/basal polarity in order to invade neighboring tis

220 However, whereas apical/basal polarity initiates, apical maturation is de

221 Furthermore, there are no obvious defects in apical/basal polarity within the neuroepithelium, sugges

222 wn for roles in asymmetric cell division and apical/basal polarity.

223 tor recycling and planar polarity but not in apical/basal polarity.

224 cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.

225 For instance, coordinated apical-basal polarization of epithelial and endothelial

226 ng, proliferation, wound-edge migration, and apical-basal polarization of Madin-Darby canine kidney (

227 Similar abnormalities of Hippo signaling and apical-basal polarization were also observed in embryos

228 biosynthetic turnover rate of DE-Cad during apical-basal polarization, and such biosynthetically sta

229 and efficient wound-edge migration, but not apical-basal polarization.

230 Epithelial cells are characterized by an "apical-basal" polarization.

231 Epithelial remodeling, in which apical-basal polarized cells switch to a migratory pheno

232 of progenitors for cell cycle exit based on apical-basal polarized signals.

233 There was no correlation between the apical-basal position of the transcribed locus and the f

234 velopment, such as in the development of the apical-basal (shoot-root) axis in the embryo, as well as

235 sym) isomer wherein both dppv ligands occupy apical-basal sites.

236 n, jagn-deficient embryos display defects in apical-basal spindle orientation in delaminated embryoni

237 adin determines lumen placement by directing apical-basal spindle orientation, resulting in a continu

238 specifies neuroblast/GMC identity, and that apical/basal spindle orientation is required for neurobl

239 generated a chimeric retina with alternating apical-basal stripes of wild-type and Rb-deficient tissu

240 s lysosomal degradation; this process allows apical-basal transcytosis of bound peptides.

241 nd this planar movement is distinct from the apical-basal transcytosis previously described in polari

242 Cdx2, defective protein trafficking impairs apical-basal transport and induces ectopic lumen formati