ライフサイエンスコーパス: apicomplexan

1 assified as a chytrid fungus, is actually an apicomplexan.

2 t the first genome-wide genetic screen of an apicomplexan.

3 itic photosynthetic algae closely related to apicomplexans.

4 he apicoplast, an indispensable organelle in apicomplexans.

5 ly, fosmidomycin has no effect on most other apicomplexans.

6 r chemotherapy against T. gondii and related apicomplexans.

7 lution of the PMTs in plants, nematodes, and apicomplexans.

8 unusual form of gliding motility utilized by apicomplexans.

9 ion available about these processes in other apicomplexans.

10 large diversity of alveolates, in particular apicomplexans.

11 ora nuclei but not to more distantly related apicomplexans.

12 ight into a divergent mRNA export pathway in apicomplexans.

13 n ancestral mechanism for parasitism used by apicomplexans.

14 ites, explaining the inherent instability of apicomplexan actin filaments.

15 Apicomplexan actin is important during the parasite's li

16 ther members of the ADF/cofilin (AC) family, apicomplexan ADFs lack key F-actin binding sites.

17 id biosynthesis, predating the divergence of apicomplexan and dinoflagellates.

18 ite of oryzalin, trifluralin, and GB-II-5 on apicomplexan and kinetoplastid alpha-tubulin is proposed

19 We show that apicomplexan and perkinsid AP2 domains cluster distinctl

20 glycan binding mode is distinct from that of apicomplexan and viral cell surface recognition ligands

21 TgCDPK1 is conserved among apicomplexans and belongs to a family of kinases shared

22 with particular emphasis on the situation in apicomplexans and other alveolates.

23 on as previously unknown specific TFs in the apicomplexans and regulate the progression of their deve

24 asites and consider how this varies in other apicomplexans and related organisms, while discussing ho

25 rids and colpodellids as the sister group to apicomplexans, and a complex distribution of retention v

26 and stramenopiles) and alveolates (ciliates, apicomplexans, and dinoflagellates) share a common ances

27 the context of host manipulation by related apicomplexans, and propose key directions for future res

28 yzoite development that encode proteins with apicomplexan AP2 (ApiAP2) DNA binding domains.

29 exes and is particularly enriched within the Apicomplexan AP2 (ApiAP2) DNA-binding protein family.

30 Orthologous Apicomplexan AP2 (ApiAP2) expression has been rearranged

31 show that PbAP2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins

32 es of two members of the recently identified Apicomplexan AP2 (ApiAP2) family of putative transcripti

33 anscription factor PfAP2-I, belonging to the Apicomplexan AP2 (ApiAP2) family, that is responsible fo

34 n AP2 DNA-binding domain from a prototypical Apicomplexan AP2 protein, PF14_0633 from Plasmodium falc

35 he major family of regulators comprising the Apicomplexan Apetala2 (AP2) proteins.

36 bacteria or from hosts, in parasites such as apicomplexans, appears to also have played a major role

37 Apicomplexans are a major lineage of parasites, includin

38 Apicomplexans are a phylum of intracellular parasites th

39 Malaria parasites and related Apicomplexans are the causative agents of the some of th

40 The intraerythrocytic apicomplexan Babesia microti, the primary causative agen

41 nts a unified entry point for the NIH-funded Apicomplexan Bioinformatics Resource Center (BRC) that i

42 rom piroplasm, coccidian, and haemosporidian apicomplexans but differs from all other currently known

43 Furthermore, how apicomplexan CAPs, which lack many domains present in ye

44 and deciphers the principle behind flexible apicomplexan cell division modes.

45 ein kinases of mammals, and the CDPK1 of the apicomplexan Cryptosporidium lack side chains that typic

46 arasite Plasmodium falciparum, the parasitic Apicomplexan Cryptosporidium parvum, the yeast Saccharom

47 rs may pose queries and search all available apicomplexan data and tools, or they may visit individua

48 f PlasmoDB as a member of a linked family of Apicomplexan databases.

49 enzymes involved in these pathways, and all apicomplexans express one or both of fructose 1,6-bispho

50 recycling and organellar positioning and an apicomplexan family.

51 s and progress in the tools available to the Apicomplexan field will allow for a closer look at the i

52 of interest, we generated three knockouts of apicomplexan genes considered essential for host-cell in

53 has been learned about the evolution of the apicomplexan genome as well as the significance and impa

54 CLAMP is present throughout sequenced apicomplexan genomes and is essential during the asexual

55 A number of apicomplexan genomes have been sequenced, but the accura

56 and naming protein phosphatases in available apicomplexan genomes, and summarizing the progress of th

57 me-associated connector (GAC), that mediates apicomplexan gliding motility, invasion, and egress by c

58 Apicomplexans harbor a mitochondrion that is essential f

59 Furthermore, while no other apicomplexan has been found to possess retrotransposons,

60 other members of the superphylum Alveolata, apicomplexans have regulated exocytosis of specialized s

61 complex of Toxoplasma gondii and some other apicomplexans includes a cone-shaped assembly, the conoi

62 dii rhomboids have clear homologues in other apicomplexans including malaria; thus, our findings prov

63 , but is thought to have been lost from some apicomplexans including the malaria-causing genus Plasmo

64 The apicomplexan intestinal parasites of the genus Cryptospo

65 Apicomplexans invade a variety of metazoan host cells th

66 Apicomplexans invade host cells by a multistep process i

67 Cysteine proteases play key roles in apicomplexan invasion, organellar biogenesis, and intrac

68 ironmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-reg

69 argeting a broad range of AMA-RON2 pairs and apicomplexan invasive stages.

70 for efficient control of infection by these Apicomplexans involves the induction of potent T cell re

71 This apicomplexan is the causative agent of toxoplasmosis, a

72 During the evolution of the apicomplexan LDH, however, specificity switched via an i

73 rection, we find that specificity evolved in apicomplexan LDHs by classic neofunctionalization charac

74 or how cell cycle flexibility is achieved in apicomplexan life cycles.

75 NA data are further supported by the several apicomplexan-like structural features in Nephromyces, in

76 lication event prior to the expansion of the apicomplexan lineage.

77 asite genetics and genomics have transformed apicomplexans, long considered hard to study, into highl

78 Motility of the apicomplexan malaria parasite Plasmodium falciparum is e

79 The Library of Apicomplexan Metabolic Pathways is a web database that p

80 ntify as an invasion factor the claudin-like apicomplexan microneme protein (CLAMP), which resembles

81 adhesins, challenging the current model for apicomplexan motility and invasion.

82 plicating a central role for these motifs in apicomplexan motility.

83 In contrast, a closely related apicomplexan, Neospora caninum, was unable to inhibit IF

84 sequencing of many new eukaryotic parasite (apicomplexan or kinetoplastid) species or strains.

85 Malaria parasites belong to the diverse apicomplexan order Haemospororida and use a variety of v

86 cal and structural analyses demonstrated the apicomplexan orthologue to be a functional, homodimeric

87 The apicomplexan parasite Cryptosporidium causes diarrheal d

88 The apicomplexan parasite Cryptosporidium causes significant

89 p in TgPRF with the homologous loop from the apicomplexan parasite Cryptosporidium parvum does not af

90 an cells to infection with the intracellular apicomplexan parasite Cryptosporidium parvum, infected a

91 Cryptosporidiosis, caused by the apicomplexan parasite Cryptosporidium parvum, is a diarr

92 actin filament disassembly is essential for apicomplexan parasite development but not for motility,

93 nal inflammation driven by the intracellular apicomplexan parasite Eimeria falciformis.

94 We show that Eimeria falciformis, an apicomplexan parasite infecting the mouse caecum, induce

95 Apicomplexan parasite invasion of host cells is a multis

96 ymerisation of new actin filaments regulates apicomplexan parasite motility.

97 t in cells infected with the closely related apicomplexan parasite Neospora caninum.

98 The apicomplexan parasite Plasmodium falciparum causes malig

99 Severe malaria is caused by the Apicomplexan parasite Plasmodium falciparum, and results

100 he beta subunit, the CP alpha subunit of the apicomplexan parasite Plasmodium is refractory to target

101 Toxoplasma gondii, an apicomplexan parasite prevalent in developed nations, in

102 g infection, including Toxoplasma gondii, an apicomplexan parasite related to Plasmodium, the agent o

103 Neospora caninum is an apicomplexan parasite responsible for major economic los

104 Toxoplasma gondii (T. gondii) is an apicomplexan parasite that can cause eye disease, brain

105 Toxoplasma gondii is a ubiquitous apicomplexan parasite that can cause severe disease in f

106 Toxoplasma gondii is an apicomplexan parasite that causes morbidity and mortalit

107 a causative agent of bovine abortions, is an apicomplexan parasite that is closely related to the hum

108 The apicomplexan parasite Toxoplasma gondii can cause severe

109 As an obligate intracellular pathogen, the apicomplexan parasite Toxoplasma gondii evades immune sy

110 The apicomplexan parasite Toxoplasma gondii expands during a

111 The apicomplexan parasite Toxoplasma gondii is able to suppr

112 The life cycle of the apicomplexan parasite Toxoplasma gondii requires that an

113 (ABA) controls calcium signalling within the apicomplexan parasite Toxoplasma gondii, an opportunisti

114 te infection with the obligate intracellular apicomplexan parasite Toxoplasma gondii.

115 re recombinase-mediated recombination in the apicomplexan parasite Toxoplasma gondii.

116 cably linked and essential processes for the apicomplexan parasite Toxoplasma gondii.

117 e heparan sulfate acts as a receptor for the Apicomplexan parasite Toxoplasma gondii.

118 smodium falciparum, the mosquito-transmitted Apicomplexan parasite, causes the most severe form of hu

119 nternalization of the obligate intracellular apicomplexan parasite, Cryptosporidium parvum, results i

120 y against primary infection with the enteric apicomplexan parasite, Eimeria vermiformis, depends on t

121 ngly, Toxoplasma gondii, a highly successful apicomplexan parasite, expresses F16BP aldolase (TgALD1)

122 double beta-sandwich structure from another apicomplexan parasite, Toxoplasma gondii.

123 ifferences in actin filament dynamics for an apicomplexan parasite, which could be due to specific pr

124 bioinformatics resource for the AIDS-related apicomplexan-parasite, Cryptosporidium.

125 Apicomplexan parasites (including Plasmodium spp. and To

126 e host cell invasion by T. gondii or related apicomplexan parasites (including Plasmodium spp., which

127 mponent of the nucleotide salvage pathway in apicomplexan parasites and a potential target for drug d

128 AMA1 proteins are conserved among apicomplexan parasites and are of intense interest as ma

129 f a unique family of transporters present in apicomplexan parasites and Dictyostelium discoideum.

130 synthesis pathways are specific to different apicomplexan parasites and emphasize the distinct requir

131 nvolved in erythrocyte invasion by these two Apicomplexan parasites and paves the way for a comparati

132 xocytosis is essential to the lytic cycle of apicomplexan parasites and required for the pathogenesis

133 dence of an intracellular purine permease in apicomplexan parasites and suggests a novel biological f

134 highly adaptive direct physical interface of apicomplexan parasites and their hosts, by providing a b

135 Calcium-dependent protein kinases (CDPKs) of Apicomplexan parasites are crucial for the survival of t

136 Plasmodium and other apicomplexan parasites are deficient in purine biosynthe

137 Apicomplexan parasites are leading causes of human and l

138 ry complexes I and III, whereas Vitrella and apicomplexan parasites are missing only complex I.

139 Apicomplexan parasites are motile and invade host cells.

140 Apicomplexan parasites are responsible for high impact h

141 Apicomplexan parasites are the cause of numerous importa

142 Apicomplexan parasites are typified by an apical complex

143 for chemotherapy against T. gondii and other apicomplexan parasites as well.

144 Malaria in humans is caused by apicomplexan parasites belonging to 5 species of the gen

145 Apicomplexan parasites can change fundamental features o

146 ations and biochemical studies indicate that apicomplexan parasites can synthesize fatty acids via a

147 cine against any human parasitic disease and apicomplexan parasites cause enormous human suffering; t

148 Apicomplexan parasites cause numerous important human di

149 Apicomplexan parasites cause serious human and animal di

150 Apicomplexan parasites contain a conserved protein CelTO

151 Apicomplexan parasites contain a relict chloroplast, the

152 Apicomplexan parasites critically depend on a unique for

153 Gliding motility and host-cell invasion by apicomplexan parasites depend on cell-surface adhesins t

154 Apicomplexan parasites exhibit an unusual mechanism of h

155 e point of divergence of dinoflagellates and apicomplexan parasites from ciliates and may have accomp

156 the malaria-causing Plasmodium spp., and in Apicomplexan parasites generally, remain poorly understo

157 Most apicomplexan parasites harbor a relict chloroplast, the

158 Apicomplexan parasites harbor a secondary plastid that h

159 The nature of energy metabolism in apicomplexan parasites has been closely investigated in

160 Apicomplexan parasites have unique apical rhoptry and mi

161 t deploy their contents at the apical tip of apicomplexan parasites in a regulated manner.

162 Apicomplexan parasites include those of the genera Plasm

163 n found in several extracellular proteins of apicomplexan parasites including Plasmodium, Toxoplasma,

164 B(1), B(5) and B(6) by Plasmodium and other apicomplexan parasites is discussed.

165 One defining feature of apicomplexan parasites is their special ability to activ

166 The obligate intracellular lifestyle of apicomplexan parasites necessitates an invasive phase un

167 Cryptosporidium spp. are apicomplexan parasites of global importance that cause h

168 ma gondii and Neospora canine, single-celled apicomplexan parasites of humans and domestic animals.

169 he genus Theileria includes tick-transmitted apicomplexan parasites of ruminants with substantial eco

170 Following intracellular replication, the apicomplexan parasites Plasmodium falciparum and Toxopla

171 Experimental evidence suggests that apicomplexan parasites possess bipartite promoters with

172 The life cycles of apicomplexan parasites progress in accordance with fluxe

173 Apicomplexan parasites rely on actin-based gliding motil

174 Apicomplexan parasites rely on actin-based motility to d

175 K-lysin, have antimicrobial activity against apicomplexan parasites such as Eimeria spp., via membran

176 ne drives motility and host-cell invasion of apicomplexan parasites such as Plasmodium falciparum and

177 lay an important role in invasion by related Apicomplexan parasites such as the malaria parasite Plas

178 The substrate-dependent movement of apicomplexan parasites such as Toxoplasma gondii and Pla

179 Apicomplexan parasites such as Toxoplasma gondii rely on

180 In apicomplexan parasites such as Toxoplasma gondii, the ap

181 derstood, largely through studies in related apicomplexan parasites such as Toxoplasma.

182 on of Ca(2+)-related phenotypes in these two apicomplexan parasites suggests that depletion of intrac

183 ession during the life cycle stages in three apicomplexan parasites suggests that the two RPA1 types

184 a parasite Plasmodium falciparum and related apicomplexan parasites synthesize certain vitamins de no

185 Cryptosporidium species are waterborne apicomplexan parasites that cause diarrheal disease worl

186 Plasmodium and Toxoplasma are genera of apicomplexan parasites that infect millions of people ea

187 MA1) is a conserved transmembrane adhesin of apicomplexan parasites that plays an important role in h

188 s caused by protozoans of the genus Babesia, apicomplexan parasites that replicate within erythrocyte

189 elict plastid essential for viability of the apicomplexan parasites Toxoplasma and Plasmodium.

190 Apicomplexan parasites Toxoplasma gondii and Plasmodium

191 Apicomplexan parasites utilize a unique form of 'gliding

192 Gene regulation in apicomplexan parasites, a phylum containing important pr

193 Apicomplexan parasites, an ancient protozoan clade that

194 um species as well as more distantly related apicomplexan parasites, and contains two clusters of dis

195 ns, including Mycobacterium tuberculosis and apicomplexan parasites, and differs from the classical m

196 is an essential metabolic pathway in plants, apicomplexan parasites, and many species of bacteria.

197 bacteria, some gram-positive bacteria, some apicomplexan parasites, and plant chloroplasts.

198 itochondrial function, host cell invasion by apicomplexan parasites, and protein translocation across

199 ced in free-living phototrophic ancestors of apicomplexan parasites, and such reduction is not associ

200 Like subtilisin proteases in other Apicomplexan parasites, BdSUB-1 undergoes two steps of p

201 The obligate intracellular apicomplexan parasites, e.g. Toxoplasma gondii and Plasm

202 dent protein kinases (CDPKs) are expanded in apicomplexan parasites, especially in Toxoplasma gondii

203 Apicomplexan parasites, including Plasmodium falciparum

204 ) is a micronemal protein conserved in other apicomplexan parasites, including Plasmodium, Neospora,

205 ique group of myosin motor proteins found in apicomplexan parasites, including those that cause malar

206 us vacuole is a unique replicative niche for apicomplexan parasites, including Toxoplasma gondii.

207 vel molecular insight into cell traversal by apicomplexan parasites, our work facilitates the design

208 ry organelles unique to Toxoplasma and other apicomplexan parasites, play critical roles in parasite

209 During their life cycle, apicomplexan parasites, such as the malaria parasite Pla

210 nner two membranes of the apicoplasts of the apicomplexan parasites, Toxoplasma gondii and Plasmodium

211 that in medically and economically important apicomplexan parasites, two unique RPA complexes may exi

212 Toxoplasma gondii, like all apicomplexan parasites, uses Ca(2+) signaling pathways t

213 c aspects of cell biology in early-diverging Apicomplexan parasites, which do not divide by canonical

214 bundant mRNA-binding domains are enriched in apicomplexan parasites, while strong depletion of mRNA-b

215 centrate on serine/threonine phosphatases in apicomplexan parasites, with the focus on comprehensivel

216 nates motility, cell invasion, and egress by apicomplexan parasites, yet the key mediators that trans

217 ntly become the focus of research within the apicomplexan parasites.

218 tal transitions, biology and pathogenesis of apicomplexan parasites.

219 be crucial for the motility and survival of apicomplexan parasites.

220 que glimpse into the evolutionary history of apicomplexan parasites.

221 s observed between these two closely related apicomplexan parasites.

222 ife cycle of Plasmodium falciparum and other apicomplexan parasites.

223 stence of an alternative invasion pathway in apicomplexan parasites.

224 , being present in organisms from mammals to apicomplexan parasites.

225 y conserved function of CAPs from mammals to apicomplexan parasites.

226 an important experimental model for studying apicomplexan parasites.

227 ed for gliding motility and cell invasion by apicomplexan parasites.

228 the few actin-binding proteins conserved in apicomplexan parasites.

229 protein hub 1 (CPH1), which is conserved in apicomplexan parasites.

230 ing, mitochondrial dynamics, and invasion by apicomplexan parasites.

231 a shared but tailored invasion pathway among apicomplexan parasites.

232 lity, secretion, cell invasion and egress by apicomplexan parasites.

233 a significant role in host cell invasion by apicomplexan parasites.

234 tyostelium, Entamoeba), 4 plants/algae and 7 apicomplexan parasites.

235 eukaryotic cells and is poorly understood in apicomplexan parasites.

236 features of mitochondrial protein import in apicomplexan parasites.

237 proteins are conserved across the phylum of apicomplexan parasites.

238 whose homologs have been identified in many apicomplexan parasites.

239 t roles in protein trafficking mechanisms of apicomplexan parasites.

240 Calcium flux is essential for entry in apicomplexan parasites.

241 nction in motility and host cell invasion of apicomplexan parasites.

242 te the ever important CD8 T cell response to apicomplexan parasites.

243 domain) that is almost exclusively found in apicomplexan parasites.

244 ential for motility, invasion, and egress in apicomplexan parasites.

245 trolling stage and life cycle transitions of apicomplexan parasites.

246 eristics previously linked to the origins of apicomplexan parasitism and find that virtually all are

247 Here, we examine the origin of apicomplexan parasitism by resolving the evolutionary di

248 The apicomplexan pathogen Cryptosporidium parvum poses major

249 Apicomplexan pathogens are obligate intracellular parasi

250 a parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid orga

251 Cell invasion by apicomplexan pathogens such as the malaria parasite and

252 we superimposed this map on genomes of three apicomplexan pathogens--Plasmodium yoelii, Toxoplasma go

253 the survival of many important bacterial and apicomplexan pathogens.

254 cular, the C-terminal extension found in all apicomplexan PBGS enzymes forms an intersubunit beta-she

255 netic, enzymatic, and structural features of apicomplexan PBGS offer scope for developing selective i

256 el of conformity of RON2 proteins within the apicomplexan phylum, particularly that of the AMA1-RON2

257 tem disease caused by Babesia species of the apicomplexan phylum.

258 tiple types of RPA1 are present in the other apicomplexans Plasmodium and Toxoplasma.

259 and cytosolic metabolic pathways related to apicomplexan plastid function revealed an ancient depend

260 sequence profile searches, we show that the apicomplexans possess a lineage-specific expansion of a

261 we show that Plasmodium falciparum and other apicomplexans possess a unique heterodimeric glutamyl-tR

262 mbrane antigen 1 (AMA1) which is a conserved apicomplexan protein present in the micronemes and then

263 cal membrane antigen-1 (AMA1) is a conserved apicomplexan protein that plays an important but undefin

264 We have identified two sets of apicomplexan proteins that are homologous to plastid mem

265 Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of th

266 Apicomplexan protozoa such as Toxoplasma gondii invade h

267 dii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite that can cause fetal dam

268 l cell line (ARPE-19) and tachyzoites of the apicomplexan protozoan parasite Toxoplasma gondii (T. go

269 Apicomplexan protozoan pathogens avoid destruction and e

270 Diseases caused by the apicomplexan protozoans Toxoplasma gondii and Cryptospor

271 Our research suggests that the novel apicomplexan R2 subunit may be a promising candidate for

272 teins with an RNA-binding domain abundant in Apicomplexans (RAP domain) that is almost exclusively fo

273 (OPR) and an RNA-binding domain abundant in apicomplexans (RAP) domain.

274 Apicomplexan-related diseases may be controlled via inhi

275 nce data, we describe the diversity of these apicomplexan-related lineages and select five species th

276 Apicomplexan RPA1 proteins are phylogenetically more rel

277 amed RAP (for RNA-binding domain abundant in Apicomplexans), shared by all six members of the family.

278 specific TFs is paradoxical, given that the apicomplexans show a complex developmental cycle in one

279 apicoplast, a non-photosynthetic plastid of apicomplexan species, has an extremely reduced but highl

280 us proteins between phylogenetically distant Apicomplexan species.

281 We find that the Apicomplexan-specific ALBA4 RNA-binding protein acts to

282 fDHHC1 to be a member of a highly conserved, apicomplexan-specific clade of PATs.

283 not monophyletic and consistently placed the apicomplexan-specific clade sister to the remaining clas

284 Governing this balance is the apicomplexan-specific DAG-kinase-1, which interconverts

285 er, two recent studies have revealed that an apicomplexan-specific DNA-binding protein is essential f

286 a defect in secretion of the micronemes, an apicomplexan-specific organelle that contains adhesion p

287 rison of actins revealed a limited number of apicomplexan-specific residues that likely govern the un

288 pecialized secretory organelles, such as the apicomplexan-specific rhoptries and micronemes that are

289 Our analyses revealed that the apicomplexan-specific sequences share characteristics wi

290 semblance of Nephromyces infective stages to apicomplexan sporozoites.

291 The comparative genomics of apicomplexans, such as the malarial parasite Plasmodium,

292 Like most apicomplexans, T. gondii possesses several plant-like fe

293 family in Cryptosporidium, a basal-branching apicomplexan that is the second leading cause of infant

294 tions for the many genera and life stages of apicomplexans that express SPATR.

295 We present here a report of a beneficial apicomplexan: the mutualistic marine endosymbiont Nephro

296 Here, we demonstrate that the apicomplexan Toxoplasma gondii harbors homologues of pro

297 that modulate Ca(2+) signaling in the model apicomplexan Toxoplasma gondii In doing so, we took adva

298 osomatids, but associated with the conoid in apicomplexan Toxoplasma.

299 may provide clues to the ancestral state of apicomplexan transcriptional regulation, pre-AP2 dominat

300 Apicomplexans utilize a multiprotein complex that includ