ライフサイエンスコーパス: apolar

1 not be explained by the change in polar and apolar accessible surface areas.

2 up shuttles the reducing equivalent from the apolar active site to the protein surface.

3 alpha H58L replacement creates a completely apolar active site, which prevents electrostatic stabili

4 ing any polar functional groups) behave like apolar adsorbents and exhibit very interesting and unexp

5 al mechanism is not based on saponification, apolar adsorption or anion exchange, but most probably a

6 lar balances to measure interactions between apolar alkyl chains in 31 organic, fluorous and aqueous

7 They also suggest that an apolar amino acid corresponding to Ile(238) of the AT(1)

8 eleasing hormone (GnRH) receptor contains an apolar amino acid in this region at a constant distance

9 central region between the dimers, where an apolar amino acid is located.

10 Introduction of apolar amino acids at H74 resulted in distinct effects o

11 The apolar amino acids Leu(89), Ile(99), and Leu(104) "water

12 ectron micrographs reveal that filaments are apolar and made of stacked tetramers oriented with expos

13 Overall, mutation of apolar and polar amino acids to charged amino acids are

14 Water structuring around apolar and polar groups is an important factor in their

15 proteins albumin and lysozyme to LHA and to apolar and polar model surfaces.

16 molecular recognition of monosaccharides in apolar and polar protic solvents.

17 l contains an unusual alternating pattern of apolar and polar residue pairs that generate a rare righ

18 via two different routes in shape space--an apolar and polar route.

19 The apolar and polar routes may have evolved in order to fac

20 block, and random copolymers combining both apolar and polar vinylic repeat units.

21 s in apolar, polar, or aggregate (sum of the apolar and polar) buried surface area in the V(L)92 muta

22 ses in our scoring, particularly overweighed apolar and underweighted polar terms.

23 ydrophilic, whereas at pH 7.4 it is neutral, apolar, and hydrophobic.

24 Both polar and apolar aromatic compounds, including pyridine, benzene,

25 Small, apolar aromatic groups, such as phenyl rings, are common

26 eractions are the major driving force behind apolar association in solution.

27 ganization, namely bundled filaments, linked apolar asters, and a lattice of polar asters.

28 lity, the compressibility of water hydrating apolar atoms is somewhat larger than bulk water compress

29 s focused on separation of petrochemicals in apolar backgrounds, but the attention has moved now to t

30 amphiphilic peptides embedded near the polar/apolar bilayer interface.

31 eptide, mutations within thrombin's aryl and apolar binding site were explored.

32 referentially docked to the polar versus the apolar binding site were tested experimentally.

33 en BRCA1 and PALB2 is primarily mediated via apolar bonding between their respective coiled-coil doma

34 exist linear correlations between losses of apolar buried surface and decreases in binding free ener

35 correlation between binding free energy and apolar buried surface area corresponds to 21 cal mol(-1)

36 The losses in apolar buried surface area in the mutant complexes, rela

37 From their difference in apolar buried surface area, hydrophobic interaction is p

38 that DosC is a globin-coupled sensor with an apolar but accessible heme pocket that binds oxygen with

39 mperature using the slightly polar CDCl3 and apolar C6D6 as solvents in 5 mM and 54 mM concentrations

40 ins, the detection of water molecules within apolar cavities and the determination of crystallographi

41 The extent to which water is present within apolar cavities in proteins remains unclear.

42 In contrast to apolar cavities in rigid carbon structures, such as nano

43 ide a representative sample of predominantly apolar cavities of varying size and shape.

44 99A/M102Q) but do not detectably bind to the apolar cavity (L99A).

45 al phases, we estimate that occupancy of the apolar cavity in IL-1beta by solvent is close or equal t

46 The database was first screened against the apolar cavity site created by the mutation Leu99Ala (L99

47 ate that water is not present in the central apolar cavity.

48 wo fully occupied water molecules within the apolar cavity.

49 meres that allocate polar cells to outer and apolar cells to inner positions initiate the first cell

50 mal hyphal growth and endocytosis defects in apolar cells.

51 and outer polarised cells become inner-like apolar cells.

52 to be dominant in driving the association of apolar chains in aqueous solution.

53 der Waals forces in the self-association of apolar chains.

54 In contrast, blocking the entrance to the apolar channel by increasing the size of Ala-55(E18) to

55 ze of the E7 gate and closing the end of the apolar channel in CerHb by site-directed mutagenesis.

56 gly polar channels are coupled to completely apolar channels, in which case auxin in the apolar part

57 Sec17(F21S,M22S), with diminished apolar character to its hydrophobic loop, fully supporte

58 ionic guests increases continuously with its apolar character, as shown by the significant change of

59 contributions of dispersion interactions in apolar cohesion were found to be strongly attenuated in

60 erature for the resolution of both polar and apolar complex mixtures components by NMR spin diffusion

61 re amphoteric in nature with the dispersive (apolar) component of surface energy dominating the speci

62 n-specific in polar compounds but less so in apolar compounds and a diffusive IE that is not position

63 e in water's heat capacity upon hydration of apolar compounds is one signature of the hydrophobic eff

64 ing the molecular interactions made by these apolar compounds with biological membranes or their effe

65 ctive site, the xylan backbone makes limited apolar contacts with the enzyme, and the hydroxyls are s

66 ce of interhelical salt bridges here exposes apolar core atoms to solvent.

67 use of this stabilizing contribution in the apolar core of the bilayer.

68 nteract in a complicated fashion through the apolar core of the folded antibody.

69 d they also form an integral part of a small apolar core.

70 Conventionally, the contribution of apolar desolvation to affinity is attributed to gain of

71 te in the E7 channel that can accommodate an apolar diatomic ligand and enhances ligand uptake partic

72 ) and PIN2-GFP displayed abnormal, partially apolar distribution.

73 The apolar domain consists of a perfluorohexyl main chain an

74 drophobicity while keeping the length of the apolar domain short.

75 o promote lipid mixing and must be small and apolar (e.g., Gly or Ala) to support both lipid and cont

76 ned to minimize autoxidation of the unstable apolar E7 mutants.

77 th 7alpha-OH groups of bile acids, and (iii) apolar EL1 residues map to hydrophobic ligand pharmacoph

78 ophobic transmembrane (TM) segments into the apolar environment of the lipid bilayer.

79 approximately 2125 cm(-1), indicative of an apolar environment, is observed for CNRs bound to H64A o

80 with burial of the tryptophan residues in an apolar environment.

81 els are often incompletely reduced in highly apolar environments.

82 2, WAVE2, and activation of CDC42 results in apolar F-actin localization, leading to defects in adhes

83 in which EPM expression was expressed in an apolar fashion on the surface of mammary epithelial cell

84 I present arguments here that ParM may be an apolar filament, in which the two helical strands are an

85 omplexes, which serve as building blocks for apolar filamentous structures that differ among cell typ

86 s, which in turn are able to polymerize into apolar filaments and higher-order structures.

87 Endocytosis was severely impaired in apolar fimA disruption cells.

88 educing equivalents are transferred from the apolar flavin binding site to the protein substrate by d

89 dapted a UV photolabeling approach, using an apolar fluorescent probe, 4,4'-dianilino-1,1'-binaphthyl

90 condary structure and its ability to bind an apolar fluorophore.

91 nctionally critical approximately 20-residue apolar "fusion peptide" (HFP) that associates with targe

92 gesting that hydrophobic partitioning of the apolar gas from the aqueous phase into the relatively ap

93 In this study an apolar glycolipid, presumably corresponding to dimycolyl

94 th a severe decrease in the level of a major apolar glycolipid.

95 higher affinity natural ligand, occupying an apolar groove between its alpha(1) and alpha(2) domain h

96 ce shows that the enthalpy of dehydration of apolar groups at the HMG-D/DNA interface is not fully co

97 The transfer free energy of apolar groups from water to TMAO consists of favorable e

98 es around polar and apolar groups: polar and apolar groups have a deficit or excess, respectively, of

99 The differential solubility of polar and apolar groups in water is important for the self-assembl

100 The interaction between TMAO and apolar groups is slightly favorable.

101 folded state results in hydration of exposed apolar groups of the interface and the disruption of hel

102 by extensive van der Waals contacts between apolar groups, i.e. a more tightly packed interface form

103 butions for the interaction between urea and apolar groups.

104 icity ( approximately 21 amino acids) in the apolar groups.

105 ferent hydration structures around polar and apolar groups: polar and apolar groups have a deficit or

106 apolar pockets can be designed to recognize apolar guests in water, complementary strategies are req

107 Cry1Ab adsorption to relatively apolar HAs at I = 50 mM exhibited rapid initial rates, w

108 ccharomyces cerevisiae, four septins form an apolar hetero-octamer (Cdc11-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3

109 tricted assembly into distinct categories of apolar heterohexamers and heterooctamers.

110 ntributed to Cry1Ab protein adsorption to an apolar humic acid (HA).

111 operative activation of protic, hydridic and apolar HX bonds across a Group 13 metal/activated beta-d

112 ith the most prominent effects shown for the apolar hydrocarbon solvents and 2-propanol.

113 er a minimalistic model interface between an apolar hydrophobic phase (n-decane) and an aqueous phase

114 egates polarized trophectoderm cells from an apolar inner cell mass (ICM).

115 d might participate in sugar binding through apolar interactions.

116 this amphipathic structure matches the polar/apolar interface of the lipid bilayer very well.

117 ever, the presence of the Met residue in the apolar interface of the tetramer markedly alters its loc

118 e PE and PPE proteins mate along an extended apolar interface to form a four-alpha-helical bundle, wh

119 /L, the peptide primarily binds on the polar-apolar interface with its helical axis parallel to the b

120 rom simple starting materials at other polar-apolar interfaces; this could have numerous materials an

121 s the 4E10 epitope was immersed in the polar-apolar interfacial region of the lipid bilayer.

122 Strong loss-of-function mutants assemble apolar intersecting microtubule arrays, whereas weaker m

123 In the apolar L99A cavity, affinity for Ab dropped only slightl

124 arity, with higher Cry1Ab affinities to more apolar LHA regions due to the hydrophobic effect.

125 ing hemoglobin, suggesting an unhindered and apolar ligand binding pocket.

126 uried sites: a hydrophobic cavity that binds apolar ligands, a slightly polar cavity that binds aryl

127 solvation energies improved ranking of known apolar ligands, and better distinguished them from more

128 igh-density lipoproteins (HDL); they have an apolar lipid core and polar surface composed of exchange

129 complexes containing a triacylglycerol-rich apolar lipid core and polar surface composed of phosphol

130 Mature spherical HDL contain the apolar lipid core and polar surface of proteins and phos

131 tion reflects HDL rupture and release of the apolar lipid core.

132 involves particle rupture and release of the apolar lipid core.

133 Apolar lipids are known to form lipid droplets or lipopr

134 rmation of larger particles and repacking of apolar lipids but no global protein unfolding.

135 of compact bones indicated a high content of apolar lipids, including triglycerides and cholesterol e

136 bserved in glycopeptidolipids, polar lipids, apolar lipids, or mycolic acids of the cell wall.

137 phosphatidylinositol mannosides, and highly apolar lipids, similar to the Minnikin model of 1982.

138 bmicrolitre aqueous droplets submerged in an apolar liquid containing lipid can be tightly connected

139 ctly requires Sec18 and Sec17, and the Sec17 apolar loop has functions beyond membrane anchoring.

140 ayer of the SNARE complex and its N-terminal apolar loop.

141 s-SNARE complexes, oligomerizes, and inserts apolar loops into the apposed membranes, locally disturb

142 n of an uncompensated electric charge in the apolar, low-dielectric protein interior.

143 T by the addition or removal of water to the apolar medium.

144 to HOPS and a C-terminal SNARE domain but no apolar membrane anchor.

145 urfactant migration entails a net shift from apolar membrane spanning regions to more polar regions o

146 ckbone hydrogen bonds should be strong in an apolar membrane, potentially rigidifying helices.

147 dissolved in DMSO-d6/GL (8:2, v/v) and of an apolar mixture made of beta-ionone, (+/-)-citronellal, (

148 lized by a favorable packing of the ligand's apolar moieties with the hCAII "hydrophobic wall".

149 rophobic pocket in HCAII that stabilizes the apolar moiety of sulfonamide inhibitors is replaced with

150 that has frequent dynamic interactions with apolar molecules; both hexane and a long-chain fatty aci

151 e this hypothesis, acidic, basic, polar, and apolar mutations were introduced at positions 94-98.

152 mechanism minimizes aqueous exposure of the apolar mycolates.

153 s are consistent with the model in which the apolar N-terminal and central regions of the peptides pe

154 on rate of HFPtr because of placement of the apolar N-terminal regions of all strands on the same sid

155 ith intermolecular hydrogen bonding of 15-16 apolar N-terminal residues and this hydrogen-bonding pat

156 The apolar nature of TMDs necessitates the use of membrane-m

157 Cdc3, Cdc10, Cdc11, and Cdc12 form an apolar octameric rod with Cdc11 at each tip, which polym

158 d groups, whereas stimulatory compounds were apolar oils.

159 others are required for transitions via the apolar or polar route and not amoeboid or mesenchymal mo

160 ed transformations involve the activation of apolar or weakly polar sigma-bonds (E-H and E-E' bonds,

161 stigating the coordination and activation of apolar or weakly polar sigma-bonds at copper using chela

162 thacrylate) (PMMA) colloids, suspended in an apolar organic medium.

163 ferentially populates a helical structure in apolar organic solvent, while in pure water, the peptide

164 mply bubbling CO2 through their solutions in apolar organic solvents (CHCl3, benzene) and even in the

165 and 8 also adopted helical conformations in apolar organic solvents.

166 The apolar outer barrel surface with large sidechains is imm

167 ted molecules resulting from the addition of apolar oxygen under high pressure.

168 Apolar oxygen, which is known to partition with an incre

169 apolar channels, in which case auxin in the apolar part is 'dragged along' by the polar part in a so

170 protein-binding site, comprising an unusual apolar patch on the surface together with surrounding ch

171 ) (PEO-b-PCL) block polymers modified at the apolar PCL terminus with thioctic acid and at the polar

172 hat was achieved choosing the immunodominant apolar peptide from alpha2-gliadin as a target for selec

173 The polar and apolar phases of the limonene/methanol/water 10/9/1 v/v

174 ABCB19 exhibits a predominantly apolar plasma membrane (PM) localization and stabilizes

175 t two specific locations within the spacious apolar pocket and an ordering effect of endogenous resid

176 Our results indicate that apolar pocket interactions are a common feature of tande

177 a beta-barrel structure with a predominately apolar pocket representing a potential binding site for

178 mic acid analogues interact with the dynamic apolar pocket that surrounds the C4 and C5 hydroxyl grou

179 ged hydrophobic channel that merges with the apolar pocket.

180 two different lipid-binding modes within the apolar pocket.

181 the hydrophobic channel that merges with the apolar pocket.

182 hanced hydrophobic effect upon binding to an apolar pocket.

183 ves as a gate for passage of ligand into the apolar pocket; and (iii) that this loop and the adjacent

184 Equivalent occupied apolar pockets are also seen in the tandem LIM domain st

185 cognized approach to this challenge in which apolar pockets can be designed to recognize apolar guest

186 of classical monopartite NLSs by generating apolar pockets for the P3 and the P5 lysine/arginine sid

187 e residues from Arp7A that occupy equivalent apolar pockets in both LIM domains as well as an interve

188 orrelation was observed between decreases in apolar, polar, or aggregate (sum of the apolar and polar

189 e for association than Asn residues near the apolar/polar interface.

190 pare nanoparticles that have a gold core, an apolar polyester layer for drug loading, a polar PEO cor

191 pocket that is capable of accommodating the apolar Pro(P+1) residue of the peptide.

192 s from the aqueous phase into the relatively apolar protein interior lowers the free energy barrier f

193 ntial contributions from charged, polar, and apolar protein-water interfaces.

194 ion of cofilin expression in MTLn3 cells (an apolar randomly moving amoeboid metastatic tumor cell) c

195 NaY and zeolite beta were used as polar and apolar reference adsorbents, respectively.

196 in increased conformational disorder of the apolar region and further dehydration of the interfacial

197 itionally, the N-terminal domain contains an apolar region comprising almost half its solvent accessi

198 ermediate between that of bulk water and the apolar region of micelle.

199 re was a good match between the width of the apolar region of the bilayer and the hydrophobic length

200 (HIV) fusion peptide (HFP) is the N-terminal apolar region of the HIV gp41 fusion protein and interac

201 se data show that Asn side chains within the apolar region of the transmembrane helix provide a signi

202 Changes in the apolar regions of the lipid bilayer are minimal, whereas

203 s affording a combination of hydrophobic and apolar regions on one hand and dipolar, protic, and posi

204 nment for membrane proteins and can serve as apolar reservoirs for lipid-derived second messengers or

205 Remarkably, a single mutation of an apolar residue at the bottom of an otherwise hydrophobic

206 Prior work showed that converting K84 to an apolar residue or converting V96 to an acidic residue im

207 often occupying the same face, whereas polar/apolar residue pairs tend to occupy opposite faces.

208 the HDAC4 tetramer lacks regularly arranged apolar residues and an extended hydrophobic core.

209 is postulated that propensities possessed by apolar residues are due in part to peptide-solvent inter

210 A central constriction of six apolar residues has been shown to form a seal, but also

211 rees C, consistent with favorable packing of apolar residues in the membrane.

212 essivity in which wedging of Leu78 and other apolar residues into the base pairs of the DNA restricts

213 The approximately 20 N-terminal apolar residues of gp41 are called the HIV fusion peptid

214 , which is 5.8 A from Pro-1 and is one of 12 apolar residues within 9 A of Pro-1.

215 winding of the DNA is facilitated by several apolar residues, including Leu78, that wedge into the ba

216 ments used to determine the propensities for apolar residues, plus glycine, asparagine, and glutamine

217 three Pro moieties and a high percentage of apolar residues.

218 bstitutions in the guide strand of U for the apolar ribo-2,4-difluorotoluyl nucleotide (rF) as well a

219 ed on identifying novel substituents for the apolar S2 pocket of cathepsin L and was conducted entire

220 These filaments are assembled from apolar septin hetero-octamers.

221 or the hydrogen bonds, thus resulting in an "apolar" sheet.

222 The hydrophobic interface is stabilized by apolar side chains from adjacent sheets, whereas the hyd

223 vely charged, positively charged, polar, and apolar side chains) into live cells.

224 Our measurements reveal parity for apolar side-chain contributions between soluble and memb

225 roteins are alpha-helical with predominantly apolar side-chains packing in a hydrophobic interface.

226 ices in parallel and in register so that the apolar sides face each other, and the oppositely charged

227 ability of copper to promote the addition of apolar sigma-bonds to CC multiple bonds via a 2e redox s

228 ps by increasing contact within the aryl and apolar sites.

229 l electrostatic fields in the presence of an apolar solute.

230 dynamics simulation the solubility of small apolar solutes in a solvent whose particles interact via

231 ate (K(D) > or = 10(6) M(-1) per capsule) in apolar solution with the formation of linear self-assemb

232 ion with cyclohexanol and cyclohexene in the apolar solvent decalin has been studied using in situ (1

233 applied to a pure component suspension in an apolar solvent, a strong inhomogeneous electric field in

234 pam on the MIP columns was achieved using an apolar solvent, and the binding capacity of the polymer

235 s and, similarly, correlates with changes in apolar solvent-accessible surface area.

236 d correlates well with calculated changes in apolar solvent-accessible surface area.

237 n with either fluorine content or changes in apolar solvent-accessible surface area.

238 on of contributions from charged, polar, and apolar solvent-accessible surfaces.

239 orm with t-BuNCO and an inorganic base in an apolar solvent.

240 CO(2) rapidly reacts with chains 1n in apolar solvents and cross-links them with the formation

241 gh a concerted mechanism in gas phase and in apolar solvents but a stepwise mechanism in polar solven

242 phylloxanthobilin Z isomers photodimerize in apolar solvents by regio- and stereospecific thermorever

243 we show that using non-interacting anions in apolar solvents can maximize favorable interactions betw

244 to the O5 atom of alpha-D-hexopyranosides in apolar solvents is evidenced in (1)H NMR spectra.

245 The use of apolar solvents is particularly useful for assigning the

246 Studies in apolar solvents such as CD(2)Cl(2) and benzene-d(6) reve

247 pyrrolidinopyridine (PPY) are much larger in apolar solvents than in DMF.

248 r (cis) around the carbonyl-nitrogen bond in apolar solvents, in contrast to other aliphatic secondar

249 This is in contrast to partitioning into apolar solvents, which exhibits the classic hydrophobic

250 hese isoprostanyl phospholipids aggregate in apolar solvents.

251 at about 530 nm with good quantum yields in apolar solvents.

252 nts and an inverted micelle-like assembly in apolar solvents.

253 tion that the two glycocalixarenes assume in apolar solvents.

254 cooperative formation of cyclic hexamers in apolar solvents.

255 ]2.L (coordinated L = Et2O: 2b, dman: 2c) in apolar solvents.

256 and mei-1(-) mutants assemble monopolar and apolar spindles, respectively.

257 -C) was identified, which has a crystalline, apolar structure and exhibited significant antioxidant a

258 h hydrophobicity due to long alkyl chains or apolar substituents appears to stabilize the interaction

259 ved in the presence of Ca(2+), suggests that apolar surface area buried in the Ca(2+)-bound state bec

260 The increased solvent exposure of apolar surface area in the Ca(2+)-free protein is consis

261 the proportionality between free energy and apolar surface area is discussed.

262 l affinity of a binding site in terms of its apolar surface area is proposed.

263 is inferred to result from the reduction of apolar surface area of the enzyme ensuing from a conform

264 c parameterization to estimate the polar and apolar surface area of the interface.

265 The exposure of substantial apolar surface area suggests the intriguing possibility

266 such denaturation decreased with increasing apolar surface area, all proteins exhibited high melting

267 t accompany DNA binding, derived from buried apolar surface area, coupled folding, and restriction of

268 a simple model including terms for polar and apolar surface area, surface complexity, and pocket dime

269 lated estimate indicates burial of polar and apolar surface areas in equal measure upon ligand bindin

270 used to generate cavities with increasingly apolar surface areas inside a dodecameric ferritin-like

271 served hydrophobic region forms an extensive apolar surface at a dimer interface on the opposite side

272 cause the correlation of entropy change with apolar surface burial is relatively weak, it cannot, on

273 is found between the binding free energy and apolar surface burial upon complex formation.

274 rgetics correlates better with the amount of apolar surface buried upon sugar stacking on top of the

275 inct from the Ca(2+)-bound protein, exposing apolar surface for interaction with ANS.

276 attribute this discrepancy to burial of the apolar surface in the N fragment (as burial of the polar

277 V, perhaps due to greater solvent-accessible apolar surface in the native form.

278 ng indicate no significant burial of protein apolar surface nor altered accessibility of Trp-121 upon

279 configure a docking site that complements an apolar surface of the CKA1 PTB domain.

280 rophobic binding pocket that accommodates an apolar surface on R(CE) dimers.

281 tic difference, on average, in the burial of apolar surface or polar surface area, implying that van

282 gest that burial of about 1000--1600 A(2) of apolar surface takes place in the N fragment (probably a

283 his corresponds to 648 +/- 36 A(2) of buried apolar surface upon Nkx2.5(C56S) binding duplex B-DNA.

284 ATH is accompanied by diminished exposure of apolar surface, relative to Ca(2+)-free rat beta-PV, per

285 c lectins" which employ oligophenyl units as apolar surfaces.

286 r branching in the chemical structure of the apolar tails.

287 mann equation, with a surface-area-dependent apolar term and contributions from conformational change

288 ation combined with a surface area-dependent apolar term.

289 vided that the organic layer is sufficiently apolar, the resultant Meisenheimer adduct is considerabl

290 polarity: It is deactivated/switched-off in apolar toluene, while in polar benzonitrile it is activa

291 amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that e

292 ed photoproduct, together implicate both the apolar tunnel and the static and dynamic properties of t

293 ork within the distal heme pocket and a long apolar tunnel linking the external solvent to the distal

294 ccessible side chain positions; and (iv) the apolar tunnel linking the heme site to the solvent biase

295 e distal heme pocket, (ii) from the adjacent apolar tunnel prior to conformational relaxation, and (i

296 onformational relaxation, and (iii) from the apolar tunnel subsequent to conformational relaxation.

297 utating these negatively charged residues to apolar uncharged residues completely blocks activity, ev

298 t; and (iii) that this loop and the adjacent apolar V59-W63 loop form a surface patch with two expose

299 NAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the

300 cations, i.e. RHO-ZMOF, and (iii) two rather apolar zeolitic imidazolate framework (ZIF) materials wi