ライフサイエンスコーパス: apoptotic body

1 untingtin generated the most cell fragments (apoptotic bodies).

2 ompetent cell fragments (matrix vesicles and apoptotic bodies).

3 uring apoptosis to catalyze the formation of apoptotic body.

4 is, chromatin condensation, and formation of apoptotic bodies.

5 marker for assessing apoptosis or detecting apoptotic bodies.

6 ted with particles of a size consistent with apoptotic bodies.

7 RA on VSMCs and blocks phagocytic removal of apoptotic bodies.

8 contain abnormal microtubule arrangement and apoptotic bodies.

9 mmunogen expression before the generation of apoptotic bodies.

10 and increased the subsequent level of total apoptotic bodies.

11 d [3H]-membrane lipid release and release of apoptotic bodies.

12 pases arrested the maturation and release of apoptotic bodies.

13 functional properties of chondrocyte-derived apoptotic bodies.

14 f chromatin condensation, cell shrinkage and apoptotic bodies.

15 ntation, membrane blebbing, and formation of apoptotic bodies.

16 uclear DNA, and the subsequent appearance of apoptotic bodies.

17 the presence of cytoplasmic nucleosomes and apoptotic bodies.

18 udies demonstrate the ubiquitous presence of apoptotic bodies.

19 frequently sheared off the 'string' to form apoptotic bodies.

20 ts in the exclusion of nuclear contents from apoptotic bodies.

21 ation of 'beads-on-a-string' protrusions and apoptotic bodies.

22 teins that were specifically absent in HiBEC apoptotic bodies.

23 res were also obtained from intact cells and apoptotic bodies.

24 loid P component (SAP)-mediated clearance of apoptotic bodies.

25 rmation by constructing "blebbishields" from apoptotic bodies.

26 f its contents into membrane vesicles called apoptotic bodies.

27 These nucleosomal units are then included in apoptotic bodies.

28 phosphatidylserine exposed on the surface of apoptotic bodies.

29 present at the surface of apoptotic cells or apoptotic bodies.

30 de did not alter the rate of newly generated apoptotic bodies.

31 fragmentation, and the deposition of B cell apoptotic bodies.

32 rovesicles (MVs), but not exosomes (Exos) or apoptotic bodies (Abs), are the main type of EVs found i

33 normally surrounds the cells is degraded and apoptotic bodies accumulate within and in the vicinity o

34 d in a significant increase in the number of apoptotic bodies after 4-6 hours.

35 ytosis is also required for the clearance of apoptotic bodies, an essential aspect of tissue homeosta

36 on, orally applied OTP reduced the number of apoptotic bodies and activated caspase-3-positive cells

37 o dehydration from that due to detachment of apoptotic bodies and can be used on samples where cell v

38 studies showing the formation and release of apoptotic bodies and cell death, and both processes are

39 ors have been implicated in the clearance of apoptotic bodies and could compensate for the TIM-4 defi

40 translocate immunologically intact PDC-E2 to apoptotic bodies and create an apotope.

41 ectable at 24 h postinfection as revealed by apoptotic bodies and DNA fragmentation, indicating that

42 reased cell viability and marked decrease of apoptotic bodies and DNA laddering.

43 oside, WT or NRKvector exhibited significant apoptotic bodies and DNA laddering; in contrast, NRKproH

44 and internalization of sialic acid decorated apoptotic bodies and exosomes derived from tumors.

45 proteins or lipids or in vesicles, including apoptotic bodies and exosomes.

46 ed at the outer membrane surface to resemble apoptotic bodies and phosphatidic acid (PA) at the inner

47 with increased frequency of hepatocytes with apoptotic bodies and positivity for proliferating cell n

48 play an important role in the generation of apoptotic bodies and their recognition by phagocytosing

49 lar mechanisms followed by the generation of apoptotic bodies and their subsequent rapid elimination

50 eleased was proteinaceous in nature, free of apoptotic bodies, and had an apparent m.w. much larger t

51 ere detected in the cells with intracellular apoptotic bodies, and immunohistochemistry documented tr

52 Increased numbers of mitotic cells, apoptotic bodies, and polyploid keratinocytes were evide

53 atin condensation, PARP cleavage, release of apoptotic bodies, and release of labeled lipid, DEVD-tre

54 ion of microbial pathogens, senescent cells, apoptotic bodies, and retinal outer segment fragments.

55 The levels of pyrophosphate produced by apoptotic bodies are increased by pretreatment of the ch

56 el cell cleavage process in which developing apoptotic bodies are rescued by the virus and differenti

57 at encompasses microparticles, exosomes, and apoptotic bodies) are emerging as a novel mean of cell-t

58 lular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circu

59 mbrane and nuclear blebbing and formation of apoptotic bodies, are not observed in dying aleurone cel

60 ith a threefold increase in the frequency of apoptotic bodies as detected by terminal deoxynucleotidy

61 s and epithelial cells were found to contain apoptotic bodies at 3 times the rate of nonexpressing ce

62 erine macrophages resulting in a build up of apoptotic bodies at the uteroplacental interface that el

63 Several Kupffer cells were seen containing apoptotic bodies but did not show evidence of apoptosis.

64 ese cells show neither DNA fragmentation nor apoptotic bodies, but display lethal damage of the cell

65 re resistant to the Fas-induced formation of apoptotic bodies, but had an enhanced externalization of

66 Engulfment of the apoptotic bodies, but not latex beads, stimulated Kupffe

67 ic process, the induction of phagocytosis of apoptotic bodies by hepatic stellate cells.

68 r aim was to ascertain whether engulfment of apoptotic bodies by Kupffer cells promotes hepatic infla

69 The disposal of apoptotic bodies by professional phagocytes is crucial t

70 Our ability to improve the disposal of apoptotic bodies by professional phagocytes is impaired

71 e have previously shown that phagocytosis of apoptotic bodies by stellate cells induces procollagen a

72 ly we have demonstrated that phagocytosis of apoptotic bodies by stellate cells is profibrogenic.

73 th EM studies we showed that phagocytosis of apoptotic bodies by stellate cells occurs in vivo.

74 drug delivery by phagocytosis of drug-loaded apoptotic bodies by the tumor cells and by increased dru

75 Alcohol-induced hepatocyte apoptotic bodies can be phagocytosed by HSCs and Kupffer

76 Apoptotic bodies can be used to target delivery of DNA-e

77 Apoptotic bodies can readily be ingested, with their nut

78 Because apoptotic bodies can serve as nucleation sites for calci

79 ents (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic de

80 Apoptotic bodies contain alkaline phosphatase and NTP py

81 r vesicles (EVs; exosomes, microvesicles and apoptotic bodies) containing proteins, lipids and RNAs i

82 Here we show that antigen-laden apoptotic bodies created by vectors co-expressing influe

83 optosis precedes VSMC calcification and that apoptotic bodies derived from VSMCs may act as nucleatin

84 uding cell shrinkage, rounding, formation of apoptotic bodies, detachment and nuclear condensation an

85 asma membrane blebbing, and the formation of apoptotic bodies do not occur when aleurone cells die.

86 In particular, the clearance of apoptotic bodies (efferocytosis) is enabled by externali

87 ese results suggest that chondrocyte-derived apoptotic bodies express functional properties that may

88 ed (BDL) mice were phenotypically similar to apoptotic body-"fed" Kupffer cells with enhanced death l

89 levels [Ca(2+)](i), cell membrane integrity, apoptotic body formation and DNA fragmentation in cultur

90 These data uncover a new mechanism of apoptotic body formation in monocytes and also compounds

91 vealed a block in chromatin condensation and apoptotic body formation when nuclei from HeLa cells exp

92 ladder formation, cell surface blebbing, and apoptotic body formation.

93 ladder formation, cell surface blebbing, and apoptotic body formation.

94 plasmic vacuolization, DNA condensation, and apoptotic body formation.

95 ular DNA into oligonucleosomal fragments and apoptotic body formation.

96 gamma-H2AX formation, DNA fragmentation, and apoptotic body formation.

97 5% loss in cell volume, DNA degradation, and apoptotic body formation.

98 ude cell contraction, membrane blebbing, and apoptotic body formation.

99 uding membrane blebbing, cell shrinkage, and apoptotic body formation.

100 rogenase complex immunologically intact into apoptotic bodies, forming an apotope.

101 at macrophages have a function in scavenging apoptotic bodies from cells undergoing programmed cell d

102 ntation of the 19-kDa lipoprotein as well as apoptotic bodies from M. tuberculosis-infected cells.

103 Apoptotic bodies generated by recombinant MVA (rMVA)-Ag8

104 ed murine Kupffer cells efficiently engulfed apoptotic bodies generated from UV-treated mouse hepatoc

105 hagocytic cell activity was maintained after apoptotic bodies had been removed.

106 hagocytic uptake and lysosomal fusion of the apoptotic body harboring the bacterium.

107 s platform for proteomic characterization of apoptotic bodies in an effort to define the complex prot

108 significantly greater numbers of glomerular apoptotic bodies in C1q-deficient mice compared with con

109 istribution and association with well-formed apoptotic bodies in Cux-1(C)-infected cells.

110 ycotoxin induced cell death, DNA ladders, or apoptotic bodies in CV-1 cells expressing simian virus 4

111 of VP3 and a general lack of VP3-associated apoptotic bodies in infections of CIA-1 and chimeras con

112 Phagocytosis of apoptotic bodies in LX-1 cells significantly increased s

113 ntration-induced activation of caspase-3 and apoptotic bodies in mIMCD3 cells.

114 Apoptotic bodies in the mammary tumor were higher by abo

115 plement split products were deposited on the apoptotic bodies in the platelet pack.

116 MDMphis from PBC patients cultured with BEC apoptotic bodies in the presence of AMAs markedly increa

117 ages and B-1 cells do not efficiently engulf apoptotic bodies in vitro, or clear apoptotic bodies in

118 that TIM-4 is critical for the clearance of apoptotic bodies in vivo, and that lack of TIM-4 results

119 y engulf apoptotic bodies in vitro, or clear apoptotic bodies in vivo.

120 duced by lymphoid radiation, suggesting that apoptotic body ingestion by CD8(+) DCs initiates toleran

121 ther we demonstrate that the phagocytosis of apoptotic bodies inhibits both spontanous and UV-irradia

122 The presence of apoptotic bodies is considered important for the generat

123 Functional analysis shows that apoptotic bodies isolated from NO-treated chondrocytes o

124 of TIM-4 results in aberrant persistence of apoptotic bodies leading to dysregulated lymphocyte acti

125 re nuclear shrinkage and disintegration into apoptotic body-like fragments.

126 Results show that these apoptotic body-like liposomes carrying PA (ABL/PA) (i) a

127 Altogether, these results suggest that apoptotic body-like liposomes may be used as a Janus-fac

128 RECENT FINDINGS: Microvesicles, exosomes, apoptotic bodies, lipoproteins, and large microparticles

129 nfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macropha

130 ystem opsonin which binds nuclear debris and apoptotic bodies, may protect against autoimmunity.

131 three types of extracellular vesicles (EVs): apoptotic bodies, microvesicles and exosomes.

132 extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emer

133 mechanisms could include antigens present in apoptotic bodies, necrotic debris, exosomes or even rele

134 generated from CD14+ precursors, pulsed with apoptotic bodies of an allogeneic NSCLC cell line that o

135 cells as well as dendritic cells pulsed with apoptotic bodies of CLL cells to generate autologous and

136 re 11 proteins that localize specifically to apoptotic bodies of HiBEC and eight proteins that were s

137 wild-type mice affected either the number of apoptotic bodies or the number of live macrophages.

138 o exosomes, microvesicles/microparticles, or apoptotic bodies, originating from different subcellular

139 Histopathology studies revealed fewer apoptotic bodies (P<0.05) in both the normal (1.70+/-0.1

140 dular VSMCs was unaltered, but the number of apoptotic bodies per nodule increased approximately 3-fo

141 Both apoptotic body phagocytosis and death ligand generation

142 A count of all of the apoptotic bodies positively labeled for nuclear DNA frag

143 e a mechanistic link between phagocytosis of apoptotic bodies, production of oxidative radicals, and

144 iver injury where Kupffer cell engulfment of apoptotic bodies promotes inflammation and fibrogenesis.

145 eed to acidify immediately in order to clear apoptotic bodies rapidly and effectively.

146 sis of large extracellular particles such as apoptotic bodies requires delivery of the intracellular

147 DCs cultured with apoptotic bodies stimulated significantly greater T-cell

148 ssion correlated with a dramatic increase in apoptotic bodies, suggesting that Xist-mediated X chromo

149 iruses encode caspases or form such modified apoptotic bodies, suggesting this caspase plays a direct

150 toplasm, cell shrinkage, and budding-off of 'apoptotic bodies' that are engulfed by glia.

151 vesicles (EVs; exosomes, microvesicles, and apoptotic bodies) that differ in biogenesis, composition

152 response to the larger numbers of persistent apoptotic bodies, the number of live macrophages in thes

153 inflammatory sites it can bind bacteria and apoptotic bodies to trigger alternative pathway (AP) act

154 nsistent with these observations, binding of apoptotic bodies to VSMCs was decreased in the presence

155 Generation of apoptotic bodies via this mechanism can facilitate a sor

156 s morphologically unaltered and formation of apoptotic bodies was evident.

157 HCC-derived cells, and the ultimate fate of apoptotic bodies was phagocytosis and degradation by nei

158 eutic HIV-1 vaccine based on DCs loaded with apoptotic bodies was safe and induced T-cell activation

159 hagocytosis model, engulfment of GFP-labeled apoptotic bodies was seen, and the expression of alpha-s

160 of mitochondria was thickening, and the cell apoptotic body was observed.

161 off of portions of cytoplasm and nucleus as "apoptotic bodies." We have combined our previously estab

162 Extensive apoptotic bodies were characteristic of c-Myc-induced tu

163 After exposure, B cell apoptotic bodies were deposited in the spleen, lymph nod

164 procedure revealed that approximately 70% of apoptotic bodies were GST-II positive.

165 Internucleosomal DNA fragmentation and apoptotic bodies were observed between 3 and 4 d after i

166 of decreased calreticulin, CDKN2B-deficient apoptotic bodies were resistant to efferocytosis and not

167 ed) exhibited a high incidence of apoptosis (apoptotic bodies were seen in 55-75% of cells; 67-73% ha

168 ably, macrophages, which readily phagocytose apoptotic bodies, were very inefficient at acquiring lab

169 virus infection, but disassemble into small apoptotic bodies when DFNA5 is deleted.

170 ng microvesicles (distinct from exosomes and apoptotic bodies), which induce proliferation in neighbo

171 Furthermore, incubation of VSMC-derived apoptotic bodies with (45)Ca demonstrated that, like mat

172 Confocal images confirm internalization of apoptotic bodies within KIM-1-expressing epithelial cell