ライフサイエンスコーパス: apoptotic cell death

1 age, culminating in activity-dependent, non-apoptotic cell death.

2 h death receptor 4 (DR4) and DR5 can trigger apoptotic cell death.

3 ntenance of tissue homeostasis by triggering apoptotic cell death.

4 ith esxA showed an increased protection from apoptotic cell death.

5 ells exposed to KA or NMDA appear to undergo apoptotic cell death.

6 estrogen ICI 182,780 synergistically induces apoptotic cell death.

7 esponse to endoplasmic reticulum stress, and apoptotic cell death.

8 UNEL) and used to estimate the occurrence of apoptotic cell death.

9 tion of the mTOR/S6K signaling and increased apoptotic cell death.

10 ochondrial superoxide species and subsequent apoptotic cell death.

11 marrow, but fail to persist due to increased apoptotic cell death.

12 adaptive and pro-survival signals, or induce apoptotic cell death.

13 ligand-induced UPR or autophagy accelerates apoptotic cell death.

14 ER-mitochondrial-Ca(2+) axis by IL-1beta in apoptotic cell death.

15 ough induction of G2/M cell cycle arrest and apoptotic cell death.

16 ontributing to mitochondrial dysfunction and apoptotic cell death.

17 ol, which in turn activates caspase-mediated apoptotic cell death.

18 on and tumorigenesis, but it can also induce apoptotic cell death.

19 spase and plays a central role in activating apoptotic cell death.

20 DNA ladder) are considered the hallmarks of apoptotic cell death.

21 unction, release of apoptogenic factors, and apoptotic cell death.

22 creased cell proliferation and inhibition of apoptotic cell death.

23 G suppressed HTLV-1 replication and promoted apoptotic cell death.

24 etion did not induce the KSHV lytic cycle or apoptotic cell death.

25 to induce severe aneuploidy and, ultimately, apoptotic cell death.

26 ize outer mitochondrial membranes to trigger apoptotic cell death.

27 NA damage with ensuing cell cycle arrest and apoptotic cell death.

28 rogression and repair processes that control apoptotic cell death.

29 Caspase-3 is a main executioner of apoptotic cell death.

30 ay, increase in ER size, and p53-independent apoptotic cell death.

31 est at the G2/M phase, and caspase-dependent apoptotic cell death.

32 s reactive oxygen generation, DNA damage and apoptotic cell death.

33 ention in cancer cells that are resistant to apoptotic cell death.

34 d oxidizing agents while having no effect on apoptotic cell death.

35 produced caspase-3 activation and consequent apoptotic cell death.

36 lization (MOMP) is essential for "intrinsic" apoptotic cell death.

37 signaling through IkappaBbeta would prevent apoptotic cell death.

38 ses to fragment their chromosomes and induce apoptotic cell death.

39 tubular epithelial cells to progress towards apoptotic cell death.

40 s to undergo multipolar mitoses resulting in apoptotic cell death.

41 xpression prevented oxidative stress-induced apoptotic cell death.

42 age and cytochrome c release, thus promoting apoptotic cell death.

43 e of 1 to 5 mumol/L and were associated with apoptotic cell death.

44 d prostate epithelial cells RWPE-1 increased apoptotic cell death.

45 ces mitochondrial permeability, and leads to apoptotic cell death.

46 scavenging of NO enhanced cisplatin-induced apoptotic cell death.

47 to mitochondrial fragmentation and enhanced apoptotic cell death.

48 re highly toxic to cultured cells and induce apoptotic cell death.

49 diphosphate ribose) polymerase cleavage, and apoptotic cell death.

50 duced the number of dead cells by inhibiting apoptotic cell death.

51 nd subsequently induces PGE(2) synthesis and apoptotic cell death.

52 deficiency increases cIAP1 stability during apoptotic cell death.

53 heir numbers start decreasing as a result of apoptotic cell death.

54 that ultimately leads to mitotic arrest and apoptotic cell death.

55 te synthesizing enzymes, mediates p53-linked apoptotic cell death.

56 prevented cellular senescence and increased apoptotic cell death.

57 silencing was accompanied by a promotion of apoptotic cell death.

58 with mutated p53 undergo differentiation or apoptotic cell death.

59 tion, and loss of TAX1BP1 is associated with apoptotic cell death.

60 S generation, subsequent PGE(2) release, and apoptotic cell death.

61 rtant ramifications in diseases that involve apoptotic cell death.

62 and ultimately face mitotic catastrophe and apoptotic cell death.

63 G54, independent of IFN stimulation, elicits apoptotic cell death.

64 mide (>2.5 microm) or S1P (10 microm) led to apoptotic cell death.

65 s (e.g. p21 and PUMA), cell cycle arrest and apoptotic cell death.

66 where it promotes chromatin condensation and apoptotic cell death.

67 causes cell cycle arrest at mitotic exit and apoptotic cell death.

68 t progresses, NC derivatives are lost due to apoptotic cell death.

69 tion of caspase-3-dependent, p53-independent apoptotic cell death.

70 at least partially prevented MPP(+)-mediated apoptotic cell death.

71 slippage and multinucleation, triggering an apoptotic cell death.

72 enhances cell survival and limits programmed apoptotic cell death.

73 tor activity followed by rapid and extensive apoptotic cell death.

74 t decrease in cell proliferation and induced apoptotic cell death.

75 inositol pentakisphosphate (IP7), influences apoptotic cell death.

76 or phosphorylation of Akt (p-Akt) to prevent apoptotic cell death.

77 n regulation of PEITC-induced autophagic and apoptotic cell death.

78 al number of donor cells are lost because of apoptotic cell death.

79 y tissue abnormalities, such as necrosis and apoptotic cell death.

80 one of the most fundamental processes during apoptotic cell death.

81 roptosis, parthanatos, or other forms of non-apoptotic cell death.

82 als that cause mitochondrial dysfunction and apoptotic cell death.

83 ple tumor suppressive pathways, particularly apoptotic cell death.

84 age of lysosomal contents that culminates in apoptotic cell death.

85 activation, and mitotic catastrophe-induced apoptotic cell death.

86 CN cell proliferation and inducing intrinsic apoptotic cell death.

87 tion of the p38 MAPK pathway associated with apoptotic cell death.

88 eased proliferation but was due to decreased apoptotic cell death.

89 reast cancer cells to doxorubicin leading to apoptotic cell death.

90 steryl ester load without causing detectable apoptotic cell death.

91 ium, mitochondrial depolarization, and necro-apoptotic cell death.

92 for sensitizing TNBC to chemotherapy-induced apoptotic cell death.

93 ects mitochondria dynamics and protects from apoptotic cell death.

94 to ABT-263 and ABT-199, which induced rapid apoptotic cell death.

95 with Abeta resulted in mitochondria-mediated apoptotic cell death.

96 endent manner, followed by caspase-dependent apoptotic cell death.

97 smic reticulum to the mitochondria result in apoptotic cell death.

98 then the UPR activates pathways that promote apoptotic cell death.

99 d lipids blocks autophagic flux and leads to apoptotic cell death.

100 oinflammatory IL-1beta as well as to promote apoptotic cell death.

101 nal repressor was originally associated with apoptotic cell death.

102 that targets AM for mitochondrial-associated apoptotic cell death.

103 r ability to hamper TrxR activity leading to apoptotic cell death.

104 is an iron-dependent, oxidative form of non-apoptotic cell death.

105 unfolded protein response (UPR) which led to apoptotic cell death.

106 n MCF-7 and T47D breast cancer cells induced apoptotic cell death.

107 spondin-1 type I repeats (3TSR) induced more apoptotic cell death (36.5 +/- 9.6%) in vitro compared t

108 citriol-pretreated tumors underwent enhanced apoptotic cell death after ALA-based PDT.

109 This was associated with increased apoptotic cell death and accumulation of complement acti

110 rocytes were infected with WNV, resulting in apoptotic cell death and astrogliosis.

111 Even though apoptotic cell death and debris accumulation are key fea

112 ndrial transmembrane potential indicative of apoptotic cell death and decreased platelet life span.

113 dose- and time-dependent manner, increasing apoptotic cell death and decreasing clonogenic survival.

114 xamined by flow cytometric quantification of apoptotic cell death and detection of poly (ADP-ribose)

115 ine the mechanisms by which phagocytes sense apoptotic cell death and discuss how phagocytosis is int

116 a1 involved in the control of proliferation, apoptotic cell death and HCC progression.

117 ced tumor size was associated with amplified apoptotic cell death and increased expression of activat

118 sion of MUC1-C expression is associated with apoptotic cell death and loss of clonogenic survival.

119 tenuated TNF secretion and thereby prevented apoptotic cell death and not necrosis.

120 d CBC cell loss, with reduced proliferation, apoptotic cell death and reduced efficiency of organoid

121 -inspired nanovesicle can efficiently induce apoptotic cell death and significantly inhibit tumor gro

122 cells toward inflammation rather than toward apoptotic cell death and suggest that CGN exposure may c

123 Our findings showed that PL induced apoptotic cell death and suppressed the DNA binding acti

124 tituents, ultimately leading to induction of apoptotic cell death and the pathogenesis of various dis

125 m) biofilm on epithelial cell proliferation, apoptotic cell death, and basement membrane constituent

126 believed to die through caspase 8-dependent apoptotic cell death, and chemotherapy is thought to pro

127 ent cardiovascular malformation, progressive apoptotic cell death, and embryonic lethality at E10.5.

128 ycated LDL, induced PGIS nitration, enhanced apoptotic cell death, and impaired blood-retinal barrier

129 neurotoxicity of dopaminergic (DA) neurons, apoptotic cell death, and inflammation.

130 mice displayed profound tissue destruction, apoptotic cell death, and inflammatory cell infiltration

131 ion of tyrosine kinases, exploitation of non-apoptotic cell death, and interference with angiogenesis

132 ers Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that th

133 resulted in PUMA upregulation and increased apoptotic cell death, and the Ctcf-null forebrain was hy

134 8 and P22 through Sox17-mediated increase in apoptotic cell death, and thereafter significantly excee

135 event intervenes in global ischemia-induced apoptotic cell death are unclear.

136 Bax and Bak, which are central regulators of apoptotic cell death, are also required for mitochondria

137 re we review some of the evidence supporting apoptotic cell death as a contributing mechanism of diab

138 totoxic agents have been developed to target apoptotic cell death as a main method of treating cancer

139 This response reveals that PSCs rely on apoptotic cell death as an important defense to avoid mu

140 s associated with caspase-3/7 activation and apoptotic cell death as evidenced by annexin V staining

141 The process of apoptotic cell death, as defined at the molecular level,

142 ation was not associated with an increase in apoptotic cell death, as shown by TUNEL analysis.

143 he stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal l

144 e observed caspase-8- and caspase-9-mediated apoptotic cell death, beginning with neutrophils.

145 reased levels of reactive oxygen species and apoptotic cell death both at baseline and in response to

146 SNRPE or SNRPD1 depletion did not lead to apoptotic cell death but autophagy, another form of cell

147 gy under starvation or chemotherapy utilized apoptotic cell death but not at low levels of autophagy.

148 of Nox4 in cultured cardiac myocytes induced apoptotic cell death but not hypertrophy.

149 ion of G4C2 repeats of varying length caused apoptotic cell death, but failed to generate DPRs.

150 Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remain

151 crotubule stabilization, mitotic arrest, and apoptotic cell death, but recent data suggest that taxan

152 If stress persists, the UPR induces apoptotic cell death, but the mechanisms remain elusive.

153 aspase inhibitor and an important barrier to apoptotic cell death, but the mechanisms that determine

154 These cellular responses delay apoptotic cell death by inducing the IRE1alpha-XBP-1 pat

155 ddition, knockdown of ASncmtRNAs potentiates apoptotic cell death by inhibiting survivin expression,

156 d kidney injury, acute tubular necrosis, and apoptotic cell death by the endoplasmic reticulum stress

157 he IP3 R has been proposed to play a role in apoptotic cell death by uncoupling regions important for

158 an upstream regulator of a novel form of non-apoptotic cell death, called ferroptosis, whereas the mi

159 eath is not limited to this natural turnover-apoptotic cell death can be induced by infection, inflam

160 decreases during necrotic, necroptotic, and apoptotic cell death caused by demyelinating, ischemic,

161 ly, both miR-25 and miR-30d adversely affect apoptotic cell death, cell cycle arrest and cellular sen

162 We found that MVC infection induces an apoptotic cell death characterized by Bax translocalizat

163 ilencing RNAs there was a 3-fold increase in apoptotic cell death compared to parental cells.

164 r cell lines undergo an abortive S phase and apoptotic cell death due to loss of a p53-dependent Cdc7

165 Transient activation of apoptotic cell death during early age correlated well wi

166 ndrocyte (OL) precursor cells, which undergo apoptotic cell death during early postnatal brain develo

167 nd squirrel tubular cells are protected from apoptotic cell death during IBA.

168 at the CED-3 caspase, well known as the core apoptotic cell death executioner, acts in early response

169 ed tumor cells to CQ, resulting in increased apoptotic cell death following treatment.

170 ssion of a phosphomutated variant of the pro-apoptotic cell death gene, hid, from A. ludens, that was

171 evels, and renal lesions including extensive apoptotic cell death, glomerulosclerosis, afferent and e

172 son's disease (PD) are not completely known, apoptotic cell death has been suggested to be involved a

173 rane phospholipids, but an ability to induce apoptotic cell death has not previously been reported.

174 Although the molecular effectors of apoptotic cell death have been largely annotated over th

175 y an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutation

176 to silence oxidative metabolism, suppresses apoptotic cell death in a murine cellular model of polyg

177 Although proteasome inhibition can induce apoptotic cell death in actively proliferating cells, it

178 e level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cel

179 e NF-kappaB pathway in HeLa cells and induce apoptotic cell death in both HeLa and Kym-1 cells.

180 cell population growth through induction of apoptotic cell death in both hepatic and nonhepatic cell

181 pletion or inhibition of aPKC induces robust apoptotic cell death in Caco-2 cells, significantly redu

182 5 was shown to be more effective in inducing apoptotic cell death in cancer cells as compared to norm

183 We first confirmed that ART induces apoptotic cell death in cancer cells.

184 erapeutic reagents that target regulators of apoptotic cell death in cancer cells.

185 ed by the fact that ANT1 expression leads to apoptotic cell death in commonly utilized replicating ce

186 itochondrial abnormalities and activation of apoptotic cell death in CryAB(R120G) transgenic hearts.

187 acetylation and its role in dieldrin-induced apoptotic cell death in dopaminergic neuronal cells.

188 to cisplatin-induced growth suppression and apoptotic cell death in EC cells.

189 These data indicate that: (a) apoptotic cell death in FLCN-null cells can be triggered

190 function has been shown previously to cause apoptotic cell death in glioblastoma and breast cancer c

191 nstitutively activates caspase-8 and induces apoptotic cell death in human lung epithelial cells.

192 e of p66(Shc) in regulation of PEITC-induced apoptotic cell death in human prostate cancer cells.

193 erts a novel autophagic response followed by apoptotic cell death in human prostate cancer PC-3 cells

194 Mdivi-1 treatment blocked apoptotic cell death in ischemic retina, and significant

195 that combined checkpoint inhibition induces apoptotic cell death in KRAS- or BRAF-mutant tumor cells

196 of DNA ligase 3alpha abolished resistance to apoptotic cell death in KRAS-mutated cells.

197 Importantly, plinabulin also induces apoptotic cell death in MM cell lines and tumor cells fr

198 ith the anti-HSF1 compounds strongly induced apoptotic cell death in MM cells.

199 t zebrafish embryos also exhibited increased apoptotic cell death in multiple brain regions, emphasiz

200 that acts by mimicking BH3 proteins, induces apoptotic cell death in multiple cancer types.

201 sensitive kinase that plays a causal role in apoptotic cell death in neuronal cells.

202 together with PGE2) also increased levels of apoptotic cell death in organotypic slices.

203 tion, inhibited proliferation, and triggered apoptotic cell death in primary neonatal pig GMCs.

204 uction resulted in reduced proliferation and apoptotic cell death in Raji cells in which EPHB4 is met

205 permeability, and induce a caspase-dependent apoptotic cell death in resistant cells.

206 Gene silencing of Rora attenuated apoptotic cell death in response to cigarette smoke extr

207 wn of FAIM2 expression increases Fas-induced apoptotic cell death in SCLC cells.

208 hypertrophic lysosomes as well as localized apoptotic cell death in the retina, optic tectum and cer

209 ic potential, anoikis resistance and induced apoptotic cell death in therapy-resistant EOC cells.

210 tor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

211 -) mice were found to be more susceptible to apoptotic cell death in two models of TNF-dependent acut

212 e deacetylase inhibitors (HDACIs) may reduce apoptotic cell death in various model systems.

213 inhibit cancer cell proliferation and induce apoptotic cell death in vitro and inhibit tumor growth i

214 inhibitors caused a shift from autophagic to apoptotic cell death in vitro.

215 irst time that ILK disruption results in non-apoptotic cell death in vivo.

216 o reduced in GBDK brains in association with apoptotic cell death in white matter regions of the brai

217 cAMP/PKA-Calpha and PKA-R1alpha/Bim mediate apoptotic cell death in WT S49 cells, kin(-) cells resis

218 ation of this peptide is suggested to induce apoptotic cell-death in insulin-producing beta-cells.

219 ted caspase-8 signaling, without substantial apoptotic cell death, in triggering alveolar epithelial

220 sphorylation, and p38 activity contribute to apoptotic cell death induced by Hsp90 inhibition.

221 vage of SIRT 1 in EPCs and blunting SIPS and apoptotic cell death induced by relevant cardiovascular

222 ermore, loss of LRRK2 dramatically increases apoptotic cell death, inflammatory responses, and oxidat

223 lasts are more sensitive than p53 mutants to apoptotic cell death initiated by agents that activate e

224 Apoptotic cell death is a hallmark of the loss of insuli

225 Apoptotic cell death is characterized by nuclear fragmen

226 Apoptotic cell death is essential for development and ti

227 Apoptotic cell death is important for embryonic developm

228 Apoptotic cell death is important for the normal develop

229 It is widely recognized that the evasion of apoptotic cell death is one of the hallmarks of cancer.

230 cells through a combination of autophagy and apoptotic cell death mechanisms.

231 orhabditis elegans induces both necrotic and apoptotic cell death, mimicking an early event of liver

232 lasmic reticulum stress, calpains leading to apoptotic cell death, NF-kappaB and JAK/STAT pathways, a

233 s, whereas fmk treatment induced significant apoptotic cell death not only in FLT3-ITD-positive Ba/F3

234 In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the ca

235 nied by shortened lifespan and age-dependent apoptotic cell death of both glia and neurons.

236 leads to increased caspase-3 expression and apoptotic cell death of both nondifferentiated and diffe

237 n synthesis of MCL1, which, in turn, induces apoptotic cell death of cancer cells.

238 Sorafenib caused apoptotic cell death of cardiac- and bone-derived c-kit+

239 erence-mediated silencing of DCLK1 triggered apoptotic cell death of colon cancer cells in vitro and

240 s is through promotion of activation-induced apoptotic cell death of mast cells and that this likely

241 tau-phosphorylation, which culminated in the apoptotic cell death of neurons.

242 Suppression of PAX8 selectively induces apoptotic cell death of ovarian cancer cells.

243 Apoptotic cell death of photoreceptors occurs rapidly be

244 stered at low doses, VCD specifically causes apoptotic cell death of primordial follicles but does no

245 ss of the NPM-ALK protein and, consequently, apoptotic cell death of the lymphoma cells.

246 genic pathways led to growth retardation and apoptotic cell death of the Tax2-established T cell line

247 nd and TNF-alpha, can activate the extrinsic apoptotic cell death pathway on binding to cognate death

248 a 2 (Bcl-2) family proteins in the intrinsic apoptotic cell death pathway.

249 properties of molecules of the mitochondrial apoptotic cell death pathway.

250 at Galphaq/PKCzeta complexes link Galphaq to apoptotic cell death pathways.

251 ath (LCD) is a morphologically conserved non-apoptotic cell death process operating in Caenorhabditis

252 occurring to the NE, during the necrotic and apoptotic cell death process, using the xCELLigence syst

253 t, they become subject to elimination via an apoptotic cell death program known as anoikis.

254 e hallmark of cancer cells is defects in the apoptotic cell death program.

255 sustained Jnk activation which turned on the apoptotic cell death program.

256 rough necrosis induces inflammation, whereas apoptotic cell death provides an important signal for to

257 cle arrest - and, in the absence of p53, non-apoptotic cell death - redundantly limit growth in ATR-d

258 f stress-responsive signaling, and increased apoptotic cell death relative to controls.

259 hat Drosophila endocycling cells repress the apoptotic cell death response to genotoxic stress.

260 omas of various origins, through an enhanced apoptotic cell death response.

261 The intriguing cell biology of apoptotic cell death results in the externalization of n

262 block human B-cell proliferation and promote apoptotic cell death selectively in antibody-secreting B

263 2 transporters and induces caspase-dependent apoptotic cell death selectively in resistant cells.

264 ever, whereas wild type mast cells underwent apoptotic cell death, serglycin(-/-) cells died predomin

265 ssion can be attributed to cell loss through apoptotic cell death, surprisingly we find that the ecto

266 MX ~10-fold and induced a greater degree of apoptotic cell death than MX treatment alone.

267 a required step in the induction of type II apoptotic cell death that involves calcium mobilization

268 TcdA intoxication results in an apoptotic cell death that is dependent on the glucosyltr

269 in mouse MIN6 insulinoma cells resulting in apoptotic cell death that was found to be associated wit

270 ad, thymol induced a significant increase in apoptotic cell death that was seen both in vitro and in

271 CX-5461 (ie, the induction of p53-dependent apoptotic cell death), the inhibition of Pol I transcrip

272 ine included those predominantly involved in apoptotic cell death, the plant hypersensitive response,

273 or these cells upon IFN treatment indicating apoptotic cell death; these effects were less pronounced

274 to prevent pancreatic tumor proliferation by apoptotic cell death, thus promising therapeutic prospec

275 cement in tamoxifen or staurosporine-induced apoptotic cell death together with a reduction in the S-

276 sed on a semi-quantitative histologic score, apoptotic cell death (TUNEL), and inflammatory cytokine

277 these molecules are surface-exposed (during apoptotic cell death), ubiquitously expressed, protease-

278 is possibly due to a switch from necrotic to apoptotic cell death, ultimately resulting from reduced

279 opic expression of the Kv1.5 channel induces apoptotic cell death under conditions of hypoxia.

280 eld duodenum, there was a trend for elevated apoptotic cell death under most irradiation conditions;

281 ctive oxygen species and were susceptible to apoptotic cell death under normal culture conditions.

282 rs has resulted in an acquired resistance to apoptotic cell death, undermining the effectiveness of c

283 dence on this transcriptional CDK and suffer apoptotic cell death upon CDK7 inhibition.

284 cumulation of ZnPc in MCF-7 cells, improving apoptotic cell death upon irradiation.

285 bed adherens junction proteins and increased apoptotic cell death via an extrinsic pathway of apoptos

286 (177)Lu-LCP inhibits tumor growth by causing apoptotic cell death via double-stranded DNA breaks whil

287 Simvastatin induced apoptotic cell death via the intrinsic apoptotic pathway

288 Apoptotic cell death was assessed by TUNEL staining.

289 TAZ depletion in HeLa and D645 cells caused apoptotic cell death, we propose that isoform-specific Y

290 Increased inflammatory response and apoptotic cell death were also confirmed in the injured

291 se activation or ultrastructural features of apoptotic cell death were observed.

292 Caspase-8 is a key initiator of apoptotic cell death where it functions as the apical pr

293 p62/SQSTM1-positive protein aggregates, and apoptotic cell death, whereas MG132-treated quiescent ce

294 e associated with a significant reduction in apoptotic cell death, which may provide a therapeutic ra

295 eptor substrate 2 (IRS2) suppression induced apoptotic cell death, which was associated with an incre

296 ssion in mouse MIN6 insulinoma cells induced apoptotic cell death with an increase in Bax activation

297 e of Nrf2 in control of Bcl-2 expression and apoptotic cell death with implications in antioxidant pr

298 cells exhibited increased susceptibility and apoptotic cell death with oxidative stress.

299 cytokeratin-18 (CK-18) fragment and thereby apoptotic cell death, with the M65 ELISA, which detects

300 ulation of p53 protein, inducing significant apoptotic cell death without affecting the cell cycle pr