ライフサイエンスコーパス: apoptotic cell death

1 ly, mitochondria also have a central role in apoptotic cell death.

2 tion of the p38 MAPK pathway associated with apoptotic cell death.

3 eased proliferation but was due to decreased apoptotic cell death.

4 steryl ester load without causing detectable apoptotic cell death.

5 ilization (MOMP) is a crucial event enabling apoptotic cell death.

6 ium, mitochondrial depolarization, and necro-apoptotic cell death.

7 for sensitizing TNBC to chemotherapy-induced apoptotic cell death.

8 to ABT-263 and ABT-199, which induced rapid apoptotic cell death.

9 with Abeta resulted in mitochondria-mediated apoptotic cell death.

10 cribe its biological activity and effects on apoptotic cell death.

11 endent manner, followed by caspase-dependent apoptotic cell death.

12 smic reticulum to the mitochondria result in apoptotic cell death.

13 then the UPR activates pathways that promote apoptotic cell death.

14 l or, in the event of chronic damage, induce apoptotic cell death.

15 d lipids blocks autophagic flux and leads to apoptotic cell death.

16 oinflammatory IL-1beta as well as to promote apoptotic cell death.

17 nal repressor was originally associated with apoptotic cell death.

18 that targets AM for mitochondrial-associated apoptotic cell death.

19 r ability to hamper TrxR activity leading to apoptotic cell death.

20 n of ER homeostasis; that failing, it drives apoptotic cell death.

21 unfolded protein response (UPR) which led to apoptotic cell death.

22 n MCF-7 and T47D breast cancer cells induced apoptotic cell death.

23 h death receptor 4 (DR4) and DR5 can trigger apoptotic cell death.

24 ntenance of tissue homeostasis by triggering apoptotic cell death.

25 ith esxA showed an increased protection from apoptotic cell death.

26 estrogen ICI 182,780 synergistically induces apoptotic cell death.

27 new insights into how mitochondria regulate apoptotic cell death.

28 esponse to endoplasmic reticulum stress, and apoptotic cell death.

29 UNEL) and used to estimate the occurrence of apoptotic cell death.

30 tion of the mTOR/S6K signaling and increased apoptotic cell death.

31 haperone protein BiP, inducing ER stress and apoptotic cell death.

32 ochondrial superoxide species and subsequent apoptotic cell death.

33 marrow, but fail to persist due to increased apoptotic cell death.

34 adaptive and pro-survival signals, or induce apoptotic cell death.

35 ligand-induced UPR or autophagy accelerates apoptotic cell death.

36 ER-mitochondrial-Ca(2+) axis by IL-1beta in apoptotic cell death.

37 ontributing to mitochondrial dysfunction and apoptotic cell death.

38 ol, which in turn activates caspase-mediated apoptotic cell death.

39 on and tumorigenesis, but it can also induce apoptotic cell death.

40 DNA ladder) are considered the hallmarks of apoptotic cell death.

41 unction, release of apoptogenic factors, and apoptotic cell death.

42 creased cell proliferation and inhibition of apoptotic cell death.

43 G suppressed HTLV-1 replication and promoted apoptotic cell death.

44 etion did not induce the KSHV lytic cycle or apoptotic cell death.

45 totic cell death into immunologically silent apoptotic cell death.

46 ize outer mitochondrial membranes to trigger apoptotic cell death.

47 NA damage with ensuing cell cycle arrest and apoptotic cell death.

48 rogression and repair processes that control apoptotic cell death.

49 Caspase-3 is a main executioner of apoptotic cell death.

50 ay, increase in ER size, and p53-independent apoptotic cell death.

51 est at the G2/M phase, and caspase-dependent apoptotic cell death.

52 s reactive oxygen generation, DNA damage and apoptotic cell death.

53 ention in cancer cells that are resistant to apoptotic cell death.

54 d oxidizing agents while having no effect on apoptotic cell death.

55 produced caspase-3 activation and consequent apoptotic cell death.

56 lization (MOMP) is essential for "intrinsic" apoptotic cell death.

57 iating immune and inflammatory responses and apoptotic cell death.

58 signaling through IkappaBbeta would prevent apoptotic cell death.

59 ses to fragment their chromosomes and induce apoptotic cell death.

60 s to undergo multipolar mitoses resulting in apoptotic cell death.

61 xpression prevented oxidative stress-induced apoptotic cell death.

62 age and cytochrome c release, thus promoting apoptotic cell death.

63 e of 1 to 5 mumol/L and were associated with apoptotic cell death.

64 d prostate epithelial cells RWPE-1 increased apoptotic cell death.

65 ces mitochondrial permeability, and leads to apoptotic cell death.

66 scavenging of NO enhanced cisplatin-induced apoptotic cell death.

67 heir stress response, followed by a surge in apoptotic cell death.

68 to mitochondrial fragmentation and enhanced apoptotic cell death.

69 re highly toxic to cultured cells and induce apoptotic cell death.

70 diphosphate ribose) polymerase cleavage, and apoptotic cell death.

71 ow a wider community of researchers to study apoptotic cell death.

72 duced the number of dead cells by inhibiting apoptotic cell death.

73 nd subsequently induces PGE(2) synthesis and apoptotic cell death.

74 heir numbers start decreasing as a result of apoptotic cell death.

75 that ultimately leads to mitotic arrest and apoptotic cell death.

76 te synthesizing enzymes, mediates p53-linked apoptotic cell death.

77 prevented cellular senescence and increased apoptotic cell death.

78 silencing was accompanied by a promotion of apoptotic cell death.

79 with mutated p53 undergo differentiation or apoptotic cell death.

80 S generation, subsequent PGE(2) release, and apoptotic cell death.

81 cancer cell proliferation and induces their apoptotic cell death.

82 and ultimately face mitotic catastrophe and apoptotic cell death.

83 also recognized as an important mediator of apoptotic cell death.

84 owed by nucleolar stress, p53 activation and apoptotic cell death.

85 that act directly on mitochondria to trigger apoptotic cell death.

86 s in impaired mitochondrial function and non-apoptotic cell death.

87 hondrial dysfunction and sensitized cells to apoptotic cell death.

88 gets cell proliferation, mitosis and induces apoptotic cell death.

89 on, rescued TSG expression, and induced ALCL apoptotic cell death.

90 age, culminating in activity-dependent, non-apoptotic cell death.

91 tion in that leads to MESN-subtype-dependent apoptotic cell death.

92 roptosis, parthanatos, or other forms of non-apoptotic cell death.

93 reast cancer cells to doxorubicin leading to apoptotic cell death.

94 ects mitochondria dynamics and protects from apoptotic cell death.

95 is an iron-dependent, oxidative form of non-apoptotic cell death.

96 ells exposed to KA or NMDA appear to undergo apoptotic cell death.

97 ough induction of G2/M cell cycle arrest and apoptotic cell death.

98 spase and plays a central role in activating apoptotic cell death.

99 to induce severe aneuploidy and, ultimately, apoptotic cell death.

100 tubular epithelial cells to progress towards apoptotic cell death.

101 deficiency increases cIAP1 stability during apoptotic cell death.

102 tion, and loss of TAX1BP1 is associated with apoptotic cell death.

103 rtant ramifications in diseases that involve apoptotic cell death.

104 al number of donor cells are lost because of apoptotic cell death.

105 y tissue abnormalities, such as necrosis and apoptotic cell death.

106 one of the most fundamental processes during apoptotic cell death.

107 als that cause mitochondrial dysfunction and apoptotic cell death.

108 ple tumor suppressive pathways, particularly apoptotic cell death.

109 age of lysosomal contents that culminates in apoptotic cell death.

110 activation, and mitotic catastrophe-induced apoptotic cell death.

111 CN cell proliferation and inducing intrinsic apoptotic cell death.

112 spondin-1 type I repeats (3TSR) induced more apoptotic cell death (36.5 +/- 9.6%) in vitro compared t

113 citriol-pretreated tumors underwent enhanced apoptotic cell death after ALA-based PDT.

114 This was associated with increased apoptotic cell death and accumulation of complement acti

115 rocytes were infected with WNV, resulting in apoptotic cell death and astrogliosis.

116 Even though apoptotic cell death and debris accumulation are key fea

117 ndrial transmembrane potential indicative of apoptotic cell death and decreased platelet life span.

118 dose- and time-dependent manner, increasing apoptotic cell death and decreasing clonogenic survival.

119 xamined by flow cytometric quantification of apoptotic cell death and detection of poly (ADP-ribose)

120 ine the mechanisms by which phagocytes sense apoptotic cell death and discuss how phagocytosis is int

121 a1 involved in the control of proliferation, apoptotic cell death and HCC progression.

122 sion of MUC1-C expression is associated with apoptotic cell death and loss of clonogenic survival.

123 tenuated TNF secretion and thereby prevented apoptotic cell death and not necrosis.

124 d CBC cell loss, with reduced proliferation, apoptotic cell death and reduced efficiency of organoid

125 -inspired nanovesicle can efficiently induce apoptotic cell death and significantly inhibit tumor gro

126 Our findings showed that PL induced apoptotic cell death and suppressed the DNA binding acti

127 tituents, ultimately leading to induction of apoptotic cell death and the pathogenesis of various dis

128 ens, such as aflatoxin B(1) (AFB(1)), induce apoptotic cell death and the resulting cell debris stimu

129 m) biofilm on epithelial cell proliferation, apoptotic cell death, and basement membrane constituent

130 believed to die through caspase 8-dependent apoptotic cell death, and chemotherapy is thought to pro

131 ent cardiovascular malformation, progressive apoptotic cell death, and embryonic lethality at E10.5.

132 ycated LDL, induced PGIS nitration, enhanced apoptotic cell death, and impaired blood-retinal barrier

133 neurotoxicity of dopaminergic (DA) neurons, apoptotic cell death, and inflammation.

134 mice displayed profound tissue destruction, apoptotic cell death, and inflammatory cell infiltration

135 ers Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that th

136 resulted in PUMA upregulation and increased apoptotic cell death, and the Ctcf-null forebrain was hy

137 8 and P22 through Sox17-mediated increase in apoptotic cell death, and thereafter significantly excee

138 Bax and Bak, which are central regulators of apoptotic cell death, are also required for mitochondria

139 re we review some of the evidence supporting apoptotic cell death as a contributing mechanism of diab

140 totoxic agents have been developed to target apoptotic cell death as a main method of treating cancer

141 This response reveals that PSCs rely on apoptotic cell death as an important defense to avoid mu

142 s associated with caspase-3/7 activation and apoptotic cell death as evidenced by annexin V staining

143 The process of apoptotic cell death, as defined at the molecular level,

144 ation was not associated with an increase in apoptotic cell death, as shown by TUNEL analysis.

145 he stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal l

146 e observed caspase-8- and caspase-9-mediated apoptotic cell death, beginning with neutrophils.

147 reduced proliferation with no difference in apoptotic cell death between control and Ddr1(-/-) anima

148 reased levels of reactive oxygen species and apoptotic cell death both at baseline and in response to

149 SNRPE or SNRPD1 depletion did not lead to apoptotic cell death but autophagy, another form of cell

150 gy under starvation or chemotherapy utilized apoptotic cell death but not at low levels of autophagy.

151 ion of G4C2 repeats of varying length caused apoptotic cell death, but failed to generate DPRs.

152 Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remain

153 crotubule stabilization, mitotic arrest, and apoptotic cell death, but recent data suggest that taxan

154 If stress persists, the UPR induces apoptotic cell death, but the mechanisms remain elusive.

155 aspase inhibitor and an important barrier to apoptotic cell death, but the mechanisms that determine

156 These cellular responses delay apoptotic cell death by inducing the IRE1alpha-XBP-1 pat

157 ddition, knockdown of ASncmtRNAs potentiates apoptotic cell death by inhibiting survivin expression,

158 d kidney injury, acute tubular necrosis, and apoptotic cell death by the endoplasmic reticulum stress

159 he IP3 R has been proposed to play a role in apoptotic cell death by uncoupling regions important for

160 an upstream regulator of a novel form of non-apoptotic cell death, called ferroptosis, whereas the mi

161 eath is not limited to this natural turnover-apoptotic cell death can be induced by infection, inflam

162 decreases during necrotic, necroptotic, and apoptotic cell death caused by demyelinating, ischemic,

163 events the NADPH oxidation, redox stress and apoptotic cell death caused by the activation of glycoly

164 ilencing RNAs there was a 3-fold increase in apoptotic cell death compared to parental cells.

165 Transient activation of apoptotic cell death during early age correlated well wi

166 nd squirrel tubular cells are protected from apoptotic cell death during IBA.

167 at the CED-3 caspase, well known as the core apoptotic cell death executioner, acts in early response

168 ed tumor cells to CQ, resulting in increased apoptotic cell death following treatment.

169 ssion of a phosphomutated variant of the pro-apoptotic cell death gene, hid, from A. ludens, that was

170 rane phospholipids, but an ability to induce apoptotic cell death has not previously been reported.

171 Although the molecular effectors of apoptotic cell death have been largely annotated over th

172 y an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutation

173 Although proteasome inhibition can induce apoptotic cell death in actively proliferating cells, it

174 Depleting ELP proteins promoted apoptotic cell death in an EGFR inhibition-dependent man

175 e level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cel

176 e NF-kappaB pathway in HeLa cells and induce apoptotic cell death in both HeLa and Kym-1 cells.

177 he unfolded protein response, and ultimately apoptotic cell death in breast and lung cancer cell line

178 pletion or inhibition of aPKC induces robust apoptotic cell death in Caco-2 cells, significantly redu

179 5 was shown to be more effective in inducing apoptotic cell death in cancer cells as compared to norm

180 We first confirmed that ART induces apoptotic cell death in cancer cells.

181 erapeutic reagents that target regulators of apoptotic cell death in cancer cells.

182 ed by the fact that ANT1 expression leads to apoptotic cell death in commonly utilized replicating ce

183 to cisplatin-induced growth suppression and apoptotic cell death in EC cells.

184 These data indicate that: (a) apoptotic cell death in FLCN-null cells can be triggered

185 function has been shown previously to cause apoptotic cell death in glioblastoma and breast cancer c

186 ewly synthesized mu1 protein does not affect apoptotic cell death in HeLa cells but enhances necropto

187 phorylation of p38MAPK and STAT1, as well as apoptotic cell death in HG-treated hRECs.

188 nstitutively activates caspase-8 and induces apoptotic cell death in human lung epithelial cells.

189 rinsic antiviral control, it drove increased apoptotic cell death in infected fibroblasts.

190 Mdivi-1 treatment blocked apoptotic cell death in ischemic retina, and significant

191 that combined checkpoint inhibition induces apoptotic cell death in KRAS- or BRAF-mutant tumor cells

192 of DNA ligase 3alpha abolished resistance to apoptotic cell death in KRAS-mutated cells.

193 e its deficiency results in TNFalpha-induced apoptotic cell death in luminal breast cancer subtype.

194 Importantly, plinabulin also induces apoptotic cell death in MM cell lines and tumor cells fr

195 ith the anti-HSF1 compounds strongly induced apoptotic cell death in MM cells.

196 t zebrafish embryos also exhibited increased apoptotic cell death in multiple brain regions, emphasiz

197 sensitive kinase that plays a causal role in apoptotic cell death in neuronal cells.

198 tion, inhibited proliferation, and triggered apoptotic cell death in primary neonatal pig GMCs.

199 Gene silencing of Rora attenuated apoptotic cell death in response to cigarette smoke extr

200 of Wnt/beta-catenin activation and underwent apoptotic cell death in response to proliferative stimul

201 ite increased replication stress, leading to apoptotic cell death in S-phase and mitotic catastrophe.

202 wn of FAIM2 expression increases Fas-induced apoptotic cell death in SCLC cells.

203 hypertrophic lysosomes as well as localized apoptotic cell death in the retina, optic tectum and cer

204 ic potential, anoikis resistance and induced apoptotic cell death in therapy-resistant EOC cells.

205 tor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

206 -) mice were found to be more susceptible to apoptotic cell death in two models of TNF-dependent acut

207 an inhibitor of glutamate release, promoted apoptotic cell death in vitro and in vivo.

208 inhibit cancer cell proliferation and induce apoptotic cell death in vitro and inhibit tumor growth i

209 N3A caused reexpression of TSG, induced ALCL apoptotic cell death in vitro, and hindered ALCL tumorig

210 inhibitors caused a shift from autophagic to apoptotic cell death in vitro.

211 irst time that ILK disruption results in non-apoptotic cell death in vivo.

212 o reduced in GBDK brains in association with apoptotic cell death in white matter regions of the brai

213 cAMP/PKA-Calpha and PKA-R1alpha/Bim mediate apoptotic cell death in WT S49 cells, kin(-) cells resis

214 ation of this peptide is suggested to induce apoptotic cell-death in insulin-producing beta-cells.

215 ted caspase-8 signaling, without substantial apoptotic cell death, in triggering alveolar epithelial

216 The proportion of cortical cells undergoing apoptotic cell death increased, suggesting that cell dea

217 sphorylation, and p38 activity contribute to apoptotic cell death induced by Hsp90 inhibition.

218 vage of SIRT 1 in EPCs and blunting SIPS and apoptotic cell death induced by relevant cardiovascular

219 lasts are more sensitive than p53 mutants to apoptotic cell death initiated by agents that activate e

220 The induction of apoptotic cell death involved loss of mitochondrial oute

221 Apoptotic cell death is a hallmark of the loss of insuli

222 Regulation of apoptotic cell death is an important component in the co

223 Apoptotic cell death is characterized by nuclear fragmen

224 Apoptotic cell death is essential for development and ti

225 Apoptotic cell death is important for embryonic developm

226 Apoptotic cell death is important for the normal develop

227 It is widely recognized that the evasion of apoptotic cell death is one of the hallmarks of cancer.

228 As a cell undergoes apoptotic cell death, it experiences changes in morpholo

229 tion of VEGF is associated with induction of apoptotic cell death mainly through increasing activatio

230 ne potential loss, and lack of activation of apoptotic cell death markers.

231 orhabditis elegans induces both necrotic and apoptotic cell death, mimicking an early event of liver

232 lasmic reticulum stress, calpains leading to apoptotic cell death, NF-kappaB and JAK/STAT pathways, a

233 s, whereas fmk treatment induced significant apoptotic cell death not only in FLT3-ITD-positive Ba/F3

234 In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the ca

235 n synthesis of MCL1, which, in turn, induces apoptotic cell death of cancer cells.

236 Sorafenib caused apoptotic cell death of cardiac- and bone-derived c-kit+

237 erence-mediated silencing of DCLK1 triggered apoptotic cell death of colon cancer cells in vitro and

238 s is through promotion of activation-induced apoptotic cell death of mast cells and that this likely

239 tau-phosphorylation, which culminated in the apoptotic cell death of neurons.

240 Suppression of PAX8 selectively induces apoptotic cell death of ovarian cancer cells.

241 stered at low doses, VCD specifically causes apoptotic cell death of primordial follicles but does no

242 ss of the NPM-ALK protein and, consequently, apoptotic cell death of the lymphoma cells.

243 genic pathways led to growth retardation and apoptotic cell death of the Tax2-established T cell line

244 Apoptotic cell death of the treated HeLa and BE(2)-C cel

245 a 2 (Bcl-2) family proteins in the intrinsic apoptotic cell death pathway.

246 properties of molecules of the mitochondrial apoptotic cell death pathway.

247 at Galphaq/PKCzeta complexes link Galphaq to apoptotic cell death pathways.

248 ath (LCD) is a morphologically conserved non-apoptotic cell death process operating in Caenorhabditis

249 occurring to the NE, during the necrotic and apoptotic cell death process, using the xCELLigence syst

250 Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various dege

251 t, they become subject to elimination via an apoptotic cell death program known as anoikis.

252 cle arrest - and, in the absence of p53, non-apoptotic cell death - redundantly limit growth in ATR-d

253 f stress-responsive signaling, and increased apoptotic cell death relative to controls.

254 hat Drosophila endocycling cells repress the apoptotic cell death response to genotoxic stress.

255 omas of various origins, through an enhanced apoptotic cell death response.

256 The intriguing cell biology of apoptotic cell death results in the externalization of n

257 block human B-cell proliferation and promote apoptotic cell death selectively in antibody-secreting B

258 2 transporters and induces caspase-dependent apoptotic cell death selectively in resistant cells.

259 ever, whereas wild type mast cells underwent apoptotic cell death, serglycin(-/-) cells died predomin

260 MX ~10-fold and induced a greater degree of apoptotic cell death than MX treatment alone.

261 a required step in the induction of type II apoptotic cell death that involves calcium mobilization

262 TcdA intoxication results in an apoptotic cell death that is dependent on the glucosyltr

263 in mouse MIN6 insulinoma cells resulting in apoptotic cell death that was found to be associated wit

264 ad, thymol induced a significant increase in apoptotic cell death that was seen both in vitro and in

265 ochondrial oxidative stress, DNA damage, and apoptotic cell death that were prevented by the antioxid

266 CX-5461 (ie, the induction of p53-dependent apoptotic cell death), the inhibition of Pol I transcrip

267 ine included those predominantly involved in apoptotic cell death, the plant hypersensitive response,

268 or these cells upon IFN treatment indicating apoptotic cell death; these effects were less pronounced

269 to prevent pancreatic tumor proliferation by apoptotic cell death, thus promising therapeutic prospec

270 cement in tamoxifen or staurosporine-induced apoptotic cell death together with a reduction in the S-

271 erate light illumination induces substantial apoptotic cell death, transient mild light illumination

272 sed on a semi-quantitative histologic score, apoptotic cell death (TUNEL), and inflammatory cytokine

273 these molecules are surface-exposed (during apoptotic cell death), ubiquitously expressed, protease-

274 is possibly due to a switch from necrotic to apoptotic cell death, ultimately resulting from reduced

275 opic expression of the Kv1.5 channel induces apoptotic cell death under conditions of hypoxia.

276 suppressed activation of STAT1 and decreased apoptotic cell death under HG conditions.

277 eld duodenum, there was a trend for elevated apoptotic cell death under most irradiation conditions;

278 ctive oxygen species and were susceptible to apoptotic cell death under normal culture conditions.

279 rs has resulted in an acquired resistance to apoptotic cell death, undermining the effectiveness of c

280 dence on this transcriptional CDK and suffer apoptotic cell death upon CDK7 inhibition.

281 cumulation of ZnPc in MCF-7 cells, improving apoptotic cell death upon irradiation.

282 bed adherens junction proteins and increased apoptotic cell death via an extrinsic pathway of apoptos

283 (177)Lu-LCP inhibits tumor growth by causing apoptotic cell death via double-stranded DNA breaks whil

284 Simvastatin induced apoptotic cell death via the intrinsic apoptotic pathway

285 Apoptotic cell death was assessed by TUNEL staining.

286 Apoptotic cell death was evaluated, and FITC conjugated

287 TAZ depletion in HeLa and D645 cells caused apoptotic cell death, we propose that isoform-specific Y

288 Increased inflammatory response and apoptotic cell death were also confirmed in the injured

289 se activation or ultrastructural features of apoptotic cell death were observed.

290 Caspase-8 is a key initiator of apoptotic cell death where it functions as the apical pr

291 p62/SQSTM1-positive protein aggregates, and apoptotic cell death, whereas MG132-treated quiescent ce

292 esult of downregulation of M1BP also induces apoptotic cell death, which can be significantly restore

293 In the BubR1 mutant, massive apoptotic cell death, which is likely due to the comprom

294 e associated with a significant reduction in apoptotic cell death, which may provide a therapeutic ra

295 eptor substrate 2 (IRS2) suppression induced apoptotic cell death, which was associated with an incre

296 ssion in mouse MIN6 insulinoma cells induced apoptotic cell death with an increase in Bax activation

297 e of Nrf2 in control of Bcl-2 expression and apoptotic cell death with implications in antioxidant pr

298 cells exhibited increased susceptibility and apoptotic cell death with oxidative stress.

299 cytokeratin-18 (CK-18) fragment and thereby apoptotic cell death, with the M65 ELISA, which detects

300 ulation of p53 protein, inducing significant apoptotic cell death without affecting the cell cycle pr