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1 kemia cell death through a caspase-dependent apoptotic pathway.
2 2 induced cas8 gene at 24 hpf, suggesting an apoptotic pathway.
3 ability, through inhibition of the extrinsic apoptotic pathway.
4 cell death induced by the ligands follows an apoptotic pathway.
5 ts which involves the PI3K/Akt signaling and apoptotic pathway.
6 the BAX mRNA and concurrently activates the apoptotic pathway.
7 aspase 3, the final executor protease of the apoptotic pathway.
8 can find a way to impair the IRF-3-dependent apoptotic pathway.
9 is without affecting the caspase-independent apoptotic pathway.
10 nd activation of the intrinsic mitochondrial apoptotic pathway.
11 pase-8 activation, implicating the intrinsic apoptotic pathway.
12 considered the guardian of the mitochondrial apoptotic pathway.
13 ax-dependent committed step of the intrinsic apoptotic pathway.
14 PS), which is caused by mutations in the FAS apoptotic pathway.
15 verlapping, essential roles in the intrinsic apoptotic pathway.
16 ex, freeing Bim to trigger the mitochondrial apoptotic pathway.
17 P53) encodes p53, the central protein in the apoptotic pathway.
18 scavenger and a gatekeeper of the intrinsic apoptotic pathway.
19 rization and for activation of the intrinsic apoptotic pathway.
20 ockdown also triggered a caspase-independent apoptotic pathway.
21 that include the inhibition of the intrinsic apoptotic pathway.
22 regulates the p53-induced transcription and apoptotic pathway.
23 plays an important role in inducing the Fas apoptotic pathway.
24 genes is the consequence of activation of an apoptotic pathway.
25 preceded the committed step of the intrinsic apoptotic pathway.
26 this initiator protease of the mitochondrial apoptotic pathway.
27 onged mitotic arrest partially activates the apoptotic pathway.
28 of caspase 3 and PARP1, and execution of the apoptotic pathway.
29 that it induces the intrinsic mitochondrial apoptotic pathway.
30 es with cytokine triggering of the intrinsic apoptotic pathway.
31 ostasis, resulting from mutations in the Fas apoptotic pathway.
32 al apoptosis via activation of the extrinsic apoptotic pathway.
33 aspase-3, -8, and Poly(ADP-ribose)polymerase apoptotic pathway.
34 aspase-8 independently of the death receptor apoptotic pathway.
35 ediated by the caspase-8-dependent extrinsic apoptotic pathway.
36 idative stress occurs early in the intrinsic apoptotic pathway.
37 decreased in mice lacking the Bid-dependent apoptotic pathway.
38 ative cell death by acting downstream on the apoptotic pathway.
39 nositol 3 kinase/Protein kinase B (PI3K/Akt) apoptotic pathway.
40 on and abrogates p53-dependent activation of apoptotic pathway.
41 ranslocation revealed the involvement of the apoptotic pathway.
42 tes the apoptosis signal-regulating kinase-1 apoptotic pathway.
43 higher levels of apoptosis via the intrinsic apoptotic pathway.
44 ns implicate the initiation of the extrinsic apoptotic pathway.
45 s with phosphate activates the mitochondrial apoptotic pathway.
46 he resulting activation of the mitochondrial apoptotic pathway.
47 t of cancer therapies based on the extrinsic apoptotic pathway.
48 survival caused by dysregulation of the Fas apoptotic pathway.
49 2 family members that regulate the intrinsic apoptotic pathway.
50 ion of the caspase-9-dependent mitochondrial apoptotic pathway.
51 ught to be involved in regulating LC8 in the apoptotic pathway.
52 requires the engagement of the mitochondrial apoptotic pathway.
53 mycin, with each agent triggering a distinct apoptotic pathway.
54 which in turn triggers the induction of the apoptotic pathway.
55 urothelial cells by activating the intrinsic apoptotic pathway.
56 se to neural insults by activating a caspase apoptotic pathway.
57 ss, suppresses the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway.
58 tivating the BAX/BAK-dependent mitochondrial apoptotic pathway.
59 Here, we focus on the BCL2 anti-apoptotic pathway.
60 point but independent of the downstream core apoptotic pathway.
61 ceptor superfamily involved in the extrinsic apoptotic pathway.
62 me c release and activation of the intrinsic apoptotic pathway.
63 tosis of CLL cells through the mitochondrial apoptotic pathway.
64 to occur via activation of a p53-independent apoptotic pathway.
65 on neoplastic cells and induce the extrinsic apoptotic pathway.
66 duced apoptotic cell death via the intrinsic apoptotic pathway.
67 and gradually terminated through a caspase-9 apoptotic pathway.
68 rioles prevent activation of a p53-dependent apoptotic pathway.
69 pression of inflammatory genes and promoting apoptotic pathways.
70 IR often triggers the onset of p53-dependent apoptotic pathways.
71 ound not to be associated with activation of apoptotic pathways.
72 uction of ROS, DNA double-strand breaks, and apoptotic pathways.
73 at nsPEF exposure triggers both necrotic and apoptotic pathways.
74 eventing the induction of caspase 2-mediated apoptotic pathways.
75 cing inflammasome activation and suppressing apoptotic pathways.
76 ting both caspase-dependent and -independent apoptotic pathways.
77 s cleaved by caspases upon the activation of apoptotic pathways.
78 onsequent activation of ER stress-associated apoptotic pathways.
79 could be inducing angiogenin for inhibiting apoptotic pathways.
80 NK is well known to have roles in activating apoptotic pathways.
81 is known about proteins counteracting these apoptotic pathways.
82 by direct interaction with highly conserved apoptotic pathways.
83 atins, possibly through the induction of pro-apoptotic pathways.
84 ssors, which largely utilize Bcl-2-dependent apoptotic pathways.
85 ssociated caspase-dependent and -independent apoptotic pathways.
86 eins; Ca(2+) influx also initiates competing apoptotic pathways.
87 pha production, and activation of cell death/apoptotic pathways.
88 elial cells (ECs) via competing survival and apoptotic pathways.
89 ophagy, but not by inhibition of the MAPK or apoptotic pathways.
90 he activation of the extrinsic and intrinsic apoptotic pathways.
91 e activation of both extrinsic and intrinsic apoptotic pathways.
92 nogenesis rather than causing cell death via apoptotic pathways.
93 Caspases are key components of apoptotic pathways.
94 initiate cell death through induction of pro-apoptotic pathways.
95 a PERK-eIF2alpha signalling axis and Fas-JNK apoptotic pathways.
96 g those involved in catabolic, anabolic, and apoptotic pathways.
97 unctional p53 nor activation of conventional apoptotic pathways.
98 l TMZ generates the more robust induction of apoptotic pathways.
100 Thus, our mechanistic data characterize an apoptotic pathway, activated by the selective synergy of
103 Jun N-terminal kinase (JNK) was required for apoptotic pathway activation through phosphorylation of
104 ding death receptor up-regulation, extrinsic apoptotic pathway activation, and DNA damage induction.
106 tinol induced the activation of an intrinsic apoptotic pathway along with increased surface expressio
107 e investigated the role of the mitochondrial apoptotic pathway and cell energy level during different
108 ption factor is upregulated to initiate this apoptotic pathway and directly activates puma transcript
109 ivation of caspase-3 and -9 of the intrinsic apoptotic pathway and enhances expression of antiapoptot
110 entify a novel Fos/FoxO1/Stat3-Bim intrinsic apoptotic pathway and establish the centrality of oxidat
111 associated with activation of the intrinsic apoptotic pathway and induction of late apoptosis/necros
113 ondria is required to initiate the intrinsic apoptotic pathway and subsequent cell death, but how cer
116 ve as essential gatekeepers of the intrinsic apoptotic pathway and, when activated, transform into po
117 ecrease in activation of ER stress-dependent apoptotic pathways and a preservation of beta-cell mass
118 ore, CF pig airways exhibited an increase in apoptotic pathways and a suppression of ciliary and flag
120 s through mechanisms involving mitochondrial apoptotic pathways and by reducing reactive oxygen speci
122 membrane can connect extrinsic and intrinsic apoptotic pathways and can serve as sites of apoptosome
124 explants, oxygen deprivation (OD) activated apoptotic pathways and increased neuronal cell death in
126 mensacarcin activates caspase-3/7-dependent apoptotic pathways and induces cell death in melanoma ce
127 lls restored checkpoint function, suppressed apoptotic pathways and markedly increased clonogenic sur
128 .1 AHR, the dioxin receptor involved in anti-apoptotic pathways and melanoma progression; and 9q34.3
129 d the profound effects of signaling defects, apoptotic pathways and the ramifications of homeostatic
130 onstrate that EsxA interferes with host cell apoptotic pathways and, together with EsxB, mediates the
131 into the cytosol to engage in the intrinsic apoptotic pathway, and enters the nucleus where it imped
132 Fas is a critical mediator of the extrinsic apoptotic pathway, and its role in mediating lymphoproli
133 beta processing, activation of the extrinsic apoptotic pathway, and regulation of Hedgehog and Wnt li
134 activation of the p53- and caspase-dependent apoptotic pathway, and silencing of p53 decreased cell d
135 aspartic proteases) are induced early in the apoptotic pathway, and so we used their induction to mea
137 36 on MVECs activates a caspase-mediated pro-apoptotic pathway, and this effect is abrogated by histi
138 f viral gene expression, viral subversion of apoptotic pathways, and avoidance of clearance by the im
139 inflammatory neuronal loss is independent of apoptotic pathways, and is inhibited by blocking the PS/
140 caspase-3 cleavage to suggest activation of apoptotic pathways, and no increase in neutrophil gelati
141 ws of transcriptional signaling by RA and of apoptotic pathways, and then addresses available informa
142 asmic phosphatidylinositol-3-kinase/AKT anti-apoptotic pathway; and nuclear PTEN affects the cell cyc
143 ect of HSV-2 gene expression on the cellular apoptotic pathway appears to depend on the specific cell
145 ial and endoplasmic reticulum stress-induced apoptotic pathways are activated by the combination of v
146 cal distortions, we have determined that pro-apoptotic pathways are activated by the formation of tri
147 ted, both Caspase-dependent and -independent apoptotic pathways are activated in the sensory ganglia
150 ld be reduced in aging,and unique aspects of apoptotic pathways are potentially involved in the patho
153 ), the thyroid regulation pathway (DIO2) and apoptotic pathways as involved in genetic risk of large
154 al-regulating kinase 1 and activation of the apoptotic pathway, as evidenced by p38 MAPK and poly-ADP
155 Cytotoxicity was mediated by the intrinsic apoptotic pathway, as shown by an increase in Bcl2-like
156 accelerated by a cytokine-receptor mediated apoptotic pathway, as shown in a transgenic rat overexpr
157 they do not activate the caspase-independent apoptotic pathway associated with the apoptosis-inducing
158 death was a consequence of activation of the apoptotic pathway, because the cell death was rescued wi
159 7 can induce apoptosis through the intrinsic apoptotic pathway, but the mechanism by which Nur77 kill
165 Mutational inactivation in cancer of key apoptotic pathway components, such as TP53/p53, undermin
166 th receptor-mediated extrinsic and intrinsic apoptotic pathways, confirmed in vivo for Ezh2-null IFN-
167 mitochondria and a critical component of the apoptotic pathway, contains a heme cofactor covalently a
170 on-induced apoptosis and that targeting this apoptotic pathway could be a novel therapeutic strategy
171 2+) stores, and is mediated by the intrinsic apoptotic pathway; down-regulation of AE2 in primary bil
172 ceptor (CSF-1R), which confers resistance to apoptotic pathways driven by tumor necrosis factor (TNF)
173 ns damaged in ALS activate the mitochondrial apoptotic pathway early in the disease process and that
175 iated in part by modulation of the intrinsic apoptotic pathway, exhibiting synergy with the BCL-2 inh
179 inhibit or activate certain proteins in the apoptotic pathway have great potential as novel chemothe
180 activation of p53-dependent and -independent apoptotic pathways have been explored experimentally and
181 hereby inhibit the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway, identifying miR-30b-5p and miR-30c-5p
182 t the LVS delays activation of the intrinsic apoptotic pathway in a TolC-dependent manner, both durin
183 ith hallmarks of activation of the intrinsic apoptotic pathway in a tumor suppressor protein p53-depe
185 unappreciated role for DR4 and the extrinsic apoptotic pathway in cell fate choice following p53 acti
191 planation for abrogation of the p53-mediated apoptotic pathway in melanoma, implicating novel approac
192 e potential of targeting the BCL-2-regulated apoptotic pathway in previously untreatable lymphoid mal
193 angiotensin (Ang) II activates the intrinsic apoptotic pathway in primary endothelial cells (ECs) via
194 that monoclonal FLCs activated the intrinsic apoptotic pathway in renal epithelial cells by activatio
195 e after infection and died via the intrinsic apoptotic pathway in response to diverse proliferative s
200 ither drug alone in activating the intrinsic apoptotic pathway in transformed cells, as evidenced by
201 on, and induced both intrinsic and extrinsic apoptotic pathway in vitro with a dose-dependent manner.
205 ion of NF-kappaB inhibited the activation of apoptotic pathways in cultured primary rat hepatocytes.
206 tes survival through acute downregulation of apoptotic pathways in effector T cells and by permanentl
207 t be mediated by inhibiting the p53 mediated apoptotic pathways in neurons through inhibition of Drp1
208 that may lead to the premature activation of apoptotic pathways in neurons, as well as current and pr
209 gh the activation of intrinsic and extrinsic apoptotic pathways in ovarian cancer but only the intrin
210 2 regulates proinflammatory cytokine-induced apoptotic pathways in pancreatic beta-cells by crosstalk
211 y which redox-sensitive molecules signal via apoptotic pathways in response to PD-relevant toxic stre
213 pro-survival cascades and inhibition of pro-apoptotic pathways in the striatum and/or cortex, which
215 mozygous deletion of Sirt1 triggers cellular apoptotic pathways, increases cell death, diminishes aut
220 B cells, show that a mitochondria-dependent apoptotic pathway involving p53 contributes to the high
223 to examine the hypothesis that an intrinsic apoptotic pathway is activated by DMBA and that the ulti
226 A signature event during the cell intrinsic apoptotic pathway is mitochondrial outer membrane permea
227 sly reported findings that the developmental apoptotic pathway is not involved in photoreceptor cell
229 c studies to determine whether the intrinsic apoptotic pathway is required for radiation to produce a
231 icating that this Myc-induced miRNA-mediated apoptotic pathway is suppressed in malignant cells, but
233 culum stress and activation of the intrinsic apoptotic pathway is widely believed to contribute to be
235 f its cell cycle dysregulation, and impaired apoptotic pathways is yielding many potential therapeuti
237 dominantly via the mitochondrial (intrinsic) apoptotic pathway, is thought to be a major determinant
238 targeting of HER2 and the BCL-XL/BCL-2 anti-apoptotic pathway may increase responses to anti-HER2 th
239 mbine MEK inhibitors with agents that target apoptotic pathways may be a promising therapeutic approa
240 he concept that targeting metabolic and anti-apoptotic pathways may be an effective therapeutic strat
242 ata show that the inability of EBOV to block apoptotic pathways may open up new strategies toward the
244 objective was to evaluate the expression of apoptotic pathway members in synovial sarcomas and inter
245 eneration on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using di
250 emical cytotoxic modality that activates the apoptotic pathway, reduced ABCG2 expression to increase
252 nce of RIG-I, IPS1, TRAF3 and TBK1, only the apoptotic pathway required the presence of TRAF2 and TRA
253 pies that induce cell death through multiple apoptotic pathways required inhibition of cIAP1, cIAP2,
254 Commitment to death via the mitochondrial apoptotic pathway requires activation of the mitochondri
256 of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis.
258 programmed necrosis, how they intersect with apoptotic pathways, roles of necrosis in heart disease,
260 ally, B56epsilon regulates the p53-dependent apoptotic pathway solely through controlling the stabili
261 allowed spatial and temporal control of the apoptotic pathway specifically in mature, myelin basic p
262 dramatically inhibited the SubAB-stimulated apoptotic pathway: SubAB-induced Bax/Bak conformational
263 ests that direct activators of the intrinsic apoptotic pathway, such as BH3 mimetics, may be useful f
264 caspase-2, the cells exhibited hallmarks of apoptotic pathway, such as mitochondrial damage and tran
265 ng evidence and consideration of related non-apoptotic pathways suggest that ferroptosis could be an
266 ropose a mathematical model of the intrinsic apoptotic pathway that captures three key dynamical feat
267 rough alpha-MSH mediating suppression of the apoptotic pathway that is post-Caspase 3, but before DNA
269 This caspase has also been implicated in non-apoptotic pathways that regulate Fas-associated via deat
270 sted reduced activation of the mitochondrial apoptotic pathway, the death response to other stimuli s
272 f cellular apoptosis by triggering intrinsic apoptotic pathway through depolarization of mitochondria
273 te the contribution of this newly discovered apoptotic pathway to the host's overall antiviral respon
276 s in GBM tumor cells despite deregulation of apoptotic pathways, underscoring its potential use as a
277 uced toxicity by mediating the mitochondrial apoptotic pathway via the induction and oligomerization
278 myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for progression in cancer.
280 Ontology analysis of 88 genes related to apoptotic pathways was performed in gingival biopsies of
282 t analysis showed that the genes involved in apoptotic pathways were enriched in glaucomatous RGCs.
283 eased, the caspase-dependent and independent apoptotic pathways were mildly activated in the Irbp(-/-
284 y and induced multiple DNA damage repair and apoptotic pathways when compared with control siRNAs.
285 S2-VP10 cells results in cell death via the apoptotic pathway whereas inhibition of both autophagy a
286 ritic cell death through a caspase-dependent apoptotic pathway, whereas sera from nonsurviving patien
287 ti-tumor effects by activating the extrinsic apoptotic pathway which could overcome the cytoprotectiv
288 LigIIIalpha activated a caspase 1-dependent apoptotic pathway, which is known to be part of inflamma
289 o alterations of specific checkpoints in the apoptotic pathway, which may represent important molecul
290 iates retrograde activation of a somatic pro-apoptotic pathway, which, in turn, is required for dista
291 d cell death by reactivation of an extrinsic apoptotic pathway whose function is suppressed in the on
292 s-inducing ligand (TRAIL)-mediated extrinsic apoptotic pathway with the help of c-Jun N-terminal kina
293 1 activated both the extrinsic and intrinsic apoptotic pathways with activation of initiator caspases
295 and initiating both extrinsic and intrinsic apoptotic pathways with reduced systemic toxicity compar
296 have documented activation of the extrinsic apoptotic pathway, with specific cleavage of caspase-8 a
297 duction of ROS by DDC consistently activated apoptotic pathways, with increased cell death in combina
298 miR-10b targeting, such metastasis-dependent apoptotic pathways would offer attractive targets for fu
299 nt an essential gateway to the mitochondrial apoptotic pathway, would protect against motor neuron de
300 on is attributable in part to suppression of apoptotic pathways, yet the mechanisms by which cancer c
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