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1 r DAT inhibitors, which exhibited no loss in apparent affinity.
2  the radical reductase activity but of lower apparent affinity.
3 an cooperate to bind bivalent AP-2 with good apparent affinity.
4 tude lower (0.1 microM), indicating a higher apparent affinity.
5 ith large internal loops or bulges with high apparent affinity.
6 ope accessibility, epitope conservation, and apparent affinity.
7 ed TRPM2 channel gating, albeit with reduced apparent affinity.
8 esence or in the absence of Ca(2+) with high apparent affinity.
9 S, but with an almost 1000-fold reduction in apparent affinity.
10 ed Ca(2+)-dependent movements with different apparent affinities.
11 ctivator of hAChE, when analyzed in terms of apparent affinity (1/K(ox)) and maximum reactivation rat
12 in the agonist-bound state increased agonist apparent affinity 15-fold, and slowed both deactivation
13 all culture times with only slightly greater apparent affinity after extended culture in the absence
14 mbrane-proximal, and V1/V2 MAbs with similar apparent affinities, although the T/F Envs bound with hi
15                                          The apparent affinities and other thermodynamic parameters d
16 to a heteromeric complex increases glutamate apparent affinity and also enables receptor activation b
17  domain of the channel showed reduced proton apparent affinity and biphasic proton activation curves.
18  is more effective than Unc45b with a higher apparent affinity and greater extent of folding.
19       The results demonstrated that both the apparent affinity and intrinsic affinity of the Abs stud
20 ot related to an avidity-related increase in apparent affinity and points instead to a crucial role o
21 increases in ionic strength, despite the low apparent affinity and poor stability with which UL42 bin
22 , has a dramatically different effect on the apparent affinity and transport rate for N-acetylneurami
23  phosphatase (AP) and examined the impact on apparent affinity and utility.
24 al AChR to which it bound with sub-nanomolar apparent affinity, and detected the presence of fetal AC
25 nds Cu(+), Ag(+), and ATP with the same high apparent affinities as the wild-type CopA.
26 , 2-O-, or 6-O-sulfates bind with equivalent apparent affinity as a disulfated DS tetrasaccharide.
27       ATP interacts with the enzyme with two apparent affinities (ATPase K(m) = 0.25 mm; phosphorylat
28 r, Cu+ interacts with the enzyme with higher apparent affinity (ATPase stimulation, Ag+ K(12) = 29.4
29  larger interaction energy than the measured apparent affinity between the tetraloop and the free rec
30 nctions, however, are influenced not only by apparent affinities but also by alternate factors, inclu
31 II binds to beta1b and beta2a with a similar apparent affinity but does not bind to beta3 or beta4.
32                                          The apparent affinity constant of Con A binding to mannose w
33                                          The apparent affinity constants determined using surface pla
34 MAbs to virions and allowed determination of apparent affinity constants in solution.
35 t's results showed a correlation between the apparent affinity constants measured for the NIP and MIP
36                                          The apparent affinity constants of lactose binding with ECL
37                                              Apparent affinity constants of Sc(3+) with membrane tran
38  for each glycan-lectin pair, from which the apparent affinity constants were obtained.
39 or resistance to E, can be correlated to the apparent affinities determined by in vivo multicopy supp
40 IR-AB1/IgY interaction allows an increase in apparent affinity due to avidity effects when the recept
41  in the absence of phospholipids with a high apparent affinity (EC50 of approximately 1.3-2.3 microM)
42                                        Their apparent affinity, epitope complementarity, and epitope
43  vivo to all three T antigens with different apparent affinities estimated as 1:7:100 (large T antige
44 nd that TAAR4 is exquisitely sensitive, with apparent affinities for a preferred ligand, phenylethyla
45  for an epitope peptide as WT 4E10 but lower apparent affinities for both viral membrane mimetic lipo
46 The tetracaine analogues described here have apparent affinities for CNGA1 channels that vary over ne
47     The isozymes were found to share similar apparent affinities for cofactors.
48 immunosorbent assay technology to assess the apparent affinities for each isotype and IgG subclass of
49                Variants also exhibited lower apparent affinities for Env(+) virions and failed to sig
50 on additional membrane sites and had altered apparent affinities for factor X.
51 ltose uptake than the wild type and enhanced apparent affinities for maltose.
52  into NRK-52E cells resulted in reduction of apparent affinities for Na(+) and K(+).
53 wed modest to significant decreases in their apparent affinities for Na(+) o and/or H(+) i.
54                                              Apparent affinities for substrates were unaffected by th
55  through a mechanism that does not alter the apparent affinities for the cosubstrates glutamate or so
56 e quantified the mutational effects based on apparent affinities for the respective inactivated state
57 void interference), the L subunit had a high apparent affinity for 3-phosphoglycerate and substrates
58                                              Apparent affinity for [(3)H]MeTRH was increased 8-fold i
59 gle strand DNA or single strand RNA, yet the apparent affinity for a DNA activator is 11-fold higher
60               The loop 2 mutants altered the apparent affinity for actin (K(ATPase)) without altering
61 al kinetic differences explain the increased apparent affinity for activation by cytosolic Ca2+ and t
62                            Intriguingly, the apparent affinity for activation of TPC1 by its ligand N
63 C and D345C channels by MTSET reduced proton apparent affinity for activation.
64  more than 10,000-fold without affecting the apparent affinity for ADP-Glc and glycogen binding.
65                                          The apparent affinity for aspartate binding depended on the
66                        While Sky1p has a low apparent affinity for ATP compared to other protein kina
67  by F6P compared to that of WT but increased apparent affinity for ATP in the presence of F6P.
68 r the InsP3R1-SII(-) and InsP3R1-opt; 4) the apparent affinity for ATP is sixfold lower for the InsP3
69              The dissociation step showed an apparent affinity for ATP that was very weak (K(1/2),ATP
70 ns (NBDs) as the mutation does not alter the apparent affinity for ATP, and the mutant channels respo
71                          We have tested this apparent affinity for betaproteobacteria by examining th
72 al time, we observe that PAR(2) has a higher apparent affinity for both beta-arrestins than does NK1R
73 meric channels that exhibited an increase in apparent affinity for both cAMP and cGMP compared with w
74 e activity was related to an increase in the apparent affinity for Ca(2+) and an increase in the phos
75 ulin-activated enzyme without increasing the apparent affinity for Ca(2+).
76  decreased by approximately 30% although the apparent affinity for Ca2+ was unchanged in heterozygous
77  linked dimer and has a significantly higher apparent affinity for calcium than the wild-type recepto
78  citrate and succinate but larger changes in apparent affinity for cations and substrate specificity
79                                          The apparent affinity for CCCP decreased in a linear manner
80 hannels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night.
81 hannels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night.
82 oncentration from 200 to 10 mM decreased the apparent affinity for d-galactose without altering the m
83 m) and etomidate (100 mum) and for increased apparent affinity for direct gating by the IV anesthetic
84 rating phenotype as determined by the cells' apparent affinity for dissolved inorganic carbon.
85 rNav1.2a (G1079C), which results in a higher apparent affinity for externally applied PaurTx3 and Pro
86  to have a approximately 15-fold decrease in apparent affinity for F6P compared to that of WT while A
87 s of 4% PS, and 3 mutants also had decreased apparent affinity for factor X.
88 le, metalloelastase (MMP-12) displays higher apparent affinity for fEln-100, while MMP-2 displays fas
89 ly open the channel of mutant G219F, and the apparent affinity for GABA was increased, and desensitiz
90 d-point of the inhibition being close to its apparent affinity for GDP-bound FtsZ.
91 mutants had 1 or 2 orders of magnitude lower apparent affinity for Glc-1-P compared with the wild typ
92 determinations of ADP-Glc PPases having high apparent affinity for glucose 1-phosphate.
93 luK2(E738D) mutation lowers the steady state apparent affinity for glutamate by 9000-fold in comparis
94 exhibit slowed kinetics and a shift in their apparent affinity for glutamate.
95 for proline and leucine and a low millimolar apparent affinity for glutamine.
96 at is similar to that in *Talpha is that the apparent affinity for guanine nucleotides is decreased i
97  in a functionally bivalent manner, with the apparent affinity for IgA1 related to the number of expo
98                             In addition, the apparent affinity for Ins(3,4,5)P(3) is affected by the
99 oximately 10 ms; 4), InsP3R2 has the highest apparent affinity for InsP(3) (0.10 microM), followed by
100 Trp38, causes decreased quenching, decreased apparent affinity for L-fucose, and significant inhibiti
101 tPh-L130W/T352A exhibited an ~15-fold higher apparent affinity for l-glutamate than the wild type tra
102               An even larger increase of the apparent affinity for l-glutamate, around 130-fold highe
103 g yielded less than a 4-fold decrease in the apparent affinity for melibiose at saturating Na(+) or L
104 syt VII, which we show has a relatively high apparent affinity for metals.
105   In general, taxane derivatives with higher apparent affinity for microtubules induced tubulin assem
106 entration from 20 to 0.5 mM reduced both the apparent affinity for Na(+) and the maximum quench at sa
107 Pase, and while TM5 showed modest changes in apparent affinity for Na(+), TM4, TM6, and TMAll display
108 tive transport and efflux, and decreased the apparent affinity for Na(+).
109  which upon binding estrogen shows increased apparent affinity for nuclear components (tight nuclear
110 , however, TgPhyA had a significantly higher apparent affinity for O(2).
111 ing several at position 223, that reduce the apparent affinity for oseltamivir in vitro.
112 ion neurons from Pirt knock-out mice have an apparent affinity for PIP2 indistinguishable from that o
113 2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low mill
114 oup interactions control Ca(2+) sensitivity, apparent affinity for RetGC, and maximal level of cyclas
115 iminates DksA function without affecting its apparent affinity for RNAP.
116 ents also revealed that PLB has a 50% higher apparent affinity for SERCA1a relative to SERCA2a.
117                                          The apparent affinity for sildenafil increased from the nano
118  voltage dependence, indicating an increased apparent affinity for sodium.
119 in impaired transport activity and a reduced apparent affinity for sodium.
120 oltage-dependence indicative of an increased apparent affinity for sodium.
121 ant determinant of functional differences in apparent affinity for substrate and cations.
122                     This chimera has similar apparent affinity for succinate and sodium as the wild-t
123                                 That is, the apparent affinity for sugar and driver cation Na(+) exhi
124              The S subunit had a typical low apparent affinity for the activator 3-phosphoglycerate,
125 fect the specific activity but did alter the apparent affinity for the activator 3-phosphoglycerate,
126 sponding active conformation potentiates the apparent affinity for the agonist, effectively equating
127       Modification at N1 of cGMP reduces the apparent affinity for the channel; however, when combine
128 RQ(102), and (119)RSVL(122), reduced the RD3 apparent affinity for the cyclase 180-700-fold.
129 epolarized synaptosomes correlated well with apparent affinity for the inactivated state of sodium ch
130 MP-PNP is not disrupted by the mutation, the apparent affinity for the nucleotide is decreased by 4-f
131 te with PtdIns(4,5)P(2) for binding, but the apparent affinity for the soluble inositol phosphate is
132 pen conformation, which mostly increases the apparent affinity for the substrates (i.e. by a reductio
133     Similarly, a 30-150-fold decrease in the apparent affinity for verapamil and cyclic peptide inhib
134  TRPM3 activator, CIM0216, whose potency and apparent affinity greatly exceeds that of the canonical
135 olar concentrations of Tb(3+), indicating an apparent affinity >100-fold higher than Ca(2+).
136 in MAbs 6D8 and 13F6 bind with the strongest apparent affinity, helping to explain their effectivenes
137 SYY (i) decreased both Na(o)(+) and Na(i)(+) apparent affinities in the absence of K(o)(+), and (ii)
138 -molecule inhibitor of ASICs with a reported apparent affinity in the low micromolar range, making it
139 in a concentration-dependent manner, with an apparent affinity in the low nanomolar range.
140 T(20)) single-stranded flanking region, with apparent affinity in the micromolar range.
141 nhibits ClC-ec1 activity reversibly, with an apparent affinity in the micromolar range.
142 ichiometry in the presence of Ca(2+) with an apparent affinity in the micromolar range.
143 nds the five oriC-proximal RBMs with similar apparent affinity in units of two and four.
144 chanism of En-dependent repression, and that apparent affinity in vitro is an unreliable predictor of
145  microM; in the presence of membranes, these apparent affinities increase by up to sevenfold.
146 PF1 binds to single-stranded NAs (ssNA) with apparent affinity increasing with substrate length and w
147           ATP analogs bind MRP1 with reduced apparent affinity, inducing a partially closed conformat
148 omain of the alpha1 ILD near M3 altered GABA apparent affinity; interestingly, alpha1(K312E) exhibite
149 ith an IC50 in the high picomolar range, the apparent affinity is higher than known high affinity BK
150 , simple phenolics and cyanogens with higher apparent affinities (K(m)) and specificities (k(cat)/K(m
151                                          The apparent affinities (K(m)) for ADP were similar for both
152 ve binding of two MsrA to each CaMox with an apparent affinity (K = 70 +/- 10 nM) that is 3 orders of
153 esence of Rng3p in ATPase assays doubles the apparent affinity (K(ATPase)) of both native Myo2 and re
154           The effect of bulk-phase pH on the apparent affinity (K(d)(app)) of purified wild-type lact
155            In general, substrates have lower apparent affinities (K0.5) for hSGLT3 than hSGLT1 (D-glu
156            It is activated by Cu2+ with high apparent affinity (K1/2 = 0.28 microm) and partially by
157 at 190-HARE and 315-HARE bind HA with higher apparent affinity (Kd approximately 10-20 nM) than chond
158 or diversifying the ion-release dynamics and apparent affinity (Km ) at opposite sides of the membran
159 ximal velocity (Vmax) without any changes in apparent affinity (Km) for the substrate Na+ .
160                                         This apparent affinity matches that for its canonical dsDNA l
161             To test the idea that increasing apparent affinity might enhance neutralizing activity, w
162       We obtained excellent agreement in the apparent affinities obtained across platforms and within
163 transports uracil, adenine, and guanine with apparent affinities of 16.4, 0.4, and 6.3 muM, respectiv
164 subunits (GDP-Galpha(s) and Gbetagamma) with apparent affinities of 270 +/- 21 and 190 +/- 7 nM, resp
165 scence emission spectrum of dansyl-CaM, with apparent affinities of 87 +/- 23 nm and 1.70 +/- 0.16 mi
166 d isotypes, immunoglobulin G subclasses, and apparent affinities of anti-FVIII autoantibodies to asse
167 with the biochemical data, we found that the apparent affinities of Ca(2+) activating and inhibitory
168                             We show that the apparent affinities of DksA and GreB for RNAP are simila
169                                  Whereas the apparent affinities of DksA for RNAP core and holoenzyme
170 ey also reveal complex relationships between apparent affinities of drugs for radioligand binding and
171              We present a unique data set of apparent affinities of FVIII-specific antibodies found i
172                                    Divergent apparent affinities of Kv7.2-7.4 channels for PIP2 may u
173                             We find that the apparent affinities of P-gp for anticancer drugs actinom
174                                 Further, the apparent affinities of the membrane-displayed scFvs were
175       Fast decay amplitude data indicated an apparent affinity of 0.9 microM for the closed-state alp
176  binds three Ca2+ ions at saturation with an apparent affinity of 2 microm and Hill coefficient of 1.
177           The increased valency enhances the apparent affinity of 2G12 for Man(4) up to a limit which
178 tides ATP and cAMP block the channel with an apparent affinity of 3 and 42 microM, respectively (-80
179 e reversibly inhibits ASCT2 function with an apparent affinity of 30 muM.
180 els also suggest that binding occurs with an apparent affinity of 7 muM.
181        We hypothesized that the reduction in apparent affinity of 8-Br-cGMP for cGKI in AHR might be
182 on, high-affinity AXL decoy receptor with an apparent affinity of 93 femtomolar to GAS6.
183                                          The apparent affinity of acto-heavy meromyosin (acto-HMM) fo
184 r function and is a major determinant of the apparent affinity of agonists.
185 ired in a major transport mechanism, with an apparent affinity of approximately 0.9 mm K(+)(Rb(+)).
186  act as a modulator of Kex2 activity with an apparent affinity of approximately 20 mm.
187 that Zn(2+) inhibits these currents, with an apparent affinity of approximately 50 microM.
188                                          The apparent affinity of ASCT2 for extracellular Na(+) was d
189               These same mutations lower the apparent affinity of Ba2+ by approximately 10(3)- or app
190   One consequence of this effect is that the apparent affinity of baclofen is strongly reduced during
191                  Micromolar Ca increased the apparent affinity of CaM binding and slowed CaM dissocia
192 phosphorylation at Thr286 is to increase the apparent affinity of CaMKII for calmodulin, a phenomenon
193 g to the CNBD of HCN2 channels decreases the apparent affinity of cAMP for the CNBD.
194 gly, these mutations selectively enhance the apparent affinity of CARD11 for Bcl10, but not for other
195 e active at night in cones, and increase the apparent affinity of CNGCs for cGMP.
196                                          The apparent affinity of cytisine for surface receptors (K(d
197 vo and in vitro, primarily by increasing the apparent affinity of DksA for RNA polymerase (RNAP).
198 r RNAP core and holoenzyme are the same, the apparent affinity of DksA for RNAP decreases almost 10-f
199 ding site with alanine (N128A) increases the apparent affinity of dTC by approximately 10-fold.
200 al rate of translocation (k(trans)), and the apparent affinity of EF-G for the pretranslocation compl
201             Under neutral pH conditions, the apparent affinity of Fcepsilon for the dimeric fusion pr
202    These data suggest that proton alters the apparent affinity of GABA receptors for agonist.
203  submaximal GABA responses by increasing the apparent affinity of GABA(A)Rs for GABA.
204 nodiscs was significantly different, and the apparent affinity of Galphaq and Gbeta(1)gamma(1) to act
205  Rac membrane cycling reveals that the lower apparent affinity of GDI for RacGTP compared to RacGDP c
206                 In the presence of Mg2+, the apparent affinity of Glu-297 3Dpol for 2'-deoxyribonucle
207                     In contrast to GreB, the apparent affinity of GreA for RNAP was weaker than that
208 olesterol depletion dramatically reduced the apparent affinity of homomeric CNGA2 channels for cAMP b
209 ormation between Hsp90 and p23 increased the apparent affinity of Hsp90 for AMP-PNP and completely in
210                                          The apparent affinity of K114 for fibril binding is 20-30 nM
211 model for Kap translocation, we measured the apparent affinity of Kap95p to FG Nups representing thre
212                                          The apparent affinity of LMWH for the factor IXa-PL complex
213 h leucine and the lrp-1 mutation reduced the apparent affinity of Lrp binding to ilvIH DNA (contains
214 otein component does not alter the number or apparent affinity of magnesium ions that are either diff
215 flecting specific structural preference, the apparent affinity of mincle for ligands with hydrophobic
216 ta3 reduced and increased, respectively, the apparent affinity of Mn(2+) to the integrin.
217 y (K(d) = 8 nM) essentially identical to the apparent affinity of MRS2279 determined previously in st
218                             Accordingly, the apparent affinity of NMIIB S1 for actin in the presence
219  profile (i.e. a progressive decrease in the apparent affinity of oxotremorine-M).
220 the intramolecular binding motif reduces the apparent affinity of p53 for MdmX by a factor of 400.
221                            RGS13 reduced the apparent affinity of pCREB for both the CRE and CBP.
222  CBD1, resulted in a drastic decrease in the apparent affinity of peak exchange current for regulator
223 oss of PLB-PLB FRET due to a decrease in the apparent affinity of PLB oligomerization.
224 e, heteroligation demonstrably increases the apparent affinity of polyreactive antibodies to HIV.
225 sor." Mutations in these two areas shift the apparent affinity of protons toward a more acidic range
226 ilter binding assays, we determined that the apparent affinity of Prp22 is approximately 20-fold grea
227 ions in the region of 70- to 165-fold in the apparent affinity of receptors for glucose in which Glu1
228 y in membrane-based assays by increasing the apparent affinity of RGS4 for Gialpha and Goalpha, sugge
229                              BTS weakens the apparent affinity of S1.ADP for actin, increasing the K(
230 i) release in conjunction with the decreased apparent affinity of S1.ADP.P(i) and S1.ADP for actin.
231 tion of SERCA2a is manifested as a decreased apparent affinity of SERCA2a for Ca(2+).
232                       We also determined the apparent affinity of SOX2 and NANOG for their consensus
233                                          The apparent affinity of substrate-free EAAC1 for Na(+) was
234 ncentrations, subunit conformations, and the apparent affinity of subunits for polymer ends.
235                                          The apparent affinity of the Abs ranged from nearly 10(-10)
236 d substitutions that significantly alter the apparent affinity of the active site for beta-lactams an
237  that describe the specificity, isotype, and apparent affinity of the antibodies secreted from large
238 l-DTPA were hyperbolic, but in each case the apparent affinity of the antibody for the chelator-metal
239  F256V, I765A, and Y837A reduce not only the apparent affinity of the ATPase for TG but also the maxi
240 cket (Phe342) was replaced with alanine, the apparent affinity of the blocker was increased approxima
241  mainly due to an >200-fold reduction in the apparent affinity of the Ca2+-inhibitory site; 6), the a
242 ite to tyrosine (F226Y) has no effect on the apparent affinity of the competitive antagonist d-tubocu
243                         It is found that the apparent affinity of the complex is significantly greate
244 828A, R834A, and R837A mutations reduced the apparent affinity of the enzyme for both Na(+) and K(+)
245 ac sarcoplasmic reticulum, by decreasing the apparent affinity of the enzyme for Ca(2+).
246 ulum (SERCA2a), which acts by decreasing the apparent affinity of the enzyme for Ca(2+).
247 decrease of approximately >or=10-fold in the apparent affinity of the enzyme for sodium (Km(app)(Na+)
248              This is due largely to the high apparent affinity of the enzyme for this DNA substrate,
249 f CaMKII and a significant increase (22%) in apparent affinity of the enzyme.
250 ed from the intact antibody only in that the apparent affinity of the Fab was generally lower for a g
251 y complex, but HFE binding to TfR lowers the apparent affinity of the Fe-Tf/TfR interaction.
252 DH2 were found to be a dramatic reduction in apparent affinity of the holoenzyme for NAD(+) and a con
253                                   The higher apparent affinity of the immobilized aptamer may result
254  CTT may produce this effect by reducing the apparent affinity of the interaction between beta-cateni
255 ered Cdc25C protein partner and enhances the apparent affinity of the interaction.
256 istent with a multivalent interaction: 1) an apparent affinity of the multivalent ligand for the M2 r
257                                 However, the apparent affinity of the nonconserved mutants for GABA w
258 e p5 (as in Jdp5) dramatically increases the apparent affinity of the p5 moiety for DnaK in the prese
259 re of the regulatory complex and reduced the apparent affinity of the PLM-NKA interaction.
260 as continuous-time random walks decrease the apparent affinity of the reaction, locally slowed-down B
261 ee scenarios have distinctive effects on the apparent affinity of the reaction.
262 imetics) that activate CaR by increasing the apparent affinity of the receptor for calcium.
263 the estimated channel opening rate or on the apparent affinity of the receptor for GABA.
264 r importance in defining the specificity and apparent affinity of the receptor for germinants.
265              The two mutations increased the apparent affinity of the regulatory Ca2+ binding sites o
266 ons included 2-fold or less increases in the apparent affinity of the thin filament regulatory Ca(2+)
267 skolin results in a 100-fold increase in the apparent affinity of the two domains for one another.
268                            We determined the apparent affinity of the wild-type and the mutant RetGC-
269 193A, gammaH200A, and gammaH202A reduced the apparent affinity of the Zn(2+) activating site, gammaH2
270                                          The apparent affinity of these derivatives for GMPCPP-stabil
271      Rather, hyperpolarization increases the apparent affinity of TPC1 for NAADP by 10 nm/mV.
272        We demonstrate that Dcs1 improves the apparent affinity of Xrn1 for RNA and that Xrn1 and Dcs1
273 eplacement of Thr with Ala or Cys lowers the apparent affinity ofK+, Rb+, and Cs+ for tetramer stabil
274   The latter is thought to decrease antibody apparent affinity or avidity, thereby interfering with n
275                                         This apparent affinity reduction could result from direct com
276 rmation of an acid-stable phosphoenzyme with apparent affinities similar to those observed in the ATP
277 ed to disrupt these contacts reduced agonist apparent affinity, speeded up receptor deactivation and
278            Pyruvate activates EA with higher apparent affinity than AE, suggesting that the C-terminu
279 O-sulfate, an analog that binds with greater apparent affinity than cholesterol.
280 ars to interact with the spores with greater apparent affinity than does taurocholate.
281 r (reduced V(max(app))), with 50-fold higher apparent affinity than LMWH.
282 clathrin binds the beta2 chain with a higher apparent affinity than PIPKIgamma661.
283 III inhibitors have an up to 100-fold higher apparent affinity than that of antibodies found in patie
284 ied to inside-out patches, with differential apparent affinities that correlate with their maximal Po
285 is and diazepam to manipulate GABAA receptor apparent affinity, the decrease in arcuate miniature pos
286  (BZD efficacy) without altering BZD binding apparent affinity, three residues whose mutation altered
287 ing to free RNAP below detection limits, the apparent affinity to Mg2+ in transcription complexes for
288 ing a closed conformation that decreases the apparent affinity to protons and also slows the rise and
289 (2+), both sTnC and xxsTnC bind with similar apparent affinity to sTnC-extracted thin filaments.
290 ly dephosphorylates CMP, although with lower apparent affinity; UMP and the purine nucleotides are po
291  mibefradil block of Na(+) channels in which apparent affinity was enhanced when channels were recrui
292                      This 5-fold increase in apparent affinity was not species-specific since bovine
293                                          The apparent affinities were approximately 10-fold higher th
294                                 However, the apparent affinities were rather weak (VX-950, K(D)* of 3
295  inward currents activated by L-Arg with low apparent affinity were measured in whole-cell voltage-cl
296 apamil from the outside, with an increase in apparent affinity when the drug was applied from the ins
297 riant FlhBs had similar kinetic profiles and apparent affinities, which ranged between 1 and 10.5 mic
298 ersus 20-fold) and interacted with an higher apparent affinity with its target guanylate cyclase.
299                            In 50 mM KCl, the apparent affinity with which UL42 bound the P/T did not
300 in relatively small changes in the substrate apparent affinities, yet at several of these positions,

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