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1 r DAT inhibitors, which exhibited no loss in apparent affinity.
2 the radical reductase activity but of lower apparent affinity.
3 an cooperate to bind bivalent AP-2 with good apparent affinity.
4 tude lower (0.1 microM), indicating a higher apparent affinity.
5 ith large internal loops or bulges with high apparent affinity.
6 ope accessibility, epitope conservation, and apparent affinity.
7 ed TRPM2 channel gating, albeit with reduced apparent affinity.
8 esence or in the absence of Ca(2+) with high apparent affinity.
9 S, but with an almost 1000-fold reduction in apparent affinity.
10 ed Ca(2+)-dependent movements with different apparent affinities.
11 ctivator of hAChE, when analyzed in terms of apparent affinity (1/K(ox)) and maximum reactivation rat
12 in the agonist-bound state increased agonist apparent affinity 15-fold, and slowed both deactivation
13 all culture times with only slightly greater apparent affinity after extended culture in the absence
14 mbrane-proximal, and V1/V2 MAbs with similar apparent affinities, although the T/F Envs bound with hi
16 to a heteromeric complex increases glutamate apparent affinity and also enables receptor activation b
17 domain of the channel showed reduced proton apparent affinity and biphasic proton activation curves.
20 ot related to an avidity-related increase in apparent affinity and points instead to a crucial role o
21 increases in ionic strength, despite the low apparent affinity and poor stability with which UL42 bin
22 , has a dramatically different effect on the apparent affinity and transport rate for N-acetylneurami
24 al AChR to which it bound with sub-nanomolar apparent affinity, and detected the presence of fetal AC
26 , 2-O-, or 6-O-sulfates bind with equivalent apparent affinity as a disulfated DS tetrasaccharide.
28 r, Cu+ interacts with the enzyme with higher apparent affinity (ATPase stimulation, Ag+ K(12) = 29.4
29 larger interaction energy than the measured apparent affinity between the tetraloop and the free rec
30 nctions, however, are influenced not only by apparent affinities but also by alternate factors, inclu
31 II binds to beta1b and beta2a with a similar apparent affinity but does not bind to beta3 or beta4.
35 t's results showed a correlation between the apparent affinity constants measured for the NIP and MIP
39 or resistance to E, can be correlated to the apparent affinities determined by in vivo multicopy supp
40 IR-AB1/IgY interaction allows an increase in apparent affinity due to avidity effects when the recept
41 in the absence of phospholipids with a high apparent affinity (EC50 of approximately 1.3-2.3 microM)
43 vivo to all three T antigens with different apparent affinities estimated as 1:7:100 (large T antige
44 nd that TAAR4 is exquisitely sensitive, with apparent affinities for a preferred ligand, phenylethyla
45 for an epitope peptide as WT 4E10 but lower apparent affinities for both viral membrane mimetic lipo
46 The tetracaine analogues described here have apparent affinities for CNGA1 channels that vary over ne
48 immunosorbent assay technology to assess the apparent affinities for each isotype and IgG subclass of
55 through a mechanism that does not alter the apparent affinities for the cosubstrates glutamate or so
56 e quantified the mutational effects based on apparent affinities for the respective inactivated state
57 void interference), the L subunit had a high apparent affinity for 3-phosphoglycerate and substrates
59 gle strand DNA or single strand RNA, yet the apparent affinity for a DNA activator is 11-fold higher
61 al kinetic differences explain the increased apparent affinity for activation by cytosolic Ca2+ and t
68 r the InsP3R1-SII(-) and InsP3R1-opt; 4) the apparent affinity for ATP is sixfold lower for the InsP3
70 ns (NBDs) as the mutation does not alter the apparent affinity for ATP, and the mutant channels respo
72 al time, we observe that PAR(2) has a higher apparent affinity for both beta-arrestins than does NK1R
73 meric channels that exhibited an increase in apparent affinity for both cAMP and cGMP compared with w
74 e activity was related to an increase in the apparent affinity for Ca(2+) and an increase in the phos
76 decreased by approximately 30% although the apparent affinity for Ca2+ was unchanged in heterozygous
77 linked dimer and has a significantly higher apparent affinity for calcium than the wild-type recepto
78 citrate and succinate but larger changes in apparent affinity for cations and substrate specificity
80 hannels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night.
81 hannels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night.
82 oncentration from 200 to 10 mM decreased the apparent affinity for d-galactose without altering the m
83 m) and etomidate (100 mum) and for increased apparent affinity for direct gating by the IV anesthetic
85 rNav1.2a (G1079C), which results in a higher apparent affinity for externally applied PaurTx3 and Pro
86 to have a approximately 15-fold decrease in apparent affinity for F6P compared to that of WT while A
88 le, metalloelastase (MMP-12) displays higher apparent affinity for fEln-100, while MMP-2 displays fas
89 ly open the channel of mutant G219F, and the apparent affinity for GABA was increased, and desensitiz
91 mutants had 1 or 2 orders of magnitude lower apparent affinity for Glc-1-P compared with the wild typ
93 luK2(E738D) mutation lowers the steady state apparent affinity for glutamate by 9000-fold in comparis
96 at is similar to that in *Talpha is that the apparent affinity for guanine nucleotides is decreased i
97 in a functionally bivalent manner, with the apparent affinity for IgA1 related to the number of expo
99 oximately 10 ms; 4), InsP3R2 has the highest apparent affinity for InsP(3) (0.10 microM), followed by
100 Trp38, causes decreased quenching, decreased apparent affinity for L-fucose, and significant inhibiti
101 tPh-L130W/T352A exhibited an ~15-fold higher apparent affinity for l-glutamate than the wild type tra
103 g yielded less than a 4-fold decrease in the apparent affinity for melibiose at saturating Na(+) or L
105 In general, taxane derivatives with higher apparent affinity for microtubules induced tubulin assem
106 entration from 20 to 0.5 mM reduced both the apparent affinity for Na(+) and the maximum quench at sa
107 Pase, and while TM5 showed modest changes in apparent affinity for Na(+), TM4, TM6, and TMAll display
109 which upon binding estrogen shows increased apparent affinity for nuclear components (tight nuclear
112 ion neurons from Pirt knock-out mice have an apparent affinity for PIP2 indistinguishable from that o
113 2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low mill
114 oup interactions control Ca(2+) sensitivity, apparent affinity for RetGC, and maximal level of cyclas
125 fect the specific activity but did alter the apparent affinity for the activator 3-phosphoglycerate,
126 sponding active conformation potentiates the apparent affinity for the agonist, effectively equating
129 epolarized synaptosomes correlated well with apparent affinity for the inactivated state of sodium ch
130 MP-PNP is not disrupted by the mutation, the apparent affinity for the nucleotide is decreased by 4-f
131 te with PtdIns(4,5)P(2) for binding, but the apparent affinity for the soluble inositol phosphate is
132 pen conformation, which mostly increases the apparent affinity for the substrates (i.e. by a reductio
133 Similarly, a 30-150-fold decrease in the apparent affinity for verapamil and cyclic peptide inhib
134 TRPM3 activator, CIM0216, whose potency and apparent affinity greatly exceeds that of the canonical
136 in MAbs 6D8 and 13F6 bind with the strongest apparent affinity, helping to explain their effectivenes
137 SYY (i) decreased both Na(o)(+) and Na(i)(+) apparent affinities in the absence of K(o)(+), and (ii)
138 -molecule inhibitor of ASICs with a reported apparent affinity in the low micromolar range, making it
144 chanism of En-dependent repression, and that apparent affinity in vitro is an unreliable predictor of
146 PF1 binds to single-stranded NAs (ssNA) with apparent affinity increasing with substrate length and w
148 omain of the alpha1 ILD near M3 altered GABA apparent affinity; interestingly, alpha1(K312E) exhibite
149 ith an IC50 in the high picomolar range, the apparent affinity is higher than known high affinity BK
150 , simple phenolics and cyanogens with higher apparent affinities (K(m)) and specificities (k(cat)/K(m
152 ve binding of two MsrA to each CaMox with an apparent affinity (K = 70 +/- 10 nM) that is 3 orders of
153 esence of Rng3p in ATPase assays doubles the apparent affinity (K(ATPase)) of both native Myo2 and re
157 at 190-HARE and 315-HARE bind HA with higher apparent affinity (Kd approximately 10-20 nM) than chond
158 or diversifying the ion-release dynamics and apparent affinity (Km ) at opposite sides of the membran
163 transports uracil, adenine, and guanine with apparent affinities of 16.4, 0.4, and 6.3 muM, respectiv
164 subunits (GDP-Galpha(s) and Gbetagamma) with apparent affinities of 270 +/- 21 and 190 +/- 7 nM, resp
165 scence emission spectrum of dansyl-CaM, with apparent affinities of 87 +/- 23 nm and 1.70 +/- 0.16 mi
166 d isotypes, immunoglobulin G subclasses, and apparent affinities of anti-FVIII autoantibodies to asse
167 with the biochemical data, we found that the apparent affinities of Ca(2+) activating and inhibitory
170 ey also reveal complex relationships between apparent affinities of drugs for radioligand binding and
176 binds three Ca2+ ions at saturation with an apparent affinity of 2 microm and Hill coefficient of 1.
178 tides ATP and cAMP block the channel with an apparent affinity of 3 and 42 microM, respectively (-80
185 ired in a major transport mechanism, with an apparent affinity of approximately 0.9 mm K(+)(Rb(+)).
190 One consequence of this effect is that the apparent affinity of baclofen is strongly reduced during
192 phosphorylation at Thr286 is to increase the apparent affinity of CaMKII for calmodulin, a phenomenon
194 gly, these mutations selectively enhance the apparent affinity of CARD11 for Bcl10, but not for other
197 vo and in vitro, primarily by increasing the apparent affinity of DksA for RNA polymerase (RNAP).
198 r RNAP core and holoenzyme are the same, the apparent affinity of DksA for RNAP decreases almost 10-f
200 al rate of translocation (k(trans)), and the apparent affinity of EF-G for the pretranslocation compl
204 nodiscs was significantly different, and the apparent affinity of Galphaq and Gbeta(1)gamma(1) to act
205 Rac membrane cycling reveals that the lower apparent affinity of GDI for RacGTP compared to RacGDP c
208 olesterol depletion dramatically reduced the apparent affinity of homomeric CNGA2 channels for cAMP b
209 ormation between Hsp90 and p23 increased the apparent affinity of Hsp90 for AMP-PNP and completely in
211 model for Kap translocation, we measured the apparent affinity of Kap95p to FG Nups representing thre
213 h leucine and the lrp-1 mutation reduced the apparent affinity of Lrp binding to ilvIH DNA (contains
214 otein component does not alter the number or apparent affinity of magnesium ions that are either diff
215 flecting specific structural preference, the apparent affinity of mincle for ligands with hydrophobic
217 y (K(d) = 8 nM) essentially identical to the apparent affinity of MRS2279 determined previously in st
220 the intramolecular binding motif reduces the apparent affinity of p53 for MdmX by a factor of 400.
222 CBD1, resulted in a drastic decrease in the apparent affinity of peak exchange current for regulator
224 e, heteroligation demonstrably increases the apparent affinity of polyreactive antibodies to HIV.
225 sor." Mutations in these two areas shift the apparent affinity of protons toward a more acidic range
226 ilter binding assays, we determined that the apparent affinity of Prp22 is approximately 20-fold grea
227 ions in the region of 70- to 165-fold in the apparent affinity of receptors for glucose in which Glu1
228 y in membrane-based assays by increasing the apparent affinity of RGS4 for Gialpha and Goalpha, sugge
230 i) release in conjunction with the decreased apparent affinity of S1.ADP.P(i) and S1.ADP for actin.
236 d substitutions that significantly alter the apparent affinity of the active site for beta-lactams an
237 that describe the specificity, isotype, and apparent affinity of the antibodies secreted from large
238 l-DTPA were hyperbolic, but in each case the apparent affinity of the antibody for the chelator-metal
239 F256V, I765A, and Y837A reduce not only the apparent affinity of the ATPase for TG but also the maxi
240 cket (Phe342) was replaced with alanine, the apparent affinity of the blocker was increased approxima
241 mainly due to an >200-fold reduction in the apparent affinity of the Ca2+-inhibitory site; 6), the a
242 ite to tyrosine (F226Y) has no effect on the apparent affinity of the competitive antagonist d-tubocu
244 828A, R834A, and R837A mutations reduced the apparent affinity of the enzyme for both Na(+) and K(+)
247 decrease of approximately >or=10-fold in the apparent affinity of the enzyme for sodium (Km(app)(Na+)
250 ed from the intact antibody only in that the apparent affinity of the Fab was generally lower for a g
252 DH2 were found to be a dramatic reduction in apparent affinity of the holoenzyme for NAD(+) and a con
254 CTT may produce this effect by reducing the apparent affinity of the interaction between beta-cateni
256 istent with a multivalent interaction: 1) an apparent affinity of the multivalent ligand for the M2 r
258 e p5 (as in Jdp5) dramatically increases the apparent affinity of the p5 moiety for DnaK in the prese
260 as continuous-time random walks decrease the apparent affinity of the reaction, locally slowed-down B
266 ons included 2-fold or less increases in the apparent affinity of the thin filament regulatory Ca(2+)
267 skolin results in a 100-fold increase in the apparent affinity of the two domains for one another.
269 193A, gammaH200A, and gammaH202A reduced the apparent affinity of the Zn(2+) activating site, gammaH2
273 eplacement of Thr with Ala or Cys lowers the apparent affinity ofK+, Rb+, and Cs+ for tetramer stabil
274 The latter is thought to decrease antibody apparent affinity or avidity, thereby interfering with n
276 rmation of an acid-stable phosphoenzyme with apparent affinities similar to those observed in the ATP
277 ed to disrupt these contacts reduced agonist apparent affinity, speeded up receptor deactivation and
283 III inhibitors have an up to 100-fold higher apparent affinity than that of antibodies found in patie
284 ied to inside-out patches, with differential apparent affinities that correlate with their maximal Po
285 is and diazepam to manipulate GABAA receptor apparent affinity, the decrease in arcuate miniature pos
286 (BZD efficacy) without altering BZD binding apparent affinity, three residues whose mutation altered
287 ing to free RNAP below detection limits, the apparent affinity to Mg2+ in transcription complexes for
288 ing a closed conformation that decreases the apparent affinity to protons and also slows the rise and
289 (2+), both sTnC and xxsTnC bind with similar apparent affinity to sTnC-extracted thin filaments.
290 ly dephosphorylates CMP, although with lower apparent affinity; UMP and the purine nucleotides are po
291 mibefradil block of Na(+) channels in which apparent affinity was enhanced when channels were recrui
295 inward currents activated by L-Arg with low apparent affinity were measured in whole-cell voltage-cl
296 apamil from the outside, with an increase in apparent affinity when the drug was applied from the ins
297 riant FlhBs had similar kinetic profiles and apparent affinities, which ranged between 1 and 10.5 mic
298 ersus 20-fold) and interacted with an higher apparent affinity with its target guanylate cyclase.
300 in relatively small changes in the substrate apparent affinities, yet at several of these positions,
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