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2 that the effect is attributable to a single appended 3'-end residue, is dependent upon its single-st
3 inoids reveal that, on a per atom basis, the appended 6pi electron heterocycles of porphyrinoids conf
4 nsferase recognition motif that allows us to append a bioorthogonal azide or alkyne moiety and use th
6 eavage; 3) modification of the C terminus by appending a C-terminal tag altered the pattern of proces
7 to a well-defined octahedral protein cage by appending a C4-symmetric coiled-coil domain to the prote
9 e (TM) and cytoplasmic tail (CT) domains and appending a glycosylphosphatidylinositol (GPI) anchor si
10 lacking CSB, but these can be suppressed by appending a heterologous UBD, so ubiquitin binding is es
12 Anti-tumor activity was further enhanced by appending a polyethylene glycol moiety, which increased
14 photoRNR has been generated synthetically by appending a Re(bpy)(CO)(3)CN ([Re]) photo-oxidant next t
15 e of RNAs can be targeted to mitochondria by appending a targeting sequence that interacts with PNPAS
16 e followed by GPI-phospholipase D digestion, appending a trimeric coiled-coil (GCNt) domain (sF(GCNt)
17 esultant OH and NH(2) groups as a handle for appending a variety of substituents by means of several
20 ns in both the ligand core structure and the appended acrylic acid substituent affect SERD activity.
28 epts UDP-GlcNAz as a nucleotide-sugar donor, appending an azidosugar onto its native substrates, whic
29 o which a meso-tetraphenylporphyrin has been appended and which self-assembles to fibrils, platelets
30 e the adaptive properties of this system, we appended another DNA sequence to Dk2, which, once amplif
32 probe 5 has been designed and synthesized by appending anthracene and benzhydryl moieties through a p
34 orientation of the aryl chromophore and the appended arsenic chelate: the fluorescence is rotamer-re
37 iotin, carboxylic acid and amine) and a DHLA appended at the ends of a short PEG chain, where PEG pro
44 Diol sensors are often based on fluorophore-appended boronic acids, but these severely lack discrimi
46 transmembrane domain chimeric proteins with appended C termini of NMDA receptor subunits, these chim
50 racterization of a triazole linked quinoline appended calix[4]arene conjugate, L, and its fluorescenc
52 aled 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique
54 s a single binding mode, Doc124A directs the appended cellulase, Cel124A, to the surface of C. thermo
59 r H-bonded 1D ensemble was used to order the appended crown ethers in such a way that they roughly st
60 ic acid (DHLA) and polyethylene glycol (PEG)-appended DHLA can effectively replace the native ligands
61 stallography) of PAHs containing one or more appended dienes with the ortho-quinodimethane (o-QDM) st
62 ater-compatible using poly (ethylene glycol)-appended dihydrolipoic acid (DHLA-PEG), where a fraction
64 ential role for a tRNA synthetase-associated appended domain at the organism level, and suggest that
68 RSs expanded by acquiring novel noncatalytic appended domains, which are absent from bacteria and man
69 ny eukaryotic tRNA synthetases have acquired appended domains, whose origin, structure and function a
71 induced electron-transfer reactions with the appended dyes, but ineffective electronic energy transfe
72 ine unit and can be tuned by over 70-fold by appending electron-withdrawing substituents to the pheny
74 d cycloaddition reaction between a propargyl-appended europium complex and azidomethylferrocene yield
77 and monitoring the change in emission of an appended fluorophore, we exploit a series of host-fluoro
78 ethylphenylboronic acid-based receptors with appended fluorophores are commonly used as molecular sen
79 hanism by which dipicolylamine (DPA) chelate-appended fluorophores respond to zinc was investigated b
84 of the protease substrate in a fluorescently appended form, facile self-assembly to QDs, and the abil
85 s toward the potential utility of alkylamine-appended frameworks for the postcombustion capture of CO
87 rthermore, this offers a modular approach to append functionality to biopharmaceuticals by noncovalen
88 ng the three kingdoms, the structures of the appended glycans are markedly different and thus influen
90 OMs), with both symmetrical and asymmetrical appended groups, have been synthesized, identified using
91 120 CD4bs cavity (pocket-filling; PF2) or by appending heterologous trimerization motifs to soluble E
92 iii) that pilin subunits with a C-terminally appended hexa-histidine (6His) tag are still assembled i
95 stry, linker length, and surface area of the appended intercalators have marked impact on DNA-hybridi
97 nal half of the protein (residues 44-75) and appending it to the N-terminus (creating residues 44'-75
99 idate the importance of this alpha3-helix by appending it to the RRM of the unrelated U1A protein and
100 llow face-to-face pi-pi interactions between appended linear aromatic segments to be strong enough fo
107 enerate secondary metabolites by iteratively appending monomers to a growing serial oligomer chain.
109 utaminyl-tRNA synthetase (GlnRS) contains an appended N-terminal domain (NTD) whose precise function
111 shown that the quenched emission of thiourea-appended naphthalimides can be restored by metal binding
113 Additionally, a series of analogues with appended nucleophiles (hydrazines and amines) on the res
115 e can tailor the type of biomolecular probes appended on individual TDNs for the detection of specifi
116 ferent acyl and carbamoyl moieties (R7) were appended on the 7-amino group, as well as a para-methoxy
117 nduces an upfield shift of the fluorine atom appended on the arylimido group, the extent of which is
118 tinct (19)F NMR shifts of the fluorine atoms appended on the ligand that defines a chiral environment
119 sents two lipoic acids (higher coordination) appended onto a single end-functionalized PEG, and (ii)
125 ocycle threading by a dye conjugate with two appended PEG2000 chains is only three times slower than
126 erves a dual function, not only encoding the appended peptide but also directing the PTR by decoding
128 extracellular matrix material by genetically appending peptide domains to the amyloid protein CsgA, t
130 ated by a flash-quench sequence oxidizes the appended phenol and the proton is transferred to the hyd
132 form illustrate how type A CBMs target their appended plant cell wall-degrading enzymes to a diversit
133 oramine C contains a large macrocycle and an appended polyamine component and was shown to be both an
134 r between the 15-membered carbocycle and the appended polyamine showed improved antimigration propert
135 rmatics search showed that most of the FPm-1-appended polypeptides are putative carbohydrate-active e
136 process of transglycosylation, the quencher-appended polyprenol is released and the fluorescence of
137 in-conjugating enzymes and ubiquitin ligases append polyubiquitin chains onto misfolded protein subst
138 d Dy(3+) DOTA-tetraamide complexes with four appended primary amine groups are measured as a function
139 sting of direct conjugation to polyhistidine-appended protein and peptides, aqueous covalent-coupling
140 finity driven coordination of oligohistidine-appended proteins for chelated divalent cations was expl
143 ared published reports with their respective appended protocols with regard to primary end points, no
146 er electron-donating abilities of the methyl-appended pyridines and suggests a simple way to modulate
147 present the use of fluorinated boronic acid-appended pyridinium salts in combination with (19)F NMR
148 We have generated two persistent pyridyl-appended radical cations: 10-(pyrid-2-yl)-10H-phenothiaz
149 ue involves a series of receptors created by appending random peptides to a C(3v) symmetric scaffold
150 th the AuNPs surface thereby facilitated the appended recognition block a better upright conformation
151 the ATP5G1 mitochondrial targeting sequence appended restored viability on Krebs cycle substrates an
152 synthetic protocol to obtain oligosaccharide-appended salicylaldehydes, key intermediates for the syn
153 We developed a series of ionic head groups-appended self-assembled monolayers with C2, C6, C8, and
154 stfusion structures of sF(GCNt) and non-GCNt-appended sF could be revealed by electron microscopy and
155 Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective
156 ity of main chain hydroxyaldehyde, while the appended side-chain-protected 3,4-dihydroxypentanoic aci
157 chemical and biological sciences, since, by appending small molecules into proteins surfaces, fundam
158 s, a series of tetrahydroazepinoindoles with appended solubilizing amine functionalities were synthes
161 es were further elaborated to incorporate an appended sulfone that was reacted with a suitably protec
165 onetheless, the affinity of the FERM for the appended tail was similar to its affinity for binding to
167 re [G-3]COO- is a third-generation dendrimer-appended terphenyl carboxylate ligand and 4-RPy is a pyr
168 silyloxyfuran to a complex cyclohexanone 83 appended the butenolide, and a few additional steps prov
169 for corrective mitochondrial-encoded tRNAs, appending the 3'-UTR localization sequence was essential
170 in Grx3 abrogated Mzm1 interaction; however, appending the C-terminal 30 residues of Rip1 to the Rip1
175 ontain a variable carboxy-terminal tail that appends the conserved PL homology domain (PHD) and is im
176 n a Tat-derived cell-penetrating peptide was appended, the resulting molecule (FabRev1-Tat) was stron
178 n of this domain precludes prionogenesis and appending this domain to reporter proteins can confer pr
182 e domains necessary for protein function are appended to a central, 100-A-long beta-helical domain.
183 e that the dynamic helical elements of Ets1, appended to a conserved structural core, constitute a ph
184 ting of a cyclic polymerizable group that is appended to a drug through a cleavable linker is achieve
185 ession of the C-terminal 54 residues of Cox1 appended to a heterologous matrix protein leads to effic
186 e RNA component of the human RNase P enzyme, appended to a nonimported RNA directs the import of the
187 mediated cleavage of a commonly used HIS tag appended to a protein, we generate with high yield and p
188 etrasaccharyl triazole cluster can be easily appended to a range of acetylene-functionalized peptides
189 with a carbohydrate-binding "lectin" domain appended to a receptor-destroying sialate-O-acetylestera
190 r Staphylococcus pyogenes sortase A), can be appended to a variety of probes such as fluorophores, bi
193 t-shaped ssDNA binding claw that is flexibly appended to an APE2 endonuclease/exonuclease/phosphatase
199 ici Phylogenetic analysis showed that CBM32s appended to chitosanases are highly conserved across dif
200 is the presence of an unusual acetal moiety appended to daunosamine, which is hydrolyzed during acid
201 rarchical assembly, wherein ssDNA guides are appended to DNA hairpins that serve as a scaffold for hi
204 The classic 4-azido-3-iodo-phenyl group was appended to either the C-1 or C-5 position of the parent
206 Carbohydrate-binding modules (CBMs) are appended to glycoside hydrolases and can contribute to t
207 that a helix-turn-helix WHEP domain that was appended to GlyRS in metazoans can regulate the neomorph
209 idue domain mediates antiviral activity when appended to heterologous proteins, and we provide geneti
213 ptide from either the Fyn or Lck oncoprotein appended to M1 at the N terminus redirected M1 to the pl
215 domains of Gal4 and VP16, respectively, were appended to PC-1 downstream of its CTT domain (PKDgalvp)
217 as internal redox references were covalently appended to representative electrophores in order to cou
219 ealkylation on a dibenzylamino group that is appended to the 6-position of a pyridyl donor of a tripo
220 cts the endonuclease and helicase domains is appended to the adeno-associated virus type 5 (AAV5) hel
222 (2)], mitaplatin, in which two DCA units are appended to the axial positions of a six-coordinate Pt(I
224 tion, nature of the solubilizing side-chains appended to the backbones, and extent of structural orde
226 -terminal protease domain and another domain appended to the beta-helix spine (domain 2) is the lid s
227 nized by a carbohydrate-binding module (CBM) appended to the C terminus of the nucleotide-binding dom
228 he 6-deoxyerythronolide B synthase (DEBS TE) appended to the C-terminus, was cloned and expressed in
229 ne activity and that moieties that have been appended to the C7 position of different quinolone scaff
230 ates C4 of its native substrate, l-threonine appended to the carrier protein, SyrB1, but hydroxylates
233 TP using yeast PaP, and the short DNA strand appended to the end of the RNA by PaP acts as the initia
234 e-the latter two of which are proposed to be appended to the enediyne core via a convergent biosynthe
236 ns of the tetraalkylammonium ionized species appended to the ferrocene, such as bis(trifluoromethanes
237 ions to just one of the many hydroxyl groups appended to the ion channel-forming natural product amph
238 ed of 2,2-dimethyl-1,3-diaminopropane (dmpn) appended to the Mg(2+) sites lining the channels of Mg2(
239 ependent on the UBX and Zinc finger domains, appended to the N and C terminus of the catalytic otubai
241 Here, we show that an unstructured peptide appended to the N terminus of the A1-chain renders the t
242 ignal is generated, a COPI-binding motif was appended to the N terminus of the recombinant protein to
246 sured by antibody binding to the epitope tag appended to the prey or direct readout of split green fl
249 hanges in (a) the number of polyamine chains appended to the ring system, (b) the polyamine sequence,
251 that different SCFA (n-butyrate and acetate) appended to the same core sugar altered biological activ
252 energy migration occurs between yellow dyes appended to the same nanoparticle and, at higher loading
253 Decyl and oligo(ethylene glycol) chains were appended to the same poly(methacrylate) backbone to gene
254 receptor or IL-9 receptor, in which JAK1 is appended to the specific chain, and JAK3 is appended to
255 ween azide and cyclooctyne functional groups appended to the termini of the split aptamer fragments.
256 ron center is coordinatively unsaturated and appended to the trinuclear core through three bridging p
258 esentation of yellow-shifted pHluorin (YpH), appended to the vesicle lumen domain of Sb2, and perform
259 drawing or pi-extended conjugated groups are appended to the wide rim ortho to the methoxy-donating g
260 gulatory functions through protein sequences appended to their conserved PUF repeat RNA-binding domai
261 flanking structured and unstructured regions appended to these dynamic domains, posttranslational mod
266 s bis(bithiophene)-substituted monomers with appended transition metal or main group entities (M = Ir
270 amine functionalities, and the use of an NBD-appended urea-monomer as a binary hydrogen-bond donor ta
273 ent a detailed investigation of nine diamine-appended variants of the metal-organic framework Mg2(dob
276 s were assembled with up to six boronic acid-appended viologens (BBVs): 4,4'-o-BBV, 3,3'-o-BBV, 3,4'-
277 , we present ten principles that clarify and append what these concepts are and are not, explain how
278 transporter 5 contained a urea functionality appended with a 3,5-bis(trifluoromethyl)phenyl group and
281 -trisubstituted imidazole scaffold which are appended with aliphatic linkers that enable coupling to
282 free and target-bound states of LUMP fusions appended with capture sequences of up to 20 kDa are used
284 These spatial data, accrued over time and appended with detailed cohort information, will offer an
285 a strain promoted click reaction between DNA appended with dibenzylcyclooctyne and azide-functionaliz
286 bacterium uses diverse GH5 catalytic domains appended with different CBMs, including novel forms of C
287 or (D) to a naphthalene diimide acceptor (A) appended with either a carboxylate or sulfonate function
288 ed of a branched oligopeptide tree structure appended with glycosidic groups at its multiple N-termin
290 carbon nanotube (SWCNT) construct covalently appended with ligands allowing simultaneous dynamic posi
291 of poly(ethylene glycol) (PEG)-based ligands appended with multidentate anchoring groups and test the
293 kel complexes supported by terphenyl ligands appended with phenoxy and imine donors were synthesized.
299 mplementary monomer comprising a BB(4+) ring appended with viologen (V(2+)) and 1,5-dioxynaphthalene
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