ライフサイエンスコーパス: appreciate

1 they form in surface epithelia has long been appreciated.

2 s are more common in bacteria than currently appreciated.

3 r stronger and more pervasive than generally appreciated.

4 hromosome to be more dynamic than previously appreciated.

5 ng the inflammatory response is increasingly appreciated.

6 s in greater detail than has previously been appreciated.

7 eactivity-a trait perhaps not broadly enough appreciated.

8 in regulating host responses than previously appreciated.

9 , and dynamics have also become increasingly appreciated.

10 ects of RTT syndrome earlier than previously appreciated.

11 th inherited platelet defects than generally appreciated.

12 icrobiomes in health and disease is now well appreciated.

13 cleavage is more widespread than previously appreciated.

14 is more dynamic and flexible than previously appreciated.

15 and functional organization than previously appreciated.

16 ors is markedly more complex than previously appreciated.

17 a plant cell is much broader than previously appreciated.

18 sculature development and remodeling is well appreciated.

19 ction and response to injury than previously appreciated.

20 ransient motions being larger than generally appreciated.

21 xpression during host defense have long been appreciated.

22 ing adaptive immunity is just starting to be appreciated.

23 cancer and stem cells are being increasingly appreciated.

24 ells in infection and injury than previously appreciated.

25 in mixtures are more dynamic than previously appreciated.

26 oles in neural processes have not been fully appreciated.

27 which is considerably older than previously appreciated.

28 EC pathotype is more diverse than previously appreciated.

29 , yet concerns for their safety may be under-appreciated.

30 bacterial infections has only recently been appreciated.

31 feature of gene regulation than is currently appreciated.

32 efore the identity and function of Treg were appreciated.

33 heterogeneity across tissues than previously appreciated.

34 ty of astrocyte function becomes more widely appreciated.

35 acute and chronic rejection is increasingly appreciated.

36 more heterogeneous than has previously been appreciated.

37 regulation in tumour biology is increasingly appreciated.

38 induced by lemon essential oil were notably appreciated.

39 h mucosal surfaces, are just beginning to be appreciated.

40 cancer morbidity and mortality are not fully appreciated.

41 ntigenic distinction has not been previously appreciated.

42 ival microbial communities than is currently appreciated.

43 erns in cancer cells is only beginning to be appreciated.

44 gical membranes is significantly higher than appreciated.

45 and UTI that is more complex than previously appreciated.

46 to be substantially greater than previously appreciated.

47 ssion regulation that has only recently been appreciated.

48 f climate in the remote TWP than is commonly appreciated.

49 immune function that have thus far not been appreciated.

50 esumably, a greater impact than is currently appreciated.

51 iquid-alkane-like properties than previously appreciated.

52 ver, its role in cell-cell crosstalk is less appreciated.

53 iversality of the genetic code is now widely appreciated.

54 vastly different surveillance durations were appreciated.

55 e of glycosylation processes than previously appreciated.

56 nal network activity is only beginning to be appreciated.

57 gulatory mutations in cancer than previously appreciated.

58 idespread across vertebrates than previously appreciated.

59 ger of autoimmune diseases than is currently appreciated.

60 augmentation approaches than was previously appreciated.

61 ions in protein localization have been under-appreciated.

62 ole of monocyte-expressed CXCR3 had not been appreciated.

63 disorder could be more common than currently appreciated.

64 greater metabolic diversity than previously appreciated.

65 tes may be more interrelated than previously appreciated.

66 in the global silicon cycle than previously appreciated.

67 nt role in initial infection than previously appreciated.

68 ody is substantially broader than previously appreciated.

69 e dynamic during development than previously appreciated.

70 rotein-coding gene regulation is by now well appreciated.

71 ivities to be more intricate than previously appreciated.

72 ction in hematopoietic cells than previously appreciated.

73 considerably more prevalent than previously appreciated (accounting for more than a third of respons

74 To appreciate an understanding between the dynamics between

75 together, our work detects a hitherto under-appreciated and clinically important class of regulatory

76 and structural heterogeneity than previously appreciated and indicate that specialized proteoglycan-m

77 lating behavioral plasticity than previously appreciated and suggest that increasing sleep may benefi

78 f ADARs is much more diverse than previously appreciated and this gene regulatory function of ADARs i

79 fluence on methane emissions than previously appreciated and, further, that changes in the source poo

80 ge of developmental programs than previously appreciated, and describe a novel instance of protein do

81 iated outcomes, its value is beginning to be appreciated, and the genomics revolution promises more r

82 , that they interact with a relatively newly appreciated antiviral pathway, and that they play a role

83 1/BRCA2 deficiency (up to 22%) than hitherto appreciated ( approximately 1-5%) who could have selecti

84 Mycoplasma genitalium is increasingly appreciated as a common cause of sexually transmitted di

85 Less appreciated as a contributor to sex differences are the

86 Complement is well appreciated as a critical arm of innate immunity.

87 n Antioxidant-1 (Atox1), which is originally appreciated as a Cu chaperone and recently discovered as

88 eus tractus solitarius (dmNTS) has long been appreciated as a primary site of baroreceptor afferent t

89 number of different acyl groups is becoming appreciated as a regulatory mechanism in cellular biolog

90 ll diversity is much broader than originally appreciated as a result of variegated surface receptor,

91 In addition, glia are now increasingly appreciated as active regulators of numerous physiologic

92 communication, exosomes are beginning to be appreciated as agents of immunoregulation that can modul

93 ral abnormalities of the mitral valve became appreciated as contributing to SAM pathophysiology.

94 other than species numbers are increasingly appreciated as critical for maintaining the function of

95 res of lymphoid tissues, these cells are now appreciated as essential regulators of immune cell traff

96 Human astrocytes are increasingly appreciated as important contributors to brain function

97 LncRNAs are increasingly appreciated as important regulators of gene expression,

98 ties of HA stability have only recently been appreciated as potential determinants.

99 ficance of the T6SS is becoming increasingly appreciated, as is its intriguing mode of action.

100 A widely appreciated aspect of developmental robustness is patter

101 receptors, but its interaction is less well appreciated at the extrasynaptic receptors, which respon

102 Similar inverse relationships were also appreciated between childhood abuse burden and left ante

103 discovery in Exomiser) is perhaps not fully appreciated but may impact strongly on their utility for

104 of communication, may help decipher the well-appreciated but poorly defined logic of developmental si

105 ell death in brain development has long been appreciated, but many basic questions remain, such as wh

106 yperactivity disorder (ADHD) is increasingly appreciated, but the underlying brain mechanisms remain

107 s in supporting embryonic patterning is well appreciated, but, alternatively, the role ubiquitously e

108 uired following influenza infection are well appreciated by clinicians.

109 In patients, the most severe phenotypes appreciated by the duration of transplant-free survival

110 Circular RNAs (circRNAs) are a newly appreciated class of RNAs expressed across diverse phyla

111 eration of memory T cells, and most recently appreciated, clonal expansion of HIV-infected cells.

112 LV genome are more extensive than previously appreciated, covering 100% of the genome; contributions

113 nal Tunisian butter (TTB) is one of the most appreciated dairy products in Tunisia.

114 mune system, as well as eosinophils as newly appreciated defense cells form different levels of prote

115 odependence, has given rise to several newly appreciated designations within the commensal-to-pathoge

116 an Andean fruit from pre-Incas' times highly appreciated due to its characteristic flavor and taste i

117 ere electrochemical sensors have widely been appreciated due to its high sensitivity, selectivity, ro

118 However, E2's clinical application is less appreciated due to several limitations, including its pl

119 etween sleep disruption and AD has long been appreciated, emerging clinical studies and insights from

120 proteins in RNA virus replication have been appreciated for a decade, the equally important function

121 sites; however, a significant enrichment was appreciated for BrM (13% local vs 24% BrM; P < .001).

122 It has been appreciated for decades that optimal levels of dopamine

123 at TPL2, an MAP3 kinase that has mostly been appreciated for its physiological role in macrophage res

124 myloid precursor protein (APP) has long been appreciated for its role in Alzheimer's disease (AD) pat

125 The cerebellum is increasingly appreciated for its role in social, emotional, and cogni

126 he exocyst is a heterooctomeric complex well appreciated for its role in the dynamic assembly of spec

127 icity for duplex DnaA-boxes by DnaA has been appreciated for over 30 years, the sequence specificity

128 tabolites produced by soil bacteria has been appreciated for over a century, and advances in chemical

129 genic and monoallelic OR expression has been appreciated for over two decades, regulators of this pro

130 le signaling and effector pathways have been appreciated for some time, and the plasticity of such a

131 Mitochondria are well appreciated for their role as biosynthetic and bioenerge

132 Yet, although DCs have been appreciated for their role in initiating adaptive immune

133 tionary and bakery industries and are highly appreciated for their typical taste, aroma and crunchy t

134 mpatibility molecules were the first ligands appreciated for these receptors, but the types of ligand

135 The most appreciated formulation was that contaning 30% sugars an

136 Blood oranges are more and more appreciated from consumers for their high nutraceutical

137 Personalized health care (PHC) is being appreciated globally to combat clinical complexities und

138 Variants of this recently appreciated hemostatic function of platelets that we ref

139 Appreciating heterogeneity through the application of bi

140 otectin-mediated Mn sequestration is a newly appreciated host defense mechanism, and recent findings

141 ts and practitioners of bioethics can better appreciate how modern health professionals may be suscep

142 Our data highlight the pivotal, albeit under-appreciated, impact of maternal age on uterine adaptabil

143 es associated with symptomatic infection was appreciated in both cohorts.

144 ntified many more taste buds than previously appreciated in chickens using molecular markers to stain

145 easures for ESBL-producing bacteria are less appreciated in children.

146 Mosaicism is easily appreciated in cutaneous disorders, as phenotypically di

147 No differences were appreciated in demographic, socioeconomic, or health lit

148 ther brain regions plays a greater role than appreciated in developmental regeneration.

149 ted inflammation, which are now being better appreciated in disease pathologies.

150 em cells, but their activities remain poorly appreciated in mammals.

151 Recently, this has also been appreciated in mammals.

152 sionary tactics are perhaps more common than appreciated in predator-prey interactions.

153 e change) against the rate at which spending appreciates in value (e.g., through interest, learning,

154 It is possible to appreciate, in a single shot, Rh particles' structure an

155 What has been less well appreciated is that novel virus discoveries in distinct

156 However, what has not been fully appreciated is the ability to manipulate the hole geomet

157 One aspect of KRAS biology that is not well appreciated is the potential biological differences betw

158 However, what is not widely appreciated is their growing role as versatile energy tr

159 I appreciate it deeply now, and on this meaningful occasio

160 e and strong aroma, many consumers might not appreciate it.

161 lthough this mechanism of resistance is well appreciated, it is unclear which downstream signaling ev

162 Over-reliance on imaging and failure to appreciate its limitations can lead to unforeseen conseq

163 e evolutionary significance of this input is appreciated, its precise neurophysiological architecture

164 otein contacts, providing a previously under-appreciated layer of molecular regulation in the human H

165 s in culture has revealed a previously under-appreciated level of intrinsic cellular self-organizatio

166 d from open-source tools assistance could be appreciated, mainly in terms of lesser intervention of o

167 vern Fgf signaling is therefore important to appreciate many aspects of Fgf biology and disease.

168 The role of openness is apparent in appreciating meaning-making art that elicits interest, f

169 lly releases protected C, providing an under-appreciated mechanism for C destabilization under elevat

170 We argue that appreciating methodological complexity and integrating n

171 The recently appreciated NVU dysfunction in neurodegenerative disease

172 h as apatite-group minerals, has been a long-appreciated obstacle for proposed models of prebiotic or

173 e first organoleptic property that consumers appreciate of a foodstuff.

174 We also discuss newly appreciated pathways that modulate context-specific Treg

175 anatomical bases for these salient but under-appreciated phenotypic features of the dementias, with w

176 Patients appreciated physicians who are kind, respectful, and tho

177 ce electrodes may be smaller than previously appreciated, possibly leading to the detection of surfac

178 is short review is meant to allow readers to appreciate post hoc analysis not as an entity with a sin

179 nventional crisps', while only a few of them appreciated potato-like fresh flavour of 'vacuum crisps'

180 re of retinal vascular diseases that was not appreciated prior to the use of OCTA.

181 conductance was much larger than previously appreciated, producing saturation effects on synaptic cu

182 ugh the Portuguese sausage remained the most appreciated product.

183 signalling mode of PG-Gs as previously under-appreciated products of cyclooxygenase-2.

184 Overlooked and poorly appreciated, quantifying the impacts of native invaders

185 The past decade has appreciated rapid advance in identifying the once elusiv

186 le at crossovers, and reveals a hitherto not appreciated role for microtubule bundling.

187 mic CAs play an important but not previously appreciated role in amino acid biosynthesis.

188 Channels also play an increasingly appreciated role in microdomain structure.

189 are often unclear, despite the increasingly appreciated role of organ boundaries in disease.

190 6) and Handley et al. (2016) reveal an under-appreciated role of the enteric virome in HIV-associated

191 reservoir has important, and hitherto under-appreciated, roles in both within- and between-host vira

192 Immuno-EM imaging showed previously under-appreciated S1R presence in photoreceptor cells.

193 e of PHE for a healthy 70-year-old woman who appreciates seeing her physician annually.

194 This newly appreciated sensory capacity provides a mechanism by whi

195 with ambiguously rewarded outcomes has been appreciated since early studies on learning and memory.

196 functional connectivity of neurons have been appreciated since the classic work of Hubel and Wiesel.

197 is suaveolens) is a Mesoamerican crop highly appreciated since the pre-Hispanic cultures.

198 mediate chain 1 (DNAI1) and DNAI2, the first appreciated step in axonemal dynein arm assembly.

199 des a potential physical basis for the newly appreciated sustained G protein signaling from internali

200 Peptoanaerobacter stomatis is a newly appreciated taxon associated with periodontal diseases;

201 ral seasonings as salt alternatives are more appreciated than chemical preservatives and also enable

202 As a result, we now appreciate that COX relies on its redox-active metal cen

203 s during the past few years, we have come to appreciate that typical Weyl semimetals host many Weyl p

204 We now appreciate that, as part of two distinct complexes, mTOR

205 he eukaryotic cytoskeleton, it is less often appreciated that actin is a member of a large superfamil

206 It has recently become appreciated that activation of gamma-aminobutyric acid r

207 However, theoretical analyses have long appreciated that additional mechanisms, not restricted t

208 It has long been appreciated that adolescence represents a uniquely vulne

209 It is now well appreciated that anaphylatoxins not only act as pro-infl

210 Although it is appreciated that bacterial chemotaxis systems rely on co

211 It is now appreciated that crystals are part of the pathogenesis o

212 It has been increasingly appreciated that each mutation of a gene could have a su

213 s to acid suppressive therapy, but it is now appreciated that esophageal eosinophilia can respond to

214 However, it is now well appreciated that eukaryotic-like serine/threonine kinase

215 ansferase GatCAB(21-25), but it had not been appreciated that GatCAB may play a role in modulating mi

216 It has long been appreciated that insulin action is closely tied to circa

217 It is well appreciated that leukocytes, particularly macrophages, a

218 It is recently appreciated that many bacterial chemoreceptors have liga

219 It has been increasingly appreciated that many neurodegenerative conditions overl

220 side-in signaling events, and it is now well appreciated that material cues modulate the epigenome.

221 It has long been appreciated that mechanical forces must be applied to ch

222 It is now appreciated that mechanistic interactions between iron a

223 Although it has long been appreciated that mTOR is a sensor of amino acids and glu

224 It is widely appreciated that much of the research that has defined t

225 It has recently been appreciated that NK cells exhibit many features reminisc

226 Project and follow-up ENCODE data, it is now appreciated that only 2-3% of the genome codes for prote

227 Although it has long been appreciated that p300 acts as a critical Notch coactivat

228 It is now appreciated that signaling pathways should not be seen a

229 Although it is widely appreciated that some bacterial species express glycosid

230 While it is widely appreciated that the denatured state of a protein is a h

231 It is increasingly appreciated that the GABAB receptor forms part of larger

232 Although it is widely appreciated that the use of global translation inhibitor

233 It is now appreciated that there are two distinct types of thermog

234 It is now appreciated that these receptors can elicit different do

235 For decades it has been appreciated that two major NK cell subsets (CD56(bright)

236 While we have come to appreciate the architectural complexity of microbially s

237 Failure to appreciate the associated costs and complexities may con

238 atterns of social evolution as well as fully appreciate the biological implications of the switch fro

239 To appreciate the causes of these cytotoxic perturbations,

240 While we are beginning to appreciate the cellular roles played by long noncoding R

241 Hadza gut metagenome structure allows us to appreciate the co-adaptive functional role of the GM in

242 We appreciate the depth and breadth of comments we received

243 es of skeletal mineralization, we can better appreciate the detailed mechanisms that regulate and div

244 Clinicians should appreciate the developmental stages of adolescents, disc

245 To appreciate the diverse roles of ADP-ribosylation across

246 l rural and foraging societies allowed us to appreciate the essential co-adaptive role of the microbi

247 To fully appreciate the function and regulation of these neurotra

248 on reveal the value of refined brain maps to appreciate the genetic complexity of brain structures.

249 To appreciate the importance of these data, consider an ana

250 the importance of whole-genome sequencing to appreciate the overall genomic architecture of schizophr

251 American Journal of Clinical Nutrition did I appreciate the policy implications of how nutritional da

252 These data help to appreciate the range of disease severity observed in viv

253 al salience may contribute to inabilities to appreciate the risks inherent in this disorder.

254 We are only beginning to appreciate the role of necroptosis in different patholog

255 , as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play i

256 based on a level of generality that fails to appreciate the specific conditions of the Mongol invasio

257 mutual survival, which makes it difficult to appreciate the underlying dynamics.

258 ile families reported significant harm, many appreciated the donation attempt.

259 were employed and although many participants appreciated the importance of taking time to process and

260 d approaches to psychiatric illness, and who appreciated the strengths and limitations of his clinica

261 h photoreceptor synaptic connectivity toward appreciating the function of telodendria in visual signa

262 Appreciating the immune and nervous systems as a holisti

263 Appreciating the importance of the anterior thalamic nuc

264 lular assembly stoichiometry is critical for appreciating the initiation, propagation, and maintenanc

265 Here we lay the groundwork for appreciating the mechanisms and consequences of disulfid

266 Acknowledging and appreciating the past contributions of pioneers in catar

267 the classic autoinflammatory disorders, and appreciating the treatment modalities available.

268 anding the social determinants of health and appreciating the underlying differences associated with

269 uration of the nuclear pore is essential for appreciating the underlying mechanisms of nucleo-cytopla

270 Less appreciated, the body of work about how to control cance

271 hanics and perfusion of tumors has been long appreciated, the less mobile, gel-fluid phase has been l

272 ent mechanisms in different contexts, and we appreciate their effort to assess whether the transmissi

273 ath and warrants future validations to fully appreciate their role in East-Asian diabetes pathogenesi

274 echanisms underlying visual expectation, and appreciate their thoughtful critique, we argue here that

275 zation and translational repression are well appreciated, their involvement in endonucleolytic cleava

276 Appreciating these continuities and discontinuities must

277 Appreciating these differences may inform immunogenicity

278 Appreciating this surprising finding may allow for direc

279 Although long appreciated, this duality continues to puzzle immunologi

280 electricity in biological systems was first appreciated through electrical stimulation experiments p

281 is far more diverse than has been previously appreciated, thus raising the possibility that there may

282 Lipid metabolism is increasingly being appreciated to affect immunoregulation, inflammation and

283 ttle for Mn between host and pathogen is now appreciated to be a major determinant of the outcome of

284 tic resistance genes (ARGs) are increasingly appreciated to be important as micropollutants.

285 n involves metabolic pathways not previously appreciated to play an important role.

286 kin and kind discrimination are increasingly appreciated to shape naturally occurring microbe populat

287 ical changes in the reaction mixture must be appreciated to understand how mechanochemical reactions

288 n-1-ol) whose free forms are responsible for appreciated tropical-like flavours.

289 bolites such as glutamate, a mediator of the appreciated umami taste of the meat, were found to const

290 In view of the increasingly appreciated variability of SS, elucidation of distinct o

291 Although its biological importance is appreciated, very little is known about the genome dimer

292 functions are only now emerging, are a newly appreciated viral target in murine leukemia virus (MLV)-

293 g on organismal function and health are well appreciated, we know little about the molecular details

294 tworks whose across cancer role has not been appreciated well before.

295 the molecular physiology of PHT can also be appreciated when one considers the complex signals capab

296 ise and spatially segregated than previously appreciated, which may be a critical determinant of how

297 tially life-threatening electrolyte disorder appreciated with greater frequency in patients with rena

298 pact of Hmx1 loss is greater than previously appreciated, with a variety of lateral cranioskeletal de

299 demonstrate unique variations that cannot be appreciated within a cell pool.

300 des of these sensory benefits have long been appreciated, yet less is known of how the perception of