ライフサイエンスコーパス: approach to

1 e we demonstrate a new high-yielding modular approach to a broad range of trimeric and hexameric S- a

2 We applied our spatial approach to a set of images from patients with malarial

3 A) utilizing novel analytical and biological approaches to a water sample extract from the lower Rhin

4 ajor tasks for the future are to apply these approaches to a wider range of non-model organisms, and

5 ched using surgical, chemical, or transgenic approaches to ablate neurons.

6 Index (RDI), uses a bootstrapped subsampling approach to account for variance in sequencing depth, an

7 Here, we show a general approach to achieve inkjet-printable, water-based, two-d

8 lustrate the ability of the drift-gas doping approach to achieve separation of these analytes.

9 Whilst the focus has been on optimal approaches to achieve elimination, less attention has be

10 apacity have recently emerged as a promising approach to acquire multi-ion information about the samp

11 LOQ show that the method provides a reliable approach to acrylamide determination in different matric

12 Here we take a novel approach to address this problem and establish a causal

13 ter cycle, is considered to be an attractive approach to address water scarcity issues globally.

14 the presence of TGF-beta, suggesting a novel approach to adoptive cell therapy.

15 biting JNK activities represents a promising approach to ameliorate diet-induced obesity and leptin r

16 Different approaches to analysing the botanical origin of tannins

17 As an example, we apply our approach to analyze the concentration dependence of the

18 ria could be a useful strategy to design new approaches to antibacterial therapy.

19 five countries that have developed different approaches to antibiotic stewardship-the USA, South Afri

20 Thus, this study identifies a rapid approach to assess the drug combinations with a mechanis

21 We used a two-step Mendelian randomization approach to assess whether DNA methylation plays a media

22 We tested three SML approaches to assess the environmental impact of marine

23 Currently, there are no approaches to assess the rheological properties of mucin

24 drought, we applied a co-expression network approach to associate rhythmic gene expression changes w

25 As a fundamentally new approach to bioconjugation this methodology provides a b

26 ingly global, quantitative and comprehensive approach to biodiversity protection, most insights are s

27 A new approach to biosensing devices is demonstrated aiming an

28 We report a novel approach to block allergic reactivity by targeting the s

29 tch-dependent crosstalk may be a therapeutic approach to block metastasis.

30 tive brain is critical for a neuroscientific approach to both typical and atypical early behavioral d

31 vel neural endophenotypes can facilitate new approaches to BP prediction, diagnosis, and prevention.

32 Here we adopt this powerful approach to breast cancer and analyse 515 cells from 11

33 We devise an approach to calculation of scaling dimensions of generic

34 report an iridium-catalysed tyrosinase-like approach to catechols, employing an oxyacetamide-directe

35 This work provides a novel biospectroscopy approach to characterize the chemotaxis-related alkane b

36 Here we combine in silico and in vitro approaches to characterize the SOS transcriptional respo

37 need for better experimental and theoretical approaches to characterize the WAF structural diversity.

38 We recommend studies (i) take a multi-scale approach to characterizing risk; (ii) explicitly conside

39 mass spectrometry (ToF-SIMS) as a label-free approach to chemically map small molecules in aggregated

40 There is a need for novel approaches to classify patients with these conditions.

41 To explore approaches to classify susceptibility to TB, we infected

42 y education and their perspective on optimal approaches to clinical oncology education.

43 ancer cells has been widely considered as an approach to combat cancer progression and therapeutic re

44 , thereby providing an elegant and efficient approach to combination nanomedicines.

45 We sought an alternative approach to commonly used nanoparticle carriers by lever

46 We combined computational and experimental approaches to compare energy metabolism in the causative

47 biocompatible membrane represents a general approach to compatibly interface E-AB sensors with compl

48 A baby-led approach to complementary feeding did not result in more

49 Baby-led approaches to complementary feeding, which promote self-

50 ors use for the first time a systems biology approach to comprehensively evaluate clinical parameters

51 Here we propose a novel numerical approach to compute the whole-embryo dynamics of the act

52 ting geographically focused and age-specific approaches to confidential HIV testing with linkage to H

53 A new one-pot approach to construct alpha-carbonyl bicyclic furans fro

54 we address the question using a comparative approach to contrast diversity patterns according to the

55 man proteome microarrays, and we expect such approaches to contribute substantially to the understand

56 lation may represent a potential therapeutic approach to control breast cancer.

57 gulator YAP, thus showing the ability of our approach to control mechanotransductory signalling pathw

58 By utilizing a genetic approach to control mutant MEK expression in vivo, we we

59 Herein we show a versatile approach to control the buckling of individual domains a

60 As an alternative approach to controlling C. difficile infection, a series

61 a crystalline porous material is a promising approach to create precise arrays of qubits.

62 This work further provides a potential approach to create therapeutic vectors that can be photo

63 Here, we describe an approach to cryogenic photoactivated localization micros

64 However, a rational approach to crystallize antibodies is still lacking.

65 ic and mechanistic evolutionary neuroscience approach to cumulative culture, taking into account expe

66 This approach, to date, has mainly targeted nucleophilic func

67 ecules and highlight a powerful experimental approach to decipher specific influences on molecular pl

68 Published approaches to decipher driver mechanisms do not explicit

69 the onset of AD dementia can be a promising approach to decrease the incidence of AD.

70 trophic costs as a TB-specific cash transfer approach to defray TB-related costs only in poor househo

71 ta from multiple sources, we used a stepwise approach to derive the added sugar content of 160,713 be

72 Here we report a general approach to design cyclic homo-oligomers that employs a

73 quantitative polymerase chain reaction-based approach to determine the precise species composition of

74 Current approaches to determine the potential of regulatory SNPs

75 This work demonstrates a viable approach to develop lithium-sulfur batteries with practi

76 pitopes, this work illustrates a bioinspired approach to develop supramolecular structures modulated

77 between IRAK1 and IRAK4 and is suggestive of approaches to develop IRAK1- or IRAK4-specific inhibitor

78 Although there are some approaches to develop microchip based pesticide detectio

79 ventions as part of an integrated life cycle approach to development.

80 The traditional approach to diagnosis emphasises the importance of thoro

81 Approaches to differentiating pluripotent stem cells (PS

82 offers an effective, precise, medicine-based approach to directly impede transcription and overcome a

83 Here the authors use fluorescence microscopy approaches to directly visualize and investigate functio

84 Using a conditional mouse genetic approach to disable nonredundant subunits of mTORC1, mTO

85 enetic architecture, but also provides a new approach to disentangling the shared biological pathways

86 We apply our approach to dissect how Erk activity is decoded by immed

87 d guide best practices for a genetics-driven approach to early intervention in at-risk relatives.

88 such as pharmaceuticals, using a risk-based approach to ecotoxicity end points in conjunction with m

89 y, improve predictive models, and inform new approaches to effective intervention.

90 dministration and a mass vaccination program approach to eliminate malaria from geographically define

91 A standard approach to eliminating confinement errors in bacterial

92 A) represent a powerful functional proteomic approach to elucidate cancer-related molecular mechanism

93 is the first demonstration of an integrated approach to elucidate how heterogeneity at the transcrip

94 of time-series-based sampling and modelling approaches to elucidate multiple dimensions of historica

95 Application of this approach to emerging RGENs should enhance their engineer

96 Here we used a structure-based design approach to engineer the lactonase SsoPox from Sulfolobu

97 s been considered to be a viable therapeutic approach to enhance their antinociceptive and anti-infla

98 biphenyls (PCBs) is still challenged by slow approach to equilibrium.

99 , we present a coupled experimental/modeling approach to establish an in vitro pharmacokinetic/pharma

100 stewater-based epidemiology is an innovative approach to estimate public health status using biomarke

101 nd (ii) use quantitative population genetics approaches to estimate the contribution of selection and

102 To test this, we deployed a cell-mixing approach to evaluate the contributions of cell populatio

103 The primary analysis used a Bayesian approach to evaluate the hypothesis that the proportion

104 In this study, we took a multimodality approach to evaluate the phenotypic effects and metaboli

105 ning framework may thus provide a principled approach to examining emotions.

106 It uses a machine-learning approach to extract discriminant information from a broa

107 e, reports a remarkably facile and effective approach to fabricating anisotropic transparent films di

108 itorial, Sarah Stock and Jenny Myers discuss approaches to fetal and neonatal growth assessment.

109 f the Cdc42 FLARE biosensor using the phasor approach to FLIM-FRET.

110 in MOFs has recently emerged as a versatile approach to functionalize MOF surfaces with a wide varie

111 Here we describe an approach to functionally validate identified variants th

112 sults reveal several changing notions in the approach to G1D syndrome diagnosis and treatment, such a

113 a breath-taking pace and are revolutionizing approaches to gain a better understanding of human disea

114 A photodegradable material-based approach to generate endothelialized 3D vascular network

115 ap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical an

116 Here, we present a transformational approach to genome engineering of herpes simplex virus t

117 nce, both for prevention and novel treatment approaches to glaucoma.

118 ticipate that the suggested pull and release approach to graphene folding may find applications in th

119 ent-centered care requires an individualized approach to hemodialysis vascular access, on the basis o

120 pport the "real-world" effectiveness of this approach to HF management.

121 presents the ultimate limit of the classical approach to high-density magnetic storage media.

122 ing and implementation of novel yet unproven approaches to HIV eradication that could compromise the

123 We describe a robust statistical approach to identify loci within genes that are both sig

124 benefits of a joint theoretical-experimental approach to identify novel hA3AR antagonists through suc

125 Here, we used a systematic approach to identify novel proteins that are involved in

126 Here we used a scanning mutagenesis approach to identify residues in the extracellular loops

127 model-independent, physical/observable-based approach to identify structural properties of quiescent

128 We use our approach to identify two classes of shift current photov

129 ous enzymes and to engineering and screening approaches to identify activators and blockers with stro

130 Using multiple labeling approaches to identify pathways and their postsynaptic s

131 Here we used a microscopy-based approach to image CHIKV nsP3 inside human cells.

132 tudy assesses mediators of a more harmonized approach to implementing large-scale CHW programs for HI

133 anisms in TBI and provide a proof-of-concept approach to improve acute TBI management that may also b

134 study that could further strengthen the INAP approach to improve the quality and quantity of stillbir

135 ndothelial cells may lead to new therapeutic approaches to improve blood vessel regeneration and incr

136 hereby underscore the need for combinatorial approaches to improve treatment of chemotherapy-resistan

137 Ultimately, this approach to in vivo Treg induction could also enable nov

138 A TB-sensitive cash transfer approach to increase all poor households' income may hav

139 ombination of active and passive non-fouling approaches to increase biocompatibility and reduce infec

140 We took a unique optogenetic approach to induce and locally target a rotor in atrial

141 ides an example of an electron-hole matching approach to inducing frustration in intermetallic system

142 pression dynamics with a reverse engineering approach to infer data-driven dynamic network models of

143 ker of cell types, and through deconvolution approaches, to infer underlying cell type proportions.

144 report of a cellular protein that uses this approach to inhibit IRF7 activation.

145 e explored topical vaginal application as an approach to initiate local antigen-specific immunity, en

146 cted route to stealthin C reveals a distinct approach to install aromatic amino groups in metabolites

147 ess this problem, we developed a data-driven approach to integrate and analyze raw source data from s

148 et make our strategy a potentially universal approach to integrating functional planar nanofluidic sy

149 We investigate several approaches to interpret the phase images including signa

150 ionalized co-monomers is a long-sought-after approach to introducing polyolefin functionality.

151 assays, we sought to develop a gene editing approach to investigate the regulatory activity of 3'-UT

152 We adopted phenotypic and metagenomic approaches to investigate phosphatase genes within soils

153 combination with systems-based computational approaches to investigate the complexity of the TSC mole

154 We used a genetic approach to isolate 9 suppressors of Deltahda cold sensi

155 ing techniques enable a radically new set of approaches to limit evolution.

156 We then explore approaches to limit immunotoxicity, and discuss the futu

157 drogen-bonded framework illustrates a unique approach to limiting the self-quenching ordinarily exhib

158 we discuss the potential application of this approach to malaria.

159 Here, we used a mass spectrometry (MS)-based approach to map the complete glycosylation profile at ev

160 about these inhibitors, we developed a novel approach to map the distribution of functional SGLT2 pro

161 their effects on phenotypes, we developed an approach to mapping structural variants that segregate i

162 stem cells with anti-CD19 CAR-Ts is a novel approach to MM therapy.

163 ery reveals an unprecedented pharmacological approach to MMP inhibition, providing an opportunity to

164 this, we have developed novel computational approaches to model the association between alternative

165 s review focuses on the relative merits of 3 approaches to molecular diagnostics in hematologic malig

166 e results demonstrate the feasibility of our approach to monitor the position and dynamics of both re

167 sight into disease outcome and as a possible approach to monitor treatment efficacy.

168 develop a microprism-based cellular imaging approach to monitor visual cue responses in the insular

169 ment of highly surface-sensitive measurement approaches to monitor protein adsorption across differen

170 Here, we describe our approach to monitoring BMT survivors for risk-based scre

171 ived from a transplanted organ is a powerful approach to monitoring post-transplant injury.

172 The vision of a precision medicine-guided approach to novel cancer drug development is challenged

173 defensive (to avoid predatory detection) and approach (to obtain food) behavior.

174 report addresses such need by presenting an approach to obtain aforementioned MOS.

175 racking and a data-mining algorithm into our approach to obtain RNA element-specific, high-resolution

176 ly (ADOR) method represents one exciting new approach to obtain solids with targeted structures by se

177 The present study considers two different approaches to obtain increased sensitivity to transient

178 Laboratory approaches to operationalize molecular testing for predi

179 hardware designs, and a flowchart, a logical approach to optimal column packing, thus eliminating the

180 Here, we introduce a simple approach to orient the insertion of the light-driven pro

181 A thermodynamic approach to peptide macrocyclization inspired by the cyc

182 However, most approaches to personalize lumped parameter models have t

183 bacteria to a herbivore may provide a novel approach to pest management through indirect induction o

184 Our results provide a basis for novel approaches to pharmaceutical and diagnostic applications

185 The reaction provides a straightforward approach to pharmaceutically and synthetically useful 2-

186 Here, we use a data-driven approach to pinpoint the movements that discriminate fem

187 bstrates offers a therapeutically applicable approach to potentiate the regenerative outcome in the i

188 Our results challenge the trait-based approach to predicting ecosystem function by demonstrati

189 permanent porosity, and thus opens up a new approach to prepare porous carbon liquids.

190 In this review, we adopt a tutorial approach to present the basic physical mechanisms at sta

191 of sepsis could be an important therapeutic approach to prevent sepsis-induced inflammation, consump

192 These insights suggest possible new approaches to prevent CDI, including screening to identi

193 ggregation and suggest potential therapeutic approaches to prevent or treat PD and related disorders.

194 ecision making and may assist the advance of approaches to prevent premature diagnostic closure.

195 Here a fundamentally different approach to produce nanopores in sheet substrates under

196 Application of this approach to profile the conditions for the Buchwald-Hart

197 -fluorescence, and mass spectrometry imaging approaches to profile and visualize the metabolic distri

198 We applied this approach to project age-specific mortality to 2030 in 35

199 The need to identify promising and scalable approaches to promote uptake of HIV testing among youths

200 ted in their efficacy, we developed a unique approach to protect the heart by transplanting respirati

201 l (PEC) solar-fuel conversion is a promising approach to provide clean and storable fuel (e.g., hydro

202 We constructed a compressive-sensing approach to pseudo-randomly acquire highly subsampled, m

203 t-centered, individualized, and parsimonious approach to quality assessment needs to be maintained to

204 We developed a flexible Bayesian statistical approach to quantify allele-specific expression (ASE) in

205 We develop a pore recognition approach to quantify similarity of pore structures and c

206 This review describes current pharmacologic approaches to reactivate the latent reservoir so that in

207 One approach to realizing such films is sequential layer-by-

208 of bNAbs in HIV-1 infection, inspiring novel approaches to recapitulate and accelerate the events tha

209 t assembly, we have used a synthetic biology approach to reconstitute, in a nonnative heterologous ho

210 these organisms, we used a novel metagenomic approach to recover 227 high-quality genomes from 150 mi

211 Two groups present different approaches to reduce pathogenesis by targeting deactivat

212 One possible approach to reducing the detrimental health effects of c

213 chanism holds potential for developing novel approaches to regenerating pancreatic beta-cells.

214 erall, our results illustrate a quantitative approach to relate fluorescence signals to malignant tis

215 re of cuttlefish skins, we present a general approach to remote-controlled, smart films that undergo

216 Aggressive approaches to repeat resolution often produce misassembl

217 ust be met to ensure a fair and meritocratic approach to research assessment and the advancement of r

218 repair is essential for identifying improved approaches to revascularizing damaged myocardium in pati

219 ke it possible to utilize metatranscriptomic approaches to reveal both complete virus diversity and t

220 tecture of the D-Wave machine, initiating an approach to reversible classical computation based on st

221 In our novel, computationally tractable approach to RNA-ligand kinetics, we overcome the two mai

222 We apply this approach to selected regions in the USA, Germany and Ira

223 patio-temporal scales and used a metagenomic approach to show that these dominant members of the micr

224 d genetic, physiological and cell biological approaches to show that reorganisation of the actin cyto

225 ntegrated photonic chip with a circuit-based approach to simulate the dynamics of a spin chain and ma

226 CP1 deficiency may thus be a new therapeutic approach to SMA.SIGNIFICANCE STATEMENT Spinal muscular a

227 angeable single-molecule localization (IRIS) approach to SMLM, in the context of the fibrous actin me

228 MP-tNLP formulation, we demonstrate a unique approach to solubilizing and administering membrane-boun

229 Importantly, a competition-based approach to specifically mislocalize APC-dependent RNAs

230 Here an immunomodulatory approach to stimulating nerve repair in a nerve-guidance

231 using radionuclide imaging is a noninvasive approach to stratifying patients for targeted therapies.

232 idence for the benefits of a patient-centred approach to streamlined HIV testing and treatment that c

233 Applying this labeling approach to structured illumination microscopy resulted

234 refore lays the foundation for an integrated approach to study BG pathologies such as Parkinson's dis

235 Our results demonstrate an approach to study dynamic biochemical events in vivo.

236 monstrates the potential of our experimental approach to study predator-prey relationships in taxa th

237 This paper presents a multiscale approach to study the nonlinear vibration of fiber reinf

238 riment was designed to match the two primary approaches to studying episodic memory in an unparallele

239 plest methods and provides a straightforward approach to sulfenylation of enaminones via the cross de

240 Our results suggest a quickly actionable approach to supporting conventional therapies and overco

241 part of the review, the different synthetic approaches to synthesize propargylamines, such as A(3) c

242 We applied this approach to systematically characterize MHC ligands from

243 We designed an approach to target an extracellular matrix protein, the

244 demonstrate a more physiologically relevant approach to target discovery in glioblastoma.

245 y among gram-positive bacteria; and suggests approaches to target RRNPP systems in order to manipulat

246 ded that BNNPT is an efficient computational approach to test nonlinear correlation in real world app

247 A new approach to the analysis of Cu, Fe, Mn and Zn in flaxsee

248 Applying the GRN approach to the brain and behavior provides a quantitati

249 We advocate this more mechanistic approach to the categorization of ACS to provide a frame

250 ic to isomers, providing a fundamentally new approach to the characterization of chemical structure.

251 ed (E-AB) sensor platform provides a modular approach to the continuous, real-time measurement of spe

252 reported a convergent cyclopropanation-Cope approach to the core of ineleganolide, which was the fir

253 nd fibril formation while also suggesting an approach to the design of inhibitors of polyQ amyloid gr

254 We present an evidence-based approach to the diagnosis and suggested management of va

255 DB2CD has been created as an empirical-based approach to the generation of protein CD spectra from at

256 USPIO-enhanced MRI is a novel approach to the identification of aortic wall cellular i

257 of 11 patients (63%) undergoing a retrograde approach to the LV developed at least 1 new brain lesion

258 there is a regional variation in scientists' approach to the problem of HIV/AIDS.

259 This bottom-up strategy offers a versatile approach to the rational design of strongly coupled exci

260 nes a helix abstraction with a combinatorial approach to the RNA folding problem in order to compute

261 perties also hold for the network during the approach to the steady state as well.

262 In the present work, we apply the PFM approach to the study of a challenging set of sequences-

263 ing for the first time, and validate a novel approach to the study of smoking, and addiction more gen

264 kinetic resolution process offers a general approach to the synthesis of enantioenriched atropisomer

265 lation of Kv3.1 channels may provide a novel approach to the treatment of bipolar mania.

266 f anti-EGFR therapy in GBM and suggest a new approach to the treatment of EGFR-expressing GBM using a

267 Such a strategy may offer an important new approach to the treatment of patients awaiting LT which

268 memory processing) and review computational approaches to the analysis of sleep-associated neural co

269 Rational approaches to the case management of cholera with oral a

270 of these data to promote precision medicine approaches to the diagnosis and treatment of cancer.

271 s highlights the utility of this and related approaches to the extraction of insights and testable hy

272 The present review focuses on peptidomic approaches to the investigation of bioactive milk peptid

273 nd dermatologists have similar and divergent approaches to the management of AD.

274 fer limited effects on survival; thus, novel approaches to the treatment of advanced stages of this n

275 y be useful if situated within a two-systems approach to theory of mind (ToM) and discuss how drawing

276 1001 represents a proof of concept for a new approach to therapeutic intervention in diabetes and obe

277 ighly multiplexed single-cell DNA sequencing approach to trace the metastatic lineages of two CRC pat

278 mutations and is a real-time and noninvasive approach to tracking clonal evolution and the emergence

279 hat targeting this molecule could be a novel approach to treat allergic asthma.

280 cAMP) has emerged as a promising therapeutic approach to treat cognitive deficits.

281 nked VSTs is a feasible, safe, and effective approach to treat severe and drug-refractory infections

282 standing of these interactions could produce approaches to treat chronic pain and inflammatory diseas

283 ring loss, we sought to advance gene therapy approaches to treat genetic deafness.

284 g Ephexin5 levels may represent an effective approach to treating AD.

285 Here, we describe why a shared approach to treatment decision-making for asthma has the

286 inspired interventions may represent a novel approach to treatment development.

287 ggests substantial benefits of extending the approach to treatment of cattle sheds, or deploying othe

288 incurable malignancy of plasma cells, so new approaches to treatment are needed.

289 This study demonstrates a promising approach to tune electrocatalytic activity and selectivi

290 ion in situ of regulatory elements (CAPTURE) approach to unbiasedly identify locus-specific chromatin

291 Herein, not only do we present a new approach to understand and classify this new class of ma

292 Future research is needed, with a focused approach to understand the molecular targets, cellular e

293 We propose a new approach to understand the origin of the pseudogap in th

294 zed data collection, adopting a connectomics approach to understanding brain network architecture, em

295 th UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiac Excitation-Contraction

296 endently - will provide a much more fruitful approach to understanding mathematical abilities.

297 In this paper, we propose a new approach to use Parylene C as a versatile template for p

298 grated Climate-Economy model, we explore two approaches to valuing population: a discounted version o

299 strong associations may be the most feasible approach to vitamin D assessment over time.

300 Applying this approach to yeast, we identified the circuit dominating