ライフサイエンスコーパス: aptamer

1 ) homopolymer (PGPMA) and malathion specific aptamer.

2 ended conformations of an adenine riboswitch aptamer.

3 as we demonstrated with a novel bisphenol A aptamer.

4 bon electrode with the viral capsid-specific aptamer.

5 g interaction between hemin and the dual DNA aptamer.

6 he approach to tetracycline and streptomycin aptamers.

7 anoparticle (AuNP) complexed with a panel of aptamers.

8 nanoparticles regardless of the presence of aptamers.

9 Applying the thiol terminated aptamer (5TR1) as a recognition layer led to a sensor wi

10 To further exploit the advantages of aptamers, a simplified mix and read assay was also devel

11 We conclude that only aptamers adopting the minimal free energy (MFE) structur

12 Last, we performed aptamer-affinity enrichment coupled with mass spectromet

13 ociation constants (Kds) of the selected DNA aptamers after 10 in vitro selection cycles were charact

14 Here, we have successfully selected a DNA aptamer against GCGR by cell-SELEX, which can specifical

15 High affinity and specificity DNA aptamers against carbendazim were successfully selected

16 The selection of DNA aptamers against the two beta-LG variants A and B was su

17 ized to allow the covalent immobilization of aptamers against the two target analytes onto the sensor

18 ation of miR-195 by intravenous injection of aptamer-agomiR-195 stimulates CD31(hi)Emcn(hi) vessel an

19 The combination of Pt NPs microwires and aptamers allowed the sensitive and highly selective dete

20 We present thrombin-binding aptamer amphiphiles that self-assemble into nanoscale po

21 ricated using non-covalent conjugation of an aptamer-anchor polynucleotide sequence to near-infrared

22 lf-assembled monolayer of specific thiolated aptamer and 6-mercapto-1-hexanol (MCH), whose ratio was

23 lex formed between anti-CA125, CA125 and CDs-Aptamer and decreasing of fluorescence response signal i

24 the same interface to interact with both the aptamer and its cognate receptor IL-1RI, thereby suggest

25 he basis of the specific recognition between aptamer and MUC1 protein that overexpressed on the surfa

26 The interaction of aptamer and norovirus resulted in a decrease in the elec

27 ed due to releasing adsorbed Ru(NH3)6(3+) on aptamer and preventing AA from scavenging photogenerated

28 characterizing bioconjugation of AgNPs with aptamers and assessing biomolecular recognition events w

29 in kinetic analysis biomechanics in peptide aptamers and GO sheets.

30 g transcription, energy transfer, functional aptamers and RNA interference.

31 the surface coverage of the NP by the ssDNA aptamers and subsequent conformational changes of the ap

32 the non-specific and weaker binding between aptamers and the AuNP is broken, and the specific and st

33 RNAs including ribozyme domains, riboswitch aptamers, and viral RNA domains with a single false posi

34 Such aptamer-antibody pairing not only lowers the detection s

35 urface area which is capable of loading more Aptamer (Ap) molecules as a receptor element of TNT on t

36 we apply a novel large scale high throughput aptamer approach to identify more than 1100 proteins in

37 was presented for detection of AFB1 based on aptamer (Apt)-complementary strands of aptamer (CSs) com

38 s with the unpaired bases of the immobilized aptamer (Apt-GMNPs-GO-L-AgNPs).

39 linically relevant stimuli via its split DNA aptamer architecture.

40 Troponin I specific antibody and aptamer are used as receptors.

41 DNA aptamers are a powerful class of molecules for sensing t

42 Aptamers are a promising class of affinity reagents beca

43 Such doubly modified aptamers are also more likely to be encoded in shorter s

44 Upon the addition of AFB1, the specific aptamers are attracted to AFB1, getting distance from Au

45 three diverse proteins, and show that these aptamers are capable of outperforming high-quality monoc

46 his has been much less explored because such aptamers are challenging to discover.

47 DNA aptamers are more stable than their RNA counterparts for

48 Aptamers are short DNA or RNA oligonucleotides evolved f

49 Aptamers are short nucleic acids that interact with a va

50 Aptamers are single-stranded RNA or DNA molecules that h

51 Unfortunately, RNA aptamers are susceptible to degradation by nucleases, an

52 s achieved through the use of a BPA-specific aptamer as probe molecule and large electrodes to enhanc

53 Taking advantage of aptamers as recognition elements with extraordinary sele

54 h selectivity and sensitivity by integrating aptamers as the recognition element and field-effect tra

55 w on aptamer technology and the potential of aptamers as valuable research tools in neurosciences.

56 rs/QDs and AuNPs modified with complementary aptamer (AuNPs-S2), the ECL of QDs nanocomposites was ef

57 d newly developed nano- and micro-scaled and aptamers based biosensors for detection of salmonella pa

58 The electrochemical, aptamer-based (E-AB) sensor platform provides a modular

59 dia (e.g., undiluted serum), electrochemical aptamer-based (E-AB) sensors are promising candidates to

60 Electrochemical aptamer-based (E-AB) sensors offer advantageous analytic

61 onstrate here the ability of electrochemical aptamer-based (E-AB) sensors to support continuous, real

62 s a vehicle control, demonstrating the first aptamer-based activatable PA probe for advanced molecula

63 e describe a GWAS using a highly multiplexed aptamer-based affinity proteomics platform.

64 describes an ultrasensitive electrochemical aptamer-based assay for detection of human epidermal gro

65 We used an aptamer-based assay of 1129 plasma proteins, and patient

66 electrical conductance change upon specific aptamer-based biomolecular recognition.

67 en recently exploited for the development of aptamer-based biosensors and direct detection strategies

68 The results pave the way to develop other aptamer-based biosensors for protein biomarkers detectio

69 Cell-SELEX) and development of sandwich type aptamer-based colorimetric platforms for its detection.

70 aptamers for development of the colorimetric aptamer-based detection platform in its identification a

71 Here the authors combine aptamer-based fluorescent detection with droplet microfl

72 This article reports a novel aptamer-based impedimetric detection of carbendazim, a c

73 ) to develop diagnostic classifiers from DNA-aptamer-based measurements of 1,128 CSF proteins.

74 m Cardiovascular Disease Risk Score using an aptamer-based proteomic platform in Framingham Heart Stu

75 The expanded aptamer-based proteomic platform provides a unique oppor

76 of myocardial injury, we recently applied an aptamer-based proteomic profiling platform that measures

77 SOMAscan is an aptamer-based proteomics assay capable of measuring 1,30

78 demonstrated by impedance measurements, the aptamer-based sensors can be used for real-time drug mon

79 ls, thus making it an appropriate target for aptamer-based therapy.

80 ce area and high fraction of amine groups as aptamer binding sites.

81 To evaluate the impact of RT-aptamer binding specificity on replication, we engineere

82 The aptamer binds to each dye with submicromolar KD values,

83 e report on the successful application of an aptamer bioconjugated nanoclusters for the detection of

84 ptical biosensor, using both an antibody and aptamer bioreceptor motif has been developed for the det

85 Among the selected aptamers, BLG14 aptamer sequence has shown high affinity

86 In particular, this shorter aptamer blocked equally potently the activity of both th

87 These characteristics make aptamers broadly applicable (e.g., as an analytical, dia

88 rescence protein (GFP)-mimicking turn-on RNA aptamer, Broccoli, into two split fragments that could t

89 The synthesis of aptamers by chemical approaches opens up the possibility

90 The promiscuity of the aptamer can also be used to distinguish between cell-sur

91 Being nucleic acids, aptamers can be synthesized chemically or enzymatically.

92 Specific peptide aptamers can be used in place of expensive antibody prot

93 As a result, RNA aptamers can fold into three-dimensional structures more

94 Aptamers can function as anticoagulants if they are dire

95 strates that very-large-molecular-weight RNA aptamers can permeate across the intact human skin barri

96 ual DNA aptamer (CEA aptamer linked to hemin aptamer), capable of rapidly capturing carcinoembryonic

97 gy the carbon dots (CDs) functionalized with aptamer (CD-aptamer) used as detection probe and PAMAM-D

98 Using a dual DNA aptamer (CEA aptamer linked to hemin aptamer), capable o

99 l aptasensor was developed by fabricating an aptamer-cell-aptamer sandwich architecture on an SBA-15-

100 inated by refractive index variations of the aptamer chain in presence of the target molecule.

101 d by means of the adhesion of a CRP specific aptamer chain onto the ITO film using the Layer-by-Layer

102 On the other hand, in the absence of target, aptamer coated particles are protected from capture on t

103 The latter renders RNA aptamers compatible with the cell's own transcription ma

104 The aptamer competes for binding with the neutralizing antib

105 lpha, present the structure of the IL-1alpha/aptamer complex and show that this aptamer inhibits the

106 urrent were relevant to the formation of PSA-aptamer complex at the modified electrode surface.

107 n concentration, due to the switching in the aptamer conformation and formation of aptamer- epirubici

108 expressed on the surface of MCF-7 cells, the aptamer conjugated MBs showed a predominant capability f

109 Consequently, the aptamer-conjugated QDs bind to the GO sheets to form a G

110 Aptamer-conjugated Quantum dots (QDs) are adsorbed to Au

111 The aptamer-conjugated silver nanoclusters (Apt@AgNCs) were

112 Aptamers consist of short oligonucleotides that bind spe

113 tetracycline, which represses translation of aptamer-containing mRNAs.

114 Two highly specific aptamers, crn-1 and crn-2, were developed through 12 rou

115 ed on aptamer (Apt)-complementary strands of aptamer (CSs) complex which forms a pi-shape structure o

116 and IL-22; topical application of the IL-23 aptamer decreased both IL-17f and IL-22 by approximately

117 es to IL-23 mRNA levels, confirming that the aptamer did not globally suppress mRNA levels.

118 t differentially functionalized nucleic acid aptamer discovered by in vitro selection and should enab

119 ding between exosome surface protein and the aptamer displaces aptamers from the AuNP surface and res

120 meric micelles with a densely functionalized aptamer-displaying corona.

121 When used in an ELISA format, the aptamer displays both high precision (intermediate preci

122 ng four structures of the adenine riboswitch aptamer domain during the course of a reaction, involvin

123 It has an aptamer domain for cognate tRNA recognition and an expre

124 on of gene expression, ligand binding to the aptamer domain of a riboswitch triggers a signal to the

125 Ligand binding to the aptamer domain of the riboswitch induces premature termi

126 elements consist of two modular subunits: an aptamer domain that binds with high specificity and affi

127 progress has been made in engineering novel aptamer domains for new small molecule inducers of gene

128 hile upon analyte binding to the immobilized aptamers electron transfer was hindered, resulting in an

129 Ribonucleic acid (RNA) aptamers employed in this class of sensor offer favorabl

130 ge of recent biosensing approaches involving aptamers, enzymes, DNA probes, fluorescent probes, inter

131 in the aptamer conformation and formation of aptamer- epirubicin complex instead of aptamer on the mo

132 Non-pseudoknot RNA aptamers exhibited broad-spectrum inhibition.

133 was observed only when virus was produced in aptamer-expressing cells, indicating that encapsidation

134 trated by using a previously reported 35-mer aptamer for a small molecule, 17beta-estradiol.

135 n of a diversely functionalized nucleic acid aptamer for human alpha-thrombin.

136 unctional effects were established using the aptamer for preQ 1 as model.

137 t functional groups, a highly functionalized aptamer for thrombin was raised with a dissociation cons

138 e-binding sequence 'Spinach', a GFP-like RNA aptamer for which the RNA-fluorophore complex exhibits s

139 s the first to demonstrate use of Salmonella aptamers for development of the colorimetric aptamer-bas

140 A dual hybridization assay quantified aptamer from the epidermis and dermis, giving levels far

141 me surface protein and the aptamer displaces aptamers from the AuNP surface and results in AuNP aggre

142 w LFA design that probes the dissociation of aptamers from the surface of gold nanoparticles upon rec

143 due to the removal of the negatively charged aptamers from the surface upon protein binding.

144 ectrochemically reduce cortisol, captured by aptamer functionalized magnetic nanoparticles.

145 lack of immunogenicity, and easy synthesis, aptamer GR-3 against GCGR can be a promising tool with t

146 n assay verified that GCGR was the target of aptamer GR-3.

147 In this work, we developed an aptamer/graphene-based electrochemical biosensor for on-

148 ps at just one of the four bases in modified aptamers has recently led to dramatic improvement in the

149 ional nucleic acids in the 1980s, especially aptamers, has substantially extended the recognition cap

150 role in the control of BoHV-1 infection and aptamers have been reported to inhibit viral replication

151 These highly modified DNA aptamers have broad utility in research, diagnostic, and

152 ide (molecular weight = 20,395 Da) RNA-based aptamer, highly specific to the human IL-23 cytokine, wi

153 thus key to joint inflammation, and anti-DEK aptamers hold promise for the treatment of JIA and other

154 This concludes that aptamer IBRV-A4 efficiently inhibits viral entry of BoHV

155 Of the nine candidates, aptamer IBRV-A4 exhibited the highest affinity and speci

156 rus replication significantly decreased when aptamer IBRV-A4 was added to BoHV-1 infected MDBK cells

157 The neutralizing ability of aptamer IBRV-A4 was determined using neutralization assa

158 We have constructed an aptamer immobilized gold atomic cluster mediated, ultras

159 e specific recognition of carbendazim by the aptamer immobilized on the gold surface which leads to c

160 The integration of the novel aptamer in the graphene biosensor allows a promising way

161 the-move" fluorescence quenching of the free aptamer in the outer layer of unmodified reduced graphen

162 Here we present RNA-aptamers-in-droplets (RAPID), a method that greatly expa

163 Aptamers-in-droplets affords a general approach for evol

164 displaying epidermal growth-factor receptor aptamer inhibited orthotopic breast cancer models.

165 IL-1alpha/aptamer complex and show that this aptamer inhibits the IL-1alpha signaling pathway.

166 Herein, we report the development of an aptamer-initiated fluorescence complementation (AiFC) me

167 ry concentration values (>100,000-fold), and aptamer integrity was confirmed using an oligonucleotide

168 The IL-1alpha/aptamer interface is composed of unusual polar and hydro

169 Results demonstrate penetration of the aptamer into freshly excised human skin using two differ

170 contrast, the conversion of the streptomycin aptamer into functional riboswitches appears to be diffi

171 nition probes such as synthetic receptor and aptamer is one of the candidate recognition layers to de

172 electrode by using specific anti-E.coli DNA aptamer (Kd 14nM), screened by new in-situ developed SE

173 f these issues through the development of an aptamer, known as a slow off-rate modified DNA aptamer (

174 The fluorescent color of the aptamer-labeled EGFR can be switched between blue and re

175 for a range of detection schemes, including aptamer labels, hybridization assays, and nucleic acid a

176 Using a dual DNA aptamer (CEA aptamer linked to hemin aptamer), capable of rapidly cap

177 Encapsidation specificity suggests that aptamers may encounter dimerized GagPol in the cytosol d

178 on, establishing RT as the genetic locus for aptamer-mediated HIV-1 inhibition.

179 new insights into HIV-1's capacity to escape aptamer-mediated inhibition, the potential utility of br

180 Aptamer-mediated pull-down and gcgr knockdown assay veri

181 are being developed more and more (enzymes, aptamers, MIPs); their advantages and drawbacks are disc

182 samples, an in vitro investigation with the aptamer-modified surface was performed.

183 ode surface via both affinity interaction to aptamer molecules and electrostatic adsorption to the HE

184 The target-induced removal of aptamer molecules from the surface of the colored partic

185 -cell recording assays, we found that an RNA aptamer most likely binds to the receptor's regulatory s

186 s demonstrate the feasibility of large-scale aptamer multiplexing at a level that has not previously

187 Thus, with the aptamer obtained from cell-SELEX, real-time modification

188 tasensor via self-assembly of thiol-modified aptamer on gold electrodes.

189 Adsorption of an RNA aptamer on nfGNPs surface showed an additive aggregation

190 The interactions of epirubicin with aptamer on the AuNPs/Fe3O4@SiO2/DABCO/SPE have been stud

191 on of aptamer- epirubicin complex instead of aptamer on the modified electrode surface.

192 electivity was developed by immobilizing the aptamer on water soluble l-cysteine capped ZnS quantum d

193 oaches opens up the possibility of producing aptamers on a large scale and enables a straightforward

194 tail of the arrow results in display of RNA aptamer or folate on the outer surface of the extracellu

195 in modified enzymes, nanozymes, nanobodies, aptamers, peptides, protein scaffolds and DNazymes.

196 ity and specificity at a throughput of 10(7) aptamers per hour.

197 The aptamer portion of the riboswitch may adopt an open or c

198 The aptamer was fused to a second aptamer previously selected for binding to the epidermal

199 ly sensitive and specific sensor based on an aptamer probe and AC electrokinetics capacitive sensing

200 and subsequent conformational changes of the aptamer probe which affect the electron transfer between

201 fter the incubation of tropomyosin with TROP aptamer probe, the photocurrent signal decreased due to

202 ed to imaging in living animals because most aptamer probes are fluorescence-based, which limits imag

203 Samples where many M. tuberculosis aptamers produced high signals were rare exceptions.

204 Protein bound to the aptamer produces unique ionic current signatures which f

205 a targeting ligand (e.g., organic molecule, aptamer, protein scaffold, or antibody), spacer, cleavab

206 The nucleobases comprising DNA and RNA aptamers provide considerably less chemical diversity th

207 The GO/aptamer-QDs ensemble assay acts as a "turn-on'' fluoresc

208 gated QDs bind to the GO sheets to form a GO/aptamer-QDs ensemble.

209 raphene oxide (GO) sheets are mixed with the aptamer-QDs.

210 ination of nanopore sensing and nucleic acid aptamer recognition comes close to this ideal due to the

211 detection of adenosine triphosphate (ATP) by aptamer recognition.

212 We show that these micellar aptamers retain their native secondary structure in a cr

213 mis and dermis and that the skin-penetrating aptamer retains its biologically active conformational s

214 was developed by fabricating an aptamer-cell-aptamer sandwich architecture on an SBA-15-3-aminopropyl

215 e developed an ultrasensitive antibody-ssDNA aptamer sandwich-type fluorescence immunosensor for CA12

216 Investigations of the underlying aptamer secondary structure revealed differences between

217 y complementary nucleic acids that break the aptamers' secondary structure upon hybridization.

218 An RNA aptamer selected for binding to the fluorogenic cyanine

219 We report here a few Zika NS1-binding ssDNA aptamers selected using the conventional SELEX protocol,

220 One of the reasons is that conventional aptamer selection can only be performed either for affin

221 Since in vitro selection can obtain aptamers selective for many targets, the design demonstr

222 The aptamer self-assemble onto the gold atomic clusters make

223 Among the selected aptamers, BLG14 aptamer sequence has shown high affinity and specificity

224 letion of DEK or treatment with DEK-targeted aptamers significantly reduces joint inflammation in viv

225 itations of antibodies' cross-reactivity and aptamers' slow binding kinetics.

226 to determine whether slow off-rate modified aptamer (SOMAmer) reagents with subnanomolar affinity fo

227 tamer, known as a slow off-rate modified DNA aptamer (SOMAmer), which targets a vaccine antigen in th

228 destabilize detection probe derived from an aptamer specific to DNA polymerase containing the overha

229 ariant, providing the first demonstration of aptamer-specific resistance in cell culture.

230 ication, but little is known about potential aptamer-specific viral resistance.

231 Gint4.T aptamer specifically recognizes platelet-derived growth

232 with mass spectrometry to technically verify aptamer specificity for a subset of the new biomarkers.

233 which leads to conformational changes in the aptamer structure.

234 he design strategy are required to implement aptamer structures not corresponding to the calculated M

235 (miRNAs), antisense oligonucleotides (ASOs), aptamers, synthetic mRNAs and CRISPR-Cas9, have great po

236 ges enabling ultrasensitive detection of the aptamer target in a single step.

237 nders it applicable to a wide range of other aptamers targeting small molecules, as we demonstrated w

238 is TechSight, we provide a brief overview on aptamer technology and the potential of aptamers as valu

239 The aptamer, termed HPV-07, was selected to bind the Type 16

240 Many natural RNAP-binding aptamers, termed RAPs, were mapped to the genome.

241 Two non-specific drugs and one non-specific aptamer, tested as stringent control candidates, caused

242 This tRNA fusion carries a Spinach aptamer that becomes fluorescent upon binding of a cell-

243 Extracellular vesicles displaying an aptamer that binds to prostate-specific membrane antigen

244 implying functional potentials as a new DNA aptamer that can bind and recognize silver ions.

245 tor receptor (EGFR) to create a bifunctional aptamer that labels cell-surface EGFR on mammalian cells

246 Here we report a naphthyl modified DNA aptamer that specifically binds IL-1alpha and inhibits i

247 RNA aptamers that bind HIV-1 reverse transcriptase (RT) inhi

248 , we now report the selection of 2'-F purine aptamers that bind human neutrophil elastase (HNE).

249 volutionary approaches produced numerous RNA aptamers that bind such small ligands, but their convers

250 Once transcribed, these elements form 5'-RNA aptamers that bind to the added tetracycline, which repr

251 and demonstration of PA probes based on DNA aptamers that can hybridize to DNA strands conjugated to

252 ceptor target (i.e. GluA1/2R) to isolate RNA aptamers that can potentially inhibit both AMPA and kain

253 chemical diversity by selecting modified DNA aptamers that contain amino-acid-like modifications on b

254 As a proof of principle, we generated DNA aptamers that exhibit picomolar to low nanomolar affinit

255 old for eliciting resistance may be high for aptamers that make numerous contacts with RT.

256 In this study, nine DNA aptamers that target BoHV-1 were generated using systemi

257 Upon the interaction of AFM1 with the aptamers, the GO-L-AgNPs detach from the aptamer; the re

258 Compared to free aptamers, the increased molecular weight and size of the

259 the aptamers, the GO-L-AgNPs detach from the aptamer; the resulting ECL of luminol and H2O2 at the an

260 ized the gold nanoparticles with a thiolated aptamer to achieve the required selectivity that allowed

261 ne oxide (GO) sheets with a specific peptide aptamer to create a novel, simple and label-free tool to

262 After that, Ru(NH3)6(3+) was adsorbed on aptamer to enhance the photocurrent signal.

263 onjugation of a chloramphenicol-specific DNA aptamer to the protein shell through strain-promoted azi

264 ng in this case more redox-reporter-modified aptamers to be packed onto the surface, thus producing s

265 ion, the potential utility of broad-spectrum aptamers to overcome resistance, and molecular interacti

266 e is based on the selective recognition from aptamers to the target mycotoxins and further "on-the-mo

267 e correlated with the number of encapsidated aptamer transcripts per virion, with saturation occurrin

268 n dots (CDs) functionalized with aptamer (CD-aptamer) used as detection probe and PAMAM-Dendrimers/Au

269 of malathion, the polymer interacts with the aptamer, via electrostatic interactions thereby renderin

270 amine-functionalized mucin 1 protein (MUC1) aptamer was first covalently conjugated to carboxylated-

271 The aptamer was found to be selective for thrombin and requi

272 The aptamer was fused to a second aptamer previously selecte

273 The thiolated AFM1 aptamer was immobilized on gold nanoparticle-coated magn

274 In this project, 5'-thiole terminated aptamer was self-assembled on carbon screen printed elec

275 Norovirus specific aptamer was tagged with a ferrocene molecule, which acts

276 The aptamer was then integrated in a voltammetric biosensor

277 of CEA and hemin in the presence of the dual aptamer, was exponentially decreased with the increase o

278 lving the crystal structure of the IL-1alpha/aptamer, we provide a high-resolution structure of this

279 Using aptamers, we transduce extracellular product titer into

280 Two aptamers were identified, 2fHNE-1 and 2fHNE-2, that bind

281 Viruses inhibited by pseudoknot aptamers were rendered insensitive by a naturally occurr

282 Both aptamers were used to construct sandwich type capillary

283 The system was based on a TNT-binding aptamer which is covalently attached onto the surface of

284 The aptamer which showed the highest degree of affinity and

285 authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1alpha, present the

286 on assay by assembling a fluorescent Spinach aptamer, which is a synthetic RNA mimic of the Green Flu

287 The non-helical aptamer, which represents a highly compact nucleic acid

288 hemin competitively bound with the dual DNA aptamer while the mixture in a detection cell was incuba

289 A thiol terminated DNA aptamer with affinity for HER2 was used to prepare the b

290 ow assay (DRELFA) which pairs a nucleic acid aptamer with an antibody for use as a point-of-care plat

291 Based on the incubation of the thiolated aptamer with CT26 cells, the electron-transfer resistanc

292 The interaction of aptamer with malathion results in switching off of the f

293 RNA or single-stranded DNA aptamers with 2'-F pyrimidines have been pursued to incr

294 nanoparticles (AuNPs) due to interaction of aptamers with AuNPs leading to quenching effect on QDs f

295 The complexation of aptamers with AuNPs protects the nanoparticles from aggr

296 sing a single receptor target to develop RNA aptamers with dual activity for effectively blocking bot

297 study, we demonstrated the selection of DNA aptamers with high affinity and specificity against S.

298 or the further exploration and production of aptamers with properties optimized for various applicati

299 bility, and inhibitory potency compared with aptamers with single modifications.

300 nonoverlapping epitopes more frequently than aptamers with single modifications.