ライフサイエンスコーパス: apterous

1 group specified by the LIM-homeodomain gene apterous.

2 o those produced by mutant clones of Chip or apterous.

3 ised of Chip and the LIM-homeodomain protein Apterous.

4 in those dFMRFa neurons that do not express Apterous.

5 , E75A mRNA levels are reduced in ovaries of apterous(4) mutant adults defective in JH secretion.

6 he phenotype seen when mutant clones lacking Apterous, a LIM homeodomain protein known to be essentia

7 of the Drosophila FMRFa neuropeptide gene by Apterous, a LIM homeodomain transcription factor.

8 oof-of-principle experiments, we manipulated apterous, a regulator of wing development.

9 modimer is the functional unit through which Apterous acts during neuronal differentiation.

10 expression, and acts potently together with apterous and BMP signaling to trigger Fmrf expression ec

11 utants and of embryos doubly mutant for both apterous and Chip.

12 e developing Drosophila optic lobe, eyeless, apterous and distal-less, three genes that encode transc

13 ts in neurotransmitter production that mimic apterous and islet mutants.

14 orsal expression of the transcription factor Apterous and it has been hypothesized that apterous (ap)

15 g development, Delta is under the control of apterous and might be the Notch ligand in this process.

16 This signal acts together with apterous and squeeze to activate FMRFamide expression.

17 ing development (such as Wingless signal and apterous), and has nubbin enhancer activity.

18 n the club required bric-a-brac, aristaless, apterous, and pdm.

19 nd the tarsal PD genes, bric-a-brac 2 (bab), apterous (ap) and BarH1 (Bar).

20 The LIM homeodomain (LIM-HD) protein Apterous (Ap) and its cofactor DLDB/CHIP control dorso-

21 The LIM-HOM transcription factors apterous (ap) and Lim1 (also known as dlim1), and the ho

22 osed to exist across the DV axis, along with apterous (ap) as a dorsal selector gene [5], mediating c

23 ling is necessary and sufficient to activate apterous (ap) expression, thereby segregating the wing d

24 The Drosophila apterous (ap) gene encodes a protein of the LIM-homeodom

25 osophila wing is regulated downstream of the apterous (ap) gene, which encodes a transcription factor

26 (EGFR) signaling, which heritably activates apterous (ap) in D compartment cells and maintains Iroqu

27 n the pretarsus, Bar (B) in ta IV and V, and apterous (ap) in ta IV.

28 the LIM domains of the LIM-HD family member Apterous (Ap) in wing and nervous system development.

29 ctor for the Drosophila LIM-HD family member Apterous (Ap) in wing development.

30 We show that the Lhx gene apterous (ap) is also required for PD leg development, a

31 The selector gene apterous (ap) is expressed in dorsal cells of the wing d

32 db/Chip function cause the same phenotype as apterous (ap) lack of function; i.e. dorsal to ventral t

33 w instance of transvection at the Drosophila apterous (ap) locus.

34 r Apterous and it has been hypothesized that apterous (ap) maintains compartmentalization by directly

35 Apterous (Ap), the best studied LIM-homeodomain transcri

36 of neurons express the LIM-homeodomain gene apterous (ap).

37 g this enhancer element, we demonstrate that Apterous (Ap, a selector protein), and the Notch and Win

38 dFMRFa and Apterous are expressed in partially overlapping subsets

39 Using a Chip/Apterous chimeric molecule lacking domains normally requ

40 Apterous contributes to the initiation of dFMRFa express

41 Apterous contributes to the maintenance of dFMRFa expres

42 includes direct mechanisms, although ectopic Apterous does not induce ectopic dFMRFa.

43 We show that a small complement of 28 apterous-expressing cells (Ap-let neurons) in the ventra

44 Chip is also required cell-autonomously by Apterous-expressing neurons for proper axon guidance, an

45 ment for egghead early in the development of apterous-expressing ventral nerve cord neurons to rescue

46 ng that these interactions are important for Apterous function in vivo.

47 Expression of SOCS36E under apterous-GAL4 control resulted in outstretched wings.

48 In addition, we found that the Tribolium apterous genes are not only essential for exoskeletaliza

49 rotein interacts with the LIM domains in the Apterous homeodomain protein, and Chip interacts genetic

50 Apterous is not required for Tv neuron survival or morph

51 are a common neurotransmitter phenotype, the Apterous LIM homeoprotein helps define neurotransmitter

52 g requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells.

53 artially winged (brachypterous) or wingless (apterous) lineages, and some entire orders are secondari

54 and that a tetrameric complex comprising two Apterous molecules bridged by a Chip homodimer is the fu

55 lex and rescued the axon guidance defects of apterous mutants, of Chip mutants and of embryos doubly

56 Furthermore, neurotransmission in apterous neurons is required to elicit the SP response.

57 egghead expression in apterous neurons rescues neuronal targeting and the resp

58 Apterous regulation of dFMRFa expression includes direct

59 The LIM-homeodomain family member Apterous requires the LIM-binding protein Chip to execut

60 protein, and Chip interacts genetically with apterous, showing that these interactions are important

61 apterous specifies dorsal cell fate and directs outgrowt

62 this "code," by combined BMP activation and apterous/squeeze misexpression, triggers ectopic FMRFami

63 Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not

64 rt of the dorsal compartment by induction of apterous, the dorsal selector gene, and consequently als

65 and for the activation of the homeobox gene apterous, the Zinc-finger gene rotund and the bHLH-PAS g

66 ivity of the dorsal specific nuclear protein Apterous, which regulates the expression of the Notch li

67 ng tissue (e.g., scalloped, Beadex, cut, and apterous-Xasta), Lyra wing discs do not exhibit increase