ライフサイエンスコーパス: apurinic

1 The damaged sites studied include apurinic and apyrimidinic a basic sites, thymine glycol

2 However, apyrimidinic/apurinic (AP) endonuclease-deficient cells (xth nfo stra

3 First, MAP30 acts like a DNA glycosylase/apurinic (ap) lyase, an additional activity distinct fro

4 by adenine DNA glycosylase, MYH, creating an apurinic (AP) site.

5 clease III (Exo III) removes apyrimidinic or apurinic (AP) sites and 3'-phosphate termini in single-s

6 or 4 h, and the levels of stable adducts and apurinic (AP) sites in the DNA were determined.

7 s DNA damage arises frequently, particularly apurinic (AP) sites.

8 uracil-DNA glycosylase to remove uracil, and apurinic/apryimidinic endonuclease to nick the abasic si

9 ificities of two major human SN-BER enzymes, apurinic/aprymidinic endonuclease 1 (APE) and DNA polyme

10 In contrast, DNA glycosylases, apurinic/aprymidinic endonuclease 1 and flap endonucleas

11 e multistep repair process of damaged bases, apurinic-apyrimidic (AP) endonucleases play an essential

12 er proteins from the BER pathway, such as an apurinic-apyrimidinic (AP) endonuclease, as turnover-enh

13 T, the mismatch repair enzyme MUTYH, and the apurinic-apyrimidinic endonuclease APEX2.

14 Aberrant expression of apurinic-apyrimidinic endonuclease-1 (APEX1) has been re

15 onuclease that is related in sequence to the apurinic-apyrimidinic endonucleases that participate in

16 e HSV-1 DNA polymerase (Pol) (UL30) exhibits apurinic/apyrimidinic (AP) and 5'-deoxyribose phosphate

17 For example, it is capable of cleaving apurinic/apyrimidinic (AP) DNA via a beta-elimination re

18 oving damaged or mismatched bases, producing apurinic/apyrimidinic (AP) DNA.

19 Apurinic/apyrimidinic (AP) endonuclease (APE) is a multi

20 The mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) is a mult

21 Human apurinic/apyrimidinic (AP) endonuclease (hAPE) initiates

22 Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a ce

23 The overexpression of human apurinic/apyrimidinic (AP) endonuclease 1 (APE1/Ref-1),

24 ses TDG and 8-oxoG DNA glycosylase 1 (OGG1), apurinic/apyrimidinic (AP) endonuclease 1, DNA polymeras

25 A base excision repair protein, Apurinic/apyrimidinic (AP) endonuclease 2 (APE2, APN2, o

26 y and is responsible for >/=95% of the total apurinic/apyrimidinic (AP) endonuclease activity in huma

27 Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mamm

28 nstituted with uracil-DNA glycosylase (UDG), apurinic/apyrimidinic (AP) endonuclease and DNA ligase I

29 Ape1 is the major human apurinic/apyrimidinic (AP) endonuclease and initiates re

30 Apurinic/apyrimidinic (AP) endonuclease and polymerase g

31 Apurinic/apyrimidinic (AP) endonuclease Ape1 is a key en

32 nuclease IV is the archetype for a conserved apurinic/apyrimidinic (AP) endonuclease family that prim

33 HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells.

34 Apn1 is the major apurinic/apyrimidinic (AP) endonuclease in yeast.

35 We have identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in th

36 ammalian adenine-DNA glycosylase activity by apurinic/apyrimidinic (AP) endonuclease using murine hom

37 on during abasic site repair and between the apurinic/apyrimidinic (AP) endonuclease, Ape1, and the 8

38 purified recombinant CSB and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physicall

39 e, we report overexpression of the S. mutans apurinic/apyrimidinic (AP) endonuclease, Smx, in Escheri

40 Apurinic/apyrimidinic (AP) endonuclease-deficient cells

41 ir activity that was restored by addition of apurinic/apyrimidinic (AP) endonuclease.

42 /lyases (NEIL1, Nei, Fpg, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, an

43 s/intermediates, organisms are equipped with apurinic/apyrimidinic (AP) endonucleases and 3'-nuclease

44 In Saccharomyces cerevisiae, the apurinic/apyrimidinic (AP) endonucleases Apn1 and Apn2 a

45 organisms, uracil residues are eliminated by apurinic/apyrimidinic (AP) endonucleases in the nucleoti

46 Here we report that the apurinic/apyrimidinic (AP) endonucleases--Escherichia co

47 il DNA glycosylase (mtUDG) and mitochondrial apurinic/apyrimidinic (AP) endonucleases.

48 utagenic or lethal lesions is carried out by apurinic/apyrimidinic (AP) endonucleases.

49 g a plasmid DNA that carries a site-specific apurinic/apyrimidinic (AP) lesion as template, we have f

50 Duplex DNA containing an apurinic/apyrimidinic (AP) lesion undergoes cleavage sig

51 by a thymine glycol DNA glycosylase with an apurinic/apyrimidinic (AP) lyase activity encoded by the

52 Drosophila S3 also possesses an apurinic/apyrimidinic (AP) lyase activity in which the e

53 A subset of glycosylases has an associated apurinic/apyrimidinic (AP) lyase activity that further p

54 ntrinsic 5' deoxyribosephosphate (5'dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed th

55 oli Nth, possessing both DNA glycosylase and apurinic/apyrimidinic (AP) lyase activity.

56 ir (BER) pathway, initiated by N-glycosylase apurinic/apyrimidinic (AP) lyase proteins.

57 ndonuclease III (hNth1) is a DNA glycosylase/apurinic/apyrimidinic (AP) lyase that initiates base exc

58 an DNA is initiated by the DNA N-glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), th

59 ase (mOGG1), the two major DNA N-glycosylase/apurinic/apyrimidinic (AP) lyases involved in the repair

60 p are S. cerevisiae N-glycosylase-associated apurinic/apyrimidinic (AP) lyases that recognize a wide

61 o DNA duplexes each containing two synthetic apurinic/apyrimidinic (AP) residues, positioned on oppos

62 rted a G or less frequently an A opposite an apurinic/apyrimidinic (AP) site but was unable to extend

63 donuclease (APE1), an enzyme that cleaves an apurinic/apyrimidinic (AP) site from double stranded DNA

64 A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP en

65 An apurinic/apyrimidinic (AP) site is one of the most abund

66 ically insert a dCMP opposite a DNA template apurinic/apyrimidinic (AP) site or a uracil residue.

67 least two DNA repair lyase active sites for apurinic/apyrimidinic (AP) site processing, one within t

68 e have used a substrate containing a reduced apurinic/apyrimidinic (AP) site resistant to beta-elimin

69 st common DNA lesions arising in cells is an apurinic/apyrimidinic (AP) site resulting from base loss

70 er, Iduna facilitates DNA repair by reducing apurinic/apyrimidinic (AP) sites after MNNG exposure and

71 The mammalian AP-endonuclease (APE1) repairs apurinic/apyrimidinic (AP) sites and strand breaks with

72 m deoxyribose, resulting in the formation of apurinic/apyrimidinic (AP) sites and strand breaks.

73 Apurinic/apyrimidinic (AP) sites are alkali labile lesio

74 Apurinic/apyrimidinic (AP) sites are common DNA lesions

75 Apurinic/apyrimidinic (AP) sites are common mutagenic an

76 Apurinic/apyrimidinic (AP) sites are constantly formed i

77 Apurinic/apyrimidinic (AP) sites are continuously genera

78 Non-coding apurinic/apyrimidinic (AP) sites are generated at high f

79 Apurinic/apyrimidinic (AP) sites are one of the most fre

80 Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesi

81 Repair of apurinic/apyrimidinic (AP) sites by mammalian cell extra

82 ouble-stranded DNA treated with PAP contains apurinic/apyrimidinic (AP) sites due to the removal of a

83 , the major protein responsible for excising apurinic/apyrimidinic (AP) sites from DNA, cleaves 5' to

84 In growing cells, apurinic/apyrimidinic (AP) sites generated spontaneously

85 rimidinic endonuclease 1 (APE1) to cleave at apurinic/apyrimidinic (AP) sites in a collection of tand

86 Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually

87 in with a major role in initiating repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hy

88 Mammalian cells repair apurinic/apyrimidinic (AP) sites in DNA by two distinct

89 Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneous

90 unctional human Ape1 protein is to incise at apurinic/apyrimidinic (AP) sites in DNA via site-specifi

91 s for removal of endogenous base lesions and apurinic/apyrimidinic (AP) sites in DNA.

92 thod to detect traces of aldehyde-containing apurinic/apyrimidinic (AP) sites in nucleic acids has be

93 hality of the PARP inhibitor is dependent on apurinic/apyrimidinic (AP) sites in the DNA and the pres

94 s 2-deoxyribose-5-phosphate at an incised 5' apurinic/apyrimidinic (AP) sites via a beta-elimination

95 on product, deoxyinosine, and the numbers of apurinic/apyrimidinic (AP) sites were identical in DNA i

96 otide damage, including base loss (abasic or apurinic/apyrimidinic (AP) sites).

97 Apurinic/apyrimidinic (AP) sites, or abasic sites, which

98 Apurinic/apyrimidinic (AP) sites, the most frequently fo

99 uct of ROS damage to DNA is the formation of apurinic/apyrimidinic (AP) sites, which without removal

100 in the base excision repair of premutagenic apurinic/apyrimidinic (AP) sites.

101 endonuclease IV (endo IV), which recognizes apurinic/apyrimidinic (AP) sites.

102 he major and minor grooves of DNA containing apurinic/apyrimidinic (AP) sites.

103 DNA such as phosphoglycolates and abasic or apurinic/apyrimidinic (AP) sites.

104 damage they produce [e.g., 8-oxo-guanine and apurinic/apyrimidinic (AP) sites] have been linked to th

105 toxic double strand breaks (DSB) and abasic (apurinic/apyrimidinic (AP)) sites in DNA.

106 Abasic [apurinic/apyrimidinic (AP)] sites are common, noncoding

107 We investigated whether apurinic/apyrimidinic (AP/abasic) sites were more freque

108 that Ape1, an enzyme required for processing apurinic/apyrimidinic (known as abasic) sites, is also i

109 polymerase catalytic subunit (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase

110 of the HSV-1 DNA polymerase (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase

111 Apurinic/apyrimidinic endonuclease (AP endo) is a key en

112 Apurinic/apyrimidinic endonuclease (AP endo) is a key en

113 The endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major

114 Apurinic/apyrimidinic endonuclease (AP endo) is believed

115 e-steady state enzymatic binding kinetics of apurinic/apyrimidinic endonuclease (AP endo).

116 Apurinic/apyrimidinic endonuclease (APE) efficiently nic

117 A identified 12 property-based motifs in the apurinic/apyrimidinic endonuclease (APE) family of DNA-r

118 NG; the resulting abasic sites are nicked by apurinic/apyrimidinic endonuclease (APE).

119 ated by uracil DNA glycosylases-2 (UNG2) and apurinic/apyrimidinic endonuclease (APE).

120 We showed that human apurinic/apyrimidinic endonuclease (APE-1) has exonuclea

121 lanoma cell lines accumulated high levels of apurinic/apyrimidinic endonuclease (APE-1/Ref-1, redox e

122 Surprisingly, this enzyme was found to be apurinic/apyrimidinic endonuclease (APE1) (), a well cha

123 Human apurinic/apyrimidinic endonuclease (APE1) is an essentia

124 It is known that apurinic/apyrimidinic endonuclease (APE1) plays a crucia

125 Human DNA apurinic/apyrimidinic endonuclease (APE1) plays a key ro

126 Human apurinic/apyrimidinic endonuclease (Ape1) plays an impor

127 hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1), proliferating

128 man heat shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrat

129 hMYH and apurinic/apyrimidinic endonuclease (hAPE1) co-migrate wi

130 d DNA repair enzyme, Redox effector factor-1/apurinic/apyrimidinic endonuclease (Ref-1/Ape), facilita

131 e PQS, adopting a G-quadruplex fold in which apurinic/apyrimidinic endonuclease 1 (APE1) binds, but i

132 The apurinic/apyrimidinic endonuclease 1 (APE1) functions ar

133 Although it is presumed that the apurinic/apyrimidinic endonuclease 1 (APE1) generates DN

134 Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifu

135 Human apurinic/apyrimidinic endonuclease 1 (APE1) is an import

136 Apurinic/apyrimidinic endonuclease 1 (APE1) is the main

137 Apurinic/apyrimidinic endonuclease 1 (APE1) plays a cent

138 We have also found that apurinic/apyrimidinic endonuclease 1 (APE1) stimulates l

139 bstrates, we determined the ability of human apurinic/apyrimidinic endonuclease 1 (APE1) to cleave at

140 We found that the nuclear apurinic/apyrimidinic endonuclease 1 (APE1), a core enzy

141 Apurinic/apyrimidinic endonuclease 1 (APE1), a member of

142 athway (LP-BER), including DNA glycosylases, apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymer

143 The essential base excision repair protein, apurinic/apyrimidinic endonuclease 1 (APE1), plays an im

144 xes formed by DNA polymerase beta (Polbeta), apurinic/apyrimidinic endonuclease 1 (APE1), poly(ADP-ri

145 ehyde-3-phosphate dehydrogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1 (Ape1), the major o

146 ase in mammalian base excision repair (BER), apurinic/apyrimidinic endonuclease 1 (APE1).

147 of the essential base-excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1)/redox effect

148 A glycosylases and the downstream processing apurinic/apyrimidinic endonuclease 1 (APE1)] can be test

149 ased expression of critical DNA repair genes apurinic/apyrimidinic endonuclease 1 (Apex1) and DNA pol

150 Apurinic/apyrimidinic endonuclease 1 (APEX1) participate

151 her proteins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA proces

152 Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism.

153 molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes

154 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enz

155 We also show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the

156 We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA

157 BER intermediate, the DNA is channeled from apurinic/apyrimidinic endonuclease 1 to DNA polymerase b

158 the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other

159 Apurinic/apyrimidinic endonuclease 1, a key enzyme in re

160 red to the reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dep

161 nds with selected DNA glycosylases and human apurinic/apyrimidinic endonuclease 1.

162 The apurinic/apyrimidinic endonuclease 1/redox effector fact

163 nes potentiate radiotherapy, we investigated apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE

164 ficient for the base excision repair enzyme, apurinic/apyrimidinic endonuclease 2 (APE2) protein deve

165 The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participa

166 e IV family of DNA repair enzymes, including apurinic/apyrimidinic endonuclease activity and repair a

167 correlated with an increase in mitochondrial apurinic/apyrimidinic endonuclease activity in both H2O2

168 p53 did not influence mitochondrial apurinic/apyrimidinic endonuclease activity measured by

169 cised abasic residues, which result from the apurinic/apyrimidinic endonuclease activity of Ape1.

170 P excision by a mechanism independent of its apurinic/apyrimidinic endonuclease activity.

171 ion of the transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of c

172 The major mammalian apurinic/apyrimidinic endonuclease Ape1 is a multifuncti

173 tagenic DNA damage is initiated by the major apurinic/apyrimidinic endonuclease Ape1, which specifica

174 thetic abasic site; this site was incised by apurinic/apyrimidinic endonuclease creating a nick with

175 ion repair ung and mutY glycosylase and xthA apurinic/apyrimidinic endonuclease genes in H. pylori, m

176 ation damage and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hype

177 hosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth musc

178 In addition to its primary activity as an apurinic/apyrimidinic endonuclease in BER, Ape1 also pos

179 Apurinic/apyrimidinic endonuclease is a key enzyme in th

180 Inhibition of apurinic/apyrimidinic endonuclease may therefore be a re

181 onents (two endonuclease III homologs and an apurinic/apyrimidinic endonuclease) that might account f

182 viral uracil DNA glycosylase (UL2), cellular apurinic/apyrimidinic endonuclease, and DNA ligase IIIal

183 enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically,

184 P0/AP3, a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary

185 major base excision repair proteins, such as apurinic/apyrimidinic endonuclease, DNA polymerase beta,

186 ified human enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta,

187 specific DNA glycosylase, strand scission by apurinic/apyrimidinic endonuclease, DNA resynthesis and

188 Apurinic/apyrimidinic endonuclease-1 (APE-1) regulates t

189 Human apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzy

190 Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox facto

191 ry, we found that recombinant purified human apurinic/apyrimidinic endonuclease-1 (APE1) and APE1 fro

192 Apurinic/apyrimidinic endonuclease-1 (APE1) is a multifu

193 Apurinic/apyrimidinic endonuclease-1 (APE1) is an essent

194 Apurinic/apyrimidinic endonuclease-1/redox effector fact

195 We recently reported that the expression of apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE

196 ligase III, poly(ADP-ribose) polymerase, and apurinic/apyrimidinic endonuclease.

197 lap endonuclease-1, DNA polymerase beta, and apurinic/apyrimidinic endonuclease.

198 Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/

199 The dual-function protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/

200 Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/

201 The apurinic/apyrimidinic endonucleases (APE) contain severa

202 onuclease IV belongs to a class of important apurinic/apyrimidinic endonucleases involved in DNA repa

203 G) yields abasic sites, which are excised by apurinic/apyrimidinic endonucleases, eventually generati

204 am intermediates by the specific activity of apurinic/apyrimidinic endonucleases.

205 DNA and stimulated both the glycosylase and apurinic/apyrimidinic lyase activities of OGG1.

206 nctional enzyme that has DNA glycosylase and apurinic/apyrimidinic lyase activities.

207 However, MutY(Dr) exhibits limited apurinic/apyrimidinic lyase activity and can form only w

208 introduces a single strand break through its apurinic/apyrimidinic lyase activity to initiate base ex

209 ucture also suggest a role for Glu161 in the apurinic/apyrimidinic lyase chemistry.

210 Moreover, in vitro assays revealed that apurinic/apyrimidinic nuclease 1 provides nearly maximum

211 Thus, under our assay conditions, apurinic/apyrimidinic nuclease 1-mediated stimulation or

212 Abasic (apurinic/apyrimidinic or AP) sites are a frequent type o

213 g BER, Ape1 recruits pol beta to the incised apurinic/apyrimidinic site and stimulates 5'-dRP excisio

214 esulting abasic site is further processed by apurinic/apyrimidinic site endonuclease 1 (APE1) to crea

215 istry of the T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase (T4-pdg) has been explo

216 kDa protein, T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase.

217 ly six times more tightly toward its product apurinic/apyrimidinic site than the substrate, whereas f

218 droxypropanodeoxyguanosine adduct and (2) an apurinic/apyrimidinic site, and the initiation of repair

219 diester backbone in DNA on the 5' side of an apurinic/apyrimidinic site, was monitored by FCCS using

220 tic mobility of a DNA fragment containing an apurinic/apyrimidinic site.

221 rences of MPG binding affinity toward Hx and apurinic/apyrimidinic sites and thus is essential for th

222 e to generate single-strand breaks (SSBs) at apurinic/apyrimidinic sites do not form DSBs immediately

223 The Ape1 protein initiates the repair of apurinic/apyrimidinic sites during mammalian base excisi

224 repair enzyme that initiates the removal of apurinic/apyrimidinic sites from DNA, excises 3' replica

225 We further demonstrate that most apurinic/apyrimidinic sites in highly transcribed DNA ar

226 Here we show that the accumulation of apurinic/apyrimidinic sites is greatly enhanced in highl

227 ing of MutY with GO mispaired with T, G, and apurinic/apyrimidinic sites may be involved in the regul

228 ely, its ability to be covalently trapped to apurinic/apyrimidinic sites within duplex DNA under redu

229 DNA damage, as determined by the level of apurinic/apyrimidinic sites, also decreased significantl

230 bundance of oxidative DNA adducts, mutagenic apurinic/apyrimidinic sites, and expression of base exci

231 y, all of which fail to seal SSBs induced at apurinic/apyrimidinic sites, exhibit strongly elevated l

232 zyme is product-inhibited by both uracil and apurinic/apyrimidinic sites.

233 not fully prevent processing of 8-oxo-G and apurinic/apyrimidinic sites.

234 n complex with adenine that the abasic site (apurinic/apyrimidinic) lyase activity is alternatively r

235 DNA N-glycosylase/AP (apurinic/apyrimidinic) lyase enzymes of the endonuclease

236 from DNA and then nicks the nascent abasic (apurinic/apyrimidinic) site by beta-elimination.

237 Abasic (apurinic/apyrimidinic) sites are among the most abundant

238 ma) is active in base excision repair of AP (apurinic/apyrimidinic) sites in DNA.

239 Furthermore, mtTGendo has an associated apurinic/apyrimidinic-lyase activity.

240 Abasic (apurinic/apyrimidinic; AP) sites are generated in vivo t

241 n (Ugi)-sensitive uracil-DNA glycosylase, an apurinic/apyrimidiniclyase, and a 3'-phosphodiesterase.

242 tack the C1' of the adenosine; the resulting apurinic DNA is cleaved through beta/delta-elimination w

243 at the mitochondrial 8-oxodG DNA glycosylase/apurinic DNA lyase activity is the mitochondrial isoform

244 with 8-oxoguanine (8-oxodG) DNA glycosylase/apurinic DNA lyase activity.

245 activate a water molecule and the resulting apurinic DNA then reacts with Lys-142 to form the Schiff

246 e, could promote a beta/delta-elimination on apurinic DNA.

247 racil DNA glycosylase (UDG) and apyrimidinic/apurinic endonuclease (APE) digest G:U mismatches to com

248 C1), poly(ADP-ribose) polymerase (PARP), and apurinic endonuclease (Ape) proteins.

249 n uracil DNA glycosylase (UDG), apyrimidinic/apurinic endonuclease (APE), and DNA polymerase beta (po

250 e determined that the DNA glycosylase hNTH1, apurinic endonuclease (APE), and DNA polymerase beta (Po

251 zinc-containing DNA-repair proteins p53 and apurinic endonuclease (APE).

252 he essential base excision DNA repair enzyme apurinic endonuclease 1 (Ape1) in response to sodium ars

253 the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzym

254 ity and increased mRNA and protein levels of apurinic endonuclease 1 (APE1).

255 and the apurinic endonuclease redox factor 1/apurinic endonuclease 1 (REF1/APE1), in human breast car

256 The multifunctional enzyme apurinic endonuclease 1/redox enhancing factor 1 (Ape1/r

257 cate that RECQL4 specifically stimulates the apurinic endonuclease activity of APE1, the DNA strand d

258 s confirmed by digestion of plasmid DNA with apurinic endonuclease IV, followed by primer extension a

259 se (OGG1), the DNA glycosylase NTH1, and the apurinic endonuclease redox factor 1/apurinic endonuclea

260 limiting enzyme of DNA base excision repair, apurinic endonuclease-1 (Ape1), which is also known as r

261 he more "modern" non-LTR lineages possess an apurinic endonuclease-like domain and generally lack sit

262 ity, genetic inactivation of all known yeast apurinic endonucleases does not increase the sensitivity

263 7 bp apart, even in the absence of the major apurinic endonucleases.

264 Exo III's apurinic endonucleolytic activity differentially process

265 anded dodecamer containing a tetrahydrofuran apurinic lesion at the +2 position of a topoisomerase II

266 Second, the apurinic lesion induced a bend that was centered about t

267 The resultant apurinic lesion is subject to error-prone repair, consis

268 ough most non-LTR retrotransposons encode an apurinic-like endonuclease upstream of a common reverse

269 ir enzyme human 8-oxoguanine DNA glycosylase/apurinic lyase (hOGG1) downstream of the mitochondrial t

270 of recombinant 8-oxoguanine DNA glycosylase/apurinic lyase (OGG1) in mtDNA repair, we constructed an

271 ith its DNA substrates, its possession of 3' apurinic lyase activity is controversial.

272 removes the faulty base and an apyrimidinic/apurinic lyase activity that introduces a single-strand

273 Glycosylase/apurinic lyase activity was reduced in Rad9(-/-) mouse E

274 stimulates its glycosylase and apyrimidinic/apurinic lyase enzymatic activities.

275 phosphodiester bond 5 ' to a baseless sugar (apurinic or apyrimidinic site).

276 ei enzymes unliganded or bound to an abasic (apurinic or apyrimidinic) site, until now there was no s

277 In the apurinic simulations (i.e., when a pyrimidine is opposit

278 erted naturally to two secondary lesions, an apurinic site and an AFB(1)-formamidopyrimidine (AFB(1)-

279 adenine DNA glycosylase, and APE1, the major apurinic site endonuclease; and (b) the prevalence of mi

280 ng important for synthetic oligonucleotides, apurinic site formation in cellular DNA is a common occu

281 he latter are likely to have arisen from the apurinic site generated from the Gua-N7 adduct.

282 diation-induced (6-4) photoproduct and to an apurinic site in DNA.

283 Appearance of the apurinic site in the self-depurinating stem-loop was con

284 The resulting apurinic site is further processed by the other members

285 sidue, leading to DNA strand scission at the apurinic site.

286 ociation of thymine DNA glycosylase from the apurinic site.

287 usly crystallized bound to DNA containing an apurinic site.

288 If apurinic sites accumulate, they are mutagenic and cytoto

289 tains genetic fidelity through the repair of apurinic sites and regulates transcription through redox

290 Because apurinic sites are subject to error-prone repair, leadin

291 nstable DNA adducts are also formed and that apurinic sites in the DNA resulting from unstable PAH ad

292 op-mediated depurination leading to flexible apurinic sites may therefore serve some important biolog

293 on found to rival the stimulatory effects of apurinic sites on the DNA scission activity of eukaryoti

294 To measure apurinic sites they were converted to strand breaks, and

295 , whereas other DNA modifications, including apurinic sites, 8-oxoguanine, 8-oxoadenine and cholester

296 dissociation of thymine DNA glycosylase from apurinic sites, presumably through direct interaction wi

297 nvert 8-oxo-7,8-dihydroguanine (8-oxoGua) to apurinic sites, subsequently measured as DNA breaks usin

298 byproduct of serial elimination reactions at apurinic sites.

299 " genomic damage is endogenous generation of apurinic sites.

300 Three major features distinguished the apurinic structure ( = 0.095) from that of wild-type ( =