ライフサイエンスコーパス: apyrimidinic

1 e damaged sites studied include apurinic and apyrimidinic a basic sites, thymine glycol and urea.

2 nohistochemistry while the number of apurnic/apyrimidinic abasic sites (AP sites) was also quantified

3 e catalytic subunit (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activiti

4 SV-1 DNA polymerase (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activiti

5 NA polymerase (Pol) (UL30) exhibits apurinic/apyrimidinic (AP) and 5'-deoxyribose phosphate (dRP) lya

6 example, it is capable of cleaving apurinic/apyrimidinic (AP) DNA via a beta-elimination reaction, a

7 aged or mismatched bases, producing apurinic/apyrimidinic (AP) DNA.

8 Apurinic/apyrimidinic (AP) endonuclease (APE) is a multifunctiona

9 The mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) is a multifunction

10 Apurinic/apyrimidinic (AP) endonuclease (APE; EC 4.2.99.18) plays

11 Human apurinic/apyrimidinic (AP) endonuclease (hAPE) initiates the repa

12 Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a central par

13 The overexpression of human apurinic/apyrimidinic (AP) endonuclease 1 (APE1/Ref-1), a key enz

14 nd 8-oxoG DNA glycosylase 1 (OGG1), apurinic/apyrimidinic (AP) endonuclease 1, DNA polymerase beta, a

15 A base excision repair protein, Apurinic/apyrimidinic (AP) endonuclease 2 (APE2, APN2, or APEX2),

16 ivity and Mg2+-independent class II apurinic/apyrimidinic (AP) endonuclease activity and represents g

17 responsible for >/=95% of the total apurinic/apyrimidinic (AP) endonuclease activity in human cells.

18 Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cel

19 n was highly purified and exhibited apurinic/apyrimidinic (AP) endonuclease activity.

20 with uracil-DNA glycosylase (UDG), apurinic/apyrimidinic (AP) endonuclease and DNA ligase I, pol iot

21 Ape1 is the major human apurinic/apyrimidinic (AP) endonuclease and initiates repair of a

22 Apurinic/apyrimidinic (AP) endonuclease and polymerase gamma acti

23 Apurinic/apyrimidinic (AP) endonuclease Ape1 is a key enzyme in t

24 y reported domain homologous to the apurinic/apyrimidinic (AP) endonuclease family and shows nicking

25 IV is the archetype for a conserved apurinic/apyrimidinic (AP) endonuclease family that primes DNA re

26 so known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells.

27 Apn1 is the major apurinic/apyrimidinic (AP) endonuclease in yeast.

28 ve identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in the human p

29 ay employs a mitochondrial class II apurinic/apyrimidinic (AP) endonuclease to cleave the DNA backbon

30 adenine-DNA glycosylase activity by apurinic/apyrimidinic (AP) endonuclease using murine homolog of M

31 abasic site repair and between the apurinic/apyrimidinic (AP) endonuclease, Ape1, and the 8-oxoguani

32 recombinant CSB and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physically and fun

33 ns from the BER pathway, such as an apurinic-apyrimidinic (AP) endonuclease, as turnover-enhancing co

34 ort overexpression of the S. mutans apurinic/apyrimidinic (AP) endonuclease, Smx, in Escherichia coli

35 Apurinic/apyrimidinic (AP) endonuclease-deficient cells are sensi

36 ty that was restored by addition of apurinic/apyrimidinic (AP) endonuclease.

37 NEIL1, Nei, Fpg, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, and Nfo), t

38 diates, organisms are equipped with apurinic/apyrimidinic (AP) endonucleases and 3'-nucleases that in

39 In Saccharomyces cerevisiae, the apurinic/apyrimidinic (AP) endonucleases Apn1 and Apn2 act as alt

40 , uracil residues are eliminated by apurinic/apyrimidinic (AP) endonucleases in the nucleotide incisi

41 Here we report that the apurinic/apyrimidinic (AP) endonucleases--Escherichia coli Xth an

42 ycosylase (mtUDG) and mitochondrial apurinic/apyrimidinic (AP) endonucleases.

43 or lethal lesions is carried out by apurinic/apyrimidinic (AP) endonucleases.

44 retrotransposons and resembles the apurinic/apyrimidinic (AP) endonucleases.

45 id DNA that carries a site-specific apurinic/apyrimidinic (AP) lesion as template, we have found that

46 Duplex DNA containing an apurinic/apyrimidinic (AP) lesion undergoes cleavage significantl

47 r to that recently reported for the apurinic/apyrimidinic (AP) lyase activity associated with Drosoph

48 mine glycol DNA glycosylase with an apurinic/apyrimidinic (AP) lyase activity encoded by the Escheric

49 Drosophila S3 also possesses an apurinic/apyrimidinic (AP) lyase activity in which the enzyme cat

50 been found to contain an associated apurinic/apyrimidinic (AP) lyase activity that cleaves phosphodie

51 t of glycosylases has an associated apurinic/apyrimidinic (AP) lyase activity that further processes

52 5' deoxyribosephosphate (5'dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed this activi

53 possessing both DNA glycosylase and apurinic/apyrimidinic (AP) lyase activity.

54 y that is associated with its known apurinic/apyrimidinic (AP) lyase activity.

55 pathway, initiated by N-glycosylase apurinic/apyrimidinic (AP) lyase proteins.

56 se III (hNth1) is a DNA glycosylase/apurinic/apyrimidinic (AP) lyase that initiates base excision rep

57 kDa adenine DNA glycosylase and 3' apurinic/apyrimidinic (AP) lyase that is active on DNA substrates

58 initiated by the DNA N-glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), the homolog

59 1), the two major DNA N-glycosylase/apurinic/apyrimidinic (AP) lyases involved in the repair of oxida

60 cerevisiae N-glycosylase-associated apurinic/apyrimidinic (AP) lyases that recognize a wide variety o

61 lexes each containing two synthetic apurinic/apyrimidinic (AP) residues, positioned on opposite stran

62 ugar-phosphate bond 3' to an intact apurinic/apyrimidinic (AP) site (i.e. AP lyase activity).

63 or less frequently an A opposite an apurinic/apyrimidinic (AP) site but was unable to extend the DNA

64 Excision of an apurinic/apyrimidinic (AP) site by cutting the phosphate backbone

65 e (APE1), an enzyme that cleaves an apurinic/apyrimidinic (AP) site from double stranded DNA.

66 bond cleavage creating an abasic or apurinic-apyrimidinic (AP) site in double-stranded DNA.

67 is pathway involves formation of an apurinic/apyrimidinic (AP) site in the DNA, which is further proc

68 step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonucleas

69 An apurinic/apyrimidinic (AP) site is one of the most abundant lesio

70 sert a dCMP opposite a DNA template apurinic/apyrimidinic (AP) site or a uracil residue.

71 o DNA repair lyase active sites for apurinic/apyrimidinic (AP) site processing, one within the N-term

72 otein for both O6-methylguanine and apurinic/apyrimidinic (AP) site repair as determined by biochemic

73 ed a substrate containing a reduced apurinic/apyrimidinic (AP) site resistant to beta-elimination and

74 DNA lesions arising in cells is an apurinic/apyrimidinic (AP) site resulting from base loss.

75 5hmC) when paired with a guanine, leaving an apyrimidinic (AP) site that is subsequently incised by t

76 al nucleotide capture, avoidance of apurinic/apyrimidinic (AP) site toxicity and coupling of damage-s

77 ost prevalent lesions in DNA is the apurinic/apyrimidinic (AP) site, which is derived from the cleava

78 facilitates DNA repair by reducing apurinic/apyrimidinic (AP) sites after MNNG exposure and facilita

79 lian AP-endonuclease (APE1) repairs apurinic/apyrimidinic (AP) sites and strand breaks with 3' blocks

80 bose, resulting in the formation of apurinic/apyrimidinic (AP) sites and strand breaks.

81 Apurinic/apyrimidinic (AP) sites are alkali labile lesions that,

82 Apurinic/apyrimidinic (AP) sites are common DNA lesions that aris

83 Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotox

84 Apurinic/apyrimidinic (AP) sites are constantly formed in cellula

85 Apurinic/apyrimidinic (AP) sites are continuously generated in ge

86 Non-coding apurinic/apyrimidinic (AP) sites are generated at high frequency

87 Apurinic/apyrimidinic (AP) sites are one of the most frequent les

88 Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesions that

89 base effects DNA strand cleavage at apurinic/apyrimidinic (AP) sites arising via simple glycosylase a

90 Repair of apurinic/apyrimidinic (AP) sites by mammalian cell extracts was c

91 anded DNA treated with PAP contains apurinic/apyrimidinic (AP) sites due to the removal of adenine.

92 sphate (dRP) groups from 5'-incised apurinic/apyrimidinic (AP) sites during base excision repair.

93 or protein responsible for excising apurinic/apyrimidinic (AP) sites from DNA, cleaves 5' to natural

94 In growing cells, apurinic/apyrimidinic (AP) sites generated spontaneously or resul

95 endonuclease 1 (APE1) to cleave at apurinic/apyrimidinic (AP) sites in a collection of tandem DNA re

96 Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually created i

97 major role in initiating repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hydrolytic

98 Mammalian cells repair apurinic/apyrimidinic (AP) sites in DNA by two distinct pathways:

99 Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as

100 human Ape1 protein is to incise at apurinic/apyrimidinic (AP) sites in DNA via site-specific endonuc

101 oval of endogenous base lesions and apurinic/apyrimidinic (AP) sites in DNA.

102 om human cells with specificity for apurinic/apyrimidinic (AP) sites in DNA.

103 etect traces of aldehyde-containing apurinic/apyrimidinic (AP) sites in nucleic acids has been develo

104 the PARP inhibitor is dependent on apurinic/apyrimidinic (AP) sites in the DNA and the presence of P

105 Repair of apurinic/apyrimidinic (AP) sites is initiated by AP endonucleases

106 Apurinic/apyrimidinic (AP) sites occur frequently in DNA as a res

107 terase on DNA containing 3'-incised apurinic/apyrimidinic (AP) sites to remove the product trans -4-h

108 ribose-5-phosphate at an incised 5' apurinic/apyrimidinic (AP) sites via a beta-elimination reaction.

109 t, deoxyinosine, and the numbers of apurinic/apyrimidinic (AP) sites were identical in DNA isolated f

110 age, including base loss (abasic or apurinic/apyrimidinic (AP) sites).

111 Apurinic/apyrimidinic (AP) sites, or abasic sites, which are a co

112 Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA

113 S damage to DNA is the formation of apurinic/apyrimidinic (AP) sites, which without removal are known

114 ase excision repair of premutagenic apurinic/apyrimidinic (AP) sites.

115 ease IV (endo IV), which recognizes apurinic/apyrimidinic (AP) sites.

116 and minor grooves of DNA containing apurinic/apyrimidinic (AP) sites.

117 as phosphoglycolates and abasic or apurinic/apyrimidinic (AP) sites.

118 ey produce [e.g., 8-oxo-guanine and apurinic/apyrimidinic (AP) sites] have been linked to the pathoge

119 , is a DNA glycosylase with abasic (apurinic/apyrimidinic (AP)) lyase activity and specifically cleav

120 ble strand breaks (DSB) and abasic (apurinic/apyrimidinic (AP)) sites in DNA.

121 stos induces the DNA repair enzyme, apurinic/apyrimidinic (AP)-endonuclease, in isolated mesothelial

122 Abasic [apurinic/apyrimidinic (AP)] sites are common, noncoding DNA lesio

123 We investigated whether apurinic/apyrimidinic (AP/abasic) sites were more frequent in reg

124 Abasic (apurinic/apyrimidinic; AP) sites are generated in vivo through sp

125 However, apyrimidinic/apurinic (AP) endonuclease-deficient cells

126 tivities of uracil DNA glycosylase (UDG) and apyrimidinic/apurinic endonuclease (APE) digest G:U mism

127 hat uses human uracil DNA glycosylase (UDG), apyrimidinic/apurinic endonuclease (APE), and DNA polyme

128 activity that removes the faulty base and an apyrimidinic/apurinic lyase activity that introduces a s

129 ormation, and stimulates its glycosylase and apyrimidinic/apurinic lyase enzymatic activities.

130 The solution state structures of the apyrimidinic DNA duplex, with D6 indicating an abasic si

131 phate (dRP) termini from preincised apurinic/apyrimidinic DNA, a substrate generated during certain t

132 ts was evaluated using a preincised apurinic/apyrimidinic DNA.

133 Apurinic/apyrimidinic endonuclease (AP endo) is a key enzyme in o

134 Apurinic/apyrimidinic endonuclease (AP endo) is a key enzyme in t

135 e endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major factor in

136 Apurinic/apyrimidinic endonuclease (AP endo) is believed to play

137 Apurinic/apyrimidinic endonuclease (AP endo) makes a single nick

138 state enzymatic binding kinetics of apurinic/apyrimidinic endonuclease (AP endo).

139 Apurinic/apyrimidinic endonuclease (APE) efficiently nicks DNA at

140 ied 12 property-based motifs in the apurinic/apyrimidinic endonuclease (APE) family of DNA-repair enz

141 o assess the possible role of human apurinic/apyrimidinic endonuclease (Ape) in double-strand break r

142 The human DNA repair protein apurinic/apyrimidinic endonuclease (APE) is a dual-function prote

143 esulting abasic sites are nicked by apurinic/apyrimidinic endonuclease (APE).

144 racil DNA glycosylases-2 (UNG2) and apurinic/apyrimidinic endonuclease (APE).

145 We showed that human apurinic/apyrimidinic endonuclease (APE-1) has exonuclease activi

146 ll lines accumulated high levels of apurinic/apyrimidinic endonuclease (APE-1/Ref-1, redox effector-1

147 singly, this enzyme was found to be apurinic/apyrimidinic endonuclease (APE1) (), a well characterize

148 Human apurinic/apyrimidinic endonuclease (APE1) is an essential enzyme

149 It is known that apurinic/apyrimidinic endonuclease (APE1) plays a crucial role in

150 Human DNA apurinic/apyrimidinic endonuclease (APE1) plays a key role in the

151 Human apurinic/apyrimidinic endonuclease (Ape1) plays an important role

152 hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1), proliferating cell nuc

153 The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2

154 shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrated by coi

155 hMYH and apurinic/apyrimidinic endonuclease (hAPE1) co-migrate with the pr

156 air enzyme, Redox effector factor-1/apurinic/apyrimidinic endonuclease (Ref-1/Ape), facilitates DNA b

157 opting a G-quadruplex fold in which apurinic/apyrimidinic endonuclease 1 (APE1) binds, but inefficien

158 The apurinic/apyrimidinic endonuclease 1 (APE1) functions are altered

159 Although it is presumed that the apurinic/apyrimidinic endonuclease 1 (APE1) generates DNA strand

160 Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional

161 Human apurinic/apyrimidinic endonuclease 1 (APE1) is an important enzym

162 Apurinic/apyrimidinic endonuclease 1 (APE1) is the main abasic en

163 Apurinic/apyrimidinic endonuclease 1 (APE1) plays a central role

164 We have also found that apurinic/apyrimidinic endonuclease 1 (APE1) stimulates long patch

165 we determined the ability of human apurinic/apyrimidinic endonuclease 1 (APE1) to cleave at apurinic

166 We found that the nuclear apurinic/apyrimidinic endonuclease 1 (APE1), a core enzyme in bas

167 Apurinic/apyrimidinic endonuclease 1 (APE1), a member of the diva

168 P-BER), including DNA glycosylases, apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymerase beta

169 ntial base excision repair protein, apurinic/apyrimidinic endonuclease 1 (APE1), plays an important r

170 d by DNA polymerase beta (Polbeta), apurinic/apyrimidinic endonuclease 1 (APE1), poly(ADP-ribose) pol

171 hosphate dehydrogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1 (Ape1), the major oxidized D

172 mmalian base excision repair (BER), apurinic/apyrimidinic endonuclease 1 (APE1).

173 sential base-excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1)/redox effector factor

174 lases and the downstream processing apurinic/apyrimidinic endonuclease 1 (APE1)] can be tested simult

175 ession of critical DNA repair genes apurinic/apyrimidinic endonuclease 1 (Apex1) and DNA polymerase b

176 Apurinic/apyrimidinic endonuclease 1 (APEX1) participates in the

177 ins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and

178 t findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism.

179 r mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still

180 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme invol

181 show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processi

182 We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA-interact

183 rmediate, the DNA is channeled from apurinic/apyrimidinic endonuclease 1 to DNA polymerase beta and t

184 acterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins,

185 Apurinic/apyrimidinic endonuclease 1, a key enzyme in repairing a

186 e reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dephosphoryl

187 selected DNA glycosylases and human apurinic/apyrimidinic endonuclease 1.

188 The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE

189 tiate radiotherapy, we investigated apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1)

190 or the base excision repair enzyme, apurinic/apyrimidinic endonuclease 2 (APE2) protein develop relat

191 The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'

192 ly of DNA repair enzymes, including apurinic/apyrimidinic endonuclease activity and repair activities

193 d with an increase in mitochondrial apurinic/apyrimidinic endonuclease activity in both H2O2- and O2-

194 uced 6.8-fold, and no difference in apurinic/apyrimidinic endonuclease activity is observed.

195 p53 did not influence mitochondrial apurinic/apyrimidinic endonuclease activity measured by incision

196 sic residues, which result from the apurinic/apyrimidinic endonuclease activity of Ape1.

197 n by a mechanism independent of its apurinic/apyrimidinic endonuclease activity.

198 la ribosomal protein P0 contains an apurinic/apyrimidinic endonuclease activity.

199 e transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of chromosome

200 The major mammalian apurinic/apyrimidinic endonuclease Ape1 is a multifunctional prot

201 NA damage is initiated by the major apurinic/apyrimidinic endonuclease Ape1, which specifically recog

202 smatch repair enzyme MUTYH, and the apurinic-apyrimidinic endonuclease APEX2.

203 tudies in vitro indicate that after apurinic-apyrimidinic endonuclease cleaves immediately upstream o

204 asic site; this site was incised by apurinic/apyrimidinic endonuclease creating a nick with 3'-hydrox

205 59 amino acids with homology to the apurinic/apyrimidinic endonuclease family of DNA repair enzymes.

206 r ung and mutY glycosylase and xthA apurinic/apyrimidinic endonuclease genes in H. pylori, mutants of

207 age and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hypersensitiv

208 dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells

209 ition to its primary activity as an apurinic/apyrimidinic endonuclease in BER, Ape1 also possesses 3'

210 Apurinic/apyrimidinic endonuclease is a key enzyme in the process

211 Inhibition of apurinic/apyrimidinic endonuclease may therefore be a reasonable

212 n the A-strand by N-glycosylase and apurinic/apyrimidinic endonuclease or lyase activities.

213 nd U/G mispairs in double-stranded DNA; (ii) apyrimidinic endonuclease that cleaves double-stranded D

214 wo endonuclease III homologs and an apurinic/apyrimidinic endonuclease) that might account for this a

215 cil DNA glycosylase (UL2), cellular apurinic/apyrimidinic endonuclease, and DNA ligase IIIalpha-XRCC1

216 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with incr

217 d from yeast deficient in the major apurinic/apyrimidinic endonuclease, Apnl.

218 a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embr

219 e excision repair proteins, such as apurinic/apyrimidinic endonuclease, DNA polymerase beta, and liga

220 an enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap end

221 DNA glycosylase, strand scission by apurinic/apyrimidinic endonuclease, DNA resynthesis and ligation.

222 tions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human pol gamma was able to f

223 ssed at high levels relative to the apurinic/apyrimidinic endonuclease, increases spontaneous mutatio

224 Apurinic/apyrimidinic endonuclease-1 (APE-1) regulates transcript

225 Human apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzyme involv

226 Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-

227 und that recombinant purified human apurinic/apyrimidinic endonuclease-1 (APE1) and APE1 from human c

228 Apurinic/apyrimidinic endonuclease-1 (APE1) is a multifunctional

229 Apurinic/apyrimidinic endonuclease-1 (APE1) is an essential enzym

230 Aberrant expression of apurinic-apyrimidinic endonuclease-1 (APEX1) has been reported in

231 Apurinic/apyrimidinic endonuclease-1/redox effector factor-1 (APE

232 tly reported that the expression of apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE-1/Ref-1)

233 extraribosomal functions, including apurnic-apyrimidinic endonuclease-like activity suggested to be

234 ealed that it comprises a standalone apurnic-apyrimidinic endonuclease-like domain.

235 I, poly(ADP-ribose) polymerase, and apurinic/apyrimidinic endonuclease.

236 uclease-1, DNA polymerase beta, and apurinic/apyrimidinic endonuclease.

237 o one encoding ribosomal protein P0/apurinic/apyrimidinic endonuclease.

238 Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) (h

239 The dual-function protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/ref-1) is

240 Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) is

241 The apurinic/apyrimidinic endonucleases (APE) contain several highly

242 IV belongs to a class of important apurinic/apyrimidinic endonucleases involved in DNA repair.

243 that is related in sequence to the apurinic-apyrimidinic endonucleases that participate in DNA repai

244 abasic sites, which are excised by apurinic/apyrimidinic endonucleases, eventually generating double

245 I, FAPY DNA glycosylase, both known apurinic/apyrimidinic endonucleases, or DNA deoxyribophosphodiest

246 ediates by the specific activity of apurinic/apyrimidinic endonucleases.

247 L1 retrotransposon and also to the apurinic/apyrimidinic endonucleases.

248 The apyrimidinic gap was not penetrated by water until the a

249 , an enzyme required for processing apurinic/apyrimidinic (known as abasic) sites, is also involved i

250 stimulated both the glycosylase and apurinic/apyrimidinic lyase activities of OGG1.

251 oli has adenine DNA glycosylase and apurinic/apyrimidinic lyase activities on A/G- and A/7,8-dihydro-

252 enzyme that has DNA glycosylase and apurinic/apyrimidinic lyase activities.

253 However, MutY(Dr) exhibits limited apurinic/apyrimidinic lyase activity and can form only weak coval

254 s a single strand break through its apurinic/apyrimidinic lyase activity to initiate base excision re

255 ycosylases that possess concomitant apurinic/apyrimidinic lyase activity.

256 so suggest a role for Glu161 in the apurinic/apyrimidinic lyase chemistry.

257 with adenine that the abasic site (apurinic/apyrimidinic) lyase activity is alternatively regulated

258 DNA N-glycosylase/AP (apurinic/apyrimidinic) lyase enzymes of the endonuclease III fami

259 hermore, mtTGendo has an associated apurinic/apyrimidinic-lyase activity.

260 over, in vitro assays revealed that apurinic/apyrimidinic nuclease 1 provides nearly maximum stimulat

261 Thus, under our assay conditions, apurinic/apyrimidinic nuclease 1-mediated stimulation or other me

262 Abasic (apurinic/apyrimidinic or AP) sites are a frequent type of DNA dam

263 ichia coli exonuclease III (Exo III) removes apyrimidinic or apurinic (AP) sites and 3'-phosphate ter

264 e1 recruits pol beta to the incised apurinic/apyrimidinic site and stimulates 5'-dRP excision by pol

265 ent enzyme-DNA intermediate complex with the apyrimidinic site created by the glycosylase; and (iii)

266 abasic site is further processed by apurinic/apyrimidinic site endonuclease 1 (APE1) to create a sing

267 the T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase (T4-pdg) has been exploited, nam

268 in, T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase.

269 mes more tightly toward its product apurinic/apyrimidinic site than the substrate, whereas full-lengt

270 er bond 5 ' to a baseless sugar (apurinic or apyrimidinic site).

271 anodeoxyguanosine adduct and (2) an apurinic/apyrimidinic site, and the initiation of repair was exam

272 ackbone in DNA on the 5' side of an apurinic/apyrimidinic site, was monitored by FCCS using a double-

273 ity of a DNA fragment containing an apurinic/apyrimidinic site.

274 and then nicks the nascent abasic (apurinic/apyrimidinic) site by beta-elimination.

275 nliganded or bound to an abasic (apurinic or apyrimidinic) site, until now there was no structure of

276 trong binding by Dug to the reaction product apyrimidinic-site (AP) DNA.

277 Ung H187D binding to thymine-, uracil-, and apyrimidinic-site-containing DNA was (dT20) = (dT19-U) >

278 II poisons, the effects of position-specific apyrimidinic sites and deaminated cytosines (i.e. uracil

279 MPG binding affinity toward Hx and apurinic/apyrimidinic sites and thus is essential for the Hx clea

280 vitro assay measuring the repair of apurinic/apyrimidinic sites by untreated and oltipraz-treated HT-

281 rate single-strand breaks (SSBs) at apurinic/apyrimidinic sites do not form DSBs immediately after me

282 pe1 protein initiates the repair of apurinic/apyrimidinic sites during mammalian base excision repair

283 nzyme that initiates the removal of apurinic/apyrimidinic sites from DNA, excises 3' replication-bloc

284 We further demonstrate that most apurinic/apyrimidinic sites in highly transcribed DNA are derived

285 ver, apurinic sites dominated the effects of apyrimidinic sites in substrates that contained multiple

286 re we show that the accumulation of apurinic/apyrimidinic sites is greatly enhanced in highly transcr

287 tY with GO mispaired with T, G, and apurinic/apyrimidinic sites may be involved in the regulation of

288 ates of religation for substrates containing apyrimidinic sites or deaminated cytosines.

289 ase of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase

290 eaved and religated a DNA substrate in which apyrimidinic sites were simultaneously incorporated at e

291 ability to be covalently trapped to apurinic/apyrimidinic sites within duplex DNA under reducing cond

292 mage, as determined by the level of apurinic/apyrimidinic sites, also decreased significantly followi

293 lian species, the effects of apurinic sites, apyrimidinic sites, and deaminated cytosine residues on

294 of oxidative DNA adducts, mutagenic apurinic/apyrimidinic sites, and expression of base excision DNA

295 which fail to seal SSBs induced at apurinic/apyrimidinic sites, exhibit strongly elevated levels of

296 roduct-inhibited by both uracil and apurinic/apyrimidinic sites.

297 y prevent processing of 8-oxo-G and apurinic/apyrimidinic sites.

298 Abasic (apurinic/apyrimidinic) sites are among the most abundant DNA lesi

299 tive in base excision repair of AP (apurinic/apyrimidinic) sites in DNA.

300 tion mutant, the 5'-incision at AP (apurinic/apyrimidinic) sites is not detectable, supporting the no