ライフサイエンスコーパス: apyrimidinic endonuclease

1 o one encoding ribosomal protein P0/apurinic/apyrimidinic endonuclease.

2 I, poly(ADP-ribose) polymerase, and apurinic/apyrimidinic endonuclease.

3 uclease-1, DNA polymerase beta, and apurinic/apyrimidinic endonuclease.

4 L1 retrotransposon and also to the apurinic/apyrimidinic endonucleases.

5 ediates by the specific activity of apurinic/apyrimidinic endonucleases.

6 opting a G-quadruplex fold in which apurinic/apyrimidinic endonuclease 1 (APE1) binds, but inefficien

7 The apurinic/apyrimidinic endonuclease 1 (APE1) functions are altered

8 Although it is presumed that the apurinic/apyrimidinic endonuclease 1 (APE1) generates DNA strand

9 Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional

10 Human apurinic/apyrimidinic endonuclease 1 (APE1) is an important enzym

11 Apurinic/apyrimidinic endonuclease 1 (APE1) is the main abasic en

12 Apurinic/apyrimidinic endonuclease 1 (APE1) plays a central role

13 We have also found that apurinic/apyrimidinic endonuclease 1 (APE1) stimulates long patch

14 we determined the ability of human apurinic/apyrimidinic endonuclease 1 (APE1) to cleave at apurinic

15 We found that the nuclear apurinic/apyrimidinic endonuclease 1 (APE1), a core enzyme in bas

16 Apurinic/apyrimidinic endonuclease 1 (APE1), a member of the diva

17 P-BER), including DNA glycosylases, apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymerase beta

18 ntial base excision repair protein, apurinic/apyrimidinic endonuclease 1 (APE1), plays an important r

19 d by DNA polymerase beta (Polbeta), apurinic/apyrimidinic endonuclease 1 (APE1), poly(ADP-ribose) pol

20 hosphate dehydrogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1 (Ape1), the major oxidized D

21 mmalian base excision repair (BER), apurinic/apyrimidinic endonuclease 1 (APE1).

22 sential base-excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1)/redox effector factor

23 lases and the downstream processing apurinic/apyrimidinic endonuclease 1 (APE1)] can be tested simult

24 ession of critical DNA repair genes apurinic/apyrimidinic endonuclease 1 (Apex1) and DNA polymerase b

25 Apurinic/apyrimidinic endonuclease 1 (APEX1) participates in the

26 ins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and

27 t findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism.

28 r mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still

29 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme invol

30 show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processi

31 We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA-interact

32 rmediate, the DNA is channeled from apurinic/apyrimidinic endonuclease 1 to DNA polymerase beta and t

33 acterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins,

34 Apurinic/apyrimidinic endonuclease 1, a key enzyme in repairing a

35 e reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dephosphoryl

36 selected DNA glycosylases and human apurinic/apyrimidinic endonuclease 1.

37 The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE

38 tiate radiotherapy, we investigated apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1)

39 Apurinic/apyrimidinic endonuclease-1 (APE-1) regulates transcript

40 Human apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzyme involv

41 Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-

42 und that recombinant purified human apurinic/apyrimidinic endonuclease-1 (APE1) and APE1 from human c

43 Apurinic/apyrimidinic endonuclease-1 (APE1) is a multifunctional

44 Apurinic/apyrimidinic endonuclease-1 (APE1) is an essential enzym

45 Aberrant expression of apurinic-apyrimidinic endonuclease-1 (APEX1) has been reported in

46 Apurinic/apyrimidinic endonuclease-1/redox effector factor-1 (APE

47 tly reported that the expression of apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE-1/Ref-1)

48 or the base excision repair enzyme, apurinic/apyrimidinic endonuclease 2 (APE2) protein develop relat

49 The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'

50 nuclease activities of Rrp1 include apurinic/apyrimidinic endonuclease, 3'-phosphodiesterase, 3'-phos

51 ly of DNA repair enzymes, including apurinic/apyrimidinic endonuclease activity and repair activities

52 d with an increase in mitochondrial apurinic/apyrimidinic endonuclease activity in both H2O2- and O2-

53 uced 6.8-fold, and no difference in apurinic/apyrimidinic endonuclease activity is observed.

54 p53 did not influence mitochondrial apurinic/apyrimidinic endonuclease activity measured by incision

55 sic residues, which result from the apurinic/apyrimidinic endonuclease activity of Ape1.

56 la ribosomal protein P0 contains an apurinic/apyrimidinic endonuclease activity.

57 n by a mechanism independent of its apurinic/apyrimidinic endonuclease activity.

58 e transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of chromosome

59 cil DNA glycosylase (UL2), cellular apurinic/apyrimidinic endonuclease, and DNA ligase IIIalpha-XRCC1

60 DNA polymerase beta, apurinic/apyrimidinic endonuclease, and lactate dehydrogenase act

61 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with incr

62 Apurinic/apyrimidinic endonuclease (AP endo) is a key enzyme in o

63 Apurinic/apyrimidinic endonuclease (AP endo) is a key enzyme in t

64 e endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major factor in

65 Apurinic/apyrimidinic endonuclease (AP endo) is believed to play

66 Apurinic/apyrimidinic endonuclease (AP endo) makes a single nick

67 state enzymatic binding kinetics of apurinic/apyrimidinic endonuclease (AP endo).

68 Apurinic/apyrimidinic endonuclease (APE) efficiently nicks DNA at

69 ied 12 property-based motifs in the apurinic/apyrimidinic endonuclease (APE) family of DNA-repair enz

70 o assess the possible role of human apurinic/apyrimidinic endonuclease (Ape) in double-strand break r

71 The human DNA repair protein apurinic/apyrimidinic endonuclease (APE) is a dual-function prote

72 esulting abasic sites are nicked by apurinic/apyrimidinic endonuclease (APE).

73 racil DNA glycosylases-2 (UNG2) and apurinic/apyrimidinic endonuclease (APE).

74 We showed that human apurinic/apyrimidinic endonuclease (APE-1) has exonuclease activi

75 ll lines accumulated high levels of apurinic/apyrimidinic endonuclease (APE-1/Ref-1, redox effector-1

76 The apurinic/apyrimidinic endonucleases (APE) contain several highly

77 The major mammalian apurinic/apyrimidinic endonuclease Ape1 is a multifunctional prot

78 NA damage is initiated by the major apurinic/apyrimidinic endonuclease Ape1, which specifically recog

79 singly, this enzyme was found to be apurinic/apyrimidinic endonuclease (APE1) (), a well characterize

80 Human apurinic/apyrimidinic endonuclease (APE1) is an essential enzyme

81 It is known that apurinic/apyrimidinic endonuclease (APE1) plays a crucial role in

82 Human DNA apurinic/apyrimidinic endonuclease (APE1) plays a key role in the

83 Human apurinic/apyrimidinic endonuclease (Ape1) plays an important role

84 hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1), proliferating cell nuc

85 smatch repair enzyme MUTYH, and the apurinic-apyrimidinic endonuclease APEX2.

86 d from yeast deficient in the major apurinic/apyrimidinic endonuclease, Apnl.

87 a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embr

88 tudies in vitro indicate that after apurinic-apyrimidinic endonuclease cleaves immediately upstream o

89 asic site; this site was incised by apurinic/apyrimidinic endonuclease creating a nick with 3'-hydrox

90 an proteins uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta and DNA l

91 e excision repair proteins, such as apurinic/apyrimidinic endonuclease, DNA polymerase beta, and liga

92 an enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap end

93 DNA glycosylase, strand scission by apurinic/apyrimidinic endonuclease, DNA resynthesis and ligation.

94 abasic sites, which are excised by apurinic/apyrimidinic endonucleases, eventually generating double

95 59 amino acids with homology to the apurinic/apyrimidinic endonuclease family of DNA repair enzymes.

96 r ung and mutY glycosylase and xthA apurinic/apyrimidinic endonuclease genes in H. pylori, mutants of

97 The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2

98 shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrated by coi

99 hMYH and apurinic/apyrimidinic endonuclease (hAPE1) co-migrate with the pr

100 tions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human pol gamma was able to f

101 age and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hypersensitiv

102 dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells

103 ition to its primary activity as an apurinic/apyrimidinic endonuclease in BER, Ape1 also possesses 3'

104 ssed at high levels relative to the apurinic/apyrimidinic endonuclease, increases spontaneous mutatio

105 IV belongs to a class of important apurinic/apyrimidinic endonucleases involved in DNA repair.

106 Apurinic/apyrimidinic endonuclease is a key enzyme in the process

107 extraribosomal functions, including apurnic-apyrimidinic endonuclease-like activity suggested to be

108 ealed that it comprises a standalone apurnic-apyrimidinic endonuclease-like domain.

109 Inhibition of apurinic/apyrimidinic endonuclease may therefore be a reasonable

110 purified Crc proteins show neither apurinic/apyrimidinic endonuclease nor exonuclease activity.

111 n the A-strand by N-glycosylase and apurinic/apyrimidinic endonuclease or lyase activities.

112 I, FAPY DNA glycosylase, both known apurinic/apyrimidinic endonucleases, or DNA deoxyribophosphodiest

113 Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) (h

114 Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) is

115 The dual-function protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/ref-1) is

116 air enzyme, Redox effector factor-1/apurinic/apyrimidinic endonuclease (Ref-1/Ape), facilitates DNA b

117 nd U/G mispairs in double-stranded DNA; (ii) apyrimidinic endonuclease that cleaves double-stranded D

118 that is related in sequence to the apurinic-apyrimidinic endonucleases that participate in DNA repai

119 wo endonuclease III homologs and an apurinic/apyrimidinic endonuclease) that might account for this a