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1 s log colony-forming units per milliliter of aqueous humor.
2 on of transforming growth factor-beta in the aqueous humor.
3 body are critical for the production of the aqueous humor.
4 both mutated and wild-type myocilin into the aqueous humor.
5 aration at the concentration levels found in aqueous humor.
6 ow that mutant MYOC is not secreted into the aqueous humor.
7 nalyze myocilin complex formation in porcine aqueous humor.
8 which clearly distinguished POAG from normal aqueous humor.
9 a2 levels are elevated in glaucomatous human aqueous humor.
10 (DMEM) or DMEM supplemented with 50% porcine aqueous humor.
11 ents, but only after incubation with porcine aqueous humor.
12 etermined by direct measurement of aspirated aqueous humor.
13 s and functions to produce components of the aqueous humor.
14 ed by reduced pressure-dependent drainage of aqueous humor.
15 ributes to the immunosuppressive activity of aqueous humor.
16 that ranged the level of SOM found in normal aqueous humor.
17 flat cells that separate the cornea from the aqueous humor.
18 when novobiocin (0.1 mM) was present in the aqueous humor.
19 d in reliably high ESBA105 concentrations in aqueous humor.
20 of impedance of nutritional support from the aqueous humor.
21 ll infiltration and protein concentration in aqueous humor.
22 ng hormone, at concentrations present in the aqueous humor (10-9 M), as well as melanocyte-stimulatin
23 , urine (64 days), amniotic fluid (38 days), aqueous humor (101 days), cerebrospinal fluid (9 months)
24 able Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 week
25 ly if myocilin was preincubated with porcine aqueous humor (78% +/- 77% when preincubated in DMEM con
26 generation of regulatory T cells (Tregs) by aqueous humor (AH) and identified TGF-beta as a critical
27 beta 2 (TGFbeta(2)) is often elevated in the aqueous humor (AH) and trabecular meshwork (TM) of patie
28 trophozoites can enter the AC; however, the aqueous humor (AH) contains factors that either induce e
29 lar pressure (IOP) resulting from diminished aqueous humor (AH) drainage through the trabecular pathw
31 rmed by enzyme-linked immunosorbent assay in aqueous humor (AH) obtained from human donor eyes (POAG
33 ribution of MRP4 in human TM (HTM) cells and aqueous humor (AH) outflow pathway was determined by RT-
34 intraocular pressure (IOP) due to increased aqueous humor (AH) outflow resistance, which is associat
35 tension arising from increased resistance to aqueous humor (AH) outflow through the trabecular meshwo
37 P results from the resistance to drainage of aqueous humor (AH) produced by the ciliary body in a pro
40 ed interleukin (IL)-6 and IL-8 levels in the aqueous humor and a concomitant approximately twofold (P
41 ting the secretion of mutant myocilin in the aqueous humor and by decreasing intracellular accumulati
42 Best2 appears to antagonize the formation of aqueous humor and cause an inhibition of both F(c) and F
43 els of TNF-alpha, CCL-2/MCP-1, and ICAM-1 in aqueous humor and CCL-2/MCP-1 and ICAM-1 levels in retin
45 ommunicate via soluble agents present in the aqueous humor and implicate Best2 as a critical mediator
46 In addition, Gremlin was present in human aqueous humor and in the perfusate medium of perfusion-c
47 AG) based on elevated levels in glaucomatous aqueous humor and its ability to induce extracellular ma
48 ntercellular adhesion molecule-1 (ICAM-1) in aqueous humor and retina and nuclear translocation of nu
49 fate proteoglycan (HSPG) was found in bovine aqueous humor and that it directly inhibits binding of b
51 antioxidant- and UV-trapping molecule in the aqueous humor and the lens, was used to investigate the
52 active form (hDE-117) was maintained in the aqueous humor and the target tissue (iris-ciliary body)
53 that regulate pressure-dependent drainage of aqueous humor and thus intraocular pressure (IOP) are un
55 egment, and comparing myocilin levels in the aqueous humor and trabecular meshwork of Tg-MYOC(Y437H)
58 Further, a single dose of DPT-GFX sustained aqueous humor and vitreous humor drug levels during the
59 lenses are capable of protecting the cornea, aqueous humor, and crystalline lens of rabbits from UV-i
61 modeling, that the concentration of HSPG in aqueous humor (approximately 4 microg/ml), when combined
64 tic lymphocytes were found to be absent from aqueous humor (AqH) of virtually all patients with recen
65 ere killed when the disease was at its peak; aqueous humor (AqH) was collected from one eye, and the
66 s after LPS injection, eyes were enucleated, aqueous humor (AqH) was collected, and the number of inf
71 mammals in which secretion and absorption of aqueous humor are circumferential around and through the
72 iliary body and the activity of MMP-2 in the aqueous humor are increased whereas tissue inhibitor of
74 after injection of killed bacteria into the aqueous humor at any time point; however, injection of S
77 Mutant myocilin was not secreted into the aqueous humor but accumulated in the ER of the trabecula
80 sustained therapeutic drug concentrations in aqueous humor can be achieved for long-term (i.e., 28 da
81 much better efficacy with significantly less aqueous humor cells and lower vitreous opacity scores (p
82 and the mechanisms causing elevated IOP from aqueous humor circulation, we pursued proteomic analyses
84 regions, oxygen levels were decreased in the aqueous humor closest to the pars plicata of the ciliary
88 l growth factor (VEGF) concentrations in the aqueous humor decreased (P = 0.0003), whereas the concen
89 omes after treatment with IFN-gamma, porcine aqueous humor, dexamethasone, or a calcium ionophore in
91 re grown in DMEM supplemented with 50% human aqueous humor (DMEM-AH), heat-denatured DMEM-AH, 10% fet
93 odeling of ECM is crucial to maintain normal aqueous humor drainage and intraocular pressure (IOP).
95 sure as the result of abnormal resistance to aqueous humor drainage is a major contributing, and the
96 d intraocular pressure (IOP) due to impaired aqueous humor drainage is a major risk factor for the de
97 of the anterior chamber angle containing the aqueous humor drainage tissue in situ were imaged by TPE
98 is characterized by increased resistance to aqueous humor drainage, elevated IOP, optic nerve degene
100 TNF-alpha is elevated in the cornea and aqueous humor during allograft rejection and anterior uv
104 arding the effects of glaucoma medication on aqueous humor dynamics and the impact of this on intraoc
105 igates the correlation between parameters of aqueous humor dynamics and the influence of CCT in healt
108 macologic agents or genetic manipulations on aqueous humor dynamics in mice and other animal models.
111 fluorescence provides a noninvasive index of aqueous humor dynamics in the mouse eye that facilitates
112 ure of the tissues and cells specialized for aqueous humor dynamics in zebrafish show conservation wi
117 on the molecular and cellular mechanisms of aqueous humor dynamics using this species, the authors h
120 with NO's having a mechanoregulatory role in aqueous humor dynamics, with eNOS induction at elevated
122 itric oxide (NO) increases the rate at which aqueous humor exits the eye; however, the involvement of
124 toprost that in humans increases the rate of aqueous humor flow as measured by fluorophotometry.
125 cantly during the nocturnal period, although aqueous humor flow decreases by 50% or more at night.
128 of topical ibopamine on pupillary diameter, aqueous humor flow measured by fluorophotometry, and int
131 c outflow facility (C) and fluorophotometric aqueous humor flow rates (F) were measured in nine norma
132 d in the regulation of outflow resistance of aqueous humor flow through the trabecular meshwork (TM).
134 These observations support the posit that aqueous humor flow, which is a factor that contributes t
136 trabecular meshwork (TM) cells might detect aqueous humor fluid shear stress via interaction of the
137 of the eye, particularly in the drainage of aqueous humor fluid, which are believed to bring about c
140 cannulation under pentobarbital anesthesia, aqueous humor formation (AHF), anterior chamber volume,
141 in understanding the mechanisms controlling aqueous humor formation and thereby intraocular pressure
146 ar meshwork (TM) tissue controls drainage of aqueous humor from the anterior chamber of the eye prima
147 rog/ml), when combined with the clearance of aqueous humor from the eye due to circulation, is suffic
148 ns to maintain fluid homeostasis by draining aqueous humor from the eye into the systemic circulation
149 le, with a resultant increase in drainage of aqueous humor from the eye, we compared the effects of t
150 structure in the eye that functions to drain aqueous humor from the intraocular chamber into systemic
151 to quantify the effect of dynamic motion of aqueous humor from the posterior to the anterior chamber
154 n the levels of immunoglobulin G in serum or aqueous humor in microMT mice, and there was no increase
156 athology in the primary drainage pathway for aqueous humor in the eye is responsible for ocular hyper
160 tive conclusions about the relative roles of aqueous humor inflow and outflow in conditions with alte
164 rming growth factor-beta2 (TGF-beta2) in the aqueous humor is the main cause of fibrosis of TM in POA
165 drug concentrations in intraocular tissues (aqueous humor, lens, and iris) versus eyes not receiving
166 Patients with AMD had significantly higher aqueous humor levels of cadmium (median: 0.70 micromol/L
167 No significant differences were observed in aqueous humor levels of manganese and selenium between p
169 ation of MMC to the endothelium and into the aqueous humor may lead surgeons to reassess appropriate
170 y demonstrated presence of leukocytes in the aqueous humor, migration of PMNs into infected tissue, c
172 an unclassified uveitis, 7 of whom underwent aqueous humor (n = 5) or vitreous humor (n = 2) analysis
173 liary body and level of IL-18 protein in the aqueous humor of DBA/2J mice are dramatically increased
174 r testing 16 clinical samples collected from aqueous humor of patients undergoing therapeutic anterio
175 d compare the cytokine concentrations in the aqueous humor of patients with acute nonarteritic anteri
176 sure alterations of trace elements levels in aqueous humor of patients with non-exsudative (dry) AMD.
178 os with free metalloproteinases (MMP) in the aqueous humor of patients with primary open angle glauco
179 of 6-carboxyfluorescein elimination from the aqueous humor of the perfused eye was reduced 80% when n
181 f SC has been proposed to underlie increased aqueous humor outflow (AHO) resistance, which leads to e
182 is characterized by increased resistance to aqueous humor outflow and a stiffer human trabecular mes
183 leton disruptor that decreases resistance to aqueous humor outflow and decreases intraocular pressure
184 on of the eye, plays a key role in promoting aqueous humor outflow and maintenance of normal intraocu
185 ligands that offer the potential to improve aqueous humor outflow and protect RGCs simultaneously, a
186 cides with a reduction in available area for aqueous humor outflow and the confinement of outflow to
188 or 96 hours caused a significant increase in aqueous humor outflow facility (110%) compared with cont
189 way, blocked both PEA-induced enhancement of aqueous humor outflow facility and PEA-induced phosphory
190 ate that the administration of AEA increases aqueous humor outflow facility and that this effect of A
191 cine eyes produced a significant decrease in aqueous humor outflow facility from baseline of 37% (n =
192 as used to measure the effects of statins on aqueous humor outflow facility in the anterior segments
194 dding 3, 30, or 300 nM of noladin ether, the aqueous humor outflow facility increased concentration d
199 is study was to investigate the variation of aqueous humor outflow facility with body position change
200 ed to significantly reduced IOP and improved aqueous humor outflow facility, which was sustained for
210 ilocarpine and latanoprost, known to enhance aqueous humor outflow in humans, accelerated the decay o
211 was efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myo
212 lar pressure (IOP) caused by a resistance to aqueous humor outflow in the trabecular meshwork (TM).
213 hat selective inhibition of myosin II in the aqueous humor outflow pathway leads to increased aqueous
214 tructure or alterations in morphology of the aqueous humor outflow pathway were observed after treatm
215 fy druggable targets within the conventional aqueous humor outflow pathway, which is thought to be re
217 and organization is required to maintain the aqueous humor outflow resistance and intraocular pressur
218 ontribute to the homeostatic modification of aqueous humor outflow resistance are also upregulated or
219 he trabecular meshwork (TM) provides most of aqueous humor outflow resistance in the eye, an in vitro
220 assess versican's potential contributions to aqueous humor outflow resistance, its segmental distribu
221 se, they make homeostatic corrections in the aqueous humor outflow resistance, partially by increasin
223 ity of the TM tissue and consequently impede aqueous humor outflow resulting in elevated intraocular
224 In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in el
226 and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) a
227 Our results demonstrate that PEA increases aqueous humor outflow through the TM pathway and these e
228 ular pressure due to increased resistance of aqueous humor outflow through the trabecular meshwork (T
231 ins in the aqueous outflow pathway increases aqueous humor outflow, possibly through altered cell adh
235 ll volume changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular m
236 al (SC) cells may also provide resistance to aqueous humor outflow; therefore, this study tests the i
241 (EVP), conventional outflow facility (C(t)), aqueous humor production (F(a)), and anterior chamber vo
242 m of the mouse eye results in a reduction in aqueous humor production and complete loss of the vitreo
243 is consistent with a major role of alpha2 in aqueous humor production and suggests that, potentially,
245 normal monkeys appeared to have no effect on aqueous humor production or tonographic outflow facility
249 n, as there was no significant difference in aqueous humor protein concentration between treated and
257 ry cytokines, and correlate levels with IOP, aqueous humor samples were analyzed from 23 eyes with op
261 urther by determining the phosphorylation of aqueous humor sCD44 in normal and primary open-angle gla
263 gh two mechanisms: CA inhibition to decrease aqueous humor secretion (reduce inflow) and NO release t
264 the ocular anterior segment responsible for aqueous humor secretion and absorption have been well ch
265 were used to identify and study the sites of aqueous humor secretion and absorption in adult zebrafis
266 IOP is controlled by the balance between aqueous humor secretion from the ciliary body (CB) and i
268 d by cell culture from blood, saliva, urine, aqueous humor, semen, and breast milk from infected or c
269 (0.1 mM) or novobiocin (0.1 mM) added to the aqueous humor side of the tissue, or MK571 (5-(3-(2-(7-c
270 in reaction detected parasite DNA in 8/60 OT aqueous humor specimens but failed to identify Type II s
274 freezing, IL-1beta released by PMNs into the aqueous humor stimulates FGF-2 synthesis in corneal endo
275 oid, a calcium ionophore, and a component of aqueous humor, suggesting that TM cells respond to envir
277 yocilin appears to form a complex in porcine aqueous humor that enables it to bind specifically withi
278 ncrease was diminished in cells treated with aqueous humor that was first passed through a 3-kDa or a
280 chnique was developed to measure the flow of aqueous humor through the uveoscleral pathway in porcine
281 e mammalian eye is responsible for secreting aqueous humor to maintain intraocular pressure, which is
282 dy in the Ussing chambers was greater in the aqueous humor-to-blood direction than in the blood-to-aq
285 and uveoscleral outflow (F(u)), and rate of aqueous humor turnover, were calculated from measured da
288 when preincubated in DMEM containing porcine aqueous humor versus 13% +/- 15% when preincubated with
290 freezing, and IL-1beta concentration in the aqueous humor was elevated in a time-dependent manner af
291 TUNEL and caspase-3 ELISA; ascorbate in the aqueous humor was evaluated by nuclear magnetic resonanc
293 ocilin in the iridocorneal angle tissues and aqueous humor was studied by immunohistochemistry and We
295 (2)) and myeloperoxidase (MPO) activities of aqueous humor were determined up to 25 hours postinfecti
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