ライフサイエンスコーパス: arachidonic acid

1 with exogenous unsaturated free fatty acid (arachidonic acid).

2 immunity, cell signaling, proliferation and arachidonic acid.

3 circulating n-3 and n-6 fatty acids, except arachidonic acid.

4 ukotrienes, are lipid mediators derived from arachidonic acid.

5 Bs and PGF2alpha were modulated by exogenous arachidonic acid.

6 onses associated with aberrant metabolism of arachidonic acid.

7 yl linoleic but efficiently oxidized alkynyl arachidonic acid.

8 c acid were compared to that of linoleic and arachidonic acid.

9 ly prevent activation of the ARC channels by arachidonic acid.

10 roteins, and this effect was counteracted by arachidonic acid.

11 docosapentaenoic acid, total n-3 PUFAs, and arachidonic acid.

12 ctor arachidonic acid metabolite, 20-hydroxy arachidonic acid.

13 sion protein that produces prostacyclin from arachidonic acid.

14 y various cytochrome P450 (Cyp) enzymes from arachidonic acid.

15 polytic effects by catalyzing the release of arachidonic acid.

16 imulated by the iPLA(2)beta reaction product arachidonic acid.

17 aeruginosa generate hepoxilin A(3) precursor arachidonic acid.

18 essential in the biosynthesis of PGE(2) from arachidonic acid.

19 the oxygenation of endocannabinoids but not arachidonic acid.

20 sulted the most abundant, followed by omega6 arachidonic acid.

21 atty acids, including both linoleic acid and arachidonic acid.

22 dy, inhibition of platelet aggregation after arachidonic acid 1.5 mmol/L at 30 minutes, was significa

23 Subsequent addition of arachidonic acid (10 mum), a channel opener, increased t

24 lipoxygenation) was 17 kJ/mol lower than for arachidonic acid 12-lipoxygenation.

25 Glutathione peroxidase 4 (GPX4) and arachidonic acid 15-lipoxygenase (ALOX15) are antagonizi

26 n (MS1) also contained significant levels of arachidonic acid (20:4 omega-6) and the omega-3 fatty ac

27 n level of alpha-linolenic acid (18:3, ALA), arachidonic acid (20:4, AA), and docosahexanoic acid (22

28 Low levels of arachidonic acid (20:4n-6) were associated with lower pe

29 s (PUFAs) docosahexaenoic acid (22:6n-3) and arachidonic acid (20:4n-6), which were first permitted b

30 centrations of 5-lipoxygenase metabolites of arachidonic acid, 5-hydroxyeicosatetraenoic acid, and le

31 enase-2 (COX-2) catalyzes the oxygenation of arachidonic acid (AA) and endocannabinoid substrates, pl

32 donoylglyerol (2-AG) in the brain generating arachidonic acid (AA) and glycerol.

33 Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidono

34 linoleic acid (LA) induced the production of arachidonic acid (AA) and lysophosphatidylcholine (Lyso-

35 Arachidonic acid (AA) and prostaglandin D2 (PGD2) as wel

36 ventricular myocytes and is responsible for arachidonic acid (AA) and prostaglandin E2 (PGE2) releas

37 Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and the endocannabinoids 2-arachid

38 n of HXB3, 12-HETE, 8-HETE, and 15-HETE from arachidonic acid (AA) at baseline and in the presence of

39 They are produced by oxidation of arachidonic acid (AA) by cyclooxygenases (COX-1 and COX-

40 or during reduction of endogenous levels of arachidonic acid (AA) by exposure to fatty acid-free BSA

41 Plasma eicosapentaenoic acid (EPA) and arachidonic acid (AA) concentrations increase with age.T

42 sPLA2 IB enhanced podocyte arachidonic acid (AA) content in a dose-dependent manner

43 production of 5-lipoxygenase (5-LOX)-related arachidonic acid (AA) derivatives in the peritoneal flui

44 ducible PGE(2) synthesis, cPLA(2) hydrolyzes arachidonic acid (AA) from cellular phospholipids to be

45 thesis of PGE2 begins with the liberation of arachidonic acid (AA) from membrane phospholipids by cyt

46 deling the phospholipid membrane, release of arachidonic acid (AA) from the membrane, and production

47 oPC) content and circulating and erythrocyte arachidonic acid (AA) in mice with sickle cell disease (

48 responsible for Ca(2+)-activated release of arachidonic acid (AA) in mitochondria from non-failing h

49 acid (EPA), docosapentaenoic acid (DPA), and arachidonic acid (AA) in patients with generalized chron

50 Arachidonic acid (AA) increases the association of PM-re

51 ted DHA levels and revealed dysregulation of arachidonic acid (AA) levels as well ( approximately 32%

52 ncy leads to a dramatic up-regulation of the arachidonic acid (AA) metabolic pathway in human fibrobl

53 OX) is a promising strategy to intervene the arachidonic acid (AA) metabolite network and control inf

54 e effect of LMW HA on cPLA2alpha activation, arachidonic acid (AA) release, and subsequent eicosanoid

55 hospholipid-remodeling enzyme that transfers arachidonic acid (AA) to lysophosphatidylinositol to pro

56 also called cyclooxygenases (COXs), convert arachidonic acid (AA) to PGH2.

57 Coincubation with arachidonic acid (AA) was conducted to determine the sit

58 5% CI 0.85-0.94) were inversely related, and arachidonic acid (AA) was not significantly associated,

59 c acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) were quantified using RP-HPLC with

60 oxidized metabolites of linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid (DHA) wa

61 nd rs174537 had lower (P < 0.05) plasma EPA, arachidonic acid (AA), EPA/ALA, and AA/linoleic acid com

62 5(S)-HETE), the major 12/15-LO metabolite of arachidonic acid (AA), induced endothelial barrier perme

63 asil (Ocimum basilicum L.) leaves induced by arachidonic acid (AA), jasmonic acid (JA) and beta-amino

64 tuce caused by different chemical elicitors: arachidonic acid (AA), jasmonic acid (JA), and abscisic

65 PMN chemoattractant hepoxilin A3 (HXA3) from arachidonic acid (AA), promotes acute pulmonary inflamma

66 ytosolic phospholipase A2 (cPLA2), releasing arachidonic acid (AA), which is oxidized to proinflammat

67 d a strong (3)H overflow response from [(3)H]arachidonic acid (AA)-labeled cells.

68 hydrolyzes membrane phospholipids to release arachidonic acid (AA).

69 could be triggered by addition of exogenous arachidonic acid (AA).

70 of a novel antitumoral mechanism of the PUFA arachidonic acid (AA).

71 Arachidonic acid (AA, 20:4) is an omega-6 polyunsaturate

72 2; 95% CI: 0.39, 0.70; P-trend < 0.001), and arachidonic acid (AA; HR: 0.62; 95% CI: 0.46, 0.85; P-tr

73 lenic acid) and n-6 PUFAs (linoleic acid and arachidonic acid [AA]) in blood samples at age 8 years w

74 et cell membranes with EPA, thereby reducing arachidonic acid abundance, would positively impact beta

75 (CRAC) channels, and the store-independent, arachidonic acid-activated ARC channels.

76 entration-response curves were generated for arachidonic acid, ADP, collagen, epinephrine, Thrombin r

77 measured platelet aggregation in response to arachidonic acid, ADP, collagen, or epinephrine by optic

78 ion-1 study measured platelet aggregation to arachidonic acid, ADP, protease-activated receptor (PAR)

79 regation, p = 0.02) but not with collagen or arachidonic acid agonists.

80 rect incubation with gamma-linolenic acid or arachidonic acid also attenuated collagen deposits and L

81 ownstream PUFAs like gamma-linolenic acid or arachidonic acid alter the transforming growth factor-be

82 be influenced/mediated by concentrations of arachidonic acid, an n-6 polyunsaturated fat.

83 alyses of lipid mediators revealed increased arachidonic acid and 12-lipoxygenase metabolites.

84 enic actions of various compounds, including arachidonic acid and a combination of linoleic acid and

85 h total or cause-specific mortality (eg, for arachidonic acid and CHD death, the extreme-quintile haz

86 tion attenuated the fMLP-mediated release of arachidonic acid and CysLT formation by eosinophils.

87 ions for changes in plasma concentrations of arachidonic acid and DHA in phospholipids and TLs and of

88 esults support the positive role of maternal arachidonic acid and DHA on fetal neural development, al

89 Arachidonic acid and docosahexaenoic acid, two final pro

90 biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes.

91 resulted in a rapid and dramatic decrease in arachidonic acid and its eicosanoid metabolites.

92 Surprisingly, release of arachidonic acid and LDH from cPLA2alpha-deficient fibro

93 cid beta-oxidation, phospholipid catabolism, arachidonic acid and linoleic acid metabolism, sphingoli

94 ining phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise t

95 Channel activation by arachidonic acid and mechanical stretch involves convers

96 (LT) C4, LTD4, and LTE4, are metabolites of arachidonic acid and mediate inflammatory responses.

97 oluble cPLA(2)alpha fraction also stimulated arachidonic acid and prostaglandin production.

98 sis that is not contingent on the release of arachidonic acid and that is compatible with its combine

99 BP5 both promotes the hydrolysis of AEA into arachidonic acid and thus reduces brain endocannabinoid

100 osphoinositides, to form the proinflammatory arachidonic acid and, in parallel, the glycerophosphoino

101 ir hydrolysis products (oxygenated linoleic, arachidonic acids and monolysocardiolipins), is activate

102 ays (affinity comparable to pioglitazone and arachidonic acid), and in vitro murine adipocyte differe

103 (adenosine diphosphate 5 and 20 mumol/l and arachidonic acid), and vasodilator-stimulated phosphopro

104 (omega-3) FAs, 4) high linoleic acid and low arachidonic acid, and 5) high trans FAs.

105 LA), gamma-linolenic acid (GLA), dihomo-GLA, arachidonic acid, and adrenic acid were expressed as per

106 he FADS cluster on chromosome 11 with LA and arachidonic acid, and further observed novel genome-wide

107 (epoxI) given at 24 h selectively inhibited arachidonic acid- and linoleic acid-derived CYP450-epoxy

108 mega-alkynyl linoleic acid and omega-alkynyl arachidonic acid appear to be metabolically competent su

109 Arachidonic acid (ARA) is metabolized by cyclooxygenase

110 Dietary LA can then be converted to arachidonic acid (ARA) utilizing three enzymatic steps.

111 we have made alphaS multimers in vitro using arachidonic acid (ARA), one of the most abundant fatty a

112 , 0.64%, and 0.96% of total fatty acids) and arachidonic acid (ARA; 0.64%) compared with children who

113 omega-6 polyunsaturated fatty acids, such as arachidonic acid, are associated with dyslipidemia and o

114 dihydroxy, and 5,15-dihydroxy metabolites of arachidonic acid as well as DHA itself require >/=10-100

115 cosapentaenoic acid (EPA)/d together with an arachidonic acid-balanced diet compared with a control d

116 g isothermal microcalorimetry, we found that arachidonic acid binds ferritin specifically and with 60

117 Levels of arachidonic acid biomarker were not significantly associ

118 The associations between linoleic acid and arachidonic acid biomarkers and the risk of type 2 diabe

119 and had data available for linoleic acid and arachidonic acid biomarkers at baseline.

120 assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabete

121 yses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglan

122 d minor effects in the presence of exogenous arachidonic acid, but led to prominent reductions in 5LO

123 bstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the prot

124 xyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases h

125 s ago, a third pathway for the metabolism of arachidonic acid by cytochrome P450 enzymes emerged.

126 and directly participates in the release of arachidonic acid by epithelial cells.

127 f eicosanoid generation is the liberation of arachidonic acid by phospholipase A2, and the cytosolic

128 cids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s.

129 opic lipid mediator that is synthesized from arachidonic acid by the sequential actions of cyclooxyge

130 osynthesis involves sequential metabolism of arachidonic acid by two cell types expressing a combined

131 jor 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic acid, by stimulating zona occludens (ZO)-2 t

132 n of drugs inhibiting only one branch of the arachidonic acid cascade is usually accompanied by side

133 ts of lung epithelial cellular breakdown and arachidonic acid cascade metabolites were associated wit

134 synthase 1 (mPGES-1) is a key enzyme of the arachidonic acid cascade.

135 her than PGI2 production in either following arachidonic acid challenge.

136 icosapentaenoic acid, docosapentaenoic acid, arachidonic acid, CLA:9c11t and gamma linolenic acid.

137 loss of single platelets in blood exposed to arachidonic acid, collagen, U46619 or protease activated

138 owed us to explore ADP- and non-ADP-induced (arachidonic acid-, collagen-, thrombin receptor-activati

139 metabolites derived from docosahexaenoic and arachidonic acids comes from the introduction of the pol

140 ater inhibition of platelet aggregation with arachidonic acid compared with aspirin.

141 After adjustment for arachidonic acid concentrations, the association between

142 hibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates rele

143 Arachidonic acid-containing diacylglycerols (DAG) activa

144 osolic phospholipase A2 (cPLA2alpha) targets arachidonic acid-containing phospholipids but the role o

145 ements in linoleic acid, linolenic acid, and arachidonic acid (control>ASYMAD>AD) and increases in do

146 HA also reduced ( approximately 60%; P<0.05) arachidonic acid conversion by hm12-LOX and promoted con

147 on TFAs, and at the sixth month of lactation arachidonic acid correlated significantly inversely to 1

148 enerate 20-hydroxyeicosatetraenoic acid from arachidonic acid, decreasing endothelial barrier functio

149 phospholipase A2 and generating vasodilatory arachidonic acid derivatives.

150 olvins, protectins, and maresins, as well as arachidonic acid-derived (n-6) lipoxins, which promote r

151 are increased production of proinflammatory arachidonic acid-derived eicosanoids and impaired regula

152 ificantly altered metabolic steps: increased arachidonic acid-derived leukotriene B(4) (LTB(4)) and d

153 d response, suggesting that PAR(2) generates arachidonic acid-derived lipid mediators, such as 5',6'-

154 comprise a family of mediators that include arachidonic acid-derived lipoxins, omega-3 fatty acid ei

155 The balance of arachidonic acid-derived mediators in leukocytes is thou

156 t is currently understood of the role of the arachidonic acid-derived prostaglandins, lipoxins, and t

157 ent increased concentrations of linoleic and arachidonic-acid-derived oxidized TRPV1 agonists in spin

158 ls of stearic acid/palmitic acid (SA/PA) and arachidonic acid/dihomo-gamma-linolenic acid (AA/DGLA) r

159 fferent lipid classes including cholesterol, arachidonic acid, docosahexaenoic acid, and triacylglyce

160 ipheral blood using established criteria for arachidonic acid, eicosapentaenoic acid, and docosahexae

161 l techniques, we show that both linoleic and arachidonic acid elicit FABP5's translocation by permitt

162 yunsaturated fatty acids (PUFAs) such as AA (arachidonic acid), EPA (eicosapentaenoic acid) and DyLA

163 rresponding metabolites derived from omega-6 arachidonic acid, epoxyeicosatrienoic acids, increase an

164 Roles for the arachidonic acid epoxygenase metabolites, the epoxyeicos

165 atrienoic acids (EET) by the cytochrome P450 arachidonic acid epoxygenases (Cyp2c) represents a new a

166 ce of an optimal DHA balance with respect to arachidonic acid for different aspects of neurodevelopme

167 solic phospholipase A2alpha, which mobilizes arachidonic acid for PG synthesis, preferentially transl

168 cPLA2alpha releases arachidonic acid for the production of eicosanoids.

169 Light provoked the release of arachidonic acid from membrane phospholipids and product

170 e cytosolic phospholipase A2, which releases arachidonic acid from membrane phospholipids, and later

171 ivates the iPLA2gamma-mediated hydrolysis of arachidonic acid from phosphatidylcholine, thereby integ

172 ormation to LTA4 5-LOX is thought to receive arachidonic acid from the nuclear membrane-embedded 5-LO

173 pression (CSD) is associated with release of arachidonic acid, impaired neurovascular coupling, and r

174 proinflammatory lipid mediators formed from arachidonic acid in a 2-step reaction catalyzed by 5-lip

175 hains of three amino acids, allow binding of arachidonic acid in a catalytically competent conformati

176 ase of AEA and the FAAH-dependent metabolite arachidonic acid in hypoxic lungs of wild-type mice.

177 cosatetraenoic acids (HETE) and 15-HETE from arachidonic acid in the testes were significantly elevat

178 idonic acid may limit the utility of alkynyl arachidonic acid in the tracking of cyclooxygenase-based

179 icosapentaenoic acid + docosahexaenoic acid, arachidonic acid) in hepatic total lipids were lower in

180 Whereas treatment of control HEEs with arachidonic acid increased expression of inflammatory cy

181 ecreased and levels of the ALOX12 substrate, arachidonic acid, increased.

182 h n-3 fatty acids and instructions to reduce arachidonic acid intake during pregnancy and lactation r

183 ement per day and a concomitant reduction in arachidonic acid intake) or a control diet from the 15th

184 ndrial variant 3 catalyzed the metabolism of arachidonic acid into 8,9-, 11,12-, and 14,15-epoxyeicos

185 man hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, i

186 rected by exocytosis and allows shuttling of arachidonic acid into platelets.

187 s of the anti-inflammatory lipoxin A(4) from arachidonic acid is also detected.

188 We tested the hypothesis that the released arachidonic acid is metabolized by the cytochrome P450 e

189 r the prevention of type 2 diabetes and that arachidonic acid is not harmful.

190 d 2-arachidonoyl-glycerol, which derive from arachidonic acid, is influenced by dietary fatty acids (

191 Some of these compounds, including arachidonic acid, its analogues, and the cyclooxygenase

192 onic morphine administration, an increase in arachidonic acid levels through the mu-opioid receptors

193 findings, we propose that the likely role of arachidonic acid lies in inducing the actual gating of t

194 Cytochrome P450 pathway oxylipins from arachidonic acid, linoleic acid, alpha-linolenic acid an

195 lipase A2 (iPLA2beta) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids tha

196 This deviation from the metabolic profile of arachidonic acid may limit the utility of alkynyl arachi

197 nd epithelial cell mRNA expression levels of arachidonic acid metabolic enzymes.

198 expressed genes was found in eight pathways: arachidonic acid metabolism (P = 0.003849), transforming

199 Sepsis-associated changes of the arachidonic acid metabolism and the utility of arachidon

200 reveal how selenium-dependent modulation of arachidonic acid metabolism can be directed to trigger a

201 an association between vimentin, hGIIA, and arachidonic acid metabolism in synovial inflammation, av

202 Arachidonic acid metabolism is markedly affected in pati

203 A derailed arachidonic acid metabolism is regarded to be part of th

204 oxygenase (COX) and lipoxygenase branches of arachidonic acid metabolism, and then the rate constants

205 iene-C4 synthase (LTC4S) generates LTC4 from arachidonic acid metabolism.

206 ory mediators, in part, by the modulation of arachidonic acid metabolism.

207 oxidase 5 (NOX5), and PTGS2 (COX-2) mediated arachidonic acid metabolism.

208 rmed by the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism.

209 ive immune responses, tissue remodeling, and arachidonic acid metabolism.

210 by suppressing levels of the vasoconstrictor arachidonic acid metabolite, 20-hydroxy arachidonic acid

211 potent vasoconstrictive and proinflammatory arachidonic acid metabolite.

212 oleic acid metabolites (OLAMs) and oxidative arachidonic acid metabolites (OAAMs) is the action of ox

213 Several arachidonic acid metabolites and enzyme transcripts invo

214 Arachidonic acid metabolites are implicated in the patho

215 and proinflammatory signals associated with arachidonic acid metabolites differentially gate TRPV4 i

216 achidonic acid metabolism and the utility of arachidonic acid metabolites for the diagnosis of sepsis

217 ished cellular production of 15-lipoxygenase arachidonic acid metabolites in IL-4-stimulated macropha

218 Although arachidonic acid metabolites, cysteinyl leukotrienes (cy

219 lex network mediators, such as nitric oxide, arachidonic acid metabolites, cytokines, and reactive ox

220 ent studies of soluble mediators, especially arachidonic acid metabolites, have defined their proinfl

221 uble mediators of inflammation, particularly arachidonic acid metabolites, in inflammatory bowel dise

222 channels, and the production and release of arachidonic acid metabolites.

223 ic oxide, other reactive oxygen species, and arachidonic acid metabolites.

224 d lipidomic approach was used to profile the arachidonic acid metabolome of amniotic fluid.

225 products of PLA2 (lysophosphatidic acid and arachidonic acid) mimicked treatment with gossypol.

226 P2X7 receptor can induce PLA2 activation and arachidonic acid mobilization.

227 hereas it was increased by the CB1R agonist, arachidonic acid N-hydroxyethylamide (AEA), indicating t

228 atically in 1993, when anandamide, an NAE of arachidonic acid (N-arachidonylethanolamine), was shown

229 solution structure of 8R-LOX in complex with arachidonic acid obtained under anaerobic conditions.

230 en the somatic and germ cells is mediated by arachidonic acid (omega-6) and eicosapentaenoic acid (om

231 arachidonoylserotonin was similar to that of arachidonic acid, one of the previously identified fatty

232 a containing either docosahexaenoic acid and arachidonic acid or no LCPUFAs for a period of 4 mo.

233 1 progression was rescued by the addition of arachidonic acid or prostaglandin E2 (PGE2), indicating

234 with proaggregating properties derived from arachidonic acid oxidation by platelet NOX2, the catalyt

235 nts and found that, when normalized to their arachidonic acid oxygenase activities, the lipoxin synth

236 e carriage associated with lower whole-blood arachidonic acid (P </= 0.002), and minor alleles of rs1

237 8), oleic acid (p < 0.0001, p = 0.0003), and arachidonic acid (p = 0.0001, p = 0.001).

238 Alterations in the arachidonic acid pathway (leading to an imbalanced produ

239 its mechanism of action does not involve the arachidonic acid pathway affected by non-steroid anti-in

240 se involved in NAR to all NSAIDs belonged to arachidonic acid pathway and HLA antigen processing path

241 Genes involved in NAR to aspirin belonged to arachidonic acid pathway, membrane-spanning 4A gene fami

242 shifts the balance toward resolution in the arachidonic acid pathway.

243 rkers of inflammatory lipid metabolism, free arachidonic acid, phospholipases (PLA2G10), and prostagl

244 isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of sp

245 inoid 2-arachidonoylglycerol to generate the arachidonic acid precursor pool for prostaglandin produc

246 ALOX12 catalyzes the addition of oxygen to arachidonic acid, producing 12-hydroperoxyeicosatetraeno

247 ated CRAC channels and the store-independent arachidonic acid-regulated ARC channels.

248 regulated kinase 1/2 phosphorylation (MAPK), arachidonic acid release (AA), and guanosine 5'-O-(3-thi

249 LDH release temporally correlated with arachidonic acid release but did not involve cytosolic p

250 regulator, also prevented MPTP formation and arachidonic acid release induced by A23187 and H2O2.

251 l-sn-glycerol and CsA blocked cell death and arachidonic acid release not by preventing mitochondrial

252 by a direct effect on mitochondria, LDH and arachidonic acid release were blocked by CsA and 1-oleoy

253 tacyclin-mediated dilations to serotonin and arachidonic acid, respectively.

254 Metabolism of arachidonic acid results in bioactive lipid mediators be

255 chromosome 16 with LA, GLA, dihomo-GLA, and arachidonic acid (rs16966952; P=1.2x10(-15), 5.0x10(-11)

256 ome 6 with adrenic acid after adjustment for arachidonic acid (rs3134950; P=2.1x10(-10); AGPAT1).

257 otent endocannabinoid signals in addition to arachidonic acid signals, which may explain the proposed

258 me catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized

259 nimal (except for dairy) products, including arachidonic acid (standardized beta: 0.25; 95% CI: 0.15,

260 ) channel 1 (TREK1), TREK2, and Twik-related arachidonic-acid stimulated K(+) channel (TRAAK) form th

261 TRAAK (TWIK-related arachidonic acid-stimulated K(+) channel, K2P4.1) K(+) i

262 Arachidonic acid-stimulated whole blood aggregation was

263 ith a preferential release of membrane-bound arachidonic acid, stimulating the lipoxygenase (LOX) and

264 n by gamma-ketoaldehyde isomers derived from arachidonic acid, termed isolevuglandins (IsoLGs), is em

265 rome P450-epoxygenase-derived metabolites of arachidonic acid that act as endogenous signaling molecu

266 pro-inflammatory pathway gene that produces arachidonic acid, the substrate for COX-2 protein.

267 erate distinct products from their substrate arachidonic acid: the human enzyme, a 15-S-hydroperoxy p

268 rome P450 (CYP) 4A and 4F enzymes metabolize arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-

269 th enzymes transform phospholipid-esterified arachidonic acid to a 15-S-product.

270 zes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecul

271 n-3 PUFA concentrations and a lower ratio of arachidonic acid to EPA in erythrocyte membranes were as

272 ts and catalyzes the oxygenation of cellular arachidonic acid to form proinflammatory intermediates.

273 Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid to form prostaglandins, but also inacti

274 genase and 12-lipoxygenase, which metabolize arachidonic acid to generate bioactive inflammatory eico

275 arries out stereospecific oxygen addition to arachidonic acid to generate prostaglandins, plus smalle

276 ) plays a critical role in the metabolism of arachidonic acid to leukotriene A4, the precursor to the

277 lin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4.

278 so called cyclooxygenase-2 (COX-2), converts arachidonic acid to PGH2 PGHS-2 is a conformational hete

279 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin G2.

280 to a decrease in the rate of conversion from arachidonic acid to prostaglandin H2 in the PR pathway.

281 talyze the initial step in the metabolism of arachidonic acid to prostaglandins.

282 2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids in the brain.

283 cyclooxygenase1 (Cox1), an enzyme processing arachidonic acid to synthesize thromboxane A2 (TxA2).

284 alase-lipoxygenase fusion protein transforms arachidonic acid to the allene oxide 8R,9-epoxy-5,9,11,1

285 ds, including epoxyeicosatrienoic acids from arachidonic acid to the corresponding proinflammatory di

286 ndocannabinoid levels, and directly shuttles arachidonic acid to the nucleus where it delivers it to

287 drugs, and endogenous substrates, including arachidonic acid, to physiologically active epoxyeicosat

288 lgi complex stimulates cPLA2alpha release of arachidonic acid, triggering pro-inflammatory eicosanoid

289 metabolites, suggesting a metabolic shift of arachidonic acid under inhibition of the CYP2C pathway.

290 (cPLA2alpha), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid pr

291 TP-gated channels, and that Ca(2+) generates arachidonic acid via phospholipase D2 and diacylglycerol

292 Tertile 2 of n-6 and arachidonic acid was associated with fracture risk in wo

293 mega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were compared to that of linoleic and a

294 lenic acid, dihomo-gamma-linolenic acid, and arachidonic acid were not significantly associated with

295 mega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were reacted with lipoxygenase enzymes

296 arly ratios of docosahexaenoic acid (DHA) to arachidonic acid, were lower in the hippocampi and corti

297 Prostaglandin E2 (PGE2) is derived from arachidonic acid, whereas PGE3 is derived from eicosapen

298 d receptor-independent mechanism mimicked by arachidonic acid, which has no activity on cannabinoid r

299 e synoviocytes, it suppressed the release of arachidonic acid with an IC50 value of 0.6 muM.

300 lenic acid, dihomo-gamma-linolenic acid, and arachidonic acid, with total and cause-specific mortalit