ライフサイエンスコーパス: arbor

1 hrough their propagation across the neuronal arbor.

2 DB6 bipolar cells via a sparse outer axonal arbor.

3 first stable branch point in the developing arbor.

4 due to the elongated shape of the dendritic arbor.

5 HCN channels in the distal apical dendritic arbor.

6 to form the eventual mature, branched ductal arbor.

7 atively regulate the growth of the dendritic arbor.

8 receptors throughout the elaborate dendritic arbor.

9 iformly distributed throughout the dendritic arbor.

10 onal properties along their active dendritic arbor.

11 neurons extended and refined their dendritic arbor.

12 s an otherwise structurally normal dendritic arbor.

13 ilization, and organization of the dendritic arbor.

14 ive code for the size control of presynaptic arbor.

15 % in the basilar arbor and 28% in the apical arbor.

16 or whether they spread across the dendritic arbor.

17 tic synapses formed throughout the dendritic arbor.

18 lized compartment within a complex dendritic arbor.

19 in restricted areas in the forming dendritic arbor.

20 nel interactions across the active dendritic arbor.

21 successful AP propagation across the axonal arbor.

22 nd maintaining mitochondria throughout their arbors.

23 the selective removal of branches from axon arbors.

24 de to precisely target and pattern dendritic arbors.

25 tion and reconstruction of long-range axonal arbors.

26 FF RGCs lose complexity more rapidly than ON arbors.

27 tion of synaptic inputs and outputs on these arbors.

28 pression and promotes more complex dendritic arbors.

29 in part from the morphology of the dendritic arbors.

30 nd hippocampal neurons had smaller dendritic arbors.

31 asis during morphogenesis of large dendritic arbors.

32 neurons to form cell type-specific dendritic arbors.

33 al cells and the relative positions of their arbors.

34 wth in neurons with different-sized dendrite arbors.

35 urons extended axons and developed dendritic arbors.

36 emergence and leads to impoverished terminal arbors.

37 (PKA) on the formation of complex dendritic arbors.

38 ngth and a relative increase in more complex arbors.

39 ed to distinct regions of neuronal dendritic arbors.

40 ttenuates Rho activity to stabilize dendrite arbors.

41 nd generate neurons with elaborate dendritic arbors.

42 tions that define the topography of neuronal arbors.

43 r immense, architecturally complex dendritic arbors.

44 hed by the unusual behavior of its dendritic arbors.

45 receive synaptic inputs on extensive neurite arbors.

46 erminals onto staggeringly complex dendritic arbors.

47 displayed stunted, poorly branched dendritic arbors.

48 to reveal the fine structure of mouse Muller arbors.

49 sible cue from a distance to shape dendritic arbors.

50 ately to the spatial extent of its dendritic arbor [2, 3].

51 st human- and animal-origin H2 viruses A/Ann Arbor/6/1960 (H2N2) (AA60) and A/swine/MO/4296424/06 (H2

52 mperature-sensitive master donor virus A/Ann Arbor/6/1960 and HA/NA gene segments from circulating vi

53 During serial passage of A/Ann Arbor/6/1960 at low temperatures to select the desired a

54 from the cold-adapted influenza virus A/Ann Arbor/6/60 (AA ca) were generated by reverse genetics.

55 protein genes of the cold-adapted (ca) A/Ann Arbor/6/60 (H2N2) vaccine donor virus, which is the back

56 nfluenza A virus vaccine donor strain, A/Ann Arbor/6/60 ca (H2N2), the backbone of the licensed seaso

57 nternal protein gene segments from the A/Ann Arbor/6/60 ca virus were generated by plasmid-based reve

58 mperature sensitive, cold-adapted (ca) A/Ann Arbor/60 (H2N2) virus (AA/60 ca) of the licensed seasona

59 ectrophysiological properties, for dendritic arbor anatomy as well as for short-term synaptic plastic

60 trols, with reductions of 33% in the basilar arbor and 28% in the apical arbor.

61 relatively small lateral expansions of their arbor and increases in the total number of their cartrid

62 e describe new methods to apply quantitative arbor and network context to iteratively proofread and r

63 n the theta range across the somatodendritic arbor and specific STA measurements were strongly relate

64 y arises from the structure of the dendritic arbor and the pattern of excitatory and inhibitory input

65 red for development of PVD and FLP dendritic arbors and can act as a diffusible cue from a distance t

66 rowth demands in neurons with large dendrite arbors and define Path as a founding member of this grow

67 demonstrate abnormal development of dendrite arbors and dendritic spines in newly generated dentate g

68 How information is organized across arbors and how local processing in neurites contributes

69 cally uniform, with pyramidal-type dendritic arbors and locally ramifying axons, including branches e

70 estigate the possible link between astrocyte arbors and presence of OPMs.

71 le methods for reconstructing 3-D microglial arbors and quantitatively mapping microglia activation s

72 nockdown significantly destabilizes dendrite arbors and reduces dendritic spine density by compromisi

73 oss caused progressive attrition of dendrite arbors and spines in Cornu Ammonis (CA)1 pyramidal neuro

74 nd molecular mechanisms that shape dendritic arbors and synaptic distribution, enabling J-RGC connect

75 Thus, whether neuronal arbors and synaptic structures remain dynamic in the int

76 acterized by a progressive loss of dendritic arbors and the emergence of impairments to learning-rela

77 tissue in the context of fully reconstructed arbors and to explore the spatial distribution of synapt

78 e literature (both national and local to Ann Arbor) and took into account coverage levels and effects

79 cant increases in striatum volume, dendritic arbor, and elevated excitatory synaptic markers in the c

80 ropean-American Lymphoma classification, Ann Arbor, and International Prognostic Index [IPI] scores)

81 omical arrangement of Muller cells and their arbors, and how these features arise in development.

82 Satb1 mutant mice, ooDSGC dendrites lack ON arbors, and the cells selectively lose ON responses.

83 Axon arbor architecture, a major determinant of synaptic conn

84 Dendritic arbors are complex neuronal structures that receive and

85 Sensory dendrite arbors are patterned through cell-autonomously and non-c

86 The size and shape of dendritic arbors are prime determinants of neuronal connectivity a

87 re correctly partitioned onto a postsynaptic arbor, are incompletely understood.

88 tivity result in a reduced complexity of the arbors, as reflected in decreased dendritic length and n

89 iR-8 regulates the morphology of presynaptic arbors at the Drosophila neuromuscular junction (NMJ) th

90 gene permits extension of dendrite and axon arbors beyond these borders.

91 flow organizes retinotopy by regulating axon arbor branch dynamics, whereas the opposite sequence of

92 formation and was used by Abrupt to simplify arbor branching.

93 n the large scale restructuring of dendritic arbors but are rather associated with local cell-type an

94 specifically in neurons with large dendrite arbors but not in other cells.

95 ude of synaptic inputs along their dendritic arbor, but how this highly heterogeneous population of s

96 including the proper formation of dendritic arbors by forebrain neurons.

97 are required for formation of central axonal arbors by subsets of sensory neurons.

98 ns also enlarge their postsynaptic dendritic arbors, by the net addition of branches, and that these

99 ial electron micrographs from which neuronal arbors can be reconstructed and synapses can be detected

100 AIVs) against clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term

101 morphology and decreased pyramidal dendritic arbor complexity and spine density.

102 emonstrate a requirement for LPS in building arbor complexity and suggest a key role for pre-synaptic

103 Sexual dimorphism in astrocyte arbor complexity in the left MePD arises after P25, and

104 s to a significant reduction in retinal axon arbor complexity in the optic tectum, and expression of

105 branch dynamics reveals that the decrease in arbor complexity is caused by a reduction in new branche

106 h but is associated with decreased dendritic arbor complexity of cortical projection neurons.

107 Despite the reduction in axon arbor complexity seen in d-serine-treated animals, tecta

108 SPNs displayed reduced basal dendritic arbor complexity that was accompanied by chronic disturb

109 he PKA activity levels affect profoundly the arbor complexity with strongest impact on distal branche

110 ls are critical in determining the dendritic arbor complexity, one of the possible ways being through

111 (BET) family proteins in regulating dendrite arbor complexity.

112 A systematic survey of arbor configurations predicted that the arrangement of m

113 The architecture of dendritic arbors contributes to neuronal connectivity in the brain

114 The structure of axonal arbors controls how signals from individual neurons are

115 We found that regenerated arbors cover much less territory than uninjured neurons,

116 outposts during elaboration of the dendrite arbor creates a local system for guiding microtubule pol

117 The arbor densities are sorted into a number of clusters tha

118 The coverage territory and the arbor density of dendrites determine what fraction of th

119 between the coverage territory and dendritic arbor density of RGCs on a cell-by-cell basis.

120 ial distribution of the dendritic arbors, or arbor density, with reference to arbors of an abundant,

121 references (ON vs. OFF) varied across VG3-AC arbors depending on the laminar position of neurites, wi

122 A modification of the Ann Arbor descriptive terminology will be used for anatomic

123 anges in the structure of neuronal dendritic arbors disrupt proper circuit connectivity, which in tur

124 ut, while excitatory input did not vary with arbor distribution.

125 dcast as an unwavering binary pulse over its arbor, driving neurotransmission uniformly at release si

126 ity-dependent manner for sculpting dendritic arbors during early-use, critical period development of

127 axonal beta-actin mRNA translation disrupts arbor dynamics primarily by reducing new branch emergenc

128 to be critical for branch-specific dendritic arbor dynamics.

129 d by acting on neurons to increase dendritic arbor elaboration.

130 nd by acting on neurons to enhance dendritic arbor elaboration.

131 MVP2 arbors expand in Drosophila mutants null for fragile X m

132 s by Pesakou et al. tie daily cycles of axon arbor extension and retraction, mediated by Rho activity

133 k the sites of ENT formation to nascent axon arbor extensions.

134 At the morphological level, we find that TCA arbors fail to develop into discrete, concentrated patch

135 window at postnatal Days 6 to 9 when Muller arbors first colonize the synaptic layers beginning in s

136 uses the opposite outcome--reduced dendritic arbors following channelrhodopsin depolarization and exp

137 channelrhodopsin depolarization and expanded arbors following halorhodopsin hyperpolarization during

138 f synapses per connection, their overlapping arbors form ~8 million connections with ~37 million syna

139 neurosecretory terminals at the time of axon arbor formation.

140 LS Clinic of the University of Michigan, Ann Arbor, from June 18, 2014, through May 26, 2016.

141 drite morphogenesis, which include dendritic arbor growth and elaboration followed by retraction and

142 cal T3 also dramatically increased dendritic arbor growth in neurons that had already reached a growt

143 mortality significantly increased as the Ann Arbor GVHD score increased.

144 the neurite connecting the cell body to the arbor - has a smaller volume.

145 ngs imply that neurons with larger dendritic arbors have improved encoding capabilities.

146 However, whether neurons with large dendrite arbors have specialized mechanisms to support their grow

147 nstrate that the density of YFP-labeled axon arbors hinders tracing of single axons to their point of

148 at the level of individual branches or whole arbors; however, no studies have attempted to quantify r

149 ed and sham rats in either apical or basilar arbors; however, the proportion of immature to mature sp

150 unmyelinated afferents that extend dendritic arbors hundreds of microns along the cochlear spiral, co

151 ion but then retracted and reorganized their arbor in a tangential direction away from the MZ soon af

152 ape the structure and function of the axonal arbor in mature sensory neurons in the main olfactory sy

153 that are prevalent throughout the dendritic arbor in neurons.

154 We identified neurons with arbors in AF7 and found that they projected to multiple

155 Apical dendritic arbors in both simple- and complex-tufted layer 5 Tg1 py

156 s propagating along millimeter-length axonal arbors in cortical cultures with hundreds of microelectr

157 y of Mrgprd(+) nociceptors, while individual arbors in different locations are comparable in size.

158 drites shows that the geography of dendritic arbors in relation to presynaptic partner terminals is a

159 d-type neurons led to more complex dendritic arbors in vivo, suggesting that an optimal level of FLNA

160 approximately 110 min period, the dendritic arbor increases approximately 2.5-fold in size and migra

161 L) neuron, which extends elaborate dendritic arbors innervating the bases of taste hairs.

162 observed that some neurons segregated their arbors into input only and mixed input/output zones, tha

163 The shape of the dendritic arbor is one of the criteria of neuron classification an

164 The dendritic arbor is subject to continual activity-dependent remodel

165 Precise patterning of dendritic arbors is critical for the wiring and function of neural

166 The shape of their arbors is irregular but nonrandom, suggesting that local

167 cally assigned to the branches of remodeling arbors is not understood.

168 We show that the size of the dendritic arbors (its impedance load) strongly modulates the shape

169 Consistent with a repulsive role in arbor lamination, we observed complementary expression p

170 lacking gephyrin display increased dendritic arbor length and branching, increased spiny processes, d

171 hite matter astrocyte cell bodies, decreased arbor length in both white and gray matter astrocytes, a

172 Thus, VG3-AC arbors limit vertical and lateral integration of contras

173 Here we imaged retinotectal axon arbor location and structural plasticity to assess map r

174 ds to synapse, dendritic spine, and dendrite arbor loss accompanied by behavioral deficits.

175 Inhibiting RhoA prevents dendrite arbor loss following Arg knockdown in neurons, but does

176 As arbors mature, they acquire excitatory and inhibitory sy

177 al Argus II Investigator Meeting held in Ann Arbor, MI in March 2015.

178 ansmission at a hypothetical hospital in Ann Arbor, Michigan, during a 1-year seasonal epidemic (June

179 are practices in New York, New York, and Ann Arbor, Michigan.

180 transcriptional programs to create dendrite arbor morphological diversity for complex neuronal funct

181 The arbor morphologies of brain microglia are important indi

182 ectional genetics, we describe the dendritic arbor morphologies of RGC types expressing Ret in combin

183 The arbor morphologies were quantified using Scorcioni's L-m

184 Dendritic arbor morphology is a key determinant of neuronal functi

185 Complete postganglionic arbors (n = 154) in the muscle wall were digitized and a

186 The extensive dendritic arbor of a pyramidal cell introduces considerable comple

187 al integrity and complexity of the dendritic arbor of CA1 neurons that renders those cells permissive

188 their distribution over the entire dendritic arbor of motoneurons before and after nerve injury.

189 Constructing the dendritic arbor of neurons requires dynamic movements of Golgi out

190 wers the development of the signal-receiving arbor of neurons that underlies neuronal network formati

191 ate synaptic integration along the dendritic arbor of pyramidal cells.

192 of neuronal TDP-43 granules in the dendritic arbor of rat hippocampal neurons.

193 aled that RNAs were delivered throughout the arbor of the sensory neuron, but that translation was en

194 sustained RGCs were perturbed, the dendritic arbor of this cell type remained intact.

195 ed to a small portion of the broad dendritic arbor of WF cells is sufficient to trigger dendritic spi

196 nile ganglion, which included the somata and arbors of all the neurons.

197 arbors, or arbor density, with reference to arbors of an abundant, well-defined interneuronal type.

198 al amygdala and also reconstructed dendritic arbors of CA1 pyramidal neurons.

199 d to a reduced complexity of basal dendritic arbors of CA2 pyramidal neurons, but caused no alteratio

200 of synaptic calcium signals along dendritic arbors of hippocampal neurons and relate this to measure

201 ruct the complete dendritic and local axonal arbors of identified corticogeniculate neurons in the ma

202 so associated with alterations in the axonal arbors of inhibitory neurons, which underwent a parallel

203 s of Golgi-stained brain sections, dendritic arbors of male hippocampal neurons are more complex than

204 cribe a method to map the location of axonal arbors of many individual neurons simultaneously via the

205 Dendritic and axonal arbors of many neuronal types exhibit self-avoidance, in

206 espread in the nervous system, with dendrite arbors of many neurons expanding in concert with their s

207 f this approach by reconstructing the axonal arbors of multiple neurons in the motor cortex across a

208 Although arbors of neighboring cells overlap extensively, imaging

209 Indeed, OFF arbors of ON-OFF RGCs lose complexity more rapidly than

210 Surprisingly, the central arbors of plantar paw and trunk innervating nociceptors

211 ess this question, we examined the dendritic arbors of principal neurons, visualized by using the Gol

212 he skin to pattern the stereotypic dendritic arbors of PVD and FLP somatosensory neurons in Caenorhab

213 Dendritic arbors of retinal ganglion cells (RGCs) collect informat

214 of selective growth/elimination of dendritic arbors of RGCs driven by visual activity.

215 es of RGC dendrites, we found that dendritic arbors of RGCs underwent a substantial spatial rearrange

216 The dendritic arbors of spinally projecting TH neurons from sedentary

217 The dendritic arbors of the larval Drosophila peripheral class IV dend

218 Individual sympathetic axons formed complex arbors of varicose neurites within myenteric ganglia/pri

219 However, the arbors of very few long-range projection neurons have be

220 s were found between maturation of dendritic arbors on the cellular level and the loss of diffusion a

221 in transition of the enigmatic NSC terminal arbor onto long cytoplasmic processes engaging with and

222 How a complex dendritic arbor optimizes this paucity of mRNAs opens several func

223 ndrite growth in neurons with small dendrite arbors or the animal overall.

224 ne the spatial distribution of the dendritic arbors, or arbor density, with reference to arbors of an

225 ites required for dendrite stabilization and arbor outgrowth.

226 ewer dendrite branches and shorter dendritic arbor over a 48 h imaging period.

227 method detected 80.1 and 92.8% more centered arbor points, and 53.5 and 55.5% fewer spurious points t

228 highly accurate quantification of dendritic arbor position relative to neurites of other cells.

229 terization of topological motifs in neuronal arbors provides a thorough description of local features

230 s are spatially segregated on T5's dendritic arbor, providing candidate anatomical substrates for the

231 d that vision-dependent dendritic growth and arbor refinement occurred mainly in the middle portion o

232 adian rhythms in PDF accumulation and axonal arbor remodeling.

233 unipolar morphology with a single dendritic arbor restricted to the IPL.

234 exclusively (i.e., approximately 100% of an arbor's varicose branches) to myenteric plexus ( approxi

235 pathways responsible for specific dendritic arbor shapes.

236 l multiple mechanisms that shape a dendritic arbor.SIGNIFICANCE STATEMENT Visual perception begins in

237 Half decreased dendritic arbor size and Ca(2+) responses after dark and increased

238 Half increased dendrite arbor size and Ca(2+) responses following dark and decre

239 We then calculated the terminal arbor size and compared these measures with previously p

240 gnificant reductions in hippocampal dendrite arbor size and complexity, loss of dendritic spine and s

241 Terminal arbor size and other terminal field measures correlate w

242 ive dendrite self-crossing without affecting arbor size and shape.

243 n cell (RGC) density increases and dendritic arbor size decreases toward retinal locations with highe

244 postsynaptic neuron without affecting total arbor size.

245 he retina with homogenous density, and their arbor sizes change little with eccentricity.

246 ollectively scaling their cell densities and arbor sizes toward the same retinal location [4].

247 nically beyond reach due to their large axon arbor sizes.

248 We find sublayer-specific arbor specializations within the inner plexiform layer (

249 in vivo, because Ndr2-null mutant mice show arbor-specific alterations of dendritic complexity in th

250 e for integrin alpha3 in regulating dendrite arbor stability, synapse maintenance, and proper hippoca

251 Gal1 serum levels also increased with Ann Arbor stage (P = .012), areas of nodal involvement (P <

252 aking all patients into account, sex and Ann Arbor stage also seem to be DSS predictors.

253 on therapy, whereas DLBCL, MCL, and high Ann Arbor stage EMZL and FL were frequently treated with che

254 nts with primary OA-DLBCL were seen with Ann Arbor stage IE and TNM T2 disease.

255 ts with primary OA-DLBCL, 53 (93.0%) had Ann Arbor stage IE disease, and 4 (7.0%) had Ann Arbor stage

256 icular lymphoma, 38 (55%) presented with Ann Arbor stage IE lymphoma, and 31 (45%) had stage IIE lymp

257 wly diagnosed, untreated, CD20-positive, Ann Arbor stage II-IV DLBCL or grade 3b follicular lymphoma;

258 Arbor stage IE disease, and 4 (7.0%) had Ann Arbor stage IIE disease.

259 5% confidence interval [CI], 1.26-2.33), Ann Arbor stage III or IV (HR, 1.79; 95% CI ,1.35-2.38), and

260 th previously untreated, advanced stage (Ann Arbor stage III or IV) follicular lymphoma of WHO histol

261 dy, patients aged 18 years or older with Ann Arbor stage III-IV follicular lymphoma were assigned 1:1

262 treated patients) were enrolled; 93% had Ann Arbor stage III/IV disease; 49% had high Mantle Cell Int

263 en taking all 100 patients into account, Ann Arbor stage was able to predict DSS (P = .01).

264 hydrogenase (LDH), sites of involvement, Ann Arbor stage, ECOG performance status) were identified an

265 Most patients (76%) had Ann-Arbor stages III-IV and 96% of patients were treated wit

266 ctors included age (EMZL), sex (FL), and Ann Arbor staging classification (EMZL and FL).

267 = .04) in primary OA-DLBCL, whereas the Ann Arbor staging system was not.

268 h populations exhibited correlations between arbor stratification and aberrant inhibitory input, whil

269 Dendritic arbor stratification, total length, and area were measur

270 promote or restrict growth of the dendritic arbor; structural plasticity is achieved through a balan

271 ain system and suggest that regional central arbor structure could facilitate the "enlarged represent

272 Assessments of neurite arbor structure in vitro revealed CD2AP overexpression,

273 sed in neurons that extend complex dendritic arbors, such as Purkinje cells, targeted in SCA5 pathoge

274 pi, male neurons have more complex dendritic arbors than female neurons.

275 branching inside the nucleus and a dendritic arbor that differed from that of STN neurons without loc

276 MG postganglionics formed mixed, heterotypic arbors that coinnervated extensively (>15% of their vari

277 this data set we measured the proportion of arbors that contained vesicles and the types of vesicles

278 elopment to increase the density of the TN1A arbors that interact with dendrites of the hg1 motoneuro

279 ere neurons form submicron synapses but have arbors that may span millimeters in length.

280 macrine cells (ACs) with elongated dendritic arbors that show orientation tuning.

281 ns and individual thalamocortical axon (TCA) arbors that synapse with them.

282 ncreases the complexity of axon and dendrite arbors, thereby increasing the probability of contact.

283 ximizes the readiness of the entire neuronal arbor to respond to local cues.

284 positions, and their deployment of ramified arbors to cover specific neuropil territories to form a

285 inations, extend axons, and ramify dendritic arbors to establish functional circuitry.

286 that target the majority of their dendritic arbors to the scleral half or "Off" sublamina of the inn

287 Despite this extensive arbor, type II afferents are weakly activated by outer h

288 ilarities is capable of classifying neuronal arbor types as well as, or better than, traditional topo

289 During this period of laminar stability, RGC arbors undergo structural rearrangements that shift thei

290 -21, 2014 at the University of Michigan, Ann Arbor, USA.

291 Hospitalist Allied Research Program, and Ann Arbor Veterans Affairs/University of Michigan Patient Sa

292 Individual arbors were observed to span multiple cortical columns,

293 The microglial arbors were reconstructed seamlessly using an automated

294 isturbances in maturation of their dendritic arbors, which further contribute to impaired cerebral gr

295 ossess myelinated distal dendritic tree-like arbors with excitable nodes of Ranvier at peripheral and

296 ic MSNs showed a markedly immature dendritic arbor, with fewer dendritic branches, nodes, endings, an

297 ons within the areas traversed by its axonal arbor, with pockets of very high innervation density.

298 n signals from extrinsic cues to sculpt axon arbors within the CNS.

299 ndrite growth in neurons with large dendrite arbors without affecting dendrite growth in neurons with

300 n simplification and retraction of dendritic arbors, without disruption of axon initial segment integ