ライフサイエンスコーパス: archaic

1 Importantly, some archaic adaptation mechanisms appear to have reemerged a

2 enomic regions that show strong evidence for archaic adaptive introgression.

3 istory: recent African replacement (RAR) and archaic admixture (AA).

4 tter define the scope of plausible models of archaic admixture between Neandertals and anatomically m

5 Signals of archaic admixture have been identified through compariso

6 Our results establish that archaic admixture influences disease risk in modern huma

7 and fit expectations better under a range of archaic admixture scenarios.

8 samples have pointed to several instances of archaic admixture through interbreeding between the ance

9 ygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population s

10 a, Biaka, and San) to test models of African archaic admixture.

11 first whole genome-level evidence of African archaic admixture.

12 lly and chronologically intermediate between archaic African fossils and later anatomically modern La

13 When an introgressed archaic allele has a selective advantage, even rare inte

14 aic lineages, provided that the introgressed archaic allele has risen to high frequency under positiv

15 Thus, adaptive introgression of archaic alleles has significantly shaped modern human im

16 Finally, the reduction of both archaic ancestries is especially pronounced on chromosom

17 eal orientation is intermediate between late archaic and early modern humans, the ramus is exceptiona

18 indicators of lower facial projection across archaic and modern Homo indicates that Neandertal facial

19 ability to make a direct comparison between archaic and modern human genomes.

20 tals than in the ancestral lineage common to archaic and modern humans, whereas genes involved in beh

21 es of the hominins from this site with other archaic and recent human groups.

22 Proteopithecus sylviae is an archaic anthropoid from the late Eocene quarry L-41, Fay

23 However, archaic approaches, especially combinational ones, are r

24 Here, we redescribe the wings of the archaic bird Archaeopteryx lithographica and the dinosau

25 ecies are identified, including 7 species of archaic bird, representing Enantiornithes, Ichthyornithe

26 In particular, it remains unclear whether archaic birds became extinct gradually over the course o

27 des strong evidence for a mass extinction of archaic birds coinciding with the Chicxulub asteroid imp

28 e evidence for the persistence of a range of archaic birds to within 300,000 y of the K-Pg boundary.

29 covered in a secure and undisturbed Terminal Archaic burial context at Jiskairumoko, a multicomponent

30 ed by high, but short-lived, diversity of an archaic clade, Rhomaleosauridae.

31 lazed (BG) specimens from different periods (Archaic, Classical, Hellenistic) with laboratory reprodu

32 the concept of culture and ethnicity in such archaic contexts, this paper then examines three example

33 sistent with the notion of a subcortical and archaic danger recognition system and a system detecting

34 erences among more divergent populations, as archaic Denisovans have accumulated nonsynonymous mutati

35 Thus, archaic Denisovans must have lived over an extraordinari

36 approximately 5% [1] of their ancestry from archaic Denisovans, an even larger proportion than the a

37 in evidence through the identification of an archaic-derived amino acid sequence for the collagen typ

38 in Kenya from ca. 4.1 to 1.4 Ma samples two archaic early hominin genera and records some of the ear

39 It therefore presents a mosaic of archaic, early modern human and possibly Neandertal morp

40 ntext at Jiskairumoko, a multicomponent Late Archaic-Early Formative period site in the southwestern

41 r studies reveal an evolutionarily conserved archaic embryonic program in somatic cells that can be d

42 either by outcompeting them or when the more archaic faunas suddenly became extinct.

43 Postcranial remains seem also to have archaic features.

44 hologically modern overall but displays some archaic features.

45 Here we report the complete mtDNA of an archaic femur from the Hohlenstein-Stadel (HST) cave in

46 anatomically modern humans (AMH) and various archaic forms coexisted for much of the last 200,000 yr;

47 ve entered the population via gene flow with archaic forms in Eurasia.

48 A long-debated question concerns the fate of archaic forms of the genus Homo: did they go extinct wit

49 cally focused on the genetic contribution of archaic forms outside of Africa.

50 ra, including living taxa (lipotyphlans) and archaic fossil forms, is central to the question of high

51 Are they relics of the archaic genes, or are they results of rearrangement in g

52 ionships and population history of available archaic genomes and 25 present-day human genomes shows t

53 ng gene flow into Denisovans from an unknown archaic group.

54 on depended in part on the genetic legacy of archaic groups such as the Neanderthals.

55 Relative to body mass, brain mass in late archaic H. sapiens (Neanderthals) was slightly smaller t

56 on datasets to show many positively selected archaic haplotypes act as expression quantitative trait

57 analyses that identified 126 high-frequency archaic haplotypes as putative targets of adaptive intro

58 Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive

59 man genome (hg38) and appear to be unique to archaic hominids.

60 also provide insights into the evolution of archaic hominids.

61 ilable for more than 1,100 ancient human and archaic hominin (for example, Neandertal) individuals.

62 oach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome

63 to live at high altitude, was inherited from archaic hominin ancestors.

64 phenotypic, and evolutionary significance of archaic hominin DNA that persists in present-day individ

65 ortion of their ancestry from Denisovans, an archaic hominin group from Siberia.

66 s expanded and completely replaced all other archaic hominin populations.

67 e, we review recent work that has identified archaic hominin sequence that survives in modern human g

68 Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage.

69 history of introgressive hybridization from archaic hominins (most likely Asian Homo erectus) into t

70 that HPV58 variants may have coevolved with archaic hominins and dispersed across the planet through

71 ect to the genetic constitution of these two archaic hominins and Pan troglodytes (chimpanzee).

72 Ancient DNA from archaic hominins has revealed a rich history of admixtur

73 to change-containing variation acquired from archaic hominins or adaptive variants in specific popula

74 strate that hybridization between modern and archaic hominins provided an important reservoir of adva

75 Neanderthals were a group of archaic hominins that occupied most of Europe and parts

76 ptive introgression of genetic variants from archaic hominins to humans and emerging ancient genome d

77 d Denisovan sequences suggests that PRDM9 in archaic hominins was closely related to present-day huma

78 y motifs absent in other primates (including archaic hominins), with evidence for selective pressures

79 e world, they encountered and interbred with archaic hominins, including Neanderthals and Denisovans

80 etween our direct ancestors and contemporary archaic hominins, including the Neanderthals.

81 retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the influence

82 on average are similar to those of preceding archaic Homo and principally contrast with those of rece

83 oughout the globe is the question of whether archaic Homo lineages contributed to the modern human ge

84 ility of admixture between modern humans and archaic Homo populations (Neanderthals being one possibi

85 been argued to result from the expansion of archaic Homo sapiens out of Africa.

86 rm, and suggests that Neanderthals and other archaic Homo should be excluded from H. sapiens.

87 although morphologically similar to those of archaic Homo, the Saint-Cesaire 1 femoral midshaft exhib

88 hat AMHS is a distinct species from taxa of "archaic" Homo (e.g., Homo neanderthalensis).

89 S) from those attributed to various taxa of "archaic" Homo spp. (AH) and to test hypotheses about the

90 These results suggest an archaic human diaspora early in the Middle Pleistocene.

91 ed in modern humans, the deletion is also in archaic human genomes.

92 st in human evolution centers around whether archaic human populations (such as the Neanderthals) hav

93 ferences that distinguish modern humans from archaic human species.

94 n these early modern humans met preexisting 'archaic human' populations outside of Africa.

95 Earlier (archaic) human populations were biologically similar and

96 a previously undocumented mixture related to archaic humans (p = 0.0013).

97 40 y) adult mortality distributions for late archaic humans (principally Neandertals) and two samples

98 We analyzed the APOL1 sequence in modern and archaic humans and baboons along with geographic distrib

99 3 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group

100 ons and limited admixture between modern and archaic humans can be accommodated in the model while co

101 cing has revolutionised our understanding of archaic humans during the Middle and Upper Palaeolithic.

102 The Late Pleistocene archaic humans from western Eurasia (the Neandertals) ha

103 is also differentiated from western Eurasian archaic humans in aspects of its temporal, occipital, an

104 graphical spread, and eventual extinction of archaic humans outside of Africa are much debated.

105 istence of beneficial variants acquired from archaic humans that may have accelerated adaptation and

106 sm arose before the divergence of modern and archaic humans, segregates at intermediate to high frequ

107 d Neandertals in the Eurasian range of these archaic humans.

108 d a role in the evolution of both modern and archaic humans.

109 he statistical methods developed to identify archaic introgressed fragments in the genome sequences o

110 We found evidence of archaic introgression in all three populations, and the

111 population structure and the possibility of archaic introgression of Y chromosomes into anatomically

112 confound genetic signals from adaptation and archaic introgression.

113 at the first dinosaurs quickly replaced more archaic Late Triassic faunas, either by outcompeting the

114 eages and those that are only derived in one archaic lineage.

115 c lineages, those that are ancestral in both archaic lineages and those that are only derived in one

116 uestion is that low levels of admixture with archaic lineages are not expected to leave extensive tra

117 Analyses of surviving archaic lineages suggest that there were fitness costs t

118 rtunity to identify low-level admixture with archaic lineages, provided that the introgressed archaic

119 ts, including those that are derived in both archaic lineages, those that are ancestral in both archa

120 The evidence for Late Archaic maize has been limited, leading to the interpret

121 Discoveries of archaic Mesozoic fossil birds ('opposite' birds, or enan

122 In the context of an increasingly documented archaic-modern morphological mosaic among the earliest m

123 he majority MRSA clone suggest that it is an archaic MRSA isolate similar in features to early MRSA i

124 o those that accompanied the replacement of "archaic" Neanderthal by anatomically modern human popula

125 st approximately 100,000 years ago, the late archaic Neanderthals and the early modern Skhul/Qafzeh h

126 In addition, we document a remarkably archaic new fossil peramelemorphian taxon that inhabited

127 The wings of archaic Odonatoidea from the mid-Carboniferous of Argent

128 hin contemporary human genomes that may have archaic or common ancestral roots.

129 nly prior hypothesis not disproven is a late Archaic origin for BCS rock art, although our age result

130 ve scenarios of a relatively recent or super-archaic origin of Neandertal Y chromosomes.

131 inct cultural groups, including the Maritime Archaic, Palaeoeskimo, and Beothuk.

132 portance of maize (Zea mays) during the Late Archaic period (3000-1800 B.C.) in ancient Peru.

133 tural complex in this region during the Late Archaic period between 3000 and 1800 calibrated calendar

134 ical sites from the terminal Paleoindian and Archaic periods associated with the Lake Stanley low wat

135 permits the serial founder model but not the archaic persistence model to explain the three trends ob

136 om 'condylarths', a paraphyletic assembly of archaic placentals.

137 One of the USA300 isolates contained an archaic plasmid that encoded staphylococcal enterotoxins

138 ast a single admixture event from an unknown archaic population into the ancestors of AMH, likely wit

139 at introgressed approximately 35 kya from an archaic population that split from the ancestors of anat

140 tructure, with and without gene flow from an archaic population.

141 used to determine if dual ancestry in local archaic populations and earlier modern populations from

142 a 100,000 years ago and total replacement of archaic populations in Asia.

143 adaptive alleles may have introgressed from archaic populations into modern humans.

144 gration expands into a series of preexisting archaic populations produces nearly opposite patterns to

145 rom those expected if alleles from divergent archaic populations were maintained through multiregiona

146 an population or an amalgamation of distinct archaic populations.

147 r modern humans, with general replacement of archaic populations.

148 ica dispersal, and subsequently admixed with archaic populations.

149 or without interbreeding) of the preceding "archaic" populations in these regions.

150 This is, in part, due to the archaic practice of patients remaining nil per os postop

151 In this way archaic progenitors of G-protein-coupled chemical quanta

152 We use these maps of archaic sequences to show that Neandertal admixture occu

153 c regions that are significantly depleted of archaic sequences, and identify signatures of adaptive i

154 However, archaic species concepts and an inadequate fossil record

155 iroom temple, associated with the rise of an archaic state at ca. 300-100 B.C.

156 te Alban I phase (300-100 BC), the period of archaic state emergence in the region.

157 all in use during the 300-100 B.C. period of archaic state emergence.

158 ciopolitical transformation from chiefdom to archaic state in precontact Hawai'i.

159 a significant factor in the evolution of the archaic state in the northern Titicaca Basin.

160 tion of the Maui polity to form an incipient archaic state.

161 of society from hunting and gathering to the archaic state.

162 istoric accounts of late precontact Hawaiian archaic states emphasize the independence of chiefly con

163 dominant role of centralized institutions in archaic states.

164 nd resources during the rise of the Hawaiian archaic states.

165 also find evidence of introgression from the archaic Taimyr wolf lineage into present-day dog breeds

166 he western Titicaca Basin dating to the Late Archaic to Early Formative periods ( approximately 3,400

167 me comparisons identified introgression from archaic to modern humans.

168 n in habitual load levels from Eurasian late archaic, to Early Upper Paleolithic early modern, to Mid

169 pATOM36 is required for the assembly of the archaic translocase of the outer membrane (ATOM), the fu

170 ane space domain of the translocase subunit, archaic translocase of the outer membrane (ATOM)14, on t

171 owever, and use instead a protein termed the archaic translocase of the outer mitochondrial membrane

172 a conventional Tom40 and instead employs the archaic translocase of the outer mitochondrial membrane

173 y 'Zhelestidae' within a clade that includes archaic ungulates ('condylarths').

174 (Tribosphenomys), lagomorphs (Mimotona) and archaic ungulates (Protungulatum and Oxyprimus) strongly

175 ne or more mesonychians, a group of extinct, archaic ungulates, but molecular analyses have indicated

176 une system in early vertebrates by splitting archaic V genes with transposable elements.

177 ression process and investigation of whether archaic variants conferred an adaptive advantage to the