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1 nzo[h]quinazoline 7a-e as mixed analogues of archetypal 1,8-bis(dimethylamino)naphthalene ("proton sp
3 role-based systems on surfaces, we chose the archetypal 5,10,15-tris(pentafluorophenyl)corrole [H(3)(
4 tive representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic
7 collagen (Shc) proteins have been considered archetypal adaptors of epidermal growth factor receptor
8 better than Lewis acids as catalysts for the archetypal aldol cyclotrimerization of indanone (2) in a
9 other and to aspartate aminotransferase, the archetypal alpha-class pyridoxal 5'-phosphate enzyme.
11 ycle phase, highlighting differences between archetypal and variant cell cycles employed for specific
12 form of peptides and proteins represents an archetypal and widely accessible structure consisting of
13 of recombinant TbPTR1 and inhibition by the archetypal antifolate methotrexate have been characteriz
16 asymmetric induction from 28 to 78% ee in an archetypal asymmetric allylation employing BINAP (L*) as
19 study analyzed GWAS data from a selection of archetypal autoimmune diseases among 138511 individuals
20 Familial Mediterranean fever (FMF) is an archetypal autoinflammatory disorder, which is autosomal
23 We show that the spectrum of activity of an archetypal bacterial PA (SK) with animal Pgs can be prof
24 on a membrane-bound structural model of the archetypal bacterial VGSC, NaChBac in a closed pore conf
27 hronic infection of compromised hosts as the archetypal biofilm infection, which is both refractory t
28 al system of Drosophila embryos achieves its archetypal branching pattern through a series of cell mi
29 of syndiotactic propylene enchainment by the archetypal C(s)-symmetric precatalyst [Me(2)C(Cp)(Flu)]Z
30 to identify transient reactive species of an archetypal C-H amination reaction catalyzed by a dirhodi
32 found that genes with binding sites for the archetypal cancer transcription factor, E2F, were dispro
33 c phenotypes in the intestinal epithelium-an archetypal canonical, Wnt pathway-dependent, rapidly sel
35 nsisting of module 12, shown here to have an archetypal CCP structure, and module 13, which is unique
38 transbilayer position and orientation of an archetypal class A amphipathic helical peptide in orient
40 rge regions of genetic homogeneity among the archetypal clonal lineages, reflecting the relatively fe
51 ycles, because in addition to disrupting the archetypal cycle (G1-S-G2-M), mr mutations affect the ra
53 tivation of receptor-bound JAK2, based on an archetypal cytokine receptor, the growth hormone recepto
54 We have now determined the structure of the archetypal dcm-Vsr endonuclease from Escherichia coli bo
55 y to the differential effect of DELLA on the archetypal defense hormones salicylic acid (SA) and jasm
56 Pluripotent cells can be captured via the archetypal derivation of embryonic stem cells or via som
64 Here we report thermal dust emission from an archetypal early Universe star-forming galaxy, A1689-zD1
65 but more recent AFM work suggested that the archetypal EcoKI protein went through an additional dime
66 r these mutations produce a variation on the archetypal EF-hand coordination scheme, we have obtained
70 us diseases of childhood, once thought to be archetypal environmental diseases, actually may be among
71 sis that it should be possible to reengineer archetypal enzymes to achieve substrate specificities ch
76 chain in a transverse magnetic field is the archetypal example of a system that undergoes a transiti
78 in macaque primary visual cortex, V1, as an archetypal example of cortical feature selectivity and d
79 essing; or (ii) decision-formation, using an archetypal example of global perception, coherent motion
80 ontrol network of teleost fishes presents an archetypal example of how a vertebrate nervous system pr
83 are demonstrated using a 4-site model and an archetypal example of the para-benzene ring and are show
88 lastoderm and the vertebrate neural tube are archetypal examples of morphogen-patterned tissues that
90 diate acetaminophen-induced liver injury, an archetypal experimental model of sterile cell death and
95 a common active-site structure vis-a-vis the archetypal galactose 6-oxidase from Fusarium graminearum
97 utation is the first identified cause of the archetypal generalized photosensitive epilepsy syndrome,
98 ntrons of approximately 1 kb, reflecting the archetypal genomic structure of the cysteine protease fa
99 We investigated topographic evolution in the archetypal glacial landscape of Fiordland, New Zealand,
101 ophage cell lines (HL-60; RAW 264.7) to kill archetypal Gram-positive (Staphylococcus aureus), Gram-n
103 (white-eyes, Zosteropidae) that contains an archetypal "great speciator." Our analyses show that the
106 in the case of Mus81-Eme1, is as good as the archetypal HJ resolvase RuvC in single turnover kinetic
109 hritis, bacteremia, or meningitis, including archetypal human ExPEC strains 536, CP9, and RS218.
110 ividual canine and human isolates, including archetypal human ExPEC strains CFT073 (O6:K2:H1), 536 (O
111 n isolates of serogroup O6 closely resembled archetypal human pyelonephritis isolate 536 (O6:K15:H31)
112 canine fecal isolates and (clonally related) archetypal human pyelonephritis isolate 536 were found t
114 monomeric polyglutamine is twofold: It is an archetypal IDP sequence and its aggregation is associate
115 nalyses, we interpret the phase behaviour of archetypal IDP sequences and demonstrate the rational de
116 ative studies of conformational ensembles of archetypal IDP sequences such as polyglutamine and glyci
119 dle-aged and old rabbits exhibited all three archetypal indexes of cardiovascular aging, a comparable
120 Here we demonstrate that inhibition of the archetypal innate immune receptor CD11b/CD18 prevents pr
121 imer prompted us test the hypothesis that an archetypal integral membrane desaturase from Saccharomyc
122 lum Ca(2+) stores, fuelling speculation that archetypal intracellular Ca(2+) channels are the primary
123 y do some cells express small numbers of the archetypal intracellular Ca(2+) channels, IP(3)R and RyR
126 that synergistic protein design converted an archetypal "irreversible inhibitor" into a slow substrat
127 rk has shown that the Tar-Tar(*) complex, an archetypal kissing loop, can form without Mg(2+), so lon
128 r carcinoma (HCC) genomes and elucidated two archetypal L1-mediated mechanisms enabling tumorigenesis
129 aviour of common boron starting materials as archetypal Lewis acids such that common routes to organo
130 ed to the combination of apoptotic cells and archetypal ligands for Toll-like receptors (TLRs) 2, 4,
132 Drosophila sensory organs are built from an archetypal lineage, and we speculate about how this ster
133 ed polysaccharide utilization loci, with the archetypal locus sus (for starch utilisation system) enc
135 ate this through numerical simulations of an archetypal low-Reynolds-number swimmer, the "squirmer."
136 but is a potent cross-class inhibitor of the archetypal lysosomal cysteine proteinases cathepsins K,
139 study, we identify a putative proto-MHC with archetypal markers in the most basal branch of Metazoans
142 s requires the intramembrane UbiA enzyme, an archetypal member of a superfamily of prenyltransferases
145 nostatin, a clinical anticancer drug, is the archetypal member of the chromoprotein family of enediyn
146 el OMP assembly, the expression of cpxP, the archetypal member of the cpx regulon, was upregulated in
148 Eukaryotic initiation factor (eIF) 4A is the archetypal member of the DEAD box family of RNA helicase
153 alphaIIbbeta3 (glycoprotein IIb-IIIa) is an archetypal member of the integrin family of adhesive mol
155 se permease (LacY) of Escherichia coli is an archetypal member of the major facilitator superfamily o
156 ell biology, that bluetongue virus (BTV), an archetypal member of the Reoviridae, utilizes the late e
157 membrane protein bacteriorhodopsin (bR), an archetypal member of the rhodopsin photoreceptor family,
161 occus aureus Sortase A protein (SrtA) is the archetypal member of the Sortase family and is activated
162 otein (Int) from bacteriophage lambda is the archetypal member of the tyrosine recombinase family, a
168 data demonstrate a novel role for LTi cells, archetypal members of the innate lymphoid cell family, i
169 n the superconductivity of TaSe2, one of the archetypal members of the large family of layered dichal
170 80 and 945 mV, respectively, relative to the archetypal members of this class of compounds; important
171 charomyces cerevisiae Rad51 proteins are the archetypal members of two related families of proteins t
172 a numerical analysis using dimensions for an archetypal merozoite to predict the respective contribut
175 ve reported previously that macrophages, the archetypal migratory cells, use the protease- and podoso
176 e Entamoeba ADP/ATP carrier is distinct from archetypal mitochondrial ADP/ATP carriers, an observatio
177 lass-A G-protein-coupled receptors and their archetypal model, rhodopsin, such as the apparent breaki
178 iagnose the source of these problems in four archetypal models and propose a density-dependent formul
181 for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates
183 operative than that found previously for the archetypal molten globule, alpha-lactalbumin (alpha-LA);
184 spectroscopic studies of compound 1 and the archetypal Molybdenum Blue (MB) wheel, {Mo(150)}, identi
185 nd exhibited functional distinction from the archetypal motogenic scatter factors hepatocyte growth f
188 ith DEPDC5 mutations share features with the archetypal mTORopathy, tuberous sclerosis, raising the p
190 gories on the firm foundation of genes-as an archetypal natural kind-may be fundamentally flawed beca
192 ciated) subclone of E. coli O18:K1:H7 as the archetypal neonatal bacterial meningitis (NBM) isolate R
194 and structures of such intermediates for the archetypal non-heme Fe(II) and alpha-ketoglutarate-depen
195 than expensive "designer" theophylline, the archetypal non-selective phosphodiesterase inhibitor.
196 beta(2)-adrenergic receptor (beta(2)AR), the archetypal nonvisual heptahelical receptor, as a model t
197 r a soluble amide product, in contrast to an archetypal NRPS-embedded C domain that condenses two car
200 electronic states in Znq(2) and those in the archetypal organic electroluminescent molecule tris(8-hy
204 ny differences that might exist between this archetypal pair of atoms, and thereby to test the fundam
206 a list of 423 tissue-selective genes matched archetypal pathways in the corresponding human or mouse
208 reasing multigene family and EndoPDI, unlike archetypal PDI, may be a molecule with which to target t
212 of unique CHD2 variants (3/36 cases) in the archetypal photosensitive epilepsy syndrome, eyelid myoc
213 synthase and establishing ESK1/TBL29 as the archetypal plant polysaccharide O-acetyltransferase, we
214 active metabolites of the widely distributed archetypal polycyclic aromatic hydrocarbon, benzo[a]pyre
216 ture and properties of excited states in the archetypal polythiophene are investigated via aggregates
217 we screened a peptide library, based on the archetypal pore-former melittin, for loss-of-function va
218 Nucleoside O-glycosylation represents an archetypal problem in chemical selectivity, inasmuch as
219 iquid droplet bound by surface tension is an archetypal problem in the study of the equilibrium shape
220 a designed peptide, functions outside of the archetypal protein context, as long as it is tethered to
221 homologs raises the question of whether this archetypal protein exists within the third domain of lif
224 h structural bioinformatics, we generated an archetypal quaternary structural model of an ion channel
225 )-rich dentin proteins, are considered to be archetypal regulators of several aspects of extracellula
226 )ppGpp synthesis, and RNA binding unites two archetypal regulatory paradigms within a single protein.
229 bio-sciences, by developing tools to address archetypal representation and user interaction issues in
235 fluid flow and diffusion appropriate to the archetypal "rotational streaming" of algal species such
236 show that SsgB, a subfamily of SALPs, is the archetypal SALP that is functionally conserved in all sp
238 em realizes a laser-actuated analogue to the archetypal semiconductor spintronic device, the Datta-Da
240 the same as that of the previously reported archetypal sequence (type I) with only Y24EEL phosphoryl
241 ects of side chains using simulations of two archetypal sequences with amino acid compositions that a
243 Because platelets are anucleate and contain archetypal signal transduction machinery, they are ideal
244 evolutionary time frame coalesced to form an archetypal signaling pathway in bilateria that was expan
247 okalaemic periodic paralysis (hypoPP) is the archetypal skeletal muscle channelopathy caused by dysfu
248 f non-faceted, crystalline microspheroids of archetypal small molecular materials used in organic ele
249 llect high-quality binding responses for the archetypal small molecule inhibitors JM-2987 and TAK-779
250 ated cells were observed which differed from archetypal smooth muscle cells due to their knurled, tub
252 n detected outside the galactic plane of the archetypal starburst galaxy M82 (refs 4 and 5), but so f
253 ar to be ideally modeled and analyzed by one archetypal statistical framework - the Graphical Probabi
254 y stable tissue, the satellite cell exhibits archetypal stem cell properties and is competent to form
255 ng role in action of beta-estradiol (E2), an archetypal steroid superfamily hormone, upon its major t
257 ultrafast dynamics of quasi-particles in an archetypal strongly correlated charge-transfer insulator
262 onstrated by application of the method to an archetypal system involving a synthetic tripeptide known
263 honeycomb lattice provides a two-dimensional archetypal system to explore novel phenomena of geometri
265 related pathologies under the control of the archetypal T(H)2 cytokine interleukin-4 (IL-4) and was a
269 looping mediated by the Lac repressor is an archetypal test case for modeling protein and DNA flexib
273 not well understood and, paradoxically, the archetypal TNF-induced nuclear factor NFkappaB is anti-a
274 equence, ISPpu12, has been identified on the archetypal toluene-xylene TOL catabolic plasmid pWW0 fro
275 or cAMP-binding protein (CREB), which is the archetypal transcription factor binding to CRE, decrease
280 ly pathways, one of which is followed by the archetypal trimeric beta-barrel OMPs, OmpF and LamB, and
281 in which the C-O-P phosphoryl linkage of the archetypal tubule-forming molecule, 1,2-bis(10,12-tricos
285 the restriction endonuclease activity of the archetypal Type I RM enzyme, EcoKI, in vitro indicating
286 We have analyzed 15 polymorphic loci in the archetypal type I, II, and III strains and found that po
287 igher (>tenfold) than those obtained with an archetypal ubiquitous promoter in a mouse model of hemop
288 from global indoor and outdoor averages, via archetypal urban and indoor settings, to 3646 real-world
291 ere proposed for the electronic detection of archetypal volatile anesthetic molecules such as diethyl
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