ライフサイエンスコーパス: arginine deiminase

1 Protein arginine deiminase 2 (PAD2) plays a key role in the onse

2 Peptidyl arginine deiminase 2 (PAD2), an enzyme that converts pro

3 Peptidyl arginine deiminase-2 and cyclic nucleotide phosphodieste

4 lular domain of LRP1 is a target of peptidyl arginine deiminase-2-mediated deimination in vitro.

5 e identified citrullination sites in protein arginine deiminase 4 (12 sites) and in fibrinogen (25 si

6 ) to citrulline with recombinant polypeptide arginine deiminase 4 (PAD4) abolished ADAMDEC1-catalyzed

7 events in NET formation, including peptidyl arginine deiminase 4 (PAD4) activity, neutrophil nuclear

8 The presumed role of an overactive protein arginine deiminase 4 (PAD4) in the pathophysiology of rh

9 Protein arginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme

10 Protein arginine deiminase 4 (PAD4) is a transcriptional coregul

11 Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation

12 evelopment of specific inhibitors of protein-arginine deiminase 4 (PAD4), an enzyme required for NET

13 Peptidyl arginine deiminase 4 (PAD4), which binds proteins and ci

14 racellular trap formation involving peptidyl arginine deiminase 4.

15 ke use of histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate a

16 ing of the nuclear DNA catalyzed by peptidyl arginine deiminase-4.

17 Arginine deiminase accelerates substrate hydrolysis 6 x

18 y 5.2) determined that strain 1457 devoid of arginine deiminase activity (1457 DeltaADI) was signific

19 e and mutant Manfredo strains for the enzyme arginine deiminase (AD) showed that significant activity

20 L-arginine deiminase (ADI) catalyzes the hydrolysis of L-a

21 Arginine deiminase (ADI) catalyzes the hydrolytic conver

22 L-arginine deiminase (ADI) catalyzes the irreversible hydr

23 l-Arginine deiminase (ADI) catalyzes the irreversible hydr

24 ose was to evaluate the effects of pegylated arginine deiminase (ADI) in terms of toxicity, tumor res

25 Arginine deiminase (ADI) inhibits growth in various ASS-

26 is based on the use of recombinant bacterial arginine deiminase (ADI) isolated from the cells of a re

27 cA1 and arcA2) to assess the function of the arginine deiminase (ADI) pathway in organic acid resista

28 atabolism of the amino acid arginine via the arginine deiminase (ADI) pathway supplements energy prod

29 susceptible to therapeutic intervention with arginine deiminase (ADI), an enzyme responsible for cons

30 plasma arginine deprivation using pegylated arginine deiminase (ADI-PEG 20) against primary AMLs in

31 Purpose Pegylated arginine deiminase (ADI-PEG 20) depletes essential amino

32 e by the arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).

33 exploit arginine deprivation with pegylated arginine deiminase (ADI-PEG20) as a therapeutic.

34 ole of the arginine-lowering agent pegylated arginine deiminase (ADI-PEG20) has not been evaluated in

35 The development of pegylated arginine deiminase (ADI-PEG20) has renewed interest in a

36 Arg-degrading recombinant protein, pegylated arginine deiminase (ADI-PEG20), has been in clinical tri

37 nsitive to arginine depletion with pegylated arginine deiminase (ADI-PEG20).

38 Arginine deiminase (ADI; EC 3.5.3.6.), an arginine-degra

39 s, including ornithine carbamoyltransferase, arginine deiminase, alpha-enolase, and alpha- and beta-g

40 ncreased transcript levels of genes encoding arginine deiminase and a putative serine dehydratase.

41 Arginase, arginine deiminase and arginine decarboxylase are potent

42 enter phase 2 randomized clinical trial, the Arginine Deiminase and Mesothelioma (ADAM) study, was co

43 ion in the anr gene (anaerobic regulation of arginine deiminase and nitrate reduction) that controls

44 ivities for acetaldehyde dehydrogenase ExaC, arginine deiminase ArcA, and glyceraldehyde 3-phosphate

45 cristatus and P. gingivalis, and identified arginine deiminase (ArcA) of S. cristatus as the signali

46 (SAPP) derived from Streptococcus cristatus arginine deiminase (ArcA) was able to repress the expres

47 replacement mutants were constructed within arginine deiminase (arcA1 and arcA2) to assess the funct

48 TGases) (protein cross-linking) and peptidyl-arginine deiminase (conversion of arginines to citrullin

49 stability (t(1/2)=4.8h) whereas a bacterial arginine deiminase evaluated in phase II clinical trials

50 nhibitory activity correlates with levels of arginine deiminase expression in S. cristatus.

51 L-Arginine deiminase from Pseudomonas aeruginosa (PaADI) c

52 Peptidyl arginine deiminases have been shown to be hyperactive in

53 ginine in biofilm growth and the function of arginine deiminase in USA300 clones led us to geneticall

54 ue THH can be solubilized following peptidyl-arginine deiminase modification.

55 genetically inactivate the sole copy of the arginine deiminase operon by deleting the arginine/ornit

56 Peptidyl arginine deiminase (PAD) catalyzes the post-translationa

57 es into the citrulline amino acid by protein arginine deiminase (PAD) family members.

58 y foci in vivo, LL-37 is exposed to peptidyl arginine deiminase (PAD), an enzyme released by inflamma

59 ls undergo histone citrullination by protein arginine deiminase (PAD)4, exocytosis of chromatin and e

60 ation of arginine, are generated by peptidyl arginine deiminases (PAD).

61 nation of arginine to citrulline by peptidyl arginine deiminase (PAD4), change protein structure and

62 The protein arginine deiminases (PADs) are a family of enzymes that

63 Protein arginine deiminases (PADs) catalyze the hydrolysis of pe

64 Protein arginine deiminases (PADs) catalyze the post-translation

65 are generated via the actions of the protein arginine deiminases (PADs), are known to develop in the

66 zed by a group of enzymes called the protein arginine deiminases (PADs).

67 nduced in ATL included those involved in the arginine deiminase pathway and a total of 140 carbohydra

68 novel mobile genetic element that encodes an arginine deiminase pathway and an oligopeptide permease

69 d decrease in the expression of genes in the arginine deiminase pathway during stringent response act

70 P from arginine catabolism by enzymes of the arginine deiminase pathway, encoded by the arcDABC opero

71 nd appeared to be unrelated to ArcD from the arginine deiminase pathway.

72 luded the Padi family, encoding the peptidyl arginine deiminases responsible for citrulline protein m

73 Arginine metabolism by oral bacteria via the arginine deiminase system (ADS) increases the local pH,

74 The arginine deiminase system (ADS) is associated with argin

75 The arginine deiminase system (ADS) is responsible for the p

76 The arginine deiminase system (ADS) of S. gordonii enables c

77 al expression and anaerobic induction of the arginine deiminase system.

78 We show that the constitutive ACME-encoded arginine-deiminase system (Arc) allows USA300 to thrive

79 One of the citrullinating enzymes, peptidyl arginine deiminase type 4 (PAD-4), is genetically associ

80 asmic droplets is first modified by peptidyl-arginine deiminase which denatures it and makes it more