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3 1 high-quality de novo mutations (DNMs) that arose in 816 family trios provides an unprecedented view
4 eural properties important for cognition can arise in a circuit and make clear experimental predictio
5 digit phalanges and their associated joints arise in a different manner than the more sparsely joint
9 ate specification of insects, anterior fates arise in a nonelongating tissue (called the "blastoderm"
12 rates the range of novel phenomena which can arise in a topologically ordered state in the presence o
14 Auditory hair cells and supporting cells arise in a wave of differentiation that patterns them in
17 axion is a hypothetical elementary particle arising in a simple and elegant extension to the standar
18 hology was observed with a rounded phenotype arising in a subpopulation of cells, while other cells r
21 pH, where different effective pore diameters arose in a pH range of 3 to 8, as determined by the pH o
22 r, their work focused on the biases that can arise in ABMs that use parameters drawn from distinct po
26 ch, collective mechanical behaviour that can arise in aggregations of active, interacting building bl
27 ns containing CD207(+)CD1a(+) cells that can arise in almost any tissue and cause significant morbidi
28 e means by which resistance to ABT-199 might arise in AML and the extent to which those mechanisms mi
29 alled the "blastoderm"), and posterior fates arise in an elongating tissue (called the "germband").
33 of UNG and MSH2 and that DNA strand lesions arise in an UNG-dependent manner but are offset by MSH2.
34 This defect is due to two mutations that arose in an ancestor of most teleost fish, implying that
35 Although these regulatory sequences likely arose in ancient viruses, they now constitute a dynamic
36 ic reviews are also susceptible to bias that arises in any of the included primary studies, each of w
37 ween replicate populations genome-wide, than arose in any of our simulated evolutionary scenarios.
38 98I mutation and find that EGFR C797S, which arises in approximately 33% of patients after osimertini
42 dy the locations and rate at which mutations arise in bacteria with as little selection bias as possi
43 uctured multiple hypothesis testing problems arising in bioinformatics, including genome-wide associa
44 esicular tissues of various sizes and shapes arise in biological organs such as ears, guts, hearts, b
45 structure suggests how complex dynamics may arise in biological systems from elements whose combinat
46 are typically intended to address challenges arising in biopharmaceutical practice by promoting impro
49 eversing the dysfunctional T cell state that arises in cancer and chronic viral infections is the foc
50 mic regions they examined is "...unlikely to arise in cases of PTH (Oenothera-like) meiosis since hap
51 he turtle, efferent-mediated fast excitation arises in CD afferents when the predominant efferent neu
52 sing therapeutic intervention for aggression arising in certain forms of neuropsychiatric disease.
55 ermanent section margin control of melanomas arising in chronically sun-damaged skin on the head and
57 tive controls, and 6 patients with melanomas arising in CMN in adulthood were included as positive co
58 o November 12, 2009, of 13 children with PNs arising in CMN in childhood and 5 children with melanoma
62 lve the quadratic optimization problems that arise in computer vision applications, which are computa
63 positions toward prosociality are thought to arise in concert with the social and cultural environmen
65 een proliferative nodules (PNs) and melanoma arising in congenital melanocytic nevi (CMN) is crucial,
66 15 conventional melanomas (CMs), 3 melanomas arising in congenital nevi (CNMs), and 5 spitzoid melano
67 te specification of joint progenitors, which arise in conjunction with phalangeal precursors at the d
70 ne several published studies where confusion arose in data interpretation, to illustrate the challeng
75 e divergence between endometrial tumors that arise in different hormonal conditions and shows that ER
78 formed by succinyl-CoA synthetase (SCS), has arisen in diverse bacterial groups, including microbial
79 ressive tumor with metastatic potential that arises in diverse locations throughout the brain and spi
81 ma is a paediatric malignancy that typically arises in early childhood, and is derived from the devel
82 sensitivity to non-classical BCR-ABL1 drugs arises in emergent tumor subpopulations during the evolu
92 We examined the quantum Hall states that arise in high magnetic fields from anisotropic hole pock
96 nprecedented cooperation is inferred to have arisen in hunter-gather life well before the recent peri
101 a consequence of somatic genomic alterations arising in individual cells, approximately 5% of all CRC
102 atoderma (PPK) are debilitating lesions that arise in individuals with pachyonychia congenita (PC) an
104 iew is to discuss the spectrum of CNS tumors arising in individuals with NF type 1 (NF1) and NF type
105 common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on
106 Alzheimer disease in which beta-amyloidosis arises in later life on a background of preexisting stru
107 a channel found in small peripheral neurons, arose in lizards approximately 170 million years ago (my
108 tary I discusses the selection bias that may arise in longitudinal analysis of clinical data due to s
109 are difficult to resolve chromatographically arise in many contexts, including hetero-oligomeric prot
111 intruding objects with deformable materials arises in many contexts, including locomotion in fluids
112 is study, we evaluated resistance mechanisms arising in metastatic melanoma to MAPK pathway kinase in
114 this is largely ineffective with resistance arising in most tumors following exposure to chemotherap
115 del to explain how 3D motion sensitivity can arise in MT neurons and predicts how essential features
118 ly derived from the VH1-2*02 germline allele arose in multiple HIV-1-infected donors, yet targets the
119 curring electromagnetic field chirality that arises in nanobeam waveguides leads to unidirectional ph
121 ence indicating that similar mutations could arise in naturally occurring bacterial populations facin
123 ies increase the brain's resilience to noise arising in neural computations during decision-making.
129 we explore the role of different ROS sources arising in obesity and diabetes, and the effect of exces
130 posed to inhibit aberrant orexigenic signals arising in obesity as a putative mechanism of vagal bloc
131 analytically resolvable (41)K/(39)K effects arise in oceanic crust as a result of hydrothermal alter
134 as to whether similar dynamical transitions arise in other free-surface flows such as coalescence th
136 space in complex regional pain syndrome may arise in parallel with a distorted perception of the bod
140 finity between the Syt1 and Syt7 C2A domains arise in part from apparently conservative residue subst
141 ns, such as addiction and schizophrenia, may arise in part from dysregulated activity of ventral tegm
142 te that bacterium-stimulated NET release may arise in part via NADPH oxidase-independent mechanisms.
143 These differences between species could arise in part, by the rewiring of regulatory network due
144 previously reported and this difference may arise, in part, due to the lack of actual movement in pr
145 e activity in the "anterior insula" that may arise, in part, from claustrum and/or peri-insular proje
146 rences in the CSF proteome across ventricles arise, in part, from regional differences in choroid ple
147 on of complexity in eukaryotic proteomes has arisen, in part, through emergence of modular independen
148 e oropharyngeal cancers among men than women arises in part from higher number of lifetime sexual par
151 oral injection of tumor-specific antibodies, arising in part from enhanced antibody-dependent cell-me
152 DNA complex in an unwinding-competent state, arising, in part, by an enzyme-induced, back-and-forth m
154 spectrum of IgG4-related disease, and often arises in patients with other autoimmune conditions.
157 g a possible clinical solution to challenges arising in phase I trials from the dose-dependent side e
159 pothesis that distinct molecular alterations arising in primary melanoma cells might persist as these
161 ancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that
163 r two of the most common types of noise that arise in qubits: slow fluctuations of the qubit energy s
165 , there is also evidence that aneuploidy can arise in response to specific challenges and can confer
166 ation in oncogenic Ras-expressing cells, and arises in response to genotoxic stress due to the produc
167 efficiency and that a mutation that commonly arises in response to protease inhibitor therapy creates
168 rall, our results show how adaptive NK cells arising in response to CMV infection can escape MDSC-med
169 uring locomotion this alternation appears to arise in rhythm-generating circuits and transpires at al
170 r both death and severe disease, while cases arising in Saudi Arabia were more likely to be severe.
171 rovide a unified view on how arrhythmias may arise in seemingly disparate diseases that have in commo
173 to deal with imbalanced data that naturally arise in several genome-wide variant scoring problems, t
174 xtreme resistance to tetrodotoxin (TTX), has arisen in several species of snakes through coevolutiona
175 d genome complexity, but polyploidy can also arise in somatic cells of otherwise diploid plants and a
178 t increased growth and convolution of the DG arose in stem mammals concurrently with nonperiventricul
180 xtended amygdala, whereas RMTg biased inputs arise in structures with a more direct impact on motor f
182 l disease entities; (2) mutations, typically arising in subclones, that may influence prognosis but a
183 ossibility that systemic inflammation, which arises in subgroups of obese and older patients, increas
186 that aspects of general intelligence likely arose in tandem with mechanisms of adaptive motor contro
188 les capable of duplication and ciliation can arise in the absence of SAS-6 self-oligomerization.
189 inflections, steps, and hysteresis that can arise in the adsorption isotherm as a signature of the r
191 o, the first hematopoietic stem cells (HSCs) arise in the aorta-gonad-mesonephros (AGM) and mature as
193 r differences during mammalian embryogenesis arise in the blastocyst, producing the inner cell mass a
194 (VHL)-associated hemangioblastomas (VHL-HB) arise in the central nervous system (CNS), and are a lea
195 on conditions, most Top1-dependent mutations arise in the context of replication and reflect incision
196 Autoreactive B lymphocytes that commonly arise in the developing repertoire can be salvaged by re
197 Most CRCs in this age group are known to arise in the distal colon and rectum suggesting that les
198 -directed immune responses may spontaneously arise in the elderly, even in the absence of a clear tis
200 xing with pairing at hole-like pockets which arise in the energy spectrum of the cubic phase at the s
201 ons that specifically target adult-born DGCs arise in the epileptic brain, whereas axons of interneur
202 viruses with deletions in the 220 loop could arise in the field due to immune selection pressure; how
203 takeholders, over scientific trade-offs that arise in the field, to improvements scientists wish for.
205 istic patterns of linkage disequilibrium can arise in the genomic region surrounding a selected locus
209 ith a prominent lymphoid infiltrate, and can arise in the liver as hepatocellular or cholangiocarcino
213 lpha differs between endometrial tumors that arise in the presence or absence of tamoxifen, indicatin
214 ngs suggest that diverse effector cell types arise in the primary immune response as a result of hete
215 dividual cells, approximately 5% of all CRCs arise in the setting of germline mutations in genes invo
217 ormation between BPs, where crystal features arise in the submicron regime, is found to be martensiti
221 Periampullary tumors are neoplasms that arise in the vicinity of the ampulla of Vater, an enlarg
222 ent results from meta-analyses have recently arisen in the field of cell therapies for cardiovascular
223 (-) T cells with suppressive properties that arises in the absence of Kv1.3 and enhances the understa
224 at Parkinson's tremor-related activity first arises in the basal ganglia and is then propagated to th
227 , this high-level EBV reactivation typically arises in the first 3 months posttransplant, at a time w
228 ins largely unclear how phenotypic variation arises in the first place and thus leads to the construc
229 activity related to Parkinson's tremor first arises in the GPi and is then propagated to the cerebell
232 displaying exotic non-Fermi liquid behaviour arises in the intricate scenario of two conduction elect
234 a careful consideration of how consciousness arises in the only physical system that undoubtedly poss
235 se data suggest that germline chromothripsis arises in the paternal genome and may be transmitted mat
236 pregnancy-associated disease that typically arises in the peripartum period and is marked by left ve
237 n immunodeficiency virus type 1 (HIV-1), but arises in the population average as a consequence of the
238 the aged population, clinical suspect often arises in the presence of complications (autoimmune diso
241 The primary resistance to mass transfer arises in the sediment side where a concentration deplet
245 tests confirmed that many variants of [PSI+] arising in the absence of Siw14p are cured by restoring
246 -sided colon cancer was defined as any tumor arising in the cecum, ascending colon, hepatic flexure,
247 te, though the extent and form of modulation arising in the cortex de novo versus an inheritance from
248 edial prefrontal cortex (mPFC) pathways, one arising in the dorsal CA1 (dCA1) and the other in the in
249 e the most common benign tumours of infancy, arising in the first few weeks of life and exhibiting a
251 t on metastatic potential, whereas mutations arising in the metastases were much more likely to be pa
252 hat the distribution of human rearrangements arising in the mouse was generally comparable to that se
253 options for GEP-NETs are heterogeneous: NETs arising in the pancreas can be distinguished from those
254 oretical investigations of neuronal activity arising in the pre-Botzinger complex (pre-BotC), a medul
255 an additional, previously unobserved, field arising in the presence of circularly polarized light.
256 monstrate that DNA methylation abnormalities arising in the sperm of old fathers are a plausible mech
257 -sided colon cancer was defined as any tumor arising in the splenic flexure, descending colon, sigmoi
258 or metastatic or locally advanced carcinomas arising in the stomach or in the gastroesophageal juncti
259 the dynamical effects of noisy fluctuations, arising in the synthesis reaction, on the evolution of t
260 We have identified a panel of mutations arising in the viral capsid protein VP1 during persisten
262 NA (germ cell nuclear antigen) proteins that arose in the earliest eukaryotes, and feature a rapidly
265 ition and two separate inversion events that arose in the last million years of human evolution.
266 se enhancers and find that approximately 20% arose in the mammalian stem lineage, coincident with the
272 pression-like and social behavioral deficits arise in their absence.SIGNIFICANCE STATEMENT We show he
277 ignaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activatin
278 symmetries of the measurement operators that arise in these protocols and belong to the algebra of pa
279 RPi) therapy; however, resistance invariably arises in these patients and is a major clinical problem
280 After introducing the general paradigms that arise in this context, we provide a few examples to illu
284 emonstration of the quantitative issues that arise in transporting effects between populations has im
285 Here we report a new source of bias that can arise in tumor Hi-C data, which is related to the copy n
286 nonhumans implies that modular abilities can arise in two ways, primarily through automatic developme
288 ochondrial proteins, which only sporadically arise in unstressed cells but strongly accumulate upon d
290 entation are key mechanisms of action of Abs arising in vaccine or naturally acquired immunity, as we
291 r the model considered here, structures that arise in vapour-deposited materials are statistically id
292 wever, it is still not clear how perversions arise in various helical structures and which universal
293 In addition, packing of cubic salt crystals arise in various problems involving preservation of pave
294 ) constitute a heterogeneous group of tumors arising in various organs and with a large span of aggre
295 esistant P falciparum C580Y lineage probably arose in western Cambodia and then spread to Thailand an
296 orm for accessing exotic transport phenomena arising in Weyl semimetals.Weyl semimetals are interesti
298 f both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 have been geneticall
299 sure for greater interaction, situations can arise in which the expected distribution of the degree o
300 first genomic characterization of neoplasms arising in WS; and provide new histopathologic and genom
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