ライフサイエンスコーパス: aroclor

1 rs was determined by measurement of original Aroclors.

2 Three represent relatively unweathered Aroclors.

3 easured in the sediment were not detected in Aroclors.

4 East Chicago, IN and five original Monsanto Aroclors.

5 sent in above-trace quantities in commercial Aroclors.

6 ater than trace concentrations in commercial Aroclors.

7 duced deletions in vivo in the mouse embryo; Aroclor 1221 and Aroclor 1260 induced deletions in yeast

8 In this study, TCDD, Aroclor 1221, and Aroclor 1260 induced deletions in vivo

9 es strongly resembled the OH-PCB profiles of Aroclors 1221, 1242, 1248, and 1254, yet 25% of OH-PCBs

10 PLA2 that are linked to different functions: Aroclor 1242 activates a calcium-independent PLA2 that r

11 These data suggest that Aroclor 1242 and A23187 activate distinct isoforms of PL

12 Both Aroclor 1242 and A23187 caused release of [3H]AA; howeve

13 AA release and O2- production in response to Aroclor 1242 were inhibited by bromoenol lactone (BEL),

14 hat are activated by the neutrophil stimuli, Aroclor 1242, a mixture of polychlorinated biphenyls, an

15 AA release, but did not alter AA release in Aroclor 1242-stimulated neutrophils.

16 re at both Camden and New Brunswick resemble Aroclor 1242.

17 PLA2 activity was significantly enhanced by Aroclor 1242.

18 O2- production was seen only in response to Aroclor 1242.

19 adioactivity recovered from cells exposed to Aroclor 1242.

20 d placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biph

21 or 6 mg/kg/day of a commercial PCB mixture, Aroclor 1254 (A1254) by gavage from gestational day (GD)

22 Aroclor 1254 (A1254) interferes with normal dendritic gr

23 In vivo or in vitro exposure to Aroclor 1254 coupled with IL-10 deficiency significantly

24 PB and Aroclor 1254 significantly enhanced malondialdehyde and

25 Here, we show that Aroclor 1254, a mixture of structurally distinct PCBs, c

26 e effects of ecologically relevant levels of Aroclor 1254, a polychlorinated biphenyl (PCB) mixture,

27 tive stress were influenced mainly by PB and Aroclor 1254, indicative of an oxidative damage response

28 rs (beta-naphthoflavone, phenobarbital (PB), Aroclor 1254, isoniazid, pregnenolone 16alpha-carbonitri

29 ent of PCB congeners in factors, relative to Aroclor 1254, suggested biotransformation (via cytochrom

30 Aroclor 1254-treated IL-10(-/-) mice demonstrated increa

31 repared from the livers of rats treated with Aroclor 1254.

32 ow), 0.70 (intermediate), or 1.05 (high) mug Aroclor 1254/g-body weight by gavage from 1 through 18 d

33 nated most hexa- and heptachlorobiphenyls in Aroclor 1260 (50 mug/mL) leading to losses of 51% and 20

34 high molecular weight formulations, such as Aroclor 1260 and PCBs 206, 208, and 209 produced during

35 he highly chlorinated commercial PCB mixture Aroclor 1260 for organohalide respiration.

36 In this study, TCDD, Aroclor 1221, and Aroclor 1260 induced deletions in vivo in the mouse embr

37 n vivo in the mouse embryo; Aroclor 1221 and Aroclor 1260 induced deletions in yeast.

38 responsible for extensive dechlorination of Aroclor 1260, and finally to the identification of a Deh

39 D14 dechlorinated the commercial PCB mixture-Aroclor 1260-mainly by removing flanked para- and doubly

40 rcial polychlorinated biphenyl (PCB) mixture Aroclor 1260.

41 at links its growth to the dechlorination of Aroclor 1260.

42 B-209, which was manufactured at the site in Aroclor 1270 and 1271, was the most abundant congener in

43 of the five resolved factors resemble low MW Aroclors, and declined from 1996 to 2007.

44 to report levels of OH-PCBs in sediment and Aroclors, and our discovery is significant because it is

45 highly weathered as to be unrecognizable as Aroclors, and thus have probably resided in the river fo

46 factors were probably originally related to Aroclors, but they are so highly weathered as to be unre

47 The non-Aroclor congener 3,3'-dichlorobiphenyl (PCB 11) has been

48 We hypothesized that additional non-Aroclor congeners are present in serum.

49 L laboratory mesocosms containing weathered Aroclor-contaminated sediment from Baltimore Harbor, MD,

50 ilized Aroclors (gaseous PCBs) and unaltered Aroclors (dissolved PCBs) dominate in some samples, ongo

51 d factors that better resembled the original Aroclor formulations.

52 between schools and indicated the sources as Aroclors from building materials and individual PCBs ass

53 rization indicated that although volatilized Aroclors (gaseous PCBs) and unaltered Aroclors (dissolve

54 se commercial mixtures of PCBs, analogous to Aroclors in the United States) is reduced from 20- or 50

55 f non-Aroclor PCB congeners (</=0.20 wt % in Aroclor) in human serum collected from urban and rural a

56 ediment anywhere that PCB contamination from Aroclors is present.

57 We have previously shown that non-Aroclor PCB 11 is prevalent in indoor and outdoor air an

58 olescents have significantly lower total non-Aroclor PCB concentrations than mothers in East Chicago

59 Here we report the prevalence of non-Aroclor PCB congeners (</=0.20 wt % in Aroclor) in human

60 A list of 70 non-Aroclor PCB congeners was determined by measurement of o

61 There are significant differences in non-Aroclor PCBs between East Chicago community and Columbus

62 Non-Aroclor PCBs represent an average of 10% (and up to 50%)

63 Two were related to the non-Aroclor sources of diarylide yellow pigments and titaniu

64 PCBs) dominate in some samples, ongoing non-Aroclor sources such as paints/pigments (PCB 11) and coa

65 exhibited congener patterns consistent with Aroclor weathering, suggesting potential PCB metabolism

66 Aroclors with an intermediate weight percent of chlorine

67 with high potency (EC50=1.4 microM), whereas Aroclors with either high or low chlorine composition sh