ライフサイエンスコーパス: aromatization

1 or the last step, forming the pyridine ring (aromatization).

2 via 1,2-alkyl migration and dehydrogenation (aromatization).

3 on a nitrilium ion intermediate followed by aromatization.

4 naphthalene precursors followed by oxidative aromatization.

5 ogen secretion versus placental capacity for aromatization.

6 ainly androgen 19-desmethylation rather than aromatization.

7 enes with 2-methoxybenzoquinones followed by aromatization.

8 ion to the central allene carbon followed by aromatization.

9 condensation with concomitant debenzylative aromatization.

10 hol components, the dehydrogenations lead to aromatization.

11 enes and benzooxanorbornadienes, followed by aromatization.

12 Cs, which catalyze C7-C12 cyclization and/or aromatization.

13 ldehydes followed by in situ cyclization and aromatization.

14 Spengler cyclization, and a radical-mediated aromatization.

15 ing dipyrromethanes and subsequent oxidative aromatization.

16 ular electrophilic aromatic substitution and aromatization.

17 owed by Lewis acid catalyzed cyclization and aromatization.

18 ding through 1,3-diene formation followed by aromatization.

19 ssential to maintain the decarboxylation and aromatization activities and avoid rapid catalyst deacti

20 erein Diels-Alder reactions and a subsequent aromatization afford higher order iptycenes.

21 Subsequent aromatization affords the set of differently functionali

22 n, aldol-type condensation, cyclization, and aromatization, all in the absence of coenzymes or recrui

23 consistent with the above-described partial aromatization and antiaromatization.

24 l rearrangement of a diketo-dioxinone ester, aromatization and cationic diene-epoxide cyclization as

25 Mechanisms for the aromatization and deformylation sequence which are initi

26 This hydration of 5 to 6 leads to aromatization and greatly dominates over water addition

27 e the carbazole core: 6pi-electrocyclization/aromatization and indole C2-H bond activation/Heck annul

28 uent additive-free thermal treatment induced aromatization and led to exclusively para-connected, hig

29 However, studies on the mechanism of steroid aromatization and subsequent model work have provided ev

30 Biomimetic aromatization and Suzuki-Miyaura cross coupling approach

31 telomerase expression and activity mainly by aromatization and through ER alpha.

32 2 in breast tumors, as opposed to peripheral aromatization and uptake from plasma, can enhance tissue

33 polymers with varying degrees of chromophore aromatization and used them to probe the effects of synt

34 es a NIS-mediated cascade C-N bond formation/aromatization, and a series of indoles with various func

35 nt onto a furan followed by a fragmentation, aromatization, and N-Boc deprotection cascade.

36 serine mutants gave mixture of dehydrations, aromatizations, and unaltered alcohol side chains depend

37 in, intramolecular C-C bond cyclization, and aromatization as the key intermediates, all occurring in

38 ydrogenated product, which may undergo rapid aromatization, as well as formic acid.

39 e (GVL) over Zn/ZSM-5 to butene, followed by aromatization at high yield with co-feeding of water.

40 corresponding estrogens, a reaction known as aromatization because it involves conversion of the delt

41 cular bisboronate homocoupling and reductive aromatization by H2 SnCl4 .

42 ntramolecular C-N cyclization and subsequent aromatization by the elimination of thiophenol, with goo

43 esults in an unanticipated aza-Michael/aldol/aromatization cascade to give polysubstituted quinolines

44 ubsequent reductive cyclization/ring-opening aromatization cascade, as was found to occur with the re

45 from the known compound 9, via an unexpected aromatization caused by the addition of PhSeCl and subse

46 hand, the experimental studies revealed that aromatization competes with Michael addition mechanism i

47 Suzuki coupling, followed by dehydrogenative aromatization, completed the synthesis of calothrixin B.

48 Under protic acid-mediated dehydrative aromatization conditions, the central and most strained

49 Estradiol provision via neural aromatization decreases neuro-inflammation and -degenera

50 Driven by aromatization, detosylation of the dihydroquinoline inte

51 position of the allyl fragment enabled by an aromatization-driven Cope rearrangement.

52 cy for these initial cycloadducts to undergo aromatization, ene reaction, and oxidation although this

53 f central to axial chirality during a double aromatization event triggered by BF(3).OEt(2).

54 on additional driving force associated with aromatization, families of very powerful neutral organic

55 ional role of each domain in cyclization and aromatization for di-domain ARO/CYCs has remained a myst

56 s constructed via late-stage cyclization and aromatization from a diketodioxinone intermediate and ma

57 tramolecular Friedel-Crafts cyclization, and aromatization furnished the target structures.

58 ol product was investigated and elimination, aromatization, hydrogenation, regioselective O-exchange,

59 cting those in postmenopausal women, in situ aromatization in breast tumor makes a major contribution

60 d females, suggesting a role for presynaptic aromatization in cellular processes within these loci.

61 servation, indicating the lack of peripheral aromatization in OVX mice.

62 ective effects are mediated, in part, by its aromatization in the dentate gyrus.

63 istribution of aromatase suggests a role for aromatization in the regulation of pre- and postsynaptic

64 The new aromatization is also applied to functionalized indoles

65 rresponding cycloadducts, but the subsequent aromatization is complicated.

66 tobase generator (PBG) based on photoinduced aromatization is described.

67 rous dioxygen intermediate mediates androgen aromatization is explored and determined to be unlikely.

68 Radial aromatization may be a key feature in the repair of the

69 nerability of the CNS we reasoned that brain aromatization may protect circuits from the threats of p

70 An elimination-aromatization mechanism is proposed to account for these

71 based inhibitor of BioA that operates via an aromatization mechanism, irreversibly labeling the PLP c

72 thoxy, nitro, etc.) followed by an oxidative aromatization mediated by chloranil.

73 een TE and TREN, suggesting that neither the aromatization nor the 5alpha reduction of androgens is r

74 Aromatization occurs in the medial preoptic area (MPOA),

75 Cyclization and aromatization occurs under the reaction conditions to pr

76 In addition, we have proven that the aromatization occurs via a hydrogen transfer from the cy

77 If the C19 aldehyde remains unhydrated, aromatization occurs with concomitant decarbonylation an

78 nzyme of AHBA formation, which catalyzes the aromatization of 5-deoxy-5-amino-3-dehydroshikimic acid,

79 iospecific C9-C14 and C7-C16 cyclization and aromatization of a 24-carbon polyketide chain.

80 lt of enhanced uptake from plasma or in situ aromatization of androgens to estrogens.

81 atase (P450arom), which was confirmed by the aromatization of androstenedione (AD) to E2 and other es

82 d mRNA levels in fat and skin and whole-body aromatization of androstenedione were severely elevated.

83 eactivity patterns, involving stereospecific aromatization of bridges and nucleophile additions.

84 ng on structure of the starting ketones, the aromatization of intermediate dihydropyrimidines occurs

85 functional groups are obtained by oxidative aromatization of meso-tetraarylporphyrins in which pyrro

86 oporphyrins (Ar(4)(MeO)(8)TNP) via oxidative aromatization of nonaromatically fused porphyrin precurs

87 2-electron acceptor, catalyzes a remarkable aromatization of piperideine-2-carboxylate (P2C) to pico

88 types of porphyrins were obtained by direct aromatization of precursor porphyrins, annealed with eit

89 erences in response to T are associated with aromatization of T to E and that reduced sensitivity to

90 Aromatization of testosterone (T) to estradiol (E2) duri

91 Our results suggest that aromatization of testosterone into estrogen is important

92 ese increases were considerably greater when aromatization of testosterone to estradiol was also supp

93 henate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring by protonating

94 rgo further dehydration reactions until full aromatization of the cyclohexane ring is achieved.

95 nium-ion mechanism in light of the fact that aromatization of the dihydro intermediates (formed via a

96 Aromatization of the dihydrofuran rings of these arylalk

97 convergent dibromocyclopropanation and total aromatization of the furobenzocycloalkane are also repor

98 uct the dihydronaphthalene unit of 2 and the aromatization of the intermediate dihydronaphthalene der

99 Aromatization of the latter occurs via beta-C-C bond sci

100 Schiff base to product Schiff base, a facile aromatization of the latter results in a metastable N-ar

101 e is followed by cleavage of an O-H bond and aromatization of the PNN ligand to form (PNN)RuH(CO)(OH)

102 [3,3]-sigmatropic rearrangement lead to the aromatization of the product.

103 ne intermediate, followed by cyclization and aromatization of the pyrrole ring to give 7.

104 by (optional modification and) base-induced aromatization of the resulting chlorinated oxanorborn(ad

105 roxylation steps, and the third involves the aromatization of the steroid A-ring, unique to aromatase

106 r controlling specific aldol cyclization and aromatization of these mature polyketide precursors, but

107 emonstrate that at high temperatures thermal aromatizations of 2-vinylmethylenecyclopropane (at 700 d

108 provide theoretical insights for the thermal aromatizations of 2-vinylmethylenecyclopropane and 3-vin

109 ing tetrahydrocarbazole and dehydrogenation (aromatization) of this to give the target carbazole (e.g

110 This neural aromatization presumably provides estrogen to steroid-se

111 rrolylbenzenes using a two-step condensation-aromatization procedure.

112 ed by a cyclocarbopalladation/cross-coupling/aromatization process.

113 teristic of 1, by means of an acid-catalyzed aromatization process.

114 structurally closely related to the Bergman-aromatization product of enediyne C-1027.

115 wo different paths, each leading to discrete aromatization products.

116 ort that a branched primary amine bearing an aromatization-prone moiety, ethyl 4-amino-4,5-dihydrothi

117 To overcome this, a dehydrative aromatization protocol using the Burgess reagent was dev

118 These results demonstrate that in situ aromatization rather than uptake can be a determinant of

119 ose that this residue may participate in the aromatization reaction (the third step) by acting as a h

120 boxylate (P2C) to picolinate in a remarkable aromatization reaction comprising two redox cycles and a

121 essible via acid-mediated Grob fragmentation-aromatization reaction of 1,4,5,6-tetrabromo-7,7-dimetho

122 n iron(III)-catalyzed cycloisomerization and aromatization reaction produces tetracyclic benzofuran d

123 -mediated one-pot arylation, cyclization and aromatization reaction sequence from 3-acetyl/aroyl-2-pi

124 ddition, and transition metal-free oxidative aromatization reaction sequence utilizing molecular oxyg

125 sized via a facile and mild cyclodehydration-aromatization reaction starting from readily available a

126 NikD catalyzes a remarkable aromatization reaction that converts piperideine 2-carbo

127 phenylene was demonstrated utilizing a novel aromatization reaction.

128 is predicted to catalyze the final oxidation/aromatization reaction.

129 nes, and a tandem regioselective Diels-Alder/aromatization reaction.

130 es of Hopf pericyclic reactions, followed by aromatization reactions of the annulated polycyclic arom

131 arbons (PAHs) via gas phase radical mediated aromatization reactions.

132 saturation of the remaining structure, as in aromatization reactions.

133 the amino adduct against further dehydration/aromatization reactions.

134 be the development of an iterative reductive aromatization/ring-closing metathesis approach.

135 An intramolecular Diels-Alder reaction-aromatization sequence allows for access to allocolchici

136 talyzed decarboxylative prenyl migration and aromatization sequence as the key step is reported.

137 one-pot C-H alkenylation/electrocyclization/aromatization sequence has been developed for the synthe

138 A regioselective Diels-Alder reaction-aromatization sequence is utilized as the key step in th

139 of K2CO3 in THF ensured a clean deprotection-aromatization sequence to afford the desired heterocycle

140 s-decalin ring, and a 6pi-electrocyclization/aromatization sequence to produce the 2,3-fused carbazol

141 on proceeds through an oxidation/cyclization/aromatization sequence under an atmosphere of O(2) (see

142 ds, which is based on a Diels-Alder reaction-aromatization sequence.

143 Both routes avoid the need for a discrete aromatization step and offer significant advantages over

144 Although the last aromatization step proved to be cumbersome, this work un

145 ational evidence shows that a combination of aromatization, steric and stereoelectronic effects assis

146 Two complementary aromatization strategies involving in situ elimination a

147 hesized by application of Grob fragmentation-aromatization strategy to 3-(benzyloxy)-1,4,5,6-tetrabro

148 ations of the first two rings and subsequent aromatizations take place in the interior pocket.

149 ge stabilization of product arising from the aromatization that accompanies solvent addition to p-qui

150 ation reactions, culminating in an enigmatic aromatization that converts an androgen to an estrogen.

151 Upon subsequent aromatization, the corresponding fully aromatic function

152 n or reaction with a Grignard reagent before aromatization; the latter process gives compounds in whi

153 bstrates not blocked by geminal substitution aromatization to a dipyrromethane is a competing side re

154 t room temperature then results in efficient aromatization to benzene derivatives of a regiochemicall

155 ns in regulating HPA activity may be through aromatization to estradiol, or by 5alpha-reduction to th

156 en receptor-mediated mechanisms or via local aromatization to estradiol.

157 d antidepressant effects, likely mediated by aromatization to estrogen metabolites, in the sucrose pr

158 obably involves a transamination followed by aromatization to form an aromatic thiophene ring.

159 (II)-C palladacycle followed by an oxidative aromatization to generate the pyridine core.

160 in then mediates elimination of pyruvate and aromatization to give PABA.

161 by intramolecular cyclization and subsequent aromatization to give the annulated products.

162 followed by spontaneous proton loss with re-aromatization to provide the tetrahydroisoquinoline prod

163 rature results in smooth loss of bromide and aromatization to resorcinol monomethyl ethers of defined

164 Further aromatization to the corresponding xanthones is readily

165 hloride to the reaction mixture, a selective aromatization to yield the corresponding pyrroles substi

166 thesis reaction, followed by elimination and aromatization, to furnish a key pentasubstituted pyridin

167 ryl bromides and oxanorbornenes, followed by aromatization under acidic conditions.

168 ergo bent-to-planar transformation driven by aromatization under electrochemical control.

169 clohex-1-ene-4,5-diols, which are subject to aromatization upon dehydration or Nicholas diol deoxydeh

170 Subsequent aromatization using cesium carbonate gave rise to isopro

171 s five fast radical cyclizations followed by aromatization via a 1,5-H shift with a >93% yield per st

172 n to yield the formal "6-endo" products with aromatization via stereoelectronically assisted C-C bond

173 lly in all testosterone-dose groups in which aromatization was also suppressed, and this decline was

174 model, the confounding effect of peripheral aromatization was first excluded experimentally.

175 ring size on the reaction rate of oxidative aromatization was investigated.

176 Decreases in DXA BMD were observed when aromatization was suppressed but were modest in most gro

177 f experiments examining injury-induced glial aromatization, we identified aromatase in radial glia of

178 The biological effects of in situ aromatization were then directly examined.

179 Another option is methane aromatization, which produces benzene and hydrogen: 6CH4

180 recursors followed by 6pi-electrocyclization/aromatization, while isomeric TD-syn-TBDT and TD-anti-TB

181 adducts with Fe2(CO)9 followed by oxidative aromatization with 2,3-dichloro-5,6-dicyano-1,4-benzoqui

182 ed perylene derivatives by deoxygenation and aromatization with HCl/EtOH.

183 equential Diels-Alder reaction and oxidative aromatization with the preformed glycosyl diene and dien

184 Finally, the contribution of testosterone's aromatization within the dentate gyrus was assessed by l