ライフサイエンスコーパス: articular

1 itially compared four types of chondrocytes: articular (AA) versus growth plate (AG) cartilage chondr

2 Intra-articular administered triamcinolone acetonide (TAA) is

3 d the CD4(+) T-cell DNA methylome of 68 poly-articular and extended oligo-articular JIA patients, bef

4 ic inflammatory autoimmune disease with both articular and extraarticular disease manifestations, inc

5 l accounting for differential effects, intra-articular and topical therapies were superior to oral tr

6 istopathologic evaluation confirmed osseous, articular, and neurovascular invasion in 8.6%, 2.9%, and

7 Intra-articular anti-VEGF antibodies suppress OA progression,

8 ction with Porphyromonas gingivalis enhances articular bone loss.

9 ures, joint space, with special attention to articular bone surfaces and epiphyses, are analyzed.

10 ludes inflammatory changes in attachments of articular capsules, tendons, and ligaments to bone surfa

11 clude inflammatory changes in attachments of articular capsules, tendons, and ligaments to bone surfa

12 therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries.

13 xpression level of ADAM12 protein in the KBD articular cartilage (average positive chondrocyte rate =

14 rate = 47.59 +/- 7.79%) compared to healthy articular cartilage (average positive chondrocyte rate =

15 abnormalities or morphologic defects in the articular cartilage (mean age, 54 years +/- 5; 51% women

16 ition as it progresses to destruction of the articular cartilage and ankylosis of the joints.

17 characterised by progressive destruction of articular cartilage and chondrocyte cell death.

18 gen tension in the region destined to become articular cartilage and higher oxygen tension in transie

19 with enhanced EGF receptor signaling in the articular cartilage and in the abnormally formed osteoph

20 ding chondrocytes in the superficial zone of articular cartilage and in the meniscus, as well as syno

21 oint motion via adsorption to the surface of articular cartilage and its lubricating properties in so

22 ubricin) is secreted by cells that reside in articular cartilage and line the synovial joint.

23 duced joint pathology, including thinning of articular cartilage and loss of proteoglycans in the car

24 lay unique aggressive behavior, invading the articular cartilage and promoting inflammation.

25 genes that maintain the homeostasis of adult articular cartilage and regenerate its lesions, we initi

26 potential in amelioration of degeneration of articular cartilage and subchondral bone microarchitectu

27 erestingly, IL-3 reduces the degeneration of articular cartilage and subchondral bone microarchitectu

28 Changes in articular cartilage and subchondral bone were analyzed b

29 e both beneficial and detrimental effects on articular cartilage and subchondral bone, and may subseq

30 OA) is a progressive degenerative disease of articular cartilage and surrounding tissues, and is asso

31 We found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selecti

32 degeneration of joints, involving mainly the articular cartilage and the underlying bone, and severel

33 Current literature suggests that articular cartilage and transient cartilage originate fr

34 r microcomputed tomography (muCT) imaging of articular cartilage are reported.

35 Here, by using self-assembled articular cartilage as a model to examine the effects of

36 e hyaline cartilage, which expressed typical articular cartilage biomarkers, including established in

37 sion to show that chondrocytes isolated from articular cartilage biopsies of patients and subjected t

38 e Prg4 expression in the superficial zone of articular cartilage by engaging the same signaling pathw

39 identified Fgf18 as a molecule that protects articular cartilage by gene expression profiling, and th

40 hyaluronan, anchored at the outer surface of articular cartilage by lubricin molecules, complexes wit

41 lays an essential role in the maintenance of articular cartilage by preventing articular chondrocytes

42 DT imaging of articular cartilage can enable physicians to detect and

43 ific mouse tryptase plays prominent roles in articular cartilage catabolism.

44 Impact loading of articular cartilage causes extensive chondrocyte death.

45 croRNA expression profiling in healthy human articular cartilage cells (chondrocytes), we identified

46 t, similar to transient cartilage, embryonic articular cartilage cells also originate from the prolif

47 Fgf18 was strongly expressed in the articular cartilage chondrocytes of adult rats.

48 ignificantly greater agent uptake of CA4+ in articular cartilage compared to that of similar anionic

49 rocyte catabolism, not death, contributes to articular cartilage damage following injury.

50 tion of lentiviral Wnt7a strongly attenuated articular cartilage damage induced by destabilization of

51 he progeny of these cells reconstitute adult articular cartilage de novo, entirely substituting fetal

52 The development of morphologic articular cartilage defects (Whole-Organ MR Imaging Scor

53 termine the incidence with which morphologic articular cartilage defects develop over 48 months in ca

54 e the potential to therapeutically attenuate articular cartilage degeneration as part of OA.

55 uated hedgehog-induced or surgically induced articular cartilage degeneration in mouse models of OA.

56 ith losartan both delayed the progression of articular cartilage degeneration induced by DMM compared

57 Initiation or acceleration of articular cartilage degeneration was not observed by the

58 l joints were characterized for evidences of articular cartilage degeneration.

59 gery in Cre-negative control mice, including articular cartilage degradation and subchondral sclerosi

60 ession to direct interzone progeny fates and articular cartilage development and disease.

61 We conclude that Phd2 is a key regulator of articular cartilage development that acts by inhibiting

62 lycan from the extracellular matrix of their articular cartilage during inflammatory arthritis than w

63 n collagenase responsible for degradation of articular cartilage during osteoarthritis and therefore

64 We demonstrate that PPARgamma-deficient articular cartilage exhibits elevated expression of the

65 as to investigate if chondrocytes from human articular cartilage express gap junction proteins called

66 Normal human articular cartilage from a range of donors was obtained

67 Finally, mouse articular cartilage from Sirt1(-/-) presented increased

68 years it has become increasingly clear that articular cartilage harbours a viable pool of progenitor

69 Articular cartilage has little regenerative capacity.

70 more relevant in examining their effects on articular cartilage homeostasis and the development of o

71 f Prg4 in the superficial zone of knee joint articular cartilage in a COX-2-dependent fashion, which

72 wing chondrocyte progenitors, which form the articular cartilage in juvenile mice.

73 growth and differentiation of transient and articular cartilage in juxtaposed domains.

74 drocyte differentiation, and degeneration of articular cartilage in osteoarthritis (OA).

75 as a frictional behaviour resembling that of articular cartilage in the major joints.

76 isease involving the mechanical breakdown of articular cartilage in the presence of altered joint mec

77 e of COX-2 in regulating MMP-1 expression in articular cartilage in vivo was demonstrated using COX-2

78 Articular cartilage injury can result in chondrocyte los

79 Articular cartilage is exposed to a gradient of oxygen l

80 The articular cartilage is known to be highly mechanosensiti

81 nes, we propose that the collagen network in articular cartilage is near a percolation threshold that

82 Among mammalian soft tissues, articular cartilage is particularly interesting because

83 nic disease characterized by degeneration of articular cartilage leading to pain and physical disabil

84 Histologic changes seen in OA, including articular cartilage lesions and osteophytes, were presen

85 The insufficient healing capacity of articular cartilage necessitates mechanically functional

86 Chondrocytes were isolated from articular cartilage obtained during talonavicular joint

87 s of articular chondrocytes were seen in the articular cartilage of ESET-null animals.

88 creased levels of hypertrophy markers in the articular cartilage of the cKO mice.

89 e tibia and femur, and in the epiphyseal and articular cartilage of these bones.

90 However, structural changes of articular cartilage or menisci cannot be directly evalua

91 r-sized, anatomically shaped pieces of human articular cartilage over 5 wk of culture.

92 tion of the Phd2 gene in chondrocytes on the articular cartilage phenotype in mice.

93 at acts by inhibiting the differentiation of articular cartilage progenitors via modulating HIF-1alph

94 Articular cartilage quality was assessed by quantitative

95 Articular cartilage quality was assessed by quantitative

96 ls have emerged as a favourable approach for articular cartilage regeneration.

97 Aging-associated changes in articular cartilage represent a main risk factor for ost

98 The spatial organization of the articular cartilage results from a band of Nog-expressin

99 tes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoin

100 bilization of the medial meniscus (DMM), and articular cartilage samples were microdissected and subj

101 access to active TGF-beta: the synovium and articular cartilage secrete latent TGF-beta into the SF

102 Articular cartilage specimens from 8 subjects were colle

103 Physiologically, articular cartilage sustains millions of cycles of mecha

104 In both age groups, articular cartilage thickness decreased, and subchondral

105 tilage strands as building units to bioprint articular cartilage tissue.

106 lasticity of the composites approach that of articular cartilage tissue.

107 Stick-slip friction was observed in articular cartilage under certain loading and sliding co

108 ignaling and allows them to differentiate as articular cartilage under the influence of Wnt signaling

109 te-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-c

110 ion channel transduces mechanical loading of articular cartilage via the generation of intracellular

111 MATERIAL/METHODS: Labral pathology and articular cartilage were prospectively evaluated with MR

112 Chondrocytes from normal human articular cartilage were treated with glucosamine (0.1-

113 imaging in comparison with the incidence in articular cartilage without signal abnormalities at base

114 ecreted from both the synovium and all three articular cartilage zones (superficial, middle, and deep

115 res and CC/TAC (calcified cartilage to total articular cartilage), but increased SBP (subchondral bon

116 Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial ev

117 he Tak1 mutant mice showed defects in skull, articular cartilage, and mesenchymal stromal cells.

118 ent a new type of contrast agent for imaging articular cartilage, and the results demonstrate the imp

119 e exhibited hyperplasia in the glenoid fossa articular cartilage, articular disc, and synovial membra

120 ed with abnormally expressed pathways in KBD articular cartilage, identified by microarray study of K

121 findings show that RRV infection damages the articular cartilage, including a loss of proteoglycans w

122 th KBD, but also abnormally expressed in KBD articular cartilage, including REACTOME_INTRINSIC_PATHWA

123 In human articular cartilage, LfcinB antagonizes interleukin-1 be

124 ntitative ultrasound grading of knee femoral articular cartilage, osteophytes and meniscal extrusion,

125 ciated with chondrocyte hypertrophy in adult articular cartilage, the lack of which protects from car

126 is a novel adipokine that negatively impacts articular cartilage, triggering catabolic and inflammato

127 The articular cartilage, which lines the joints of the limb

128 ng, result in progressive damage and loss of articular cartilage.

129 hythm and caused progressive degeneration of articular cartilage.

130 g new insights into the impact of hypoxia in articular cartilage.

131 le in maintaining the health and function of articular cartilage.

132 e equilibrium electro-chemical properties of articular cartilage.

133 ular matrix concentration in neonatal bovine articular cartilage.

134 r targeting the surface or interior zones of articular cartilage.

135 ere co-localized in chondrocytes of degraded articular cartilage.

136 nd contribute to the growth and reshaping of articular cartilage.

137 chondral bone attenuated the degeneration of articular cartilage.

138 nsgenic mice markedly activated autophagy in articular cartilage.

139 1) histone methyltransferase is expressed in articular cartilage.

140 fibroblast growth factor 2 (FGF-2) from the articular cartilage.

141 ase and involves progressive degeneration of articular cartilage.

142 nd organized cartilage resembling the native articular cartilage.

143 nti-catabolic and anti-inflammatory in human articular cartilage.

144 MMP-13, which are constitutively present in articular cartilage.

145 icin (Prg4), the major boundary lubricant of articular cartilage.

146 ntrast agent (CA4+) is described for imaging articular cartilage.

147 ches for application of miRNAs to regenerate articular cartilage.

148 is often associated with the degeneration of articular cartilage.

149 NFkappaB and LCN2 in the pathophysiology of articular cartilage.

150 ing and the sGAG and collagen content of the articular cartilage.

151 II collagen, the major structural protein of articular cartilage.

152 esponsible for the remarkable lubrication of articular cartilage; but alone, these molecules cannot e

153 IOX2, a specific inhibitor of PHD2, promoted articular chondrocyte differentiation.

154 However, the specific role of Runx2 in articular chondrocyte function and in OA development in

155 d-type and knock-out mice indicated that the articular chondrocyte phenotype in ESET-null mutants is

156 Using RNA sequencing we identified a human articular chondrocyte repertoire of lncRNAs from normal

157 ubtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its role as

158 Human articular chondrocytes (HACs) and SW-1353 chondrosarcoma

159 primary cells with known TRPV4 expression - articular chondrocytes and astrocytes.

160 is abundantly expressed by superficial zone articular chondrocytes and has been noted to both be sen

161 etalloproteinase expression in primary human articular chondrocytes and in fibroblast-like synovial c

162 i-induced catabolic gene expression in human articular chondrocytes and is sufficient to attenuate MM

163 n, reduce levels of phosphorylated VEGFR2 in articular chondrocytes and synovial cells and reduce lev

164 Isolated human articular chondrocytes and the chondrosarcoma cell line

165 so required for postnatal differentiation of articular chondrocytes and the timely ossification of bo

166 Articular chondrocytes are distinct in producing lower l

167 al joint development is the specification of articular chondrocytes at the joint surface.

168 gulate metalloproteinase expression in human articular chondrocytes but did mediate prolonged activat

169 We found that lysis of articular chondrocytes by PBMC or polyclonal NK cells wa

170 ed gene expression and phenotypic changes in articular chondrocytes culminate in progressive loss of

171 ESET knock-out did not affect generation of articular chondrocytes during embryonic development.

172 deletion through Cre transfection in primary articular chondrocytes from Rela(fl/fl) mice.

173 tenance of articular cartilage by preventing articular chondrocytes from terminal differentiation and

174 Analysis of primary cultures of TMJ articular chondrocytes from wild-type and Ddr2(slie/slie

175 ndrocytes are stable and comparable to adult articular chondrocytes in global gene expression, extrac

176 Nivalenol (NIV) on the metabolism of bovine articular chondrocytes in vitro.

177 Because miR-146a expression in articular chondrocytes is associated with osteoarthritis

178 l cells of the developing vasculature and in articular chondrocytes of developing bone.

179 Healthy articular chondrocytes release ACVs into conditioned med

180 The exact molecular mechanisms governing articular chondrocytes remain unknown in skeletal biolog

181 50 mM) inhibits Hedgehog signaling in bovine articular chondrocytes such that the induction of GLI1 a

182 e results show that susceptibility of normal articular chondrocytes to lysis by NK cells is modulated

183 Furthermore, articular chondrocytes treated with OA derived extracell

184 nockdown of Hif-1alpha expression in primary articular chondrocytes using lentiviral vectors containi

185 Human OA articular chondrocytes were examined for miR-146b expres

186 hypertrophy, proliferation, and apoptosis of articular chondrocytes were seen in the articular cartil

187 omechano-TRP channel, is highly expressed in articular chondrocytes, and loss of TRPV4 function is as

188 Treatment of primary articular chondrocytes, in vitro, with IOX2, a specific

189 In primary articular chondrocytes, mechanically evoked Ca(2+) trans

190 ontribution of growth plate chondrocytes and articular chondrocytes, not only for long bone growth, b

191 of LfcinB-mediated genetic response in human articular chondrocytes, tissue inhibitor of metalloprote

192 To test whether ESET regulates articular chondrocytes, we carried out mesenchyme-specif

193 t through inhibition of DNA binding in human articular chondrocytes, with decreased expression of sev

194 Upon ectopic expression in primary human articular chondrocytes, Wnt7a inhibited IL-1beta-induced

195 le of autophagy in ACV production by primary articular chondrocytes.

196 on of Prg4, specifically in superficial zone articular chondrocytes.

197 V4 transduces dynamic compressive loading in articular chondrocytes.

198 the cartilage, and enhanced proliferation of articular chondrocytes.

199 hic growth plate chondrocytes, as well as in articular chondrocytes.

200 ction by LfcinB-ERK-AP-1 axis in human adult articular chondrocytes.

201 le of TCF/LEF transcription factors in human articular chondrocytes.

202 flammatory and chondroprotective cytokine in articular chondrocytes.

203 l-mediated cytotoxicity against normal human articular chondrocytes.

204 ial cells divide more slowly than underlying articular chondrocytes.

205 development of methods to direct vectors to articular chondrocytes.

206 umatoid vasculitis is the most serious extra-articular complication of rheumatoid arthritis, with hig

207 whereas 3-T MR imaging with or without intra-articular contrast material appears to improve diagnosti

208 iority of 3-T imaging, with or without intra-articular contrast material compared with 1.5-T imaging,

209 ed with 1.5-T imaging, with or without intra-articular contrast material.

210 with 1.5-T MR imaging with or without intra-articular contrast material.

211 Clinical Question: Are intra-articular corticosteroids associated with improvement in

212 Intra-articular corticosteroids could reduce cartilage damage

213 Bottom Line: Intra-articular corticosteroids may be associated with moderat

214 c autoimmune disease that causes progressive articular damage, functional loss, and comorbidity.

215 ets for therapeutic interventions that limit articular degeneration.

216 together propogate chronic inflammation and articular destruction.

217 ia in the glenoid fossa articular cartilage, articular disc, and synovial membrane.

218 d an enormous effect on our understanding of articular disease.

219 tages of temporomandibular joint (TMJ) intra-articular disorders ("TMJ intra-articular status"), repr

220 Conceptualizing worsening of TMJ intra-articular disorders as 4 stages and characterizing impac

221 trabecular bone of limb epiphyses (long bone articular ends) in modern humans and chimpanzees and in

222 ars or older with an acute, displaced, extra-articular fracture of the distal tibia from April 2013 t

223 ars or older with an acute, displaced, extra-articular fracture of the distal tibia, neither nail fix

224 Displaced intra-articular fractures should be fixed operatively.

225 sified as juxta-articular haemangioma, intra-articular haemangioma or an intermediate type of hemangi

226 They are classified as juxta-articular haemangioma, intra-articular haemangioma or an

227 The control group received intra-articular hyaluronic acid (60 mg, single dose).

228 knee joint of rat animal model, after intra-articular (i.a.) administration, and it induces systemic

229 hree key EVD sequelae (ocular, auditory, and articular) in this cohort of EVD survivors.

230 agents revealed which immune pathways drive articular inflammation and related comorbidities.

231 utologous expanded bone marrow MSCs by intra-articular injection (40x10 cells).

232 Intra-articular injection in an adjuvant-induced rat model of

233 To determine the effects of intra-articular injection of 40 mg of triamcinolone acetonide

234 ed with allogeneic bone marrow MSCs by intra-articular injection of 40 x 10(6) cells.

235 Intra-articular injection of a senolytic molecule that selecti

236 Intra-articular injection of AAT or GSN protected cartilage in

237 s determined histologically 48 h after intra-articular injection of AAT or GSN.

238 A pilot study demonstrated that intra-articular injection of Anakinra, an IL-1R antagonist, im

239 imental osteoarthritis was elicited by intra-articular injection of collagenase in wild type and Cxcr

240 cin nocifensive responses, whereas the intra-articular injection of HA in rats decreases capsaicin jo

241 Adenosine replacement by intra-articular injection of liposomal suspensions containing

242 Moreover, after intra-articular injection, NFAT5-deficient macrophages were mo

243 nfirmed these findings in vivo through intra-articular injections of lubricin in a rat OA model where

244 Much research surrounding intra-articular injections of platelet-rich plasma (PRP) has n

245 nfections associated with epidural and intra-articular injections.

246 ed to a dramatic and progressive loss of TMJ articular integrity and osteoarthritis-like changes.

247 It was substantial for articular invasion (kappa = 0.794).

248 staging systems and analysis of osseous and articular invasion were performed.

249 For articular invasion, sensitivity was 80% (both readers);

250 sing spondylitis (AS) may present with extra-articular involvement in the lungs.

251 lome of 68 poly-articular and extended oligo-articular JIA patients, before and after anti-TNF therap

252 s, and in vivo were able to retain HA in the articular joint and to bind ocular tissue surfaces.

253 Osteoarthritis (OA) is a chronic disease of articular joints that leads to degeneration of both cart

254 degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many peop

255 wn environmental factors, affecting skin and articular joints.

256 PRG4 gene, provides boundary lubrication in articular joints.

257 s involved in muscular and limb development, articular junctions, and the cardiac system, and may rep

258 scans) provide high precision monitoring of articular lesions.

259 ifferentiation program into either permanent articular-like cartilage or hypertrophic cartilage that

260 autologous nature, and potential to generate articular-like cartilage rather than fibrocartilage.

261 sed protocol for differentiating hiPSCs into articular-like chondrocytes (hiChondrocytes) within 2 we

262 avorable method for generating hiPSC-derived articular-like chondrocytes.

263 culitis remains a rare yet challenging extra-articular manifestation of rheumatoid arthritis with hig

264 lage cells are capable of differentiating as articular or transient cartilage, depending on exposure

265 spect to sex, age, and cutaneous, abdominal, articular, or renal involvement.

266 ng of the MSCs directing chondrogenesis into articular- or epiphyseal cartilage-like tissue.

267 nodes (differential model) showed that intra-articular placebo (effect size, 0.29 [95% credible inter

268 The intra-articular pressure inside the stationary joint changed e

269 The study suggests that the intra-articular pressure was transmitted through the space bet

270 e neural arch for 21 of 57 patients, and the articular process for 18 of 57 patients.

271 articular triamcinolone, compared with intra-articular saline, resulted in significantly greater cart

272 Of the potential extra-articular sites implicated in disease initiation, mucosa

273 ith higher ACPA, consistent with findings at articular sites.

274 Thus, abnormal peri-articular skeletal development and modeling, rather than

275 The correlations between TMJ intra-articular status and TMD impact were 0.05 (95% confidenc

276 Models of TMJ intra-articular status other than ours (normal structure --> D

277 TMJ intra-articular status was determined by 3 blinded, calibrated

278 model estimated the association of TMJ intra-articular status with the latent measure TMD impact as a

279 (TMJ) intra-articular disorders ("TMJ intra-articular status"), representing a transition from norma

280 The assessment of musculo-articular stiffness (MAS) with the free-oscillation tech

281 atly enhanced expression of lubricin/Prg4 in articular superficial zone cells.

282 the transport of active TGF-beta across the articular surface and into the cartilage layer.

283 omous expression of diphtheria toxin to kill articular surface chondrocytes in mice and determined th

284 solute adsorption and distribution near the articular surface of mechanically injured cartilage.

285 shed protocol, solute distributions near the articular surface of three commonly used fluorophores (f

286 Each articular surface was then evaluated at arthroscopy.

287 ence or absence of cartilage lesions on each articular surface, first by using the routine MR protoco

288 Lesions to the articular surface, which are thought to progress to OA,

289 have revealed chondrocyte progenitors at the articular surface.

290 Biological resurfacing of entire articular surfaces represents an important but challengi

291 ween juxtaposed skeletal elements, irregular articular surfaces, and hypoplasia of ligaments.

292 nals have been applied towards the repair of articular tissues in the laboratory and clinical setting

293 We also show that intra-articular treatment with the Wnt inhibitor sclerostin su

294 Intra-articular treatments were superior to nonsteroidal anti-

295 Intra-articular triamcinolone (n = 70) or saline (n = 70) ever

296 Intra-articular triamcinolone resulted in significantly greate

297 cebo-controlled, double-blind trial of intra-articular triamcinolone vs saline for symptomatic knee o

298 omatic knee osteoarthritis, 2 years of intra-articular triamcinolone, compared with intra-articular s

299 We report a new case of osteo-articular tuberculosis localized to the xiphisternum, a

300 referentially expressed and activated in the articular zone of TMJs but not knee joints.