ライフサイエンスコーパス: articular cartilage

1 icin (Prg4), the major boundary lubricant of articular cartilage.

2 is often associated with the degeneration of articular cartilage.

3 ere co-localized in chondrocytes of degraded articular cartilage.

4 ntrast agent (CA4+) is described for imaging articular cartilage.

5 chondral bone attenuated the degeneration of articular cartilage.

6 nsgenic mice markedly activated autophagy in articular cartilage.

7 1) histone methyltransferase is expressed in articular cartilage.

8 fibroblast growth factor 2 (FGF-2) from the articular cartilage.

9 ase and involves progressive degeneration of articular cartilage.

10 nti-catabolic and anti-inflammatory in human articular cartilage.

11 MMP-13, which are constitutively present in articular cartilage.

12 effect on morphologic characteristics of the articular cartilage.

13 on of sclerostin has an impact on knee joint articular cartilage.

14 of these were significantly regulated in the articular cartilage.

15 PA) is necessary for the cryopreservation of articular cartilage.

16 ches for application of miRNAs to regenerate articular cartilage.

17 ator in the development of osteoarthritis in articular cartilage.

18 1L in chondrogenic differentiation and adult articular cartilage.

19 e 2-dimensional and 3-dimensional changes of articular cartilage.

20 uce profound morphologic changes in immature articular cartilage.

21 ular chondrocytes in the mid-region of mouse articular cartilage.

22 concept of ACVs as physiologic structures in articular cartilage.

23 are extracellular organelles found in normal articular cartilage.

24 roblast growth factor (FGF)/Erk signaling in articular cartilage.

25 zed by proteoglycan loss and fibrillation of articular cartilage.

26 ndrocytes were isolated from human or bovine articular cartilage.

27 ere constitutively expressed in normal human articular cartilage.

28 was recoverable at a high yield from mature articular cartilage.

29 re difficult to achieve in tissue-engineered articular cartilage.

30 pt was abundantly expressed in normal and OA articular cartilage.

31 NFkappaB and LCN2 in the pathophysiology of articular cartilage.

32 novel endogenous chondroprotective agent in articular cartilage.

33 from old and young human and porcine hyaline articular cartilage.

34 ing and the sGAG and collagen content of the articular cartilage.

35 II collagen, the major structural protein of articular cartilage.

36 ng, result in progressive damage and loss of articular cartilage.

37 hythm and caused progressive degeneration of articular cartilage.

38 g new insights into the impact of hypoxia in articular cartilage.

39 nd contribute to the growth and reshaping of articular cartilage.

40 le in maintaining the health and function of articular cartilage.

41 nd organized cartilage resembling the native articular cartilage.

42 e equilibrium electro-chemical properties of articular cartilage.

43 ular matrix concentration in neonatal bovine articular cartilage.

44 r targeting the surface or interior zones of articular cartilage.

45 erved early degenerative changes of condylar articular cartilage, abnormal development of the articul

46 tifactorial disease that is characterized by articular cartilage (AC) degradation.

47 therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries.

48 acterized by the progressive degeneration of articular cartilage accompanied by chronic joint pain.

49 Injury to the surface of intact articular cartilage activates Src-like kinases as well a

50 mplified by increased lubricin deposition on articular cartilage and a decrease in sGAG release from

51 ition as it progresses to destruction of the articular cartilage and ankylosis of the joints.

52 ransformation responsible for destruction of articular cartilage and bone in rheumatoid arthritis and

53 Synovial fibroblasts destroy articular cartilage and bone in rheumatoid arthritis, bu

54 Expression of sclerostin was determined in articular cartilage and bone tissue obtained from mice,

55 regulate matrix metalloproteinases (MMPs) in articular cartilage and cause tissue degradation; howeve

56 characterised by progressive destruction of articular cartilage and chondrocyte cell death.

57 Articular cartilage and cultured chondrocytes from Sulf(

58 int disease that involves the destruction of articular cartilage and eventually leads to disability.

59 gen tension in the region destined to become articular cartilage and higher oxygen tension in transie

60 sing the mechanical properties of engineered articular cartilage and identifying potentially importan

61 and LC3 was analyzed in normal and OA human articular cartilage and in knee joints of mice with agin

62 with enhanced EGF receptor signaling in the articular cartilage and in the abnormally formed osteoph

63 ding chondrocytes in the superficial zone of articular cartilage and in the meniscus, as well as syno

64 oint motion via adsorption to the surface of articular cartilage and its lubricating properties in so

65 ubricin) is secreted by cells that reside in articular cartilage and line the synovial joint.

66 duced joint pathology, including thinning of articular cartilage and loss of proteoglycans in the car

67 nosis is key to preventing compromise to the articular cartilage and maximizing opportunity to perfor

68 collagen is the most prominent component of articular cartilage and other cartilage-like tissues suc

69 P38 was detected in articular cartilage and perichondrium; articular and ste

70 lay unique aggressive behavior, invading the articular cartilage and promoting inflammation.

71 genes that maintain the homeostasis of adult articular cartilage and regenerate its lesions, we initi

72 potential in amelioration of degeneration of articular cartilage and subchondral bone microarchitectu

73 erestingly, IL-3 reduces the degeneration of articular cartilage and subchondral bone microarchitectu

74 Changes in articular cartilage and subchondral bone were analyzed b

75 e both beneficial and detrimental effects on articular cartilage and subchondral bone, and may subseq

76 or specifically expressed in the SZ of human articular cartilage and supports chondrocyte survival.

77 OA) is a progressive degenerative disease of articular cartilage and surrounding tissues, and is asso

78 Samples of articular cartilage and synovial fluid were obtained fro

79 We found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selecti

80 pression of miRNA 146a was analyzed in human articular cartilage and synovium, as well as in dorsal r

81 rtant and distinct roles in growth plate and articular cartilage and that postnatal dysregulation of

82 study demonstrates the presence of D-COMP in articular cartilage and the systemic circulation, and to

83 degeneration of joints, involving mainly the articular cartilage and the underlying bone, and severel

84 Current literature suggests that articular cartilage and transient cartilage originate fr

85 ollagens in bones, as well as prominently in articular cartilages and tumors characterized by high MM

86 Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial ev

87 he Tak1 mutant mice showed defects in skull, articular cartilage, and mesenchymal stromal cells.

88 ent a new type of contrast agent for imaging articular cartilage, and the results demonstrate the imp

89 artilage did not differ from those of native articular cartilage, and were significantly greater than

90 n conclusion, miR-222 expression patterns in articular cartilage are higher in the weight-bearing ant

91 ating skeletal bone mass, but its effects in articular cartilage are not known.

92 r microcomputed tomography (muCT) imaging of articular cartilage are reported.

93 e exhibited hyperplasia in the glenoid fossa articular cartilage, articular disc, and synovial membra

94 ted tissues was compared with that in native articular cartilage as a means of assessing the progress

95 Here, by using self-assembled articular cartilage as a model to examine the effects of

96 tracellular matrix of adult human and bovine articular cartilages as covalently cross-linked polymers

97 III collagen, which is synthesized in mature articular cartilage, as a covalent modifier that may add

98 n seconds of injury to the surface of intact articular cartilage, as did activation of MAPKs and IKK.

99 crystals are universally present in hyaline articular cartilage, as well as the meniscus of the knee

100 ties of the superficial zone of young bovine articular cartilage at deformation amplitudes, delta, of

101 xpression level of ADAM12 protein in the KBD articular cartilage (average positive chondrocyte rate =

102 rate = 47.59 +/- 7.79%) compared to healthy articular cartilage (average positive chondrocyte rate =

103 e hyaline cartilage, which expressed typical articular cartilage biomarkers, including established in

104 sion to show that chondrocytes isolated from articular cartilage biopsies of patients and subjected t

105 res and CC/TAC (calcified cartilage to total articular cartilage), but increased SBP (subchondral bon

106 ave been proposed for replacement of damaged articular cartilage, but they suffer from a complete lac

107 esponsible for the remarkable lubrication of articular cartilage; but alone, these molecules cannot e

108 The degradation of articular cartilage by aggrecanases (ADAMTS-4 and ADAMTS

109 e Prg4 expression in the superficial zone of articular cartilage by engaging the same signaling pathw

110 identified Fgf18 as a molecule that protects articular cartilage by gene expression profiling, and th

111 hyaluronan, anchored at the outer surface of articular cartilage by lubricin molecules, complexes wit

112 ycans (PG) provide compressive resistance to articular cartilage by means of their fixed charge densi

113 lays an essential role in the maintenance of articular cartilage by preventing articular chondrocytes

114 DT imaging of articular cartilage can enable physicians to detect and

115 ific mouse tryptase plays prominent roles in articular cartilage catabolism.

116 e zonal composition and functioning of adult articular cartilage causes depth-dependent responses to

117 Impact loading of articular cartilage causes extensive chondrocyte death.

118 croRNA expression profiling in healthy human articular cartilage cells (chondrocytes), we identified

119 t, similar to transient cartilage, embryonic articular cartilage cells also originate from the prolif

120 Primary articular cartilage chondrocytes from Smad3(fl/fl) mice

121 Fgf18 was strongly expressed in the articular cartilage chondrocytes of adult rats.

122 In articular cartilage, chondrocytes are surrounded by a na

123 tion prevents these changes and up-regulates articular cartilage CITED2.

124 Denatured, insoluble, bovine articular cartilage collagen was digested with trypsin,

125 ignificantly greater agent uptake of CA4+ in articular cartilage compared to that of similar anionic

126 n framework of hyaline cartilages, including articular cartilage, consists largely of type II collage

127 Mature bovine articular cartilage contains about equimolar amounts of

128 rocyte catabolism, not death, contributes to articular cartilage damage following injury.

129 tion of lentiviral Wnt7a strongly attenuated articular cartilage damage induced by destabilization of

130 The articular cartilage damage present in the knee joints of

131 he progeny of these cells reconstitute adult articular cartilage de novo, entirely substituting fetal

132 y, mice underwent knee surgery to produce an articular cartilage defect and received chlorodeoxyuridi

133 The development of morphologic articular cartilage defects (Whole-Organ MR Imaging Scor

134 termine the incidence with which morphologic articular cartilage defects develop over 48 months in ca

135 ethods for clinical diagnosis and staging of articular cartilage degeneration are important to the ev

136 ate ligament (ACL) and their relationship to articular cartilage degeneration are not well characteri

137 e the potential to therapeutically attenuate articular cartilage degeneration as part of OA.

138 ecific reduction of Smad3 caused progressive articular cartilage degeneration due to imbalanced carti

139 uated hedgehog-induced or surgically induced articular cartilage degeneration in mouse models of OA.

140 ith losartan both delayed the progression of articular cartilage degeneration induced by DMM compared

141 destructive quantitative assessment of human articular cartilage degeneration may facilitate the deve

142 Reduction of DDR-2 expression attenuates the articular cartilage degeneration of knee joints induced

143 tative and quantitative assessments of early articular cartilage degeneration that strongly correlate

144 ed using Safranin O-fast green staining, and articular cartilage degeneration was graded using the Os

145 Initiation or acceleration of articular cartilage degeneration was not observed by the

146 s Runx2-inducible gene expression to prevent articular cartilage degeneration.

147 l joints were characterized for evidences of articular cartilage degeneration.

148 gery in Cre-negative control mice, including articular cartilage degradation and subchondral sclerosi

149 ufficient extracellular matrix synthesis and articular cartilage degradation, mediated by several pro

150 and causes rapid, histologically detectable articular cartilage degradation.

151 on is mild and normalizing with age, but the articular cartilage degrades with age and bones develop

152 ession to direct interzone progeny fates and articular cartilage development and disease.

153 Many of these genes are associated with articular cartilage development and maintenance, diarthr

154 ere investigated for their ability to affect articular cartilage development in a scaffoldless, 3-dim

155 We conclude that Phd2 is a key regulator of articular cartilage development that acts by inhibiting

156 Biomechanics plays a pivotal role in articular cartilage development, pathophysiology, and re

157 ve and shear properties of TGFbeta3-mediated articular cartilage did not differ from those of native

158 y a progressive and irreversible loss of the articular cartilage, due in main part to the cleavage of

159 lycan from the extracellular matrix of their articular cartilage during inflammatory arthritis than w

160 n collagenase responsible for degradation of articular cartilage during osteoarthritis and therefore

161 particularly in the middle and deep zones of articular cartilage, during CPA loading.

162 Articular cartilage enables weight bearing and near fric

163 Articular cartilage exhibited an initial acute loss of p

164 We demonstrate that PPARgamma-deficient articular cartilage exhibits elevated expression of the

165 growth factor stimulation of immature bovine articular cartilage explants in serum-free culture mediu

166 as to investigate if chondrocytes from human articular cartilage express gap junction proteins called

167 Normal human articular cartilage expressed miR-140, and this expressi

168 Normal human articular cartilage from a range of donors was obtained

169 to reduced type II collagen mRNA expression, articular cartilage from Col2-Cre;Smad3(fl/fl) mice was

170 f human MSCs in pellet cultures and in human articular cartilage from normal and OA knee joints.

171 Lipid peroxidation in articular cartilage from OA patients and from lesion-fre

172 lage was assessed in vitro by immunostaining articular cartilage from RA and OA patients and from nor

173 Finally, mouse articular cartilage from Sirt1(-/-) presented increased

174 Conditions of the articular cartilage from the knee joints of the double-h

175 n joint cavity morphogenesis and critical to articular cartilage function.

176 years it has become increasingly clear that articular cartilage harbours a viable pool of progenitor

177 Articular cartilage has little regenerative capacity.

178 e data implicate miRNA in the maintenance of articular cartilage homeostasis and are therefore target

179 de insight into the regulatory mechanisms of articular cartilage homeostasis and maintenance by morph

180 role of miR-146a in the regulation of human articular cartilage homeostasis and pain-related factors

181 polypeptide growth factors are important in articular cartilage homeostasis and repair.

182 more relevant in examining their effects on articular cartilage homeostasis and the development of o

183 ed with abnormally expressed pathways in KBD articular cartilage, identified by microarray study of K

184 f Prg4 in the superficial zone of knee joint articular cartilage in a COX-2-dependent fashion, which

185 these materials can promote regeneration of articular cartilage in a full thickness chondral defect

186 artilage and a decrease in sGAG release from articular cartilage in an animal model of posttraumatic

187 wing chondrocyte progenitors, which form the articular cartilage in juvenile mice.

188 growth and differentiation of transient and articular cartilage in juxtaposed domains.

189 oscopic-resolution cross-sectional images of articular cartilage in near real-time.

190 d therapy involving sFlt-1 and BMP-4 repairs articular cartilage in OA mainly by having a beneficial

191 ight the importance of structures other than articular cartilage in OA of the ankle and foot, and sug

192 drocyte differentiation, and degeneration of articular cartilage in osteoarthritis (OA).

193 omogeneities in the mechanical properties of articular cartilage in situ.

194 arthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been vi

195 ly expressed miRNA that were up-regulated in articular cartilage in the anterior, M1, greater weight-

196 as a frictional behaviour resembling that of articular cartilage in the major joints.

197 isease involving the mechanical breakdown of articular cartilage in the presence of altered joint mec

198 hat the chondrocytic primary cilium forms in articular cartilage in the presence or the absence of lo

199 e of COX-2 in regulating MMP-1 expression in articular cartilage in vivo was demonstrated using COX-2

200 findings show that RRV infection damages the articular cartilage, including a loss of proteoglycans w

201 th KBD, but also abnormally expressed in KBD articular cartilage, including REACTOME_INTRINSIC_PATHWA

202 Articular cartilage injury can result in chondrocyte los

203 which may be critical for the maintenance of articular cartilage integrity under normal physical acti

204 The native extracellular matrix (ECM) of articular cartilage is a 3D structure composed of protei

205 Articular cartilage is a highly efficacious water-based

206 Articular cartilage is an avascular tissue with precise

207 The superficial zone (SZ) of articular cartilage is critical in maintaining tissue fu

208 The superficial zone (SZ) of articular cartilage is critical in maintaining tissue fu

209 Articular cartilage is exposed to a gradient of oxygen l

210 The articular cartilage is known to be highly mechanosensiti

211 nes, we propose that the collagen network in articular cartilage is near a percolation threshold that

212 Among mammalian soft tissues, articular cartilage is particularly interesting because

213 analyzed for boundary lubrication of normal articular cartilage (kinetic friction coefficient [mu(ki

214 nic disease characterized by degeneration of articular cartilage leading to pain and physical disabil

215 Histologic changes seen in OA, including articular cartilage lesions and osteophytes, were presen

216 Two weeks of loading produced articular cartilage lesions only at sites of maximal con

217 and control contralateral joints, including articular cartilage lesions, osteophyte formation, and p

218 ry to immature knee joints most often causes articular cartilage lesions, this study was undertaken t

219 In human articular cartilage, LfcinB antagonizes interleukin-1 be

220 tants failed to upregulate expression of the articular cartilage marker gene Prg4.

221 The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsibl

222 abnormalities or morphologic defects in the articular cartilage (mean age, 54 years +/- 5; 51% women

223 miR-222 might be a potential regulator of an articular cartilage mechanotransduction pathway.

224 issected tissues of the joint, including the articular cartilage, meniscus, and epiphysis.

225 fication of extracellular matrix proteins in articular cartilages, meniscus, intervertebral disc, rib

226 The insufficient healing capacity of articular cartilage necessitates mechanically functional

227 Chondrocytes were isolated from articular cartilage obtained during talonavicular joint

228 olated chondrocytes from the surface zone of articular cartilage of bovine stifle joints were culture

229 s of articular chondrocytes were seen in the articular cartilage of ESET-null animals.

230 Basal characteristics of the articular cartilage of Fgf2(-/-) and Fgf2(+/+) mice were

231 ditionally overexpressing DDR2 in the mature articular cartilage of mouse knee joints requires activa

232 creased levels of hypertrophy markers in the articular cartilage of the cKO mice.

233 ce as routine MR protocol for evaluating the articular cartilage of the knee in clinical patients at

234 ed diagnostic performance for evaluating the articular cartilage of the knee joint in symptomatic pat

235 e tibia and femur, and in the epiphyseal and articular cartilage of these bones.

236 In the articular cartilages of adult joints, type III collagen

237 over time and was no different from that of articular cartilage on day 38 after surgery.

238 However, structural changes of articular cartilage or menisci cannot be directly evalua

239 ntitative ultrasound grading of knee femoral articular cartilage, osteophytes and meniscal extrusion,

240 r-sized, anatomically shaped pieces of human articular cartilage over 5 wk of culture.

241 oxidase-positive neutrophils, destruction of articular cartilage, pannus invasion, bone resorption, e

242 tion of the Phd2 gene in chondrocytes on the articular cartilage phenotype in mice.

243 Mechanical overloading of articular cartilage producing hydrostatic stress, tensil

244 at acts by inhibiting the differentiation of articular cartilage progenitors via modulating HIF-1alph

245 Articular cartilage quality was assessed by quantitative

246 Articular cartilage quality was assessed by quantitative

247 Our findings indicate that articular cartilage regeneration in mice is heritable, t

248 ls have emerged as a favourable approach for articular cartilage regeneration.

249 sources of endogenous cells that regenerate articular cartilage remain elusive.

250 n of sclerostin with Scl-Ab has no impact on articular cartilage remodeling in rats with posttraumati

251 Articular cartilage repair remains a significant and gro

252 tion, suggesting their potential utility for articular cartilage repair.

253 mensions on the nanoscale for application to articular cartilage repair.

254 p guide the application of growth factors to articular cartilage repair.

255 Aging-associated changes in articular cartilage represent a main risk factor for ost

256 s, which falls within the range reported for articular cartilage, requires the stiffness-sensitive in

257 The spatial organization of the articular cartilage results from a band of Nog-expressin

258 tes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoin

259 bilization of the medial meniscus (DMM), and articular cartilage samples were microdissected and subj

260 l voids in the middle/deep zone of sectioned articular cartilage samples.

261 access to active TGF-beta: the synovium and articular cartilage secrete latent TGF-beta into the SF

262 Articular cartilage specimens from 8 subjects were colle

263 through a mechano-adaptive response modifies articular cartilage structure and contributes to osteoar

264 ntifiable microscopic resolution data on the articular cartilage structure.

265 scence imaging were combined to characterize articular cartilage, subchondral bone, vascularization,

266 ns sometimes present, a roughened underlying articular cartilage surface, and a progressive loss of p

267 Physiologically, articular cartilage sustains millions of cycles of mecha

268 d roughly 130% more cells in the regenerated articular cartilage than did spontaneous cell migration

269 rent organization of the superficial zone of articular cartilage that normally exerts an anti-frictio

270 ded that focus on the tissues outside of the articular cartilage that play a role in osteoarthritis.

271 ciated with chondrocyte hypertrophy in adult articular cartilage, the lack of which protects from car

272 In both age groups, articular cartilage thickness decreased, and subchondral

273 ge homeostasis and are therefore targets for articular cartilage tissue engineering and regenerative

274 We found that articular cartilage tissue sections from y/y mice of up

275 tilage strands as building units to bioprint articular cartilage tissue.

276 lasticity of the composites approach that of articular cartilage tissue.

277 at underscores the need to subject the mouse articular cartilage to a destabilizing challenge in orde

278 grecan) degradation and PGE(2) production in articular cartilage treated with IL-1beta, indicating a

279 is a novel adipokine that negatively impacts articular cartilage, triggering catabolic and inflammato

280 ditions, mutation of collagens affecting the articular cartilage typically produces an epiphyseal ske

281 Stick-slip friction was observed in articular cartilage under certain loading and sliding co

282 ignaling and allows them to differentiate as articular cartilage under the influence of Wnt signaling

283 he PCM and ECM of human, porcine, and murine articular cartilage using atomic force microscopy (AFM).

284 Articular cartilage vesicles (ACVs) are extracellular or

285 te-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-c

286 ion channel transduces mechanical loading of articular cartilage via the generation of intracellular

287 uantitative assessment of parameters such as articular cartilage volume and surface area.

288 ional overexpression of DDR2 in mature mouse articular cartilage was controlled via the cartilage oli

289 Articular cartilage was harvested from the paws and knee

290 Articular cartilage was obtained from the knees of 4 nor

291 Articular cartilage was predicted to be one of the first

292 MATERIAL/METHODS: Labral pathology and articular cartilage were prospectively evaluated with MR

293 Chondrocytes from normal human articular cartilage were treated with glucosamine (0.1-

294 expressed during chondrogenesis and in adult articular cartilage, where it can regulate TGFbeta signa

295 The articular cartilage, which lines the joints of the limb

296 structural and biomechanical changes in the articular cartilage with age, some of which are consiste

297 hat of the ECM in human, porcine, and murine articular cartilage, with a ratio of PCM to ECM properti

298 imaging in comparison with the incidence in articular cartilage without signal abnormalities at base

299 ecreted from both the synovium and all three articular cartilage zones (superficial, middle, and deep

300 t miRNA expression profiles in the different articular cartilage zones as well as between regions sub