ライフサイエンスコーパス: aryl group

1 a properly positioned nitro moiety on the 3-aryl group.

2 orrelation with the electronic nature of the aryl group.

3 relation with the electronic property of the aryl group.

4 ively replacing it with an alkyl, alkenyl or aryl group.

5 ither one- or two-electron, depending on the aryl group.

6 ials that allows convenient variation of the aryl group.

7 a-carbomethoxy group has been replaced by an aryl group.

8 hosphorus donor trans to the palladium-bound aryl group.

9 uorophore is essentially determined by the 3-aryl group.

10 ynthesis of mesembrine using a 3,4-dimethoxy aryl group.

11 he weaker donor trans to the palladium-bound aryl group.

12 to the migrating alkyl group rather than the aryl group.

13 cyclic (alkyl)(amino) carbenes (CAACs) by an aryl group.

14 proach allows for simple modification of the aryl group.

15 ds, phenols, sulfonamides, and electron-rich aryl groups.

16 f the substituents on the two platinum-bound aryl groups.

17 electron-donating substituents on the ligand aryl groups.

18 mpatible with a range of substituents on the aryl groups.

19 electron rich and the electron poor terminal aryl groups.

20 nation of influences from the heteroatom and aryl groups.

21 cal mol(-1) at 298 K in spite of the bulkier aryl groups.

22 s accompanying highly selective 1,2-shift of aryl groups.

23 osition, linear or branched alkyl groups and aryl groups.

24 riginates from the twisted geometry of the N-aryl groups.

25 ting the heteroallene cation and the pendant aryl groups.

26 ectron-poor aryl groups versus electron-rich aryl groups.

27 sessing an electron-withdrawing group on the aryl groups.

28 activity relationship (SAR) studies of the 4-aryl group, a 4- and 7-fold increase in potency was obta

29 facial addition of the nitrogen atom and the aryl group across the alkene.

30 r olefins was initially limited to alkyl and aryl groups, additional efforts culminated in the expans

31 ubstituents at the meta position of the C(6) aryl group afforded substantial improvements in hPR modu

32 for a diastereoselective installation of two aryl groups along an alkyl chain.

33 alide A bearing the cyclopropoxy-substituted aryl group and a 2-phenyl-3-piperidone B.

34 at contain a basic side chain at the 2- or 3-aryl group and quickly found one that, according to the

35 d electron-withdrawing groups in the pendant aryl group and the benzo ring C, as well as H, methoxy,

36 The new structures reversed the aryl group and the benzoyl group of previous ABI structu

37 pounds, the length of the spacer between the aryl group and the tropane skeleton ranged from 1 to 4 b

38 e ligand; the ipso-carbon of the transferred aryl group and trifluoroacetate function as the third an

39 d-mediated arylation of sterically demanding aryl groups and carbon acid coupling partners in order t

40 The decreased interaction between the aryl groups and Ser 48 in GGTase-I binding site could be

41 etween the size of the bridge connecting the aryl groups and the reaction products observed.

42 s a biaryl monophosphine ligand and Ar is an aryl group, and identified conditions under which reduct

43 ost complete incorporation of the initiating aryl group, and when the aryl group was o-tolyl, only To

44 acterization revealed symmetrically bridging aryl groups, and (1)H NMR spectroscopy evidenced the sam

45 ry, of the length of the spacer linking both aryl groups, and of the decoration of the macrocycles on

46 nces of the heteroatom, ring size, number of aryl groups, and terminal side chain on retinoid recepto

47 ular steric strain was tuned via N-pyridinio aryl group (Ar) phenyl (Ph), 4-pyridyl (Py), and 4-pyrid

48 Electronically and sterically diverse aryl groups (Ar) were transferred in high yield using io

49 e in which each isoprene is replaced with an aryl group are good substrates.

50 e of aromatic substituents on the acylsilane aryl group are tolerated, affording a series of function

51 vents; phlorins containing electron-donating aryl groups are easier to oxidize and harder to reduce,

52 accessed by choosing the order in which the aryl groups are installed.

53 r folded, protophane structures in which the aryl groups are loosely pi-stacked.

54 stigations reveal that enyne-allenes with an aryl group as probe at the allene terminus follow a dyna

55 Incorporation of aryl groups as putative delta address mimics on the pyri

56 halocyclohex-2-en-1-ones bearing an alkyl or aryl group at C-5, followed by mild acid treatment and e

57 a Suzuki coupling reaction to introduce the aryl group at position 3.

58 s an efficient access to introduce alkyl and aryl group at the 1,4-position of the 1,4-diamino-2-buty

59 In all the analogs, the aryl group at the 3 position was directly bound to the t

60 ) as the catalyst, substrates with a pendant aryl group at the acetate alkynyl position were found to

61 In addition, variation of the aryl group at the amido nitrogen showed systematically t

62 Remarkably, introduction of a simple aryl group at the turn potentiates the biological effect

63 that, while the substitution patterns of the aryl groups at C2 and C4 do not exert large effects on t

64 The aryl groups at the 2- and 6-positions are derived from k

65 ate group at the 2-position and various (het)aryl groups at the 3-position.

66 tence of a helical twist in 8 imposed by the aryl groups at the 4- and 5-positions was also revealed

67 r phenylethynyl groups at the 4-position and aryl groups at the 6-position were synthesized and found

68 s further optimization of 1 by introducing 4-aryl groups at the hydroxylindoline in two series.

69 chain, oligoethyleneglycol ether chain, and aryl group) at the imide sites as well as at the bay reg

70 Oxidative coupling of activated aryl groups attached to beta-positions of the porphyrin

71 d four 2,4-diaminoquinazolines, each with an aryl groups attached to the 6-position of the heterocycl

72 A set of 3,5-disubstituted aryl groups bearing lipophilic or amphipathic groups was

73 ogressively larger as the substituent on the aryl group becomes more electron-withdrawing.

74 wded analogues with 2,6-dimethyl-substituted aryl groups, benzene coordination becomes rate-determini

75 3.0-36 muM/s) and decreases as the number of aryl groups bound to phosphorus increases (1 > 2 > 3).

76 between the S(2)P molecular orbitals and the aryl groups bound to phosphorus.

77 Aryl group bromination is accomplished with such reagent

78 Thus, replacement of the 3-aryl group by an appropriately tethered 3-alkyl ring can

79 ropane-1,1-dicarboxylates with vicinal donor aryl groups by boronic acids and potassium organotrifluo

80 coupling of various pyridines with alkyl and aryl groups can be achieved by a BF3.OEt2-mediated addit

81 ail alkyl group and a variety of substituted aryl groups can be prepared in a single step from a simp

82 c transition, we find that halide-containing aryl groups can covalently bond to the sp(2) carbon latt

83 nt of the series was the introduction of a 2-aryl group containing a basic amine onto the azaindole l

84 Complexes with aryl groups containing two ortho fluorines have barriers

85 a fundamental effect on activity, with the 5-aryl group contributing additively to the allosteric enh

86 Alkynylaziridines carrying an aryl group could be efficiently converted into aminoalle

87 tron donor group (i.e., OMe) on the sulfonyl aryl group enhances the nucleophilicity of the amido ani

88 )() orbitals on the ipso carbons of opposing aryl groups evolve into a sigma bond leading to the form

89 c studies demonstrate that 2,6-disubstituted aryl groups exert a strong effect on acyclic conformatio

90 The aryl group exo-stereochemistry in 1a and 1b is establish

91 The process occurs through transfer of an aryl group from a silyl segment present on the lateral c

92 tudies establish that transmetalation of the aryl group from boron to Cu(II) is the turnover-limiting

93 ngement wherein 1,2-migration of an alkyl or aryl group from boron to the vinyl alpha-carbon occurs c

94 on arises through a migration of the Cu(III)-aryl group from C3 to C2, and this can be controlled by

95 The reaction involves cis-addition of the aryl group from the aryl iodide to the less hindered or

96 e electron-rich end of the alkyne, while the aryl group from the arylboronic acid adds to the other e

97 fluoride to promote transfer of up to three aryl groups from germane or silicon.

98 he reaction involves the cis addition of two aryl groups from the arylboronic acid to opposite ends o

99 roducing novel indoles that incorporate both aryl groups from the reagent.

100 y, substrates containing sterically hindered aryl groups gave the highest levels of enantioselectivit

101 complexes of Pt(II) with various substituted aryl groups has been prepared.

102 Substituents on the N-aryl group have almost no effect.

103 tions 4 and 5 of the oxazole ring, where the aryl group in position 5 deactivates the reaction.

104 , C-C cleavage products are observed with an aryl group in the 3-position; this can be particularly p

105 rodrug cleavage required the presence of the aryl group in the cis-configuration, but was relatively

106 sequence of pi-complexation of nickel by the aryl group in the reagent.

107 vel LpxC inhibitors containing an additional aryl group in the threonyl-hydroxamate moiety, which exp

108 stituted TREN has been prepared in which the aryl groups in (ArylNHCH2CH2)3N are substituted at the 3

109 ands, revealing the critical role of bulky P-aryl groups in facilitating this process.

110 n with linear and branched alkyl, benzyl, or aryl groups in overall good yields.

111 ydrochloride gives branched tryptamines with aryl groups in the alpha-position to the amino group, wh

112 favored over the 1,2-shifts of H, alkyl, and aryl groups in the beta-Si-substituted Au-carbenes.

113 of conjugation between the nitrile oxide and aryl groups in the C-C bond formation step.

114 imide atoms N=C(CMe)(Cipso) and the ketimide aryl groups in the range phi = 49.1-88.8 degrees , while

115 The selective installation of two different aryl groups in these reactions is accomplished by in sit

116 tron-withdrawing -CF(3) substituent on the 7-aryl group increases activity but has little effect on b

117 nprecedented Pd(II)-mediated insertion of an aryl group into an unactivated arene.

118 The introduction of a 5-aryl group into the 1,2-dihydrocoumarino[3,4-f]quinoline

119 yridine, a central hydrophobic group, and an aryl group, into the S1, S2, and aryl subsites on thromb

120 Previously, we reported that, when the 8-aryl group is a phenyl ring with a meta-carbonyl group,

121 s of triarylamines containing a heterocyclic aryl group is also described by employing a one-flask, t

122 is no longer crucial for the binding once an aryl group is incorporated at postion-6.

123 An electronically modified N-aryl group is introduced that is responsible for high re

124 trated that electron donation of the "lower" aryl group is key to the stability of the amido complex

125 l-4-aryl-3-aza-3-ene-1,4-diynes in which the aryl group is phenyl, o-(methoxy)phenyl, or p-(methoxy)p

126 When an aryl group is present in the C3 position of cyclopentano

127 In addition, compounds in which the 2-aryl group is replaced by alkyl, cycloalkyl, and naphthy

128 n N-aryl substituent: upon lithiation, the N-aryl group is transferred cleanly from N to C.

129 Diaryl acetylenes, in which one of the aryl groups is either a pyridine or a pyrazine, undergo

130 rimary, secondary, and tertiary 4-C-alkyl or aryl groups is reported.

131 activation of a carbon-hydrogen bond in the aryl group, leading to efficient synthesis of functional

132 the morpholine moiety with the flanking meso-aryl groups leads to a sharpened, blue-shifted wavelengt

133 roup in the 3-aryltropane class with a 2beta-aryl group led to compounds possessing very similar mono

134 The new synthesized IGP analogues contain an aryl group linked to an O-phosphoethanolamine moiety thr

135 According to docking experiments, the aryl group of AC-216 interacts with position 7.35 in the

136 ariety of heterocyclic substitutions for the aryl group of the arylamide are tolerated.

137 residue hypothesized to be proximate to the aryl group of the bound agonist and a putative hydrogen

138 Both the carboxylate ligand and the aryl group of the N-heterocyclic carbene have been alter

139 ng these features with modification of the 2-aryl group of the pyrrolidine core, we have identified a

140 te H bond to Asp48 as designed, although the aryl group of the sulfonamide unexpectedly interacts int

141 teric bulk from the ortho positions of the N-aryl group of the thiazole-2-ylidene ligands, the phosph

142 gers, leading exclusively to substitution by aryl groups of diverse electronic and steric properties

143 bit an intramolecular interaction with the N-aryl groups of the carbene ligands.

144 The reaction uses both aryl groups of the diaryliodonium reagent to generate tr

145 n the alkyl groups on the substrates and the aryl groups of the manganese porphyrin.

146 However, a favorable pi-stacking between the aryl groups of thiourea/squaramide and aryl vinyl ketone

147 a method that allows for installation of an aryl group on a range of acyclic and cyclic amides conta

148 Silaaziridines with an aryl group on either the carbon or the nitrogen atom und

149 The reaction appears to require an aryl group on the end of the acetylene furthest from the

150 ligand, the phosphido substituents, and the aryl group on the ratio of diastereomers of the phosphid

151 ing mode for 3 places the 2'-halide of the 8-aryl group on top of the adenine ring, for 1 and 2, we s

152 Electron-withdrawing aryl groups on ArCCMe stabilize the azatitanacyclobutene

153 phacyclooctane diphosphine ligand with alkyl/aryl groups on N and P), have been developed for heterol

154 (II)-benzoates containing more electron-rich aryl groups on the benzamidate and benzoate react faster

155 ctivity, behavior related to the presence of aryl groups on the dideoxystreptamine scaffold.

156 ysics, as introduction of electron-releasing aryl groups on the periphery of the macrocycle is manife

157 ndary alcohols can transmit chirality to the aryl groups on the silicon resulting in a higher populat

158 Sterically bulky aryl groups on the sulfenyl moiety prevented erosion of

159 Hammett analysis of aryl groups on the urea indicates that fluoride binding

160 adical than do those with more electron-poor aryl groups on these ligands to produce the correspondin

161 r functions located at ortho-position of the aryl group, on their stereoselectivity and reactivity.

162 volving nucleophilic attack of the migrating aryl group onto the electrophilic metal center.

163 d that substitution at the 3-position of the aryl group optimized COX-2 selectivity and potency, wher

164 tes glucose substitution with small alkyl or aryl groups or its truncation to uridine 5'-diphosphate

165 When the starting imine incorporates two aryl groups or one aryl group with one electron-releasin

166 Cotton effects characteristic of the aryl groups organized into one preferred conformation we

167 As a consequence, the change in aryl group orientation appears to make the ortho-substit

168 hanols to react with site selectivity at one aryl group over the other.

169 substituted with halogen, alkyl, alkoxy, and aryl groups participate in anaerobic condensation reacti

170 and two formyl functional groups on the 1,7-aryl groups present at the azaBODIPY core were synthesiz

171 Interestingly, the removal of one aryl group prevents the N-fusion reaction, providing sta

172 In contrast, electron-releasing aryl groups promote the final N(alpha) migration stage o

173 e C(5) aryl group with variously substituted aryl groups resulted in optimization of the progestation

174 ecomposition through C-H activation of the N-aryl group, resulting in increased catalyst lifetimes.

175 these undergo intramolecular attack on an N'-aryl group, resulting in retentive arylation of the orga

176 lished with 2,4,6-tricyclopentyl-substituted aryl groups, resulting in optimized catalytic [2pi + 2pi

177 the planar molecular core and the peripheral aryl groups results in a systematic blue shift in the lo

178 that the twisted nature of the five adjacent aryl groups serves to minimize the intermolecular intera

179 AVMBs containing electron-donating aryl groups show absorption and emission in the visible

180 its, including electron-donating/withdrawing aryl groups, silyl-protected alkynyl groups, as well as

181 benzofurans substituted at C-2 by an acyl or aryl group, starting from phenolic Mannich bases and pyr

182 d a library of FPP analogues with a range of aryl groups substituting for individual isoprene moietie

183 The influence of aryl group substitution and/or conjugation axis variatio

184 However, the steric bulk of the aryl group tends to exert a leveling effect on BDEs.

185 ese compounds are characterized by having an aryl group tethered to the C-6 position of the erythrono

186 nd led to the development of a new removable aryl group that allows for the preparation of indazoles

187 onal groups and electronic properties of the aryl groups that are tolerated.

188 When both ester groups are aryl groups the hydrolysis reaction (sulfuryl transfer t

189 n-donating substituents were attached to the aryl group to a kDelta process involving formation of cy

190 changes in free energy on changing from one aryl group to another, in either the acyl group or the l

191 um and hence overall addition of an alkyl or aryl group to both carbon atoms of the urea-substituted

192 f the vinyl cation to the ipso carbon of the aryl group to give a spiral intermediate, and then migra

193 duces diastereoselective migration of the N'-aryl group to the alpha position of the amino acid, foll

194 f these species transfer their boron-bearing aryl groups to a coordinatively unsaturated palladium ce

195 his reaction enables introduction of various aryl groups to construct triaryl(heteroaryl)methanes via

196 m(II) species bearing both the aziridine and aryl groups to form the hindered C-C bond.

197 e of the ortho substituents, which force the aryl groups to rotate around the P-C bonds and reduce th

198 This transformation allows alkyl and aryl groups to serve for the first time as removable pro

199 of electron-donating or electron-withdrawing aryl groups to the 5-position of the quinolinolate ligan

200 ron-poor bridge, most electron-rich terminal aryl groups) to 1000 cm(-1) (electron-rich bridge, least

201 ar hydrocarbon substrates, such as allyl and aryl groups, to aldehydes and ketones remains a largely

202 establish that Pacman derivatives bearing an aryl group trans to the spacer possess structural flexib

203 ester group facing water and the hydrophobic aryl group tucked within the cavity of the host.

204 on the alpha-aryl ring or heterocyclic alpha-aryl groups undergo an elimination/addition sequence to

205 urs through a conrotatory motion for the two aryl groups undergoing C-C bond formation.

206 stronger donor trans to the palladium-bound aryl group underwent reductive elimination faster than t

207 lectron-withdrawing substituents on the DPPF aryl groups underwent reductive elimination faster than

208 With catalyst 3, depending on the aryl group used, at least one step in one of the NACM cy

209 or substrates with neutral and electron-poor aryl groups versus electron-rich aryl groups.

210 When the aryl group was a 2-methylnaphthyl, thermally stable atro

211 The 3-aryl group was attached in each case as a nucleophile.

212 The SAR of the 4-aryl group was found to be similar for chromenes with a

213 n of the initiating aryl group, and when the aryl group was o-tolyl, only Tol/H end groups were obser

214 aring an original N-thioalkenyl or N-(o-thio)aryl group was obtained in high yields.

215 l of the 2-iodide by radical conditions, the aryl group was smoothly oxidized to provide the correspo

216 The aryl group was subjected to extensive structural modific

217 The aryl groups were either hydrogen bond acceptors (furans)

218 Different aryl groups were introduced at C4 of the heterocyclic ri

219 d from camphor sulfonic acid) with different aryl groups were reacted with Et3B to give the correspon

220 hest levels of enantioselectivity, and these aryl groups were readily installed by a Pb-mediated aryl

221 bstituent variation at both the C-aryl and N-aryl groups were studied using a competitive method.

222 The basic amine, alkyne chain length, and aryl groups were varied.

223 e with electron-withdrawing character of the aryl groups when the trimethylsilyl interaction is via t

224 yields in substrates with ortho-substituted aryl groups, which are less reactive due to the addition

225 ring formation with the rearrangement of the aryl groups, which can be rationalized by density functi

226 ts decrease the conformational energy of the aryl group, while electron-donating substituents increas

227 a 4-phenyl-1,2,3,6-tetrahydropyridine and an aryl group with hydrogen-bonding substituents separated

228 ng imine incorporates two aryl groups or one aryl group with one electron-releasing substituent, the

229 n (F or Cl) at C(9), replacement of the C(5) aryl group with variously substituted aryl groups result

230 Cross-coupling reactions of aryl groups with alpha-fluoro carbonyl compounds catalyz

231 hers) as well as regiospecific when using 2'-aryl groups with meta-substituents, making this reaction

232 diction that a structural modification of an aryl group within the catalyst from phenyl to 3,5-dimeth

233 treptamine by the addition of guanidinylated aryl groups yielded a set of furin inhibitors with nanom