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2 h that a lengthening of one hydrogen bond by as little as 0.01 A results in a shortening of the neigh
3 s, and can be carried out in high yield with as little as 0.01 mole per cent catalyst with a moisture
4 endent manner, and a single mosquito bite or as little as 0.01 mug of SGE was effective at enhancing
5 mbrane; Kir2.1 shows measureable activity in as little as 0.01% PIP(2), and open probability increase
6 the lowest efficacious dose should be used: as little as 0.015-0.025 mg kg(-1) of neostigmine is req
7 trate that for Abeta(1-40), and Abeta(1-42), as little as 0.01mol equivalent of Zn(2+) (100nM) is suf
8 ion was seen after intracameral injection of as little as 0.02 and 0.08 EU in OVD and DPBS eyes, resp
9 s were carried out in less than a day, using as little as 0.02 milligrams of material per reaction.
11 1, 8a-e, 9, 12, and 13 can be mediated with as little as 0.05 mol % of Cu(TPMA)SO(4).5H(2)O in the p
13 ormations to be performed in the presence of as little as 0.05 mol %, which is the lowest catalyst lo
15 e, and click chemistry, we demonstrated that as little as 0.1 fg of lambda-DNA (close to copy number
17 umptive analysis of Si and phosphorus (P) in as little as 0.1 g dried and ground plant material using
18 yzed hydroaluminations can be performed with as little as 0.1 mol % catalyst and on gram scale with e
19 o efficiently reduce the catalyst loading to as little as 0.1 mol %, the lowest one described for thi
22 ute and was complete by 90 minutes-even with as little as 0.1 nM lacritin, and involved the donors ly
24 tuning the hydrogel and solution properties, as little as 0.1 U/muL protein kinase A could be detecte
26 s are described in more detail and show that as little as 0.15 nmol of nitric oxide and 0.20 nmol of
28 ectively reduced to Hg(0) in the presence of as little as 0.2 mg/L reduced HA, whereas production of
30 prevented by intracellular acidification by as little as 0.2 pH units, induced by either lowered med
33 ingent conditions, and can be performed with as little as 0.25 mole per cent catalyst in less than si
36 ear-future increases in local temperature of as little as 0.5 degrees C result in this protective mec
37 in the bone marrow was dose dependent, with as little as 0.5 Gy causing a significant long-term redu
41 is readily promoted at room temperature with as little as 0.5 mol % of catalyst, and demonstrates hig
43 O paralogues determined that we could detect as little as 0.5 SUMO-1 residue per topoisomerase I mole
46 ivity and in high yields using in most cases as little as 0.5-0.1 mol % Pd(OAc)(2) as the catalyst wi
52 The catalytic performance was measured using as little as 1 cycle of Pt ALD, which corresponded to a
53 at social interactions with adult tutors for as little as 1 d significantly enhanced vocal learning.
55 ve to thermal perturbations and temperatures as little as 1 degrees C above the average summer maxima
58 case of spores, the exposure was detected in as little as 1 h without the use of antibodies or fluore
61 we were able to isolate RNA produced during as little as 1 minute, allowing the detection of nascent
62 t and reliable method of DNA extraction from as little as 1 ml of early positive mycobacterial growth
63 lled THF, can be promoted in the presence of as little as 1 mol % of easily accessible amino acid-bas
64 tal groups with eight subjects each can take as little as 1 month if optimized for speed, or approxim
68 10) M(-1) s(-1)) radicals, besting thiols by as little as 1 order and as much as 4 orders of magnitud
69 lts show that the anti-ZIKV-PSBs can capture as little as 1 PFU of ZIKV in 100 mul of saline, human p
70 timized linker amplification method requires as little as 1 pg of DNA and is the most precise and acc
73 s were assembled for bacteria that comprised as little as 1% of the community, as well as nine partia
75 ighly efficient and is generally complete in as little as 1-2 h, giving the products in good to excel
77 n, gene modifications can be achieved within as little as 1-2 weeks, and modified clonal cell lines c
78 port that mice fed a high-fat diet (HFD) for as little as 1-3 days show increased differentiation of
79 ering of syntaxin is found to be reversed by as little as 1-5 mol % of the regulatory lipid phosphati
80 esolution can distinguish peaks separated by as little as 1.1 mDa), and high mass accuracy enables as
81 because only 1 microl of liquid is required, as little as 1.2 fmol of trypsin can be detected by usin
82 efficiency) may be accurately computed from as little as 1.5-2.0 minutes of RS functional MR imaging
83 er that substoichiometric amounts of PrP(C), as little as 1/20, relative to Abeta will strongly inhib
84 te the detection of telomerse extracted from as little as 10 cells/muL and 100 cells/muL in buffer an
85 nputs that are shifted in the sniff cycle by as little as 10 milliseconds, which is similar to the te
87 this MALDI-TOF MS method was accomplished in as little as 10 min from isolated colonies and 30 min fr
89 e taken several days, can now be obtained in as little as 10 minutes, greatly facilitating candidate
90 ots, even when administration was delayed by as little as 10 minutes, while it concurrently prevented
92 ber variation, that the assay can be used on as little as 10 ng of DNA and that massively parallel se
93 complex bisulfite sequencing libraries from as little as 10 ng of input DNA, and ample useful sequen
97 enerated high-quality RNA-seq libraries from as little as 10 pg of mRNA ( approximately 1 ng of total
99 rine pancreas development in humans and that as little as 10% NEUROG3 is sufficient for formation of
102 e an RT-QuIC assay for H-BSE that can detect as little as 10(-9) dilutions of brain tissue and neat c
104 Using this technique, it is possible to see as little as 10-100 amol of polymerase product, represen
107 luence specific neural mechanisms active for as little as 100 ms during the flow of human information
113 The reaction proceeds in high yield with as little as 1000 ppm catalyst loading, while 5 mol % ca
114 carboxyl-PEG layer, we could directly detect as little as 10fM of miRNA targets in 20microl of unproc
115 dendrite formation on cycled lithium anodes; as little as 11 wt % PP-IL in a PC-LiTFSI host produces
119 amming to full pluripotency, despite sharing as little as 13% sequence identity with mouse Nanog.
121 individual pure substance microparticles of as little as 14 mug in initial mass, in a matter of seco
125 ultaneously, obtain transcriptomic data from as little as 150 cells (as few as 2 transcripts per gene
128 t intermittent energy restriction periods of as little as 16 h can improve health indicators and coun
129 ents of 10 megabases or greater occurring in as little as 16% of the sample in exome sequencing data
131 The endothermic reverse reaction required as little as 18 min when K(2)(H(2)O)(2)B(12)F(12) at 25
137 ficiently processed to linear alcohols using as little as 2 mol % of 12 at ambient temperature, and t
139 This color change is easily observed with as little as 2 nM of target, 100-fold lower than the tar
140 recording of powder diffraction patterns in as little as 2 s, meaning that thermally induced phase c
141 how tens of thousands of routers infected in as little as 2 weeks, with the majority of the infection
142 purified DNA polymerase, the assay detected as little as 2 x 10(-11)U of enzyme ( approximately 50 m
144 equence verification-can be completed within as little as 2-3 weeks, and cancer variant stratificatio
145 ounds that increase frameshift efficiency by as little as 2-fold may be effective at suppressing HIV-
146 f DNA restriction digests can be produced in as little as 2.1 h and require less than 10(8) cells.
147 intolerant macroinvertebrate taxa occur when as little as 2.2% of contributing catchments are mined.
151 tive, detecting differences in HOS affecting as little as 2.5-5% of the molecular population, levels
153 ibed herein, we were successful in detecting as little as 2.94 fM of pathogen DNA, and using crude ex
154 Oral gavage of mice with GeRPs containing as little as 20 microg kg(-1) siRNA directed against tum
158 lumn which enables an accurate analysis from as little as 20 muL of plasma or 50 mg of tissue for typ
161 hed from control cells with incorporation of as little as 20 nM of the xenon MRI readout unit, crypto
162 DEEPER-Seq can create NGS libraries from as little as 20 pg DNA with PCR error correcting capabil
163 ing thoracic spinal cord injuries that spare as little as 20% of the total white matter cross section
164 ested, ice-free, nonurban areas operating at as little as 20% of their rated capacity could supply >4
165 served in LQTS2 patients can be explained by as little as 20% variation in the levels of ionic conduc
168 reduction of soluble extracellular Abeta by as little as 20-25% was associated with a dramatic decre
171 a polyelectrolye multilayer coating carrying as little as 200 ng of bone morphogenetic protein-2 and
172 pithelial cells (HMEC) was demonstrated from as little as 25 mug tryptic peptides from whole cell lys
173 -phosphorylating deoxyribozyme Dk2 to detect as little as 25 nM GTP even in the presence of 1 mM ATP,
174 infection of retrovirus particles containing as little as 25% of the restriction-sensitive CA protein
175 fying 1 case of hearing loss due to cCMV was as little as $27460 by universal screening or $975 by ta
177 59989 dose-dependently reduced brain KYNA to as little as 28% of basal levels, and prevented amphetam
178 that cocaine potency is increased following as little as 3 days of IntA and further augmented follow
179 ine, but increasing core body temperature by as little as 3 degrees C causes coved-type ST elevations
180 ify KPC-producing Gram-negative pathogens in as little as 3 h after isolation of pure colonies and do
183 ce, an imaging technique used clinically, in as little as 3 months after the initiation of treatment,
184 ions for a wide range of microorganisms with as little as 3 weeks of dedicated labor and at a cost of
185 ion is observed in mutant plants, which have as little as 3% of wild-type CA activity, but surprising
193 ng on the experiment, FDAA labeling can take as little as 30 s for a rapidly growing species such as
194 hands, this CHI model can be carried out in as little as 30 s per animal, with additional time requi
196 ng-standing rule-of-thumb that proteins with as little as 30% sequence identity adopt the same fold.
197 din mRNAs were found in even lesser amounts, as little as 3000 times less abundant than claudin-19.
202 K(2)(H(2)O)(2)B(12)F(12 (s)) was complete in as little as 4 min at 25 degrees C when the sample was e
205 and clearly present with tones separated by as little as 4%, near the behavioral frequency differenc
207 tants, one arm of homology can be reduced to as little as 40 bp while still promoting integration of
210 ly recorded neuronal assemblies separated by as little as 400 microm, making the gamma rhythm a poor
211 at 25 degrees C was also facile and required as little as 45 min to go to completion (H(2)O((g)) repl
213 bacterium tuberculosis-positive specimens in as little as 48 h from the time of clinical specimen rec
215 llowing for sensitive, specific detection of as little as 5 amol (50 fM in 100 muL) of target DNA.
217 of the ridge axis from the volcanic front of as little as 5 km, seafloor morphology changes from shal
219 s as low as single digit nanomolar and times as little as 5 min, a feat that cannot be matched by any
223 producibly amplified using both methods from as little as 5 ng total RNA (~equivalent to 2 x 105 baci
224 rmed with near zero sample consumption using as little as 5 pL of sample and 240 yoctomoles ( approxi
226 I-MS methods can deliver accurate results in as little as 5 to 6 h after a positive alarm from the au
227 Our data suggest that a cellular strain of as little as 5% affects the shape of transverse tubules,
228 ent of deuteration in the carbon source, and as little as 5% deuteration can be distinguished by anal
229 nt but can be fully rescued by incorporating as little as 5% of brain tubulin into the homogeneous al
230 ukocyte adhesion deficiency, mice expressing as little as 5% of kindlin-3 were viable and protected f
232 bond, in aqueous buffer solutions containing as little as 5% organic cosolvent, resulting in exclusiv
233 figurations to impart as much as 45.3 mDa or as little as 5.8 mDa per tag between labeled peptides.
240 ully generate genome wide 5hmC patterns from as little as 500 ng of genomic DNA in less than 4 days.
241 hnique works robustly and reproducibly using as little as 500 ng of starting DNA, with results correl
242 Allerod warmth halved the mass of the CIS in as little as 500 years, causing 2.5 to 3.0 meters of sea
247 assay detected norovirus in some samples in as little as 6 min, and the entire detection process can
248 WD(+) donor deer became PrP(CWD) positive in as little as 6 months postinoculation, whereas none of t
249 lifera) can use stimulus onset asynchrony of as little as 6 ms to segregate learned odor components w
252 esign to identification of founders can take as little as 6 weeks, of which <10 d is actual hands-on
253 sed to detect topoisomerase 1-DNA adducts in as little as 60 ng of DNA, corresponding to 10 000 human
260 the meningococcal chromosome can occur with as little as 80 bp, and that minor sequence differences
261 n of auxin with protein half-life reduced to as little as 9 min and proceeding to completion with fir
263 nsitive, achieving quantitative detection of as little as 9.6 attograms of target DNA, and we show th
267 th mixed populations, it can reliably detect as little as a 1% wild-type or 0.1% H274Y component.
268 all intestinal loops and colonic loops after as little as a 1-h treatment with 50 mug/ml of CPE.
271 can be reliably quantified, evidencing that as little as a few tens of copies of redox-labeled macro
273 show that GR binding sequences, differing by as little as a single base pair, differentially affect G
274 ed helicase, T7 gp4, show that heterology of as little as a single base stalls catalysed branch migra
275 mal label enrichment and can be performed on as little as a single biopsy, thereby overcoming critica
276 y related oligotypes, differing sometimes by as little as a single nucleotide, that showed dramatical
278 Importantly, our findings indicate that as little as a two- to fourfold reduction in mTOR activi
279 ve contributions from the cytoskeleton, with as little as a ~5 nm increase in non-binding protein siz
280 conds, stable network templates emerge after as little as approximately 100 s of recording and persis
281 However, when artificially clustered into as little as dimer of dimers, the type-VI kinesin-14 (a
283 Biochemical studies have demonstrated that as little as four repeats have the ability to form a sta
284 fficient protease recognition can occur with as little as four residues upstream of the CLE domain, a
286 photodetector can detect at light levels of as little as nW cm(-2) intensity with a responsivity of
287 sis, where 6-10mL of whole blood may contain as little as one bacterial colony forming unit (cfu).
290 Maximal in-gel digestion was achieved in as little as one hour, depending on incubation temperatu
291 m) values for DNA sequences that differed by as little as one nucleotide to as many as 23 polymorphis
295 shift correlation spectra can be recorded in as little as several minutes and several hours, respecti
296 l bimodality occurred in both experiments in as little as six generations of divergent adaptation des
298 how that inaccuracies begin to accumulate in as little as two decades and can remove all but decadal-
300 yase activity is also strongly suppressed by as little as two paired bases 5' of the abasic site.
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