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1 a perturbation in selectin-mediated adhesion as manifested by a 70% reduction in wild-type (WT) neutr
4 3 restored the connexin-deficient phenotype, as manifested by a dose-dependent reduction in aggregati
5 somes continue to exhibit altered maturation as manifested by a failure to acquire lysosome-associate
6 within the DNA-modified gold nanoparticles, as manifested by a faster decay rate of the excited elec
7 with X-ray photoelectron spectroscopy (XPS), as manifested by a negative shift of the binding energy
8 ited states (excitons) of the quantum wells, as manifested by a new THz frequency- and power-dependen
9 d marked inhibition of in vivo HIV infection as manifested by a profound 70-fold reduction in plasma
10 at markedly inhibit platelet COX-1 activity, as manifested by a profound decline in platelet-derived
11 n tumor cells show resistance to 6-TG damage as manifested by a reduced G(2)-M arrest and decreased a
12 ed a significant delay in mammary maturation as manifested by a reduction of the number and caliber o
13 herapy with nonmetastatic, recurrent disease as manifested by a rising PSA between 0.4 ng/mL and 6.0
14 signaling to reach intracellular substrates, as manifested by a robust increase in phosphorylation of
15 icient to induce BCD cell redifferentiation, as manifested by a significant increase in insulin expre
16 ed in an increased mitoxantrone sensitivity, as manifested by a significantly lower IC(50) value (2.4
17 the entire NC to the copper selenide phase, as manifested by a strongly sigmoidal response in optica
18 y even when they bind the same MHC molecule, as manifested by a unique twisting of the V module relat
19 ad resulted in aberrant planar cell polarity as manifested by abnormalities in the orientation of cel
20 fts and resulted in neutrophil infiltration, as manifested by an 18-fold increase in myeloperoxidase
21 emory B cells that were functionally silent, as manifested by an absence of corresponding serum Ab.
23 n lead selenide (PbSe) QD-based solar cells, as manifested by an external quantum efficiency (the spe
24 d characteristics of the malignant phenotype as manifested by anchorage independent cell growth and t
25 tions suggest that humoral immune responses, as manifested by antibody levels, isotype, and antigenic
26 an elevated level of atherogenic particles, as manifested by apoB and LDL particle count, which may
27 SM resulted in an anti-inflammatory response as manifested by attenuated expression of endotoxin-indu
28 mmigration of bone marrow T-cell precursors, as manifested by both an early increase of early thymic
29 R dynamics in the presence of ATP and AcCoA, as manifested by CBP/p300 and SRC-3 dismissal and SAGA a
32 e but decreases the occupancy by RFX1/mSin3A as manifested by chromatin immunoprecipitation assay.
33 task-related local functional connectivity, as manifested by coupling between the phase of alpha osc
34 ression of antigenic diversity in E. maxima, as manifested by cross-strain protection in a series of
35 tion of the mitochondrial apoptotic pathway, as manifested by decreased Akt phosphorylation, increase
36 in kidney ischemia-reperfusion injury (IRI) as manifested by decreased cell growth, generation of to
37 ficient mice had increased oxidative stress, as manifested by decreased NADPH levels and decreased GS
38 duced Ag-specific T cell hyporesponsiveness, as manifested by decreased T cell proliferation and IL-2
39 decreased as HIV-related disease progressed, as manifested by decreasing CD4 cell count and increasin
40 t abnormalities in distal lung morphogenesis as manifested by distinct truncation of the trachea and
41 exhibited a decrease in oncogenic signaling, as manifested by downregulation of the transcription fac
42 0 and 30 minutes of VF, stone heart occurred as manifested by dramatic thickening of the myocardium a
43 (LLR), involved the lower right atrium (RA), as manifested by early breakthrough in the lower RA, wav
45 ortant role in cell polarization by Cxcl12a, as manifested by elevation of intracellular pH and Rac1
46 ls the binding of neutravidin to the surface as manifested by enhanced scattering over the majority o
48 ability was improved with Fiix-PT monitoring as manifested by fewer tests, fewer dose adjustments, in
49 ness of SR Ca2+ release to activation by ICa as manifested by flattened and broadened voltage depende
50 bility or reduction in sympathetic activity, as manifested by heart rate, plasma norepinephrine or lo
52 onse to a mild psychological stress in rMDD, as manifested by hyperactivation and hyperconnectivity w
53 hways/processes associated with liver injury as manifested by increased blood levels of alanine trans
54 t and activation of professional phagocytes, as manifested by increased expression of Fc-gamma recept
55 ce also exhibited increased oxidative stress as manifested by increased hydrogen peroxide production
58 cause of an enhanced mitochondrial function, as manifested by increased oxidative phosphorylation, gl
59 ired Th1 responses against Leishmania major, as manifested by increased parasitemia and more severe l
60 ses in systemic arterial vascular narrowing, as manifested by increased peripheral blood pressure.
61 n the tumor cell membrane for at least 48 h, as manifested by increased recognition by EphA2-specific
62 ell barrier due to chemically induced injury as manifested by increased surface epithelial apoptosis
63 The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections
64 and clearly disinhibited sympathetic arousal as manifested by increased tail piloerection and tail-fl
65 ponsive state similar to endotoxin tolerance as manifested by inhibited TLR2/4-induced expression of
66 inst drug-resistant C. albicans in biofilms, as manifested by inhibition of biofilm formation and by
67 n these cells inhibits their differentiation as manifested by inhibition of calcium or vitamin D-indu
68 he shear stress-induced mechanotransduction, as manifested by integrin-Shc association, was abolished
69 isk of disseminated disease at presentation, as manifested by involvement of multiple noncontiguous m
70 ally required in initiating the IRI cascade, as manifested by liver function (serum alanine aminotran
71 ion of axotomised septal cholinergic neurons as manifested by loss of choline acetyltransferase and p
72 of PTEN, which includes the promoter region as manifested by loss-of-heterozygosity of 10q markers.
73 akage from endoplasmic reticulum (ER) stores as manifested by lower cytosolic calcium levels, higher
74 ed by lower post-yield displacement, weaker, as manifested by lower energy and yield and maximal load
75 diet and sex, PKU femora were more brittle, as manifested by lower post-yield displacement, weaker,
76 ically, we find that decreased angiogenesis (as manifested by lower vessel density, decreased hemoglo
77 is revealed due to hexapeptide association, as manifested by lowering of transient interactions betw
79 DR in IECs were highly resistant to colitis, as manifested by marked reductions in clinical colitis s
80 rated cardiac response to pressure overload, as manifested by markedly exacerbated cardiac maladaptiv
81 ssion develop distal renal tubular acidosis, as manifested by metabolic acidosis and alkaline urine p
82 ALPS was identified in 9 unrelated children as manifested by moderate to massive splenomegaly and ly
84 and reduced tubular epithelial cell injury, as manifested by osteopontin expression (5.57 +/- 1.60 v
85 -13 months of age exhibited signs of illness as manifested by paralysis of rear limbs, hunched postur
86 outside-in alphaIIbbeta3 signaling in vitro as manifested by poor spreading on fibrinogen and decrea
87 inflammation and to have more severe disease as manifested by poorer presenting vision and a higher r
88 loped acute physical dependence on morphine, as manifested by precipitated withdrawal signs, such as
89 of DNA-PK), are hypersensitive to high NaCl as manifested by profound inhibition of proliferation, a
90 virulence relative to the wild-type strain, as manifested by prolonged survival, reduced pulmonary f
91 in Akt activity diminish insulin signaling, as manifested by reduced Akt phosphorylation, reduced me
92 tion causes defects in synaptic transmission as manifested by reduced amplitude of both evoked and mi
93 sts that statins induce vascular remodeling, as manifested by reduced atherosclerotic burden without
94 GT and IGT display mitochondrial dysfunction as manifested by reduced ATP production but not with res
95 addition, they had less remote organ injury as manifested by reduced pulmonary capillary leakage.
96 ficantly attenuated FFC-induced liver injury as manifested by reduced serum ALT and hepatic TUNEL-pos
97 -Abl and p53 show reduced growth in culture, as manifested by reduction in the rate of proliferation,
98 hibitory signaling in ERK1/2-depleted cells, as manifested by regained cellular ability to undergo gr
103 l epithelial injury, but also to its repair, as manifested by restoration of transepithelial resistan
105 dephosphorylation of Ser-2808 aggravated CCM as manifested by shortened survival, deteriorated in viv
106 nuation of neurodepression in mice given IA, as manifested by shorter immobility time in the tail sus
108 , in turn, activates keratinocytes in vitro, as manifested by signal transducer and activator of tran
110 tween GO sheets are successfully constructed as manifested by surface-charge-governed ion transport f
111 e is associated with the intermediate range, as manifested by the appearance in the measured diffract
112 erating points of the primary visual cortex, as manifested by the coherent spontaneous ongoing activi
113 ort effective mimicry of the Bim BH3 domain, as manifested by the crystal structure of an alpha/beta-
117 es are viable for flexible macroelectronics, as manifested by the fabrication of CdS photodetector ar
119 dies of large noncovalent protein complexes, as manifested by the GroEL data where the tetradecamer d
120 kB can lead to increased expression of bcl-x as manifested by the increase in the short form of bcl-x
121 e full apoptotic machinery in this cell type as manifested by the induction of terminal deoxynucleoti
122 ed arachidonate mobilization in these cells, as manifested by the lack of an effect of the iPLA2 anti
125 lternative rather than classical activation, as manifested by the markedly reduced expression of nitr
126 e6] core leads to weaker Fe-Fe interactions, as manifested by the observation of ground states popula
128 nduced apoptosis and enterocyte dysfunction, as manifested by the passage of E. coli across an intact
129 te that the effects of the YlPMR1 disruption as manifested by the phenotypic response depend on the c
130 ice also exhibit defects in B-cell tolerance as manifested by the presence of autoantibodies against
132 the positively charged C moiety of methoxy, as manifested by the pronounced elongation of O-C bond l
133 elerate and amplify host alloresponsiveness, as manifested by the rapid expression of chemokines, cyt
134 t for efficient pRb C(term) phosphorylation, as manifested by the reduced phosphorylation of a methyl
135 degrees ) and side chains (23-29 degrees ), as manifested by the reduction in the C-H and H-H dipola
136 ed decrease in HSP60 precipitated apoptosis, as manifested by the release of cytochrome c, activation
137 AKI, patients with complete renal recovery, as manifested by the return of the discharge creatinine
138 re cytokines pivotal for B-cell development, as manifested by the severely compromised B-cell develop
139 n interacts strongly with the lipid bilayer, as manifested by the significantly reduced (2)H quadrupo
140 l precordial leads of the electrocardiogram, as manifested by the strain pattern of T-wave inversion
141 position in the ventral cord was disrupted, as manifested by the variable expression pattern of moto
142 er, deformability of the tertiary structure, as manifested by the variance of those same properties,
144 vely tolerized in nonautoimmune BALB/c mice, as manifested by their developmental arrest, follicular
145 ith loss of in vivo activity of the mutants, as manifested by their inability to complement a tempera
146 lectively with D4R silicate framework sites, as manifested by their strong (19)F-(29)Si dipolar coupl
147 le to their highly plastic genome structure, as manifested by tolerance to changing chromosome number
148 , neurotoxicity was observed at these doses, as manifested by transient muscle weakness or paresis, w
149 (1)H NMR provides further evidence of DACT, as manifested by upfield shifts of aromatic protons in t
150 but not US2, is sufficient to induce a UPR, as manifested by upregulation of the ER chaperone Bip an
151 ated candidiasis died of progressive sepsis, as manifested by worsening hypotension, tachycardia, and
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