ライフサイエンスコーパス: as observed in

1 n of the authors' experience on NITAG's role as observed in 2 particular local settings and applied t

2 ether, constraints in cage-orientation, such as observed in 4, produce unfavorable intercage steric i

3 In the long term, as observed in 6-mo-old offspring, the double insult, i.

4 patient may also provide a functional cure, as observed in a bone marrow transplant performed with h

5 s model fails to repair larger (>mm) defects as observed in a clinical setting.

6 The dominance of electrostatic parameters, as observed in a computational DFT study, is consistent

7 uences olfactory function to the same degree as observed in a number of neurodegenerative diseases in

8 ction can occur in a distal dominant pattern as observed in a proportion of patients with motor axona

9 throughout the Delta's multi-aquifer system as observed in a spatially exhaustive data set of arseni

10 nesis to probe the anesthetic-binding cavity as observed in a TASK-3 homology model.

11 ntravenously administered contrast material, as observed in a time series of three-dimensional (3D) c

12 d tumor progression, are still controversial as observed in a variety of cell types.

13 ly with these two proteins within filopodia, as observed in acceptor photobleaching FRET studies.

14 e the main features of reperfusion injuries, as observed in acute myocardial infarction (AMI).

15 substitutions of guanines in a GpC context, as observed in aflatoxin-induced liver cancers.

16 exception, to the dominant fibril morphology as observed in AFM or SEM images.

17 be acute, as seen in stroke, or more chronic as observed in age-related diseases such as Parkinson's

18 consistent with reduced mechanical tension, as observed in aged human skin.

19 Accordingly, diminished Hsp70 levels, as observed in aging or certain pathological conditions,

20 panied by a disruption of behavioral control as observed in aging or neuropsychiatric diseases such a

21 rong oscillatory regulation of spike timing, as observed in alert cortex processing complex natural s

22 d heme a(3) to the oxidized low-spin heme b, as observed in all the other aa(3) and bo(3) oxidases pr

23 ry changes in response to the neuronal loss, as observed in Alzheimer's disease (AD).

24 We explore the features of this biosignature as observed in amino acids and carboxylic acids, using p

25 ith either male or female somatic phenotypes as observed in an XY father and XY daughter, respectivel

26 ite is obstructed by the C-terminal segment (as observed in angiogenin), in RNase ZF-3e the same regi

27 ion of key gene families such as DCL and AGO as observed in angiosperms occurred early in land plants

28 apitulate age-dependent vascular dysfunction as observed in animal models and in humans but with an a

29 d the incorporation of alternative monomers, as observed in Arabidopsis mutants with altered monolign

30 ECM) in the airway smooth muscle (ASM) layer as observed in asthma may influence ASM mechanical prope

31 imited, and the PCs are not deformed or lost as observed in AT patients.

32 ns of Gly-213 abolish allosteric regulation, as observed in AtCM2.

33 ithout evidence of solvent or dopant effects as observed in atmospheric pressure photoionization (APP

34 The expression of inflammatory genes, as observed in biopsies taken at the end of surgery, as

35 2) systolic twitch forces at a similar level as observed in bona fide postnatal myocardium; (3) a pos

36 shment of metastatic cells in distant organs as observed in bone.

37 ey features of striatal population activity, as observed in brain slices.

38 The model faithfully predicts root growth, as observed in bri1 loss-of-function mutants.

39 hough they are lacking strong hydrogen bonds as observed in calixarenes, the two examples introduced

40 As observed in cancer immunotherapy, MDSCs could be a no

41 for collective invasion of new territories, as observed in cancer strands, without requirement for a

42 rate inducible, low-level pathway activation as observed in cancer, we quantified 7566 unique phospho

43 Pstpip2(cmo)mice provides similar protection as observed in caspase-1 and caspase-8-deficientPstpip2(

44 ng an explanation of transcriptional cycling as observed in cell populations, both on promoter chroma

45 Reproducing fast fusion rates as observed in cells by reconstitution in vitro has been

46 renders the spindle susceptible to breakage, as observed in cells with a variety of defects.

47 ic edema in conditions of low energy supply, as observed in cerebral ischemia.

48 ric EEG asymmetry (asymmetrical SWS or ASWS) as observed in cetaceans.

49 IV-1 infection in this model depletes ILC3s, as observed in chronic HIV-1-infected patients.

50 howed optimum emulsion and process stability as observed in CLSM images, droplet size data and in the

51 of Schwann cells did not exit the cell cycle as observed in control animals and the growth fraction i

52 odulated by additional predictive motor cues as observed in control subjects.

53 nization during rest compared with the task, as observed in controls.

54 from normal Curtin-Hammett kinetic behavior as observed in copolymerization using the normal Brookha

55 As observed in cryo-electron micrographs, AVP-p treatmen

56 ue His64 and the zinc-bound solvent molecule as observed in crystal structures at 1.5-1.6 A resolutio

57 that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a doub

58 properties can modulate pump activity, and, as observed in crystal structures, several lipids are bo

59 terification through decreasing PME activity as observed in CsF3H transgenic lines.

60 ifested as increased cytoplasmic vacuolation as observed in cultured fibroblasts.

61 nce from previously rewarded trials, exactly as observed in D(2)R transgenic mice.

62 urate LTD produced the same impairment in WT as observed in DKO mice.

63 atic fat accumulation in obese mouse models, as observed in earlier studies, and the beneficial effec

64 stress induced changes in crack properties, as observed in early laboratory studies.

65 cytokinesis and finally to multinuclearity, as observed in EBV-associated HL.

66 to a difference in oxidation peak potential as observed in electrochemical measurements.

67 cues exhibited a similar response tendency (as observed in Experiment 2) after half as many trials o

68 model reproduces the VIII-X phase transition as observed in experiment.

69 ous approaches, such as ligand-binding sites as observed in experimental complex structures, or predi

70 n patterns within the stratum corneum lipids as observed in experimental data.

71 Furthermore, comparable sized pockets as observed in experimental structures are present in ar

72 the 'tear-drop' shape of adherent leukocytes as observed in experiments are reproduced by the simulat

73 isolates were outcompeted by other subtypes, as observed in experiments with PBMC.

74 pisodes with long-range spatial correlations as observed in experiments.

75 in solution and not just when bound to Get1, as observed in experiments.

76 cal beta(2)AR stimulation of crest membrane, as observed in failing cardiomyocytes.

77 induction of the adjacent mRNAs or lncRNAs, as observed in fbp1 These Atf1-binding sites exhibit low

78 t that severe respiratory chain dysfunction, as observed in few cells leading to a mosaic in aged tis

79 hat manifest as biological oscillators, such as observed in fireflies, heartbeats, and circadian rhyt

80 endothelium was almost completely abrogated, as observed in flow chamber adhesion assays and during e

81 lt of accumulation of chlorophyll precursors as observed in fluorescent (flu)-like mutants.

82 ation of the dienoyl-coenzyme A intermediate as observed in Geobacter metallireducens and Syntrophus

83 -EF5 in hypoxic cells in certain tumor types as observed in H460 in this study.

84 e subunits form dimers instead of tetramers, as observed in HCN channels.

85 Conversely, as observed in HD knock-in ESCs (Q111 ESCs), mHtt enhanc

86 cts in MMR exist among MMR-proficient cells, as observed in healthy intestinal tissues from patients

87 duced IK1 density and gap junction coupling, as observed in heart failure, increase the probability o

88 As observed in HHS patients, these transgenic mice are h

89 sh mutant that exhibits pancreas hypoplasia, as observed in HNF1B monogenic diabetes, we show that hn

90 to possess both MAT1-1-1 and MAT1-2-1 genes as observed in homothallic filamentous Ascomycetes.

91 nib molecules do not cluster in the same way as observed in HPMC-P, where ionic interactions are pres

92 ss whether coupled theta-gamma oscillations, as observed in human auditory cortex, could underpin the

93 As observed in human BHD kidney tumors, three different

94 activation on conventional outflow facility, as observed in human eyes.

95 enes commonly associated with liver cancers, as observed in human FL-HCC.

96 TNF-like ligand 1A (TL1A), and TNF in TECs, as observed in human renal injury.

97 s with a similar pattern of ACROSIN staining as observed in human spermatids.

98 and to increase the Bifidobacterium amounts as observed in human-milk-fed infants.

99 ensitization and low food-antigen IgE titers as observed in humans with clinical food allergy.

100 e-dependent cytoplasmic inclusion pathology, as observed in humans with hnRNPA2B1-related myopathy.

101 In these mice, as observed in humans, liver steatosis and oxidative str

102 Our findings indicate that, as observed in humans, tandem or partially tandem duplic

103 rom muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical

104 ected with OROV was not as rapid or complete as observed in Ifnar(-/-) mice, indicating that other tr

105 Prolonged viral shedding, as observed in immunocompromised individuals, can lead t

106 a Th9 subtype by increasing IL-9 production, as observed in in vitro studies, or rather favors Th17 d

107 L)-10, decreased epithelial CD1d expression--as observed in inflammatory bowel disease--may contribut

108 mediated inflammation and epithelial damage, as observed in inflammatory disorders of mucosal surface

109 The catalyst is remarkably active as observed in initiation experiments showing complete c

110 of fibroblast differentiation, and its loss as observed in IPF facilitates profibrotic phenotypic ch

111 ese two ubiquitins adopt a compact structure as observed in K48 di-ubiquitin.

112 gnificantly induced erythroid-related genes, as observed in K562 cells, suggesting that DZNep induces

113 As observed in laboratory isolates, LytSR was found to b

114 ure can enhance stability and control shape, as observed in LacI loops formed with three designed seq

115 n the brain contributes to neurodegeneration as observed in Lafora disease.

116 -/-) mice no longer decreases TG degradation as observed in LDs from wild-type mice, supporting the m

117 e nucleated from the same endosomal vacuole, as observed in living cells.

118 y cell infiltration and mucus hypersecretion as observed in lung sections, and mRNA expression of ICA

119 tonotopic maps oriented along the same axis as observed in macaque and owl monkey.

120 from shape selectivity in posterior regions, as observed in macaques, indicating a considerable disso

121 al assemblies in synchrony changed with time as observed in mammalian brains.

122 ctivity declined during aging in fly brains, as observed in mammals.

123 impairing its targeting to the cell surface (as observed in many cancers) led to a further increase i

124 translate to oscillatory behavior and waves, as observed in many cellular phenomena and in vitro syst

125 scopic shells buckle into various polyhedra, as observed in many organelles.

126 dysfunction of even a portion of the raphe, as observed in many SIDS cases, can impair ability to au

127 M led to fatal anemia and myeloid dysplasia, as observed in MDS patients, and we subsequently showed

128 or alterations in striatal dopamine turnover as observed in mental diseases (e.g., in schizophrenia).

129 correlated with patient survival, including as observed in MGMT-deficient GBM patients.

130 As observed in mice, the overexpression of the gene for

131 introduction and infection of these species as observed in mixed backyard poultry during the early o

132 ed support for a parcellation into two parts as observed in monkeys, but it also highlighted a much f

133 in), in RNase ZF-3e the same region is open (as observed in more catalytically efficient homologues).

134 d antiviral IgG responses to the same extent as observed in mus(-/-) mice.

135 myocyte hyperplasia (increased cell number), as observed in Mybpc(t/t) mice.

136 As observed in myocytes, CaMKII shifted WT I(Na) availab

137 s deactivation, and enhances ramp responses, as observed in Na(V)1.7 mutations that produce IEM.

138 low density lipoproteins to the same extent as observed in Ndst1(f/f)AlbCre(+) mice.

139 Alterations in mitochondrial function, as observed in neurodegenerative diseases, lead to disru

140 associated with the presence of metal ions, as observed in neurodegenerative diseases.

141 tenuate muscle loss due to NMJ deterioration as observed in neuromuscular diseases and aging is ambig

142 restored normal baseline synaptic summation, as observed in neurons from HCN1 knock-out mice.

143 the Asp103-phenolate hydrogen bond shorter, as observed in NMR experiments.

144 by impairing the trafficking of cholesterol, as observed in NPC pathology.

145 During more excessive lipid accumulation, as observed in NS cells, promising commercial harvest as

146 exes, (3) all cells have endoreplicated DNA (as observed in nurse cells), and (4) oocyte-specific cyt

147 ) has a double-stranded beta-helix core fold as observed in other 2OG and iron-dependent oxygenase fa

148 n the strands which form the capsid surface, as observed in other AAV structures.

149 mischarged serine and glycine to tRNA(Ala), as observed in other bacteria, and also transferred alan

150 attachment of amorphous precursor particles as observed in other minerals and biominerals?

151 As observed in other patient cohorts, renal artery steno

152 ence to a metal-coordinated quinone species (as observed in other reactions of o-quinone derivatives)

153 nd developmental modules within paired fins, as observed in paired limbs.

154 damages caused by alpha-synuclein oligomers, as observed in Parkinson disease and several other neuro

155 so that prolongation of these beta episodes, as observed in Parkinson's disease, could produce delete

156 nslation of dipeptide repeat (DPR) proteins, as observed in patients with C9orf72-related disease.

157 ngs but did reduce serum creatinine and BUN, as observed in patients with CKD.

158 ciated with the aberrant FBW7/NOTCH2 pathway as observed in patients with HCS.

159 on absorption and chronic iron accumulation, as observed in patients with hemochromatosis.

160 as experimentally demonstrated in vitro and as observed in patients with HUS.

161 ese parameters, they remain highly variable, as observed in patients, impeding reliable one-dimension

162 hat TIGAR combines an accessible active site as observed in PhoE with a charged substrate-binding poc

163 are fundamental to flavoenzyme's functions, as observed in photolyase with a planar structure to len

164 lead to extraordinary behaviours in oxides, as observed in piezoelectric materials at morphotropic p

165 Furthermore, as observed in PMCA, plasminogen and kringles promoted P

166 As observed in previous studies, we find that Treponema

167 ations--or below levels found in upper soils as observed in previous studies--with the presence of an

168 s found to vary between different countries, as observed in previous studies.

169 and a 4-, 5-, and 6-fold Al-O coordination, as observed in previous studies.

170 hich are in agreement with domain boundaries as observed in protein 3D structure, and which model the

171 actions with non-polar and polar side chains as observed in protein structures and in molecular dynam

172 to the lack of regular secondary structures as observed in proteins.

173 luding cellular alternans at rates > 250 bpm as observed in rabbit myocytes, reentrant spiral waves a

174 ins) leading to formation of a compact dimer as observed in Ras crystal structures.

175 ceptor, GPR91, in the glomerular endothelium as observed in rat, mouse, and rabbit kidney sections.

176 N neurons increases dendritic spine density, as observed in rats after long-term cocaine administrati

177 metallosilylene-like (LnM-Si-R) reactivity, as observed in reactions of nonenolizable ketones, enone

178 In particular, as observed in real fluids, different points of the wave

179 the gene is silent in the majority of cells as observed in recent experiments.

180 xponent gamma ranging between 1.11 and 1.21, as observed in recent studies based on mobile phone data

181 l to lead to on-target off-tumor toxicities, as observed in recent trials.

182 h some elevation of risk, though not as much as observed in regular welders.

183 was correlated with the availability of LAE as observed in release kinetics.

184 tributes to inflammation-mediated bone loss, as observed in rheumatoid arthritis (RA) patients.

185 combat inflammation-driven bone destruction as observed in rheumatoid arthritis and other autoimmune

186 sorders with pancreatitis-causing treatments as observed in rodent acini.

187 2 protein may impair neural differentiation, as observed in RTT patients.

188 othelial activation leading to vasoocclusion as observed in SCD.

189 Oxidative stress as observed in schizophrenia affects parvalbumin interne

190 amphetamine-induced positive-symptom change, as observed in schizophrenia.

191 phenocopied the retinal lamination phenotype as observed in sec13(sq198).

192 ue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high m

193 ease, exhibited similar defects in apoptosis as observed in serglycin(-/-) cells, indicating that the

194 or cells lacking expression of the receptor, as observed in several animal models of metastasis.

195 e behavior at very short and long time lags, as observed in several experiments.

196 ic deficiency leads to cognitive malfunction as observed in several neurodevelopmental psychiatric di

197 were counteracted by EAAT and NCX blockers, as observed in SH-SY5Y and C6 cells.

198 obtain different types of sickle-shaped RBCs as observed in sickle cell anemia.

199 sulted in a major ATP hydrolysis deficiency, as observed in situ by histochemistry and in primary smo

200 sitivity and increased cross-bridge kinetics as observed in skinned papillary bundles from young tran

201 ctrophoretic mobility and aggregation state, as observed in sodium dodecyl sulfate (SDS)-polyacrylami

202 city of the remote ion-binding site in H-Ras as observed in solution.

203 iate attractive intermolecular interactions, as observed in some BPTI crystal structures, without the

204 that nonsymmetric average avalanche shapes (as observed in some experiments) occur for certain combi

205 elimination of neurons and cortical thinning as observed in some forms of mental retardation and feta

206 t initiates amyloid-beta (Abeta) generation, as observed in sporadic AD.

207 anotypic hippocampal slice cultures (OHSCs), as observed in stroke-induced acquired epilepsy.

208 tion could lead to different subtypes of CD, as observed in studies in cohorts of primarily European

209 As observed in studies of macroorganisms, the drivers of

210 ) confirmed the efficiency of the inhibitors as observed in substrate zymography.

211 likely bind in the palmitate binding cavity as observed in tablysin-15, since MpPR-1i binds palmitat

212 gamma-CD-IC-NF (2:1) preserved much more THY as observed in TGA and stability of THY/gamma-CD-IC (2:1

213 d to regression to the mean and time effects as observed in the 4 cohorts presented here.

214 es not undergo 1,2-shift of the carbon atom, as observed in the acid-catalyzed reaction.

215 substituted products (and in the same ratio) as observed in the acid-catalyzed reaction.

216 , rather than driving feedforward inhibition as observed in the adult.

217 on in atherosclerosis and diabetes mellitus, as observed in the aging population of developed societi

218 henomena arising from monopole correlations, as observed in the analogous electrical Coulomb gas, lik

219 cteristics of cascadeness and sequentiality, as observed in the budding and fission yeast cell- cycle

220 on, the effect of acetylation was cumulative as observed in the case of peptide (9)KSTGGKAPR(17), who

221 e near the exterior heme beta- or delta-edge as observed in the class of heme peroxidases.

222 e phenotypes for each of the categories and, as observed in the clinical data of PTSD patients, the s

223 Moreover, as observed in the clinical samples, ERG expression was

224 odifying large volumes of continental crust, as observed in the continents today.

225 or to methyl viologen, however, was the same as observed in the control strain.

226 model resulted in equivalent drug responses as observed in the corresponding patients.

227 he Phe side chain of the so-called DFG motif as observed in the crystal structure of compound 7m.

228 does not bind in the TMD intrasubunit cavity as observed in the crystal structure of GLIC with bound

229 exhibit few contacts between the RRMs, such as observed in the crystal structure.

230 d moves to the A site after cleavage occurs, as observed in the crystal structure.

231 ring blocks the entrance to the E7 channel, as observed in the crystal structures of Trp(E7) deoxyMb

232 th the DPP core acceptor in another molecule as observed in the crystal structures.

233 ctated by the differences in the axial ends, as observed in the crystalline order of symmetry.

234 As observed in the cytoplasm of virally infected cells,

235 , with both subtypes becoming less virulent, as observed in the data.

236 f presynaptic branches of the phrenic nerve, as observed in the diaphragm.

237 in vitro at a similar critical repeat number as observed in the diseases.

238 rom severe reduction of motor axon extension as observed in the dorsal forelimb to shortening of pres

239 t all myosin heavy chain protein degradation as observed in the electrophoresis.

240 same acute phenotypes and biomarker readouts as observed in the epithelia of E7 transgenic mice.

241 rom water, resulting in the same compression as observed in the experiment-based scale.

242 same large-scale roughening characteristics as observed in the experiment.

243 is accompanied by a catastrophic force drop as observed in the experimental or simulated force (F)-d

244 m the reactive plane to join the free stream as observed in the experiments.

245 unt for the reduction of the magnetic moment as observed in the experiments.

246 lence and intensity of sporozoite infection, as observed in the field.

247 chaeal genome-wide nucleosome occupancy map, as observed in the halophile Haloferax volcanii.

248 ies derived from blood memory B cells in RMs as observed in the HVTN 505 vaccine efficacy trial.

249 rence of millimetre-sized grains of pure ice as observed in the Imhotep debris falls is best explaine

250 talyst] and zero-order in [alkynyl alcohol], as observed in the intramolecular hydroamination/cycliza

251 F193 to rotate, resulting in a conformation as observed in the ligand-bound crystal structure.

252 e beneficial clinical effects of eplerenone (as observed in the main study) were preserved for the EM

253 ize how obesity, notably central or visceral as observed in the metabolic syndrome, leads to adipokin

254 similar morphological and enzymatic findings as observed in the murine tissues.

255 similar brain DNA methylation abnormalities as observed in the paternal sperm.

256 Abnormal perineuronal nets, as observed in the postmortem patient brain, may thus un

257 me rather than a clockwise-rotated ribosome, as observed in the presence of EF4-GDP and P site tRNA.

258 y unstacked in the RNA-theophylline complex, as observed in the previous NMR structure.

259 formation, instead of forming an alpha-helix as observed in the previously solved structure of the GC

260 l three-dimensional network of Pa3 symmetry, as observed in the pyrite model structure, at variance w

261 was compared with histopathologic regression as observed in the resection specimen.

262 hypothermia and increased survival duration as observed in the septic model developed by the laborat

263 interactions between residues of like charge as observed in the simulation.

264 , substitution of residue 172 with histidine as observed in the single nucleotide polymorphism Q172H

265 opted the same C3'-endo ribose conformations as observed in the structure of the unmodified RNA.

266 donor nuclei demonstrate a mitotic advantage as observed in the traditional reprogramming with somati

267 fiber cross-sectional area with hypertrophy as observed in the vehicle-treated group.

268 recognition responses and metabolic linkages as observed in this model system may influence carbon tr

269 celerating cognitive aging by about 4 years, as observed in this population.

270 The short-term variances as observed in this study might have been missed during

271 mical reactions on aquated aerosol surfaces, as observed in this study, are overlooked in most atmosp

272 e-bound phosphorus driven by cable bacteria, as observed in this study, contributes to the seasonalit

273 AGOSOMES to generate distinct GAG structures as observed in this study.

274 cts, multipolar mitosis, and multinuclearity as observed in time-lapse microscopy.

275 Triassic where the same level of complexity as observed in today's marine ecosystems is reached with

276 in both fumarase activity and malate content as observed in tomato fruit expressing the same construc

277 fects on distant nonirradiated tumor lesions as observed in transplanted MC38 (colorectal cancer), B1

278 e very sensitive to mechanical stresses such as observed in traumatic brain injury (TBI).

279 alculation-window duration on lifespan gain (as observed in trials) and on who gains most.

280 latent membrane protein 1 (LMP1) expression as observed in tumor cells of Epstein-Barr virus (EBV) -

281 lected by membrane disruption and cell death as observed in U937 and A549 cells.

282 (and to the same extent) in wild-type cells as observed in unchallenged HR(-) cells.

283 months of treatment remain within the range as observed in untreated patients.

284 skeleton failed to increase FGF23 expression as observed in uremic KL(fl/fl) mice.

285 type is strikingly similar to cardia bifida, as observed in vertebrate embryos when endoderm morphoge

286 ties and shape changes of rolling leukocytes as observed in vitro and in vivo.

287 ar morphological changes in effector T cells as observed in vitro, suggesting that the above process

288 dynamics of extracellular lactate and oxygen as observed in vivo in rats.

289 As observed in vivo, Epac1 inhibition prevents hypoxia/r

290 bursts of high-frequency mossy fibre input, as observed in vivo, larger inhibition-mediated gain cha

291 cate that long term supplementation with DHA as observed in vivo, resulted in deceased Notch 1/Jagged

292 egree of synchrony in 3D networks decreased, as observed in vivo.

293 xes, producing distinct tissue morphologies, as observed in vivo.

294 se variability decreased during stimulation, as observed in vivo.

295 in GPR120-deficient mice to a similar degree as observed in wild-type mice, indicating that the effec

296 ants over the background of cigarette smoke, as observed in wild-type mice, was absent in Il17a(-/-)

297 cantly reduced hepcidin expression similarly as observed in wild-type mice.

298 nfection does not result in severe symptoms, as observed in WT mice.

299 ent protection against a secondary infection as observed in WT mice.

300 s not strong ERC between crossover proteins, as observed in yeasts.