ライフサイエンスコーパス: ascertainment

1 nalysis was used to estimate completeness of ascertainment.

2 D OCT ascertainment of ERM with photographic ascertainment.

3 ed and with either random or phenotype-based ascertainment.

4 h records rather than comprehensive dementia ascertainment.

5 obably underestimated due to incomplete case ascertainment.

6 lematic because of potential difficulties in ascertainment.

7 P carriers are high even after adjusting for ascertainment.

8 stimation/extrapolation, and sources of case ascertainment.

9 ed segregation analysis, with correction for ascertainment.

10 altered the benefits and costs of mortality ascertainment.

11 on for improving the reliability of exposure ascertainment.

12 n carriers are high even after adjusting for ascertainment.

13 modified segregation analysis adjusting for ascertainment.

14 e, blinded, controlled, consecutive new case ascertainment.

15 der family sampling bias and/or case-control ascertainment.

16 reatly increases the probability of clinical ascertainment.

17 hat permit heterogeneity in case and control ascertainment.

18 the method of exposure assessment or outcome ascertainment.

19 l as the number and time points of mortality ascertainment.

20 o the interpretation modality during outcome ascertainment.

21 ave population-based ALS Registers with full ascertainment.

22 le sources were used to ensure complete case ascertainment.

23 tudy hypothesis was formulated prior to PTSD ascertainment.

24 on sample size and severity of case-control ascertainment.

25 iderations such as familial correlations and ascertainment.

26 chest compressions and had complete outcome ascertainment, 12% (29 of 247) experienced discomfort, a

27 n north London, UK, who had episodes of CSE (ascertainment 62-84%).

28 so includes a built-in approach for handling ascertainment, a helpful integrated tool for genetic dat

29 The ascertainment-adjusted incidence was between 17 and 23 e

30 Our variant ascertainment algorithm, VAAL, uses massively parallel D

31 rformed with the sample stratified by age at ascertainment and by two major advanced phenotypes for t

32 uo intervention was defined in terms of case ascertainment and capacity of EVD treatment centres on S

33 Cardiovascular risk factor ascertainment and carotid ultrasonography in all partici

34 CA1/2 genetic testing, even when barriers of ascertainment and cost were minimized.

35 disorder were identified following extensive ascertainment and diagnostic assessment and matched to 1

36 Incomplete ascertainment and follow-up may have underestimated subs

37 s the validity of ICD-9 codes in stroke case ascertainment and for AF across 3 institutions.

38 evaluate RV144 for completeness of end point ascertainment and integrity of blinding, necessary tasks

39 RATIONALE: Difficulty of asthma ascertainment and its associated methodologic heterogene

40 then the urgency of interventions to improve ascertainment and management of chronic hepatitis B in t

41 Using rigorous case ascertainment and outcome assessment in a population-bas

42 equire tackling challenges such as worldwide ascertainment and phenotypic characterization of familie

43 f subjects with 22q11DS separated by time of ascertainment and processing.

44 r these observations simply reflect pedigree ascertainment and publication bias.

45 that when appropriate corrections for panel ascertainment and rare-allele omission are used, the bia

46 s in the ICD system contributes to a lack of ascertainment and recognition of their importance for he

47 CoA varies considerably, likely secondary to ascertainment and reporting biases and inconsistent defi

48 Ascertainment and reporting of adverse events was not un

49 in some contexts, due to limitations in case ascertainment and specimen collection and processing.

50 NHL cases were identified using rapid case ascertainment and Surveillance, Epidemiology, and End Re

51 surveillance system, including the method of ascertainment and the case definitions.

52 endometrial cancer (EC) did not control for ascertainment and were susceptible to bias toward overes

53 gnostic criteria, type of IQ measure, sample ascertainment, and age at premorbid testing, contributed

54 nding EVD treatment centres, increasing case ascertainment, and allocating protective kits for contro

55 but the effect of ethnic background, subject ascertainment, and amount of missing data on the accurac

56 However, selection bias associated with case ascertainment, and differential reporting bias between c

57 disease events varied by age, sex, method of ascertainment, and geography.

58 obands were obtained by consecutive new case ascertainment, and healthy controls were from a random s

59 Patients were identified using rapid case ascertainment, and Latinas and blacks were oversampled.

60 studies with and without independent outcome ascertainment, and randomised clinical trials.

61 sed statistical methods that account for the ascertainment, and reported risks in a useable format.

62 explained by the GRS, biases in case-control ascertainment, and the limitations implicit to Mendelian

63 omission are used, the biases introduced by ascertainment are largely correctable, but recovered est

64 residual confounding (shared risk factors), ascertainment bias (sicker patients have more follow-up

65 e the potential for residual confounding and ascertainment bias and an inability to examine dosage ef

66 we present an approach that corrects for the ascertainment bias and generates an estimate of the freq

67 n populations in this study, are affected by ascertainment bias and have low levels of linkage disequ

68 n phenotypically extreme individuals display ascertainment bias and may demonstrate inflated effect-s

69 degree relatives affected with CRC to reduce ascertainment bias and overestimation of penetrance.

70 een reported twice before, which suggests an ascertainment bias attributable to a very mild phenotype

71 We accounted for possible confounding and ascertainment bias by adjusting for family-level socioec

72 The RCT study design mitigated ascertainment bias by randomizing patients to receive ei

73 rs anticipation (p = 0.002), indicating that ascertainment bias can entirely explain observed anticip

74 To account for case-control ascertainment bias for the analysis of multiple secondar

75 ifferent loci and effectively eliminates the ascertainment bias from the functional characterization

76 en populations, which is much more robust to ascertainment bias in SNP discovery than methods based o

77 We then show that there is a global ascertainment bias in the experiment-based GO annotation

78 than men, which emphasises the potential for ascertainment bias in unstratified data for a sex-limite

79 However, our general examination of ascertainment bias indicates that a priori knowledge of

80 der many parameter combinations we find that ascertainment bias introduces an elevated rate of false

81 the variant, the results are affected by an ascertainment bias known as the "winner's curse." The ac

82 A case ascertainment bias may therefore exist, with mild cases

83 or classifying psychiatric syndromes or case ascertainment bias regarding traumatic brain injury.

84 mmon allele is known a priori, introduces an ascertainment bias that must be corrected for in analyse

85 The rate adjusted for ascertainment bias was 27 of 435 (6.2%).

86 ction process of genetic markers (so-called 'ascertainment bias').

87 To adjust for potential ascertainment bias, a modified segregation analysis mode

88 ic map, haplotype phase uncertainty, and SNP ascertainment bias, affect our method.

89 data, short-term trial data showed possible ascertainment bias, and most RCTs used protocols that di

90 ed data with substantive evidence of outcome ascertainment bias, and only 2 studies with a double-bli

91 ce of infectious-disease data, missing data, ascertainment bias, consistency between molecular and ep

92 ure of these models is that they account for ascertainment bias, in that only varying, or parsimony-i

93 Ps on the X chromosome is not an artifact of ascertainment bias, nor is it specific to the population

94 effective population size, adjusted for SNP ascertainment bias, was approximately 3100, whereas the

95 After accounting for the potential of under-ascertainment bias, we found a null association between

96 e a simple and efficient correction for this ascertainment bias, which restores the false-positive ra

97 stly, our analysis also revealed evidence of ascertainment bias.

98 We can also correct for ascertainment bias.

99 males, P = 0.01), which probably relates to ascertainment bias.

100 H) have been limited by small sample size or ascertainment bias.

101 differences, inter-laboratory variation and ascertainment bias.

102 d injuries, misclassification of intent, and ascertainment bias.

103 logies used, data processing techniques, and ascertainment bias.

104 pecies than Grevy's zebra, despite potential ascertainment bias.

105 genetic prion disease are driven entirely by ascertainment bias.

106 tcomes, partly attributable to selection and ascertainment bias.

107 in the United States and avoid selection or ascertainment biases and sample size limitations.

108 ent large public databases is complicated by ascertainment biases associated with SNP discovery and t

109 because of a focus on coding polymorphisms, ascertainment biases in favor of common variation, and a

110 using whole genome sequences to correct for ascertainment biases in genome-wide genotype data, we da

111 is database are less likely to be subject to ascertainment biases or linked to sites under selection,

112 in the United States suffer from population ascertainment biases, with individuals of American India

113 ot correct for important selection and under-ascertainment biases.

114 s and is not confounded by ancestry or other ascertainment biases.

115 n specialist clinics, resulting in potential ascertainment biases.

116 erquartile range [IQR], 3.0-8.4) years after ascertainment, BRCA testing, or RRSO (whichever occurred

117 Whether the increase is due to better ascertainment, broadening diagnostic criteria, or increa

118 y with ALS was living on Guam at the time of ascertainment but had been born in the United States.

119 ds suffer a loss in power under case-control ascertainment, but no solution has been proposed.

120 Previous work has shown that this type of ascertainment can severely bias heritability estimates;

121 At ascertainment, CKD-associated polymorphisms (risk varian

122 , polygenic effects, shared environment, and ascertainment combined with confirmatory factor analysis

123 ex phenotypes, especially in the presence of ascertainment conditions, the specification of such mode

124 An ascertainment-corrected likelihood that combined populat

125 edge of the discovery samples, we perform an ascertainment correction and show how the post-correctio

126 Modified segregation analysis conditioned on ascertainment criteria was used to estimate age- and sex

127 from 1980 to 2007), definitions of SCD, case ascertainment criteria, methods of estimation/extrapolat

128 of sensitivity analyses using different case ascertainment criteria.

129 specificities from 85 to 98%, with ICD-9-CM ascertainment demonstrating the highest case sensitivity

130 re remain major limitations to accurate case ascertainment despite automated electronic laboratory re

131 results have implications in regards to case ascertainment, diagnosis, and surveillance of sCJD and p

132 Sample size and ascertainment do not seem to affect the accuracy of impu

133 fer by adiponectin assay, method of diabetes ascertainment, duration of follow-up, or proportion of w

134 ers strengthens the observation that bias of ascertainment exists when recent generations are include

135 While improvements in ascertainment explain some of these trends, deferred chi

136 at EVD treatment centres and increasing case ascertainment five-fold in November, 2014, can avert 77

137 d possibly on systems of diagnosis and trait ascertainment for developmental disorders.

138 to data collected from traditional means of ascertainment for neuropsychiatric disease genomics.

139 ths of this study include near-complete case ascertainment for state residents and well-characterized

140 1036 [29.6%] were women), 99.1% had complete ascertainment for the primary outcome.

141 1997, 2003, and 2008; and additional disease ascertainment from hospital data and registry linkage on

142 articipating physicians or staff; (2) active ascertainment from patients, who were encouraged to self

143 clinical relevance useful to assist clinical ascertainment, genetic counseling, guidance of symptomat

144 e same physician during a 12-month period of ascertainment had all images from their entire follow-up

145 Case ascertainment in most previous studies was based on auto

146 tions for left ventricular systolic function ascertainment in patients with HF and support evidence-b

147 udy illustrates the value of monitoring case ascertainment in stroke registries using external data s

148 analysis suggests that early fasting insulin ascertainment in the general population may help clinici

149 We assessed case ascertainment in the Michigan Stroke Registry by linking

150 on statistic (LTMLM) to address case-control ascertainment in unrelated samples.

151 se populations and reevaluated their initial ascertainments in the medical literature.

152 at least 593 kilobases at 16p11.2 and whose ascertainment included cognitive deficits.

153 y using multiple overlapping sources of case ascertainment (including a Scotland-wide collaboration o

154 ford Vascular Study; OXVASC), such that case ascertainment, investigation, and follow-up were complet

155 Case ascertainment is based on multiple sources (neurologic d

156 ational research in conditions in which case ascertainment is difficult.

157 Accurate case ascertainment is essential for clinical registries to be

158 Accelerated case ascertainment is needed to maximise effectiveness of exp

159 t constitutes a positive family history, and ascertainment is unreliable for many reasons.

160 Assuming ascertainment levels equivalent to that of other human p

161 simulations with family-biased case-control ascertainment, LT-Fam was correctly calibrated (average

162 cohort, downsampled to induce family-biased ascertainment, LT-Fam was correctly calibrated whereas A

163 identified hospitals that changed their case ascertainment method to a case sampling approach.

164 alue and sensitivity for each identification/ascertainment method were calculated.

165 registry information on these cancers, these ascertainment methods have not been previously validated

166 ity of neurological endpoint definitions and ascertainment methods in clinical trials has led to unce

167 by differences in patient populations, cost ascertainment methods, and length of follow-up.

168 teria, allocation, blinding, UTI definition, ascertainment methods, and proportion developing symptom

169 gher in the sites that used prospective case ascertainment methods.

170 ng methods, peer visit schedule, and outcome ascertainment methods.

171 In addition to case ascertainment, molecular typing of isolates was performe

172 The first, and most critical step, is the ascertainment of a biologically sound model to be optimi

173 endophenotype in this kindred not only aided ascertainment of additional family members but also incr

174 Complete ascertainment of AF during follow-up was identified from

175 Imprecise and unreliable ascertainment of alcohol intake is the rule in the area

176 subgroups; and correcting for assumed under-ascertainment of autism by level of maternal education.

177 ndardized epidemiological approaches for the ascertainment of cardiovascular risk factors and events.

178 t to selection bias when there is incomplete ascertainment of cases among pregnancies that are termin

179 IPSWs and the bias introduced by incomplete ascertainment of cases among terminated pregnancies cond

180 ve also been improved, as have approaches to ascertainment of cause of death by verbal autopsy, disea

181 udies may have been confounded by incomplete ascertainment of cognitive status at baseline.

182 ed by analysis of data sets with bias toward ascertainment of common alleles (e.g., HapMap and Perleg

183 specially within 24 h of birth, making under-ascertainment of community-born cases highly likely, bot

184 no method has been reported for large-scale ascertainment of CpG methylation in repeats.

185 ta, illustrating GWCoGAPS and patternMarkers ascertainment of data-driven biomarkers from whole-genom

186 between the beginning of recruitment and the ascertainment of death by National Death Index (December

187 NG, AND PARTICIPANTS: A National Death Index ascertainment of death in the long-term follow-up of a r

188 National Death Index (NDI) in improving the ascertainment of deaths among people diagnosed with acqu

189 ionnaires' disease outbreaks relies on rapid ascertainment of descriptive epidemiological data, combi

190 Ascertainment of differences between institutions might

191 Limitations of this study include the ascertainment of dysglycemia only among patients with av

192 photographs were reviewed to compare SD OCT ascertainment of ERM with photographic ascertainment.

193 Because of the high costs associated with ascertainment of families, most linkage studies of Bipol

194 Ascertainment of fungal components associated with immun

195 ausal variants include the need for complete ascertainment of genetic variants and the need to consid

196 A SACO design allows the ascertainment of genotype and exposure for cases and exp

197 Outcome assessment was not blinded, and ascertainment of harms in trials was poor.

198 Rapid ascertainment of HCV infection status with reflex testin

199 receive 1-time testing for HCV without prior ascertainment of HCV risk.

200 surface antigen (HBsAg) tests may facilitate ascertainment of hepatitis B virus (HBV) infection in se

201 Mobile application-based ascertainment of hospitalizations can be achieved with m

202 Ascertainment of hospitalizations is critical to assess

203 urban sites in Peru, Mexico, and China, with ascertainment of incident 10/66 and DSM-IV dementia 3-5

204 er Prevention II Study cohort, with baseline ascertainment of individual characteristics in 1982 and

205 We show through simulation that selective ascertainment of individuals whose onset falls within th

206 stroke rates may imply treatment advances or ascertainment of less severe strokes, possibly masking a

207 We show here that not accounting for the ascertainment of loci in such analyses leads to false in

208 h FHR </=3(rd) percentile for GA may improve ascertainment of LQTS in fetuses, neonates, and undiagno

209 h as endorsed by SM&T might not suffice for ascertainment of maximum (steady-state) bioaccessibility

210 linical diagnoses alone are insufficient for ascertainment of MI.

211 s between settings have been limited by poor ascertainment of mortality in high burden African settin

212 While bias due to under-ascertainment of mortality was minimised through death r

213 After accounting for under-ascertainment of mortality, with increasing duration on

214 Ascertainment of mothers in well-defined sensitivity gro

215 Neuronal viability was assessed through ascertainment of N-acetyl aspartate (NAA)-an amino acid

216 Observed DMF/CLU ascertainment of NDI-identified decedents increased from

217 urviving [72%]) then underwent follow-up for ascertainment of new-onset heart failure (2004-2010).

218 based on fluorescence microscopy for prompt ascertainment of non-enzymatic browning initiation in fr

219 They capitalized on their ascertainment of other endpoints in members of the cohor

220 The ascertainment of outcomes has depended on self-reporting

221 Ascertainment of outcomes was complete for 284 participa

222 al bias in the selection of participants and ascertainment of outcomes.

223 However, inaccurate ascertainment of past infrequent drinking may have less

224 everal self-reported items may be useful for ascertainment of periodontal disease in epidemiologic st

225 Ascertainment of periodontal disease using self-reported

226 zed trials are limited by lack of systematic ascertainment of pneumonia; they depended on adverse eve

227 ngths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million)

228 The overall rate of ascertainment of RAS status was 90%.

229 es depends on accurately accounting both for ascertainment of regions and for demography.

230 spective studies using refined approaches to ascertainment of RLS and depression are warranted.

231 ts, inadequate follow-up, and limitations of ascertainment of second malignancies.

232 s and to the National Crime Register enabled ascertainment of self-harm and violent offending, respec

233 Neanderthal origin, the strongest being the ascertainment of sequence identities between Neanderthal

234 Ascertainment of some measures of the quality of care an

235 77, 1978-1989, and 1990-2004), with biennial ascertainment of stroke risk factor data and active surv

236 However, ascertainment of structural variants (SVs) has been rest

237 Studies that use unblinded ascertainment of subjective infection endpoints are at r

238 design considerations that include increased ascertainment of subjects in the earliest phases of illn

239 ort of breast cancer survivors with complete ascertainment of surveillance mammograms and negligible

240 Main outcomes included ascertainment of symptoms/disease onset by questionnaire

241 s consistent with the proximity of region of ascertainment of the ancestral mice.

242 in study limitation is the difference in the ascertainment of the clinically defined CVD endpoints an

243 This requires prior ascertainment of the cSNP genotypes for all individuals.

244 outcomes in populations depends on accurate ascertainment of the history of these disorders.

245 g analytic epidemiologic studies can improve ascertainment of these factors.

246 Death Index (NDI) as the "gold standard" for ascertainment of US mortality, high search costs per yea

247 ents with similar ratings of attributes, and ascertainment of whether membership in a particular grou

248 chanism in Thalassiosira pseudonana, but the ascertainment of which proteins are responsible for the

249 monstrates the impact of differences in case ascertainment on the power to detect and replicate genet

250 in the general population, used active case ascertainment or clinic-based methods, and specified the

251 ent apparent change could be incomplete case ascertainment or potential leveling off of IRs.

252 Dec 31, 2014), adjusting for changes in case ascertainment over time.

253 They must also be aware of detection, ascertainment, performance and transfer bias in trial ex

254 e prescriptions for a statin during a 1-year ascertainment period were more likely than patients who

255 bserved KS incidence as a sentinel to assess ascertainment quality and showed that our KS incidence o

256 isk factors, and different methods of stroke ascertainment (range of RR estimates 1.30-1.42).

257 We estimate an under-ascertainment rate of about one-third (95% confidence in

258 Dementia case ascertainment relied on a consensus review of the cognit

259 By use of a whole-population ascertainment scheme, 822 individuals were enrolled from

260 the evaluation of cohorts that had different ascertainment schemes regarding ARM status and through t

261 er comparable with STRP loci (theta=10); (6) ascertainment schemes that select highly variable STRP o

262 ndependent cohorts collected using different ascertainment schemes.

263 Prospective population-based ascertainment showed that hospital-based registries will

264 Ethnicity, age and study ascertainment significantly modulated the association of

265 adjusted for age and sex, and stratified by ascertainment source (population versus clinic).

266 ication of signals in which alternative case-ascertainment strategies generated marked effect size he

267 were identified from claims data using three ascertainment strategies.

268 uency, populations sampled, and polymorphism ascertainment strategy.

269 hrough a prospective, population-based rapid ascertainment system.

270 ing of 629,433 sites with clearly documented ascertainment that was specifically designed for populat

271 Adjusted for completeness of ascertainment, there was a 21.1% (95% CI, 15.6%-27.0%) i

272 Adjusted for completeness of ascertainment, there was a 30.5% (95% CI, 17.3%-45.1%) o

273 three areas: new EVD treatment centres, case ascertainment through contact tracing, and household pro

274 r Research into Familial Breast Cancer, with ascertainment through family clinics (94%) and populatio

275 Asthma ascertainment through NLP should be considered in the er

276 ornia, and Detroit, Michigan, for rapid case ascertainment to identify a sample of women aged 20 to 7

277 s from our ENU screen in which we biased our ascertainment toward mutations affecting neurodevelopmen

278 We investigated ascertainment using capture-recapture modelling.

279 Performance of NLP-based asthma ascertainment using predetermined asthma criteria was as

280 ement and Transplantation Network, with ESRD ascertainment via Centers for Medicare and Medicaid Serv

281 ounter, agreement between the two sources of ascertainment was 48.2%, and the kappa statistic was 0.2

282 pture-recapture analysis suggested that case ascertainment was 89% (95% CI 77-97) complete.

283 HBP ascertainment was based on age-, gender-, and height per

284 Ascertainment was better than 90% in most registers.

285 We estimated that ascertainment was between 62% and 84%.

286 Mortality ascertainment was censored 31 December 2009.

287 Outcome ascertainment was complete given that the participants w

288 Ascertainment was designed to enrich the families for my

289 Follow-up ascertainment was done at three specialised clinical ser

290 Possible case under-ascertainment was only discussed in 2 studies.

291 The sensitivity of case ascertainment was significantly lower in teaching hospit

292 le sensitivity and specificity, although NLP ascertainment was superior.

293 dy population, and the methods used for case ascertainment, we analyzed 80 qualifying reports regardi

294 ted associations corrected for assumed under-ascertainment were 1.06 (0.98, 1.14) for all ASDs, 1.12

295 Positive predictive values for NMSC ascertainment were calculated.

296 CA identified using prospective, multisource ascertainment were evaluated for history of epilepsy.

297 mitations: Interventions and methods of fall ascertainment were heterogeneous.

298 Here, we consider family-biased case-control ascertainment, where case and control subjects are ascer

299 ccount for disease prevalence and non-random ascertainment, which can induce a correlation structure

300 pon how strictly the data are limited by the ascertainment window.