ライフサイエンスコーパス: ascomycin

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1 se seen in the complexes with tacrolimus and ascomycin.

2 (NFAT), and that this was blocked by CsA and ascomycin.

3 complexes with two 32-indolyl derivatives of ascomycin.

4 etitively attenuated with the small molecule ascomycin.

5 The potent immunosuppressant ascomycin (1b) was selectively alkylated at the C-32 car

6 The macrolactam ascomycin analog, ABT-281, was found to inhibit potently

7 Ascomycin and cyclosporin A, inhibitors of the Ca2+-depe

8 ycin was prepared in a two-step process from ascomycin and evaluated for its immunosuppressant activi

9 r its immunosuppressant activity relative to ascomycin and FK506.

10 ity (using cyclosporin or the FK506 analogue ascomycin, and a transfected C-terminal domain of the ca

11 analog, which was synthetically derived from ascomycin (ASC), the C21 ethyl analog of tacrolimus, by

12 thronolide B synthase gene was replaced with ascomycin AT8 and the engineered gene was expressed in S

13 These data show that ascomycin AT8 does not use malonyl- or methylmalonyl-CoA

14 CoA nor methylmalonyl-CoA is a substrate for ascomycin AT8 in its native context, both are substrates

15 s associated with the C24-hydroxyl moiety of ascomycin, C24-deoxyascomycin was found to be equipotent

16 olyl-ASC), a 32-O-(1-hydroxyethylindol-5-yl) ascomycin derivative with an improved therapeutic index

17 nists cyclosporin A and the FK-506 analogue, ascomycin, diminished costimulatory molecule and CD83 ex

18 Ascomycin (FK520) is a structurally complex macrolide wi

19 mmunosuppressant through the modification of ascomycin (FK520).

20 3)C]glycerol is incorporated into C12-C15 of ascomycin, indicating that both modules 7 and 8 of the p

21 we achieved our goal with L-732,531 (indolyl-ascomycin; indolyl-ASC), a 32-O-(1-hydroxyethylindol-5-y

22 We found that both cyclosporine A (CsA) and ascomycin inhibited removal of cyclobutane pyrimidine di

23 contrast, pretreatment with cyclosporin A or ascomycin, inhibitors of protein phosphatase 2B activity

24 FK520 (ascomycin) is a macrolide produced by Streptomyces hygro

25 ed a new specificity for an AT domain in the ascomycin polyketide synthase and present evidence that

26 the acyl transferase (AT) of domain 8 in the ascomycin polyketide synthase was replaced with heterolo

27 erization and that of its competitive binder ascomycin required for dimerization inhibition were stud

28 2-Indole ether derivatives of tacrolimus and ascomycin retain the potent immunosuppressive activity o

29 the calcineurin inhibitors, cyclosporin A or ascomycin, significantly reduced the ability of 8-pCPT-2

30 s potency was markedly reduced compared with ascomycin when administered systemically due to more rap

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