ライフサイエンスコーパス: asexual

1 produced on Osmunda spp. fronds are probably asexual.

2 nt promoting continuous reproduction through asexuals.

3 iotically reproducing lineages into obligate asexuals.

4 ferns where 10% of all species are obligate asexuals.

5 outcomes of competition between sexuals and asexuals across environmental gradients.

6 somatic telomere maintenance is different in asexual and sexual animals.

7 Parasites lacking PAT displayed normal asexual and sexual blood stage development compared to w

8 cin B is a potent inhibitor against both the asexual and sexual blood stages of malaria infection.

9 In addition, cpsA is necessary for normal asexual and sexual development.

10 the importance of histone PTMs to the entire asexual and sexual developmental cycles of the parasite,

11 emarkable reproductive strategies, combining asexual and sexual modes of reproduction that allow for

12 bstrates accumulating in the vacuole in both asexual and sexual parasites.

13 Asexual and sexual reproduction occur jointly in many an

14 we report that beta-glucan synthesis in both asexual and sexual spores is turned off by the NF-kB lik

15 ng proper levels of beta-glucan synthesis in asexual and sexual spores.

16 Asexual and sexual stages and the formation of new oocys

17 ng relative amounts of Plasmodium falciparum asexual and sexual stages from gene expression measureme

18 icated that the protein is required for both asexual and sexual stages of development.

19 The dual activity of ACT-451840 against asexual and sexual stages of P. falciparum and the activ

20 dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium falciparum.

21 Rosetting to P vivax asexual and sexual stages was evident 20 hours postretic

22 dentify AP2-G2 as a repressor active in both asexual and sexual stages.

23 uman malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as we

24 ore many microsporidian species appear to be asexual and should therefore exhibit reduced genetic div

25 Asexual animal species are rare, evolutionarily short-li

26 Asexual animals maintain telomere length somatically dur

27 capter pachys gives clues as to how 'ancient asexual' animals can exist.

28 In asexual (apomictic) plants, the absence of meiosis and s

29 m (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murin

30 ome of which showed cross-reactivity against asexual blood and liver stages.

31 id landscape during P. falciparum sexual and asexual blood stage (ABS) development.

32 as skewed toward antibody reactivity against asexual blood stage antigens.

33 t half of the genes are likely essential for asexual blood stage development, whereas six are require

34 with pantothenate phosphorylation and block asexual blood stage development.

35 The asexual blood stage involves invasion of erythrocytes by

36 the parasite during the clinically relevant asexual blood stage life cycle.

37 portant to understand intrinsic variation in asexual blood stage multiplication rates of the most vir

38 ll division cycle in the clinically relevant asexual blood stage of infection(1).

39 the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to

40 zoles have emerged as novel hits against the asexual blood stage of Plasmodium falciparum (Pf).

41 n derivatives, the frontline therapy for the asexual blood stage of the infection, is developing in s

42 reens have focused solely on the symptomatic asexual blood stage of the parasite life cycle; however,

43 eral protein kinases function redundantly in asexual blood stages and confirm the targetability of ki

44 mpart resistance to compounds active against asexual blood stages and mature gametocytes.

45 olar inhibition of the Plasmodium falciparum asexual blood stages and transmissible gametocyte forms.

46 In the asexual blood stages of malarial infection, merozoites i

47 s can increase the in vitro activity against asexual blood stages of P. falciparum by more than 1 ord

48 subnanomolar antiplasmodial activity against asexual blood stages of Plasmodium falciparum, excellent

49 Asexual blood stages of the malaria parasite, which caus

50 alaria parasites with important functions in asexual blood stages responsible for malaria symptoms, t

51 nolines, as well as compounds active against asexual blood stages, lost most of their killing activit

52 In developing intracellular asexual blood stages, MyoA was synthesized in mature sch

53 n activity against parasites during liver or asexual blood stages, their effects on transmission stag

54 rugs and inhibitors on Plasmodium falciparum asexual blood stages.

55 n culture of the malaria parasite during the asexual blood stages.

56 eomic comparison of a protein complex across asexual blood, sexual and sporozoite stages, along with

57 antibody prevalence to Plasmodium falciparum asexual blood-stage antigens, provide estimates of trans

58 rom CPS-immunized volunteers did not inhibit asexual blood-stage growth in vitro.

59 me biosynthesis pathway is not essential for asexual blood-stage growth of P. falciparum parasites bu

60 elded a nanomolar inhibitor of P. falciparum asexual blood-stage growth with improved solubility and

61 hod for conditional mutagenesis of essential asexual blood-stage malarial genes is available, hinderi

62 nt efforts in the design of vaccines against asexual blood-stage P. falciparum.

63 ity for the functional analysis of essential asexual blood-stage parasite genes.

64 of the ATP synthase only marginally reduced asexual blood-stage parasite growth but completely block

65 ctor transmission intrinsically modifies the asexual blood-stage parasite, which in turn modifies the

66 Our current understanding of the biology of asexual blood-stage parasites and gametocytes and the ab

67 In the asexual blood-stage parasites pfap2-g appears to be amon

68 that, even in a low-transmission setting, an asexual blood-stage vaccine designed to reduce clinical

69 In the asexual blood-stage, the parasite resides within erythro

70 Hydrozoan colonies normally develop through asexual budding of polyps that remain interconnected by

71 continuously regenerates entire bodies in an asexual budding process.

72 Trichogramma wasps can be rendered asexual by infection with the maternally inherited symbi

73 Evolution of large asexual cell populations underlies approximately 30% of

74 The longevity of asexual clades may be correlated with the maintenance of

75 ducing one thousand times more single-celled asexual conidial spores, three times sooner than the anc

76 ircadian clock output, yielding a pattern of asexual conidiation similar to a ras-1 mutant that is us

77 enome evolution can be placed on a sexual to asexual continuum, whether cytoplasmic male sterility (C

78 portant role for PfCDPK7 in the erythrocytic asexual cycle of malaria parasites.

79 controls the frequency of switching from the asexual cycle to sexual development.

80 gametocyte production and the length of the asexual cycle were noted between the two lines.

81 hemoglobin digestion throughout most of the asexual cycle.

82 t three time points during its erythrocytic (asexual) cycle.

83 Asexual development (conidiation) in the filamentous fun

84 almitoylation is essential for P. falciparum asexual development and influences erythrocyte invasion

85 ummary, VelB acts as a positive regulator of asexual development and regulates spore maturation, foca

86 ion and that Nox1 and NoxR are essential for asexual development in response to damage.

87 PfCDPK1 is critical for asexual development of Plasmodium falciparum, but its pr

88 kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum.

89 otryllus schlosseri is an emerging model for asexual development studies.

90 During its asexual development within the red blood cell (RBC), Pla

91 ne resulted in defects in vegetative growth, asexual development, and infection of the host plant.

92 les include regulation of hyphal morphology, asexual development, as well as amino acid, iron, and se

93 FlbB at the apex is required for triggering asexual development, the tip high nuclear gradient is no

94 VIP activity curtailed zooid resorption and asexual development.

95 ell invasion, stage-specific expression, and asexual differentiation.

96 During each cycle of asexual endomitotic division in erythrocytes, the malari

97 ble to alkylate protein target(s) within the asexual erythrocytic stage of Plasmodium falciparum (3D7

98 . yoelii Deltamif parasites grew normally as asexual erythrocytic-stage parasites and showed normal i

99 ut species delimitation in sexual as well as asexual eukaryotes.

100 irect descendants of a single nonrecombining asexual F1 hybrid individual.

101 ould induce the cascade of events leading to asexual female gamete formation in an apomictic plant.

102 The species has been considered asexual for more than 100 y, and despite concerted effor

103 al stage is known for C. beticola but in its asexual form it overwinters on infected plant debris as

104 The anamorphic (asexual) form produces prolific conidia, thought to func

105 sporozoites nor liver-stages, but kills only asexual forms in erythrocytes once released from the liv

106 The asexual forms of the malaria parasite Plasmodium falcipa

107 lifecycle, including the intra-erythrocytic asexual forms responsible for disease, the onset of symp

108 The asexual freshwater planarian is a constitutive adult, wh

109 Asexual freshwater planarians reproduce by tearing thems

110 cond, lineage-specific factors might prevent asexuals from reaching their full potential (e.g., depen

111 cifically associated with development of the asexual fruiting bodies of the fungus on certain substra

112 of broad relevance for manipulation of other asexual fungi of economic importance.

113 female offspring, leaving them irreversibly asexual, further linking host and symbiont.

114 Whole-genome analysis of 11 sexual and 11 asexual genotypes of Daphnia pulex indicates that curren

115 Ulocladium was thought to be a strictly asexual genus of filamentous fungi.

116 support the role of MAT genes in controlling asexual growth in filamentous Ascomycetes but also confi

117 PbDmc1 knockout (KO) parasites showed normal asexual growth kinetics compared to WT parasites; howeve

118 iploid sexual and both diploid and polyploid asexual (i.e., apomictic) lineages.

119 ence of the shared chromosomal haplotypes of asexuals indicates that the spread of asexuality is as r

120 s of sex are certainly important, sexual and asexual individuals, lineages, or populations may also d

121 also document high levels of variation among asexual individuals, which is attributable to recombinat

122 blood immediately following establishment of asexual infections-without the need for triggers such as

123 ed progression through the first part of the asexual intraerythrocytic development cycle.

124 may be an important step in the evolution of asexual invasive species.

125 are domesticated, partially selfing, or with asexual life cycles show strong deviations from HWE.

126 preexisting recessive deleterious alleles of asexuals, limiting their evolutionary longevity.

127 accumulation lines, we are able to age each asexual lineage.

128 ypes of Daphnia pulex indicates that current asexual lineages are in fact very young, exhibit no sign

129 Asexual lineages of plants and animals are typically pol

130 We hypothesized that new asexual lineages of Rubus could arise from hybridization

131 Although asexual lineages originate from wide crosses that introd

132 However, are new asexual lineages really those powerful invaders that cou

133 ation within the insertion allele across all asexual lineages suggests that this element may be in th

134 examine the relationship between sexual and asexual lineages, we sequenced the mitochondrial 12S and

135 tricting or altering the ecological niche of asexual lineages.

136 sinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but d

137 direct evolution of kin discrimination in an asexual microbe is analogous to the indirect evolution o

138 We emphasize evolution in asexual microbes, where next generation sequencing metho

139 as focused on either long-lived organisms or asexual microorganisms.

140 ation in the single-copy genes of putatively asexual microsporidia suggests that these species may un

141 enotypic changes were not observed following asexual mitotic reproduction.

142 pproximately 250-fold lower frequency during asexual mitotic vegetative growth.

143 We find that an asexual model with the strength of selection tuned to th

144 the Planistromellaceae and the two purported asexual morphs--Fusicladium and Aposphaeria--in the Vent

145 hitecture is shared by a long-lived clade of asexual nematodes closely related to the genetic model o

146 from queen flights, reported in the past, to asexual nest budding.

147 h dementia in a nursing home often viewed as asexual or incapable of being sexually active.

148 ionary benefits of sexual reproduction in an asexual organism.

149 ssions of whole-animal vertebrate clonality (asexual organismal-level reproduction), both in the labo

150 on and chromosomal re-assortment in strictly asexual organisms results in homologous chromosomes irre

151 deletions influence genome size evolution in asexual organisms.

152 applied this criterion to delimit species of asexual organisms.

153 Second, there seems to be no lack of asexual origins because losses of sexual reproduction ha

154 o (capital of Mali) for eligibility (>/=2000 asexual P falciparum parasites per muL of blood).

155 moderate levels of preexisting antibodies to asexual P. falciparum lysate and another that, based on

156 RMVs are quantitatively released during the asexual parasite cycle prior to parasite egress.

157 Results show that asexual parasite slide prevalence in humans has reduced

158 The ratio of gametocytemia to asexual parasitemia did not differ between acute and rec

159 t the need for triggers such as high-density asexual parasitemia or drug treatment.

160 High asexual parasitemia was associated with an increased ris

161 Of 7145 children, 1150 had microscopic asexual parasitemia, and sequencing was performed in 685

162 ommitment is observed following recrudescent asexual parasitemia, and these gametocytes are again ref

163 of relapses, particularly in those with high asexual parasitemia, is likely the most important strate

164 on 76 region was performed for children with asexual parasitemia.

165 vely associated with age and positively with asexual parasites (P < .001).

166 infectious for weeks after the clearance of asexual parasites and clinical symptoms.

167 e composite primary outcome was clearance of asexual parasites and fever by day 7, and absence of rec

168 physiological differences between sexual and asexual parasites and provide a tool and starting points

169 lood, being associated with low densities of asexual parasites and the absence of gametocytes.

170 ys to assess the presence of gametocytes and asexual parasites by microscopy.

171 Our data show that P. falciparum asexual parasites do not activate classical DC subsets b

172 re no serious adverse events (grade 2-4) and asexual parasites were cleared by day 7 in both groups.

173 ilic prodrug with nanomolar activity against asexual parasites.

174 influencing the dynamic circulation of young asexual Pf-RBCs in physiologically relevant conditions,

175 phnia pulicaria, underlies the origin of the asexual phenotype.

176 significant mechanism in the evolution of an asexual plant pathogen.

177 effect of gamma-irradiation on the growth of asexual Plasmodium falciparum was studied in erythrocyte

178 quantitatively the effect of subdividing an asexual population on the time it takes to cross a fitne

179 ies specific input and can be applied to any asexual population under persistent selection pressure.

180 Given a sample of genome sequences from an asexual population, can one predict its evolutionary fut

181 s stronger in sexual populations compared to asexual populations indicating that enhanced genetic var

182 enetic variation in genetically impoverished asexual populations of a freshwater snail, Potamopyrgus

183 tal evolution to test whether large or small asexual populations tend to evolve greater complexity.

184 We further characterize two sexual and two asexual populations with increased mutation rate and obs

185 is way, sex can reduce diversity relative to asexual populations, because it leads to a higher rate o

186 In asexual populations, the identification of beneficial al

187 is inversely correlated with genome size in asexual populations.

188 nt work that investigates these phenomena in asexual populations.

189 logies in a model of continual adaptation in asexual populations.

190 lacking, such as in small, bottlenecked, or asexual populations.

191 mutations hitchhike to fixation in adapting asexual populations.

192 iscovery of horizontal genome transfer as an asexual process generating new species and new combinati

193 that gametocytes-and not their noninfectious asexual progenitors-induce increased attractiveness of h

194 Flow cytometry is used to measure asexual proliferation and gametocyte production via DNA

195 Our results demonstrate that regulating host asexual proliferation and modifying its sexual reproduct

196 Conversion from asexual proliferation to sexual differentiation initiate

197 is restricted to reticulocytes, limiting its asexual proliferation.

198 Asexual propagation via infected rhizomes is the only me

199 [6-9], or multicellular structures, such as asexual propagules or secretory hairs (papillae) [10-12]

200 ferase that block parasite intraerythrocytic asexual replication and gametocyte differentiation in th

201 ntimalarials to block both intraerythrocytic asexual replication and gametocytogenesis.

202 d only few of the current drugs that inhibit asexual replication are also capable of inhibiting gamet

203 erozoites, all committed to either continued asexual replication or differentiation into gametocytes.

204 , the process by which parasites switch from asexual replication within human erythrocytes to produce

205 ce within its human host requires continuous asexual replication within red blood cells, while its mo

206 he effect of drugs or other perturbations on asexual replication, sexual conversion and early gametoc

207 e also free in host plasma between cycles of asexual replication.

208 from an epigenetically silenced state during asexual replication.

209 -an effect that can emerge in evolution with asexual reproduction and results in delayed fixation tim

210 Although transitions from sexual to asexual reproduction are thought to have important evolu

211 and how a planarian rips itself apart during asexual reproduction can be fully explained through biom

212 malaria are caused by the intraerythrocytic asexual reproduction cycle of Plasmodium falciparum.

213 Asexual reproduction in animals, though rare, is the mai

214 xual fertility that accompanied the shift to asexual reproduction in cultivars was reflected by signa

215 Apomixis is a naturally occurring mode of asexual reproduction in flowering plants that results in

216 ther the presence of Rickettsia is linked to asexual reproduction in Liposcelis.

217 Stolons (elongated stems) are used for asexual reproduction in the crop species potato (Solanum

218 reprogramming in methylomes is required for asexual reproduction in the fungus.

219 The commonest type of asexual reproduction is clonal growth (vegetative propag

220 Asexual reproduction is expected to reduce the adaptive

221 ature of sessile organisms, but this form of asexual reproduction is thought to interfere with sexual

222 Asexual reproduction is widespread in land plants, inclu

223 gamy and somatic embryogenesis and that such asexual reproduction may be ancient.

224 Asexual reproduction of the parasite within its host cel

225 Increasing asexual reproduction resulted in an increase in mean fit

226 Apomixis, asexual reproduction through seed, enables breeders to i

227 Introduction of apomixis, asexual reproduction through seeds, into crop species ha

228 Asexual reproduction via thelytokous parthenogenesis is

229 MAT genes can also affect similar aspects of asexual reproduction when expressed in C. heterostrophus

230 pitulate existing models, which suggest that asexual reproduction will overpower horizontal transfer

231 The two models incorporate asexual reproduction with varying levels of outcrossing

232 allocation (carbon storage, root biomass and asexual reproduction) in both treatments relative to the

233 leotide resolution during vegetative growth, asexual reproduction, and infection-related morphogenesi

234 d does not interfere with vegetative growth, asexual reproduction, differentiation of early sexual ti

235 fe history of multigenerational, stolon-like asexual reproduction, interspersed with dispersal by wat

236 rsity of mechanisms for achieving sexual and asexual reproduction, often simultaneously.

237 r switches between, for instance, sexual and asexual reproduction, or cyclic and non-cyclic life hist

238 the regulation of cell identity, sexual and asexual reproduction, secondary metabolism and pathogene

239 Under asexual reproduction, such hidden epistasis influences e

240 ce of apomixis-the transition from sexual to asexual reproduction-is a prominent feature of modern ci

241 symptomless phase and facilitating Septoria asexual reproduction.

242 ols the transition from vegetative growth to asexual reproduction.

243 eby alleviates some of the usual pitfalls of asexual reproduction.

244 tribution of macronuclear chromosomes during asexual reproduction.

245 budding program during subsequent rounds of asexual reproduction.

246 served maintenance of chromosome copy during asexual reproduction.

247 ch Hymenoptera transition between sexual and asexual reproduction.

248 obacterium Burkholderia, which controls host asexual reproduction.

249 ysiology of plant and pathogen throughout an asexual reproductive cycle of Z. tritici on wheat leaves

250 manner these amoebae reap the benefits of an asexual reproductive existence: principally, that it is

251 ich functional antagonism between sexual and asexual reproductive modes can negatively affect the fit

252 With a combination of sexual and asexual reproductive modes, such species may adapt to ne

253 How this novel asexual reproductive strategy relates to current models

254 zed Wolbachia strains infecting irreversibly asexual, resistant to horizontal transfer Trichogramma w

255 ics of adaptation in experimental sexual and asexual Saccharomyces cerevisiae populations, which allo

256 Apomixis (asexual seed production) is characterized by meiotically

257 6 promising antimalarial molecules with dual asexual/sexual activity, representing starting points fo

258 ubsets of autophagy genes were necessary for asexual/sexual differentiation and deoxynivalenol (DON)

259 t autophagy plays a critical role in growth, asexual/sexual sporulation, deoxynivalenol production an

260 First, asexuals should enjoy various growth benefits because th

261 If such traits are absent in asexuals, simple growth efficiency considerations will n

262 tential explanation for the capacity of this asexual snail to spread by adaptive evolution or plastic

263 distinct clones belonging to two obligately asexual species of the D. pulex species complex: D. midd

264 Asexual species thus provide an opportunity to gain insi

265 highlights, such as the potential for sex in asexual species, organic acid production genes being a k

266 Neurospora crassa, cell fusion occurs during asexual spore germination, where genetically identical g

267 feature of these fungi is the production of asexual spores (conidia) within fruiting bodies called c

268 a ubiquitous human fungal pathogen, produces asexual spores (conidia), which are the main mode of pro

269 gus Neurospora crassa, genetically identical asexual spores (germlings) communicate and fuse in a hig

270 is a key repressor affecting the quantity of asexual spores in Aspergillus.

271 Larvae were injected with conidia (asexual spores) of two different wild-type strains of N.

272 s in elevated accumulation of beta-glucan in asexual spores.

273 role in repressing beta-glucan synthesis in asexual spores.

274 ion of the beta-glucan synthase gene fksA in asexual spores.

275 fting from weak vegetative growth to induced asexual sporulation (conidiation) along a decreasing phe

276 DnfA is involved in asexual sporulation and polarized growth.

277 nd arrest parasites at the ring phase of the asexual stage and also gametocytogensis.

278 ion of this transmission-blocking agent with asexual stage antimalarials such as artemisinin combinat

279 Treatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exc

280 P. vivax gametocyte carriage mirrors asexual-stage infection.

281 It is characterised by delayed asexual-stage parasite clearance, which is the reference

282 l and inhibiting both Plasmodium sexual- and asexual-stage through secreted factors, thereby renderin

283 ch on transmission-blocking vaccines against asexual stages and vaccines against pregnancy-associated

284 lacking either PanK1 or PanK2 undergo normal asexual stages development and sexual stages differentia

285 The day 42 cure rate of asexual stages in the DHP + primaquine and DHP-only arms

286 ical signatures for P. falciparum sexual and asexual stages indicative of druggability and suggesting

287 genetic evidence that they are essential in asexual stages of development.

288 nation therapy is very effective in clearing asexual stages of malaria and reduces gametocytemia, but

289 omplexan genomes and is essential during the asexual stages of the malaria parasite Plasmodium falcip

290 osquito vector requires differentiation from asexual stages replicating within red blood cells into n

291 an children who were parasite free, harbored asexual stages, or had gametocytes at submicroscopic den

292 ing potential of schizonts compared to other asexual stages.

293 ) have recently been shown to play a role in asexual T. gondii daughter cell formation, yet the mecha

294 distribution of diploid sexual and polyploid asexual taxa across biogeochemical gradients and provide

295 e the persistence of sex in situations where asexual taxa are of higher ploidy level and phosphorus a

296 de the material for the continued success of asexual taxa in diverse environments.

297 Holy Grail', the master switch orchestrating asexual-to-sexual commitment and further differentiation

298 T genes play essential roles for controlling asexual traits (conidial size and number).

299 The parasite asexual trophozoite stage is susceptible to iron-induced

300 l stressors such as high aphid density cause asexual, viviparous adult female aphids to alter the dev