ライフサイエンスコーパス: asialoglycoprotein

1 ocytoses galactose-terminated glycoproteins (asialoglycoproteins).

2 (CL) were labeled with asialofetuin (AF), an asialoglycoprotein.

3 mumol/L, and was competable by an excess of asialoglycoprotein.

4 asialo-orosomucoid rather than generally to asialoglycoproteins.

5 Asialoglycoproteins (AGP) reputedly bind FK506 in blood.

6 ction of Texas red asialoorosomucoid contain asialoglycoprotein and its receptor and move and undergo

7 In contrast, antibodies to the receptors for asialoglycoproteins and mannose-6-phosphate or to the ly

8 mulate hepatic regeneration showed decreased asialoglycoprotein (ASGP) receptor binding.

9 Because the asialoglycoprotein (ASGP) receptor is specifically expre

10 rafficking mutant (Trf1) of HuH-7 alters the asialoglycoprotein (ASGPR) and transferrin receptor subc

11 and to chemically modified siRNA has enabled asialoglycoprotein (ASGPR)-mediated targeted delivery of

12 ligands, only ST3Gal-IV deficiency promotes asialoglycoprotein clearance mechanisms with a reduction

13 ed to a targetable DNA carrier consisting of asialoglycoprotein coupled to polylysine.

14 eptors for galactose-terminal glycoproteins, asialoglycoproteins, on the surface of hepatocytes.

15 leotides anti-III and anti-IV in the form of asialoglycoprotein-polylysine complexes were administere

16 e-1 (pSVK3-hBUGT1) genes were complexed with asialoglycoprotein-polylysine conjugates, and 1 mg of th

17 Pretreatment of Huh7, asialoglycoprotein receptor (+) cells, with antisense co

18 These studies showed that human asialoglycoprotein receptor (ASGP-R) and the terminal la

19 Using the asialoglycoprotein receptor (ASGP-R) as a model, we have

20 ative functional imaging techniques that use asialoglycoprotein receptor (ASGP-R) binding is based on

21 Polyclonal antibodies to the asialoglycoprotein receptor (ASGP-R) demonstrated the pr

22 Asialoglycoprotein receptor (ASGP-R) has been actively i

23 Within the liver, the asialoglycoprotein receptor (ASGP-R) has been shown to b

24 acids in their sequences, orthologues of the asialoglycoprotein receptor (ASGP-R) in different mammal

25 The hepatic asialoglycoprotein receptor (ASGP-R) internalizes desial

26 The functional human hepatic asialoglycoprotein receptor (ASGP-R) is a hetero-oligome

27 The asialoglycoprotein receptor (ASGP-R) is an abundant, car

28 The hepatic asialoglycoprotein receptor (ASGP-R) is an endocytic rec

29 The mammalian hepatic asialoglycoprotein receptor (ASGP-R) is an endocytic rec

30 The hepatic asialoglycoprotein receptor (ASGP-R) is posttranslationa

31 ae lipooligosaccharide (LOS) can bind to the asialoglycoprotein receptor (ASGP-R) on human sperm.

32 ly in situ, the endocytic trafficking of the asialoglycoprotein receptor (ASGP-R) was impaired in eth

33 nd was partially prevented by ligands of the asialoglycoprotein receptor (ASGP-R), thyroglobulin, asi

34 s of the experimentally intractable trimeric asialoglycoprotein receptor (ASGP-R), which consists of

35 s have not, to date, been identified for the asialoglycoprotein receptor (ASGP-R), which is abundantl

36 endocytic receptor on hepatocytes called the asialoglycoprotein receptor (ASGP-R), which is known to

37 may be preferentially localized through the asialoglycoprotein receptor (ASGP-R).

38 S mutant of alpha1-AT and H2a subunit of the asialoglycoprotein receptor (ASGPR H2a) were expressed i

39 In addition, protein content of the asialoglycoprotein receptor (ASGPR) and three traffickin

40 The asialoglycoprotein receptor (ASGPR) is a high-capacity g

41 The mammalian asialoglycoprotein receptor (ASGPR) is located on the si

42 Likewise, asialoglycoprotein receptor (ASGPR) was up-regulated in

43 -affinity ligand for the hepatocyte-specific asialoglycoprotein receptor (ASGPR), enhances the potenc

44 ific antibody to the thyroid apical membrane asialoglycoprotein receptor (ASGPR), which is related to

45 Asialoglycoprotein receptor (ASGPR)-mediated endocytosis

46 dged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR).

47 bohydrate-specific, endocytic receptors, the asialoglycoprotein receptor (ASGR) and the mannose recep

48 Expression of the asialoglycoprotein receptor (ASGR) by the human hepatoce

49 ligonucleotides (ASO) to hepatocytes via the asialoglycoprotein receptor (ASGR) has improved the pote

50 ell-surface receptors for asialoorosomucoid (asialoglycoprotein receptor (ASGR)), transferrin, and ma

51 dylethanolamine (Lac-DOPE), a ligand for the asialoglycoprotein receptor (ASGR), and an antibiotic pe

52 Liver-mediated uptake is through the asialoglycoprotein receptor (ASGR), since clearance can

53 ylgalactosamine (GalNAc)-conjugated ASOs for Asialoglycoprotein Receptor (ASGR)-mediated uptake into

54 into cultured hepatic cells (HepG2) via the asialoglycoprotein receptor (ASGR).

55 The mannose receptor (ManR, Mrc1) and asialoglycoprotein receptor (ASGR, Asgr1 and Asgr2) are

56 DC-asialoglycoprotein receptor (DC-ASGPR), a lectinlike rec

57 did not detect the minor subunits of the rat asialoglycoprotein receptor (RHL-2/3) in p45 preparation

58 nal HLCs using the hepatocyte surface marker asialoglycoprotein receptor 1 (ASGR1).

59 We show that the two subunits of asialoglycoprotein receptor [rat hepatic lectin 1 (RHL1)

60 This asialoglycoprotein receptor activity remains a key facto

61 4 degrees C with metal did not lose surface asialoglycoprotein receptor activity.

62 of the CRD is very similar to the CRD of the asialoglycoprotein receptor and other galactose-specific

63 cells produce a functional apically located asialoglycoprotein receptor and provide a model for rece

64 rate-recognition domain (CRD) of the hepatic asialoglycoprotein receptor at endosomal pH requires a s

65 We recently reported that the rat asialoglycoprotein receptor binds oligosaccharides termi

66 Expression of the asialoglycoprotein receptor by the human hepatocellular

67 Asialoglycoprotein receptor colocalized with asialooroso

68 inetic analysis that estimates the subject's asialoglycoprotein receptor concentration [R]o.

69 The human asialoglycoprotein receptor H2a subunit contains a charg

70 d ERAD substrate, the uncleaved precursor of asialoglycoprotein receptor H2a, its nonglycosylated mut

71 COS-7 cells with deletion constructs of the asialoglycoprotein receptor H2b subunit localized the cG

72 cells with deletion constructs encoding the asialoglycoprotein receptor H2b subunit localized the cG

73 tudies on the functional role of the hepatic asialoglycoprotein receptor in mammals.

74 f binding to the mannose receptor and/or the asialoglycoprotein receptor in the liver.

75 keratinocytes; cell surface levels of human asialoglycoprotein receptor increase following gonococca

76 The hepatic asialoglycoprotein receptor is responsible for rapid cle

77 ells lost approximately 50% of their surface asialoglycoprotein receptor ligand binding activity; zin

78 ation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetyl

79 erases mask galactose linkages implicated as asialoglycoprotein receptor ligands, only ST3Gal-IV defi

80 The asialoglycoprotein receptor localizes to the basolateral

81 In a cell-free system, initiation of asialoglycoprotein receptor mRNA translation was depende

82 acting factor associating with the 5'-UTR of asialoglycoprotein receptor mRNAs, thereby inhibiting tr

83 gA binding to HT-29/19A cells was due to the asialoglycoprotein receptor or beta-1, 4-galactosyltrans

84 The asialoglycoprotein receptor or other lectin-like recepto

85 he red cell anion exchange protein (Band 3), asialoglycoprotein receptor subunits, sucrase-isomaltase

86 We have previously used the asialoglycoprotein receptor system to elucidate the path

87 SRCL shares with the asialoglycoprotein receptor the ability to mediate endoc

88 Here, we address this problem for the asialoglycoprotein receptor using ensemble FRET imaging,

89 corresponding to residue 256 of the hepatic asialoglycoprotein receptor was found to cause a 14-fold

90 The hepatic asialoglycoprotein receptor was the first of the mammali

91 t of the transmembrane domain of CD74 or the asialoglycoprotein receptor with Astn2 TM2 leads to the

92 n 4 of ASGR1, which encodes a subunit of the asialoglycoprotein receptor, a lectin that plays a role

93 The mammalian hepatic asialoglycoprotein receptor, a member of the C-type anim

94 ral colorectal cancer cell lines express the asialoglycoprotein receptor, although no significant lev

95 docytosed transferrin, transferrin receptor, asialoglycoprotein receptor, and low amounts of the cati

96 simultaneous detection of asialoorosomucoid, asialoglycoprotein receptor, caveolin 1, and microtubule

97 hat an IgA receptor, distinct from the pIgR, asialoglycoprotein receptor, galactosyltransferase, and

98 0 nm; asialofetuin, a natural ligand for the asialoglycoprotein receptor, inhibited this process by u

99 TM2 by the transmembrane domain of CD4, the asialoglycoprotein receptor, or the transferrin receptor

100 Asialoglycoprotein receptor-1 (ASGR1) mediates capture a

101 s confirmed 40 days after transplantation by asialoglycoprotein receptor-directed nuclear scanning.

102 DNA delivered to the liver by asialoglycoprotein receptor-mediated endocytosis is degr

103 ical to the major subunit (RHL-1) of the rat asialoglycoprotein receptor.

104 l for studying apically localized endogenous asialoglycoprotein receptor.

105 uent of N-acetylgalactosamine in the hepatic asialoglycoprotein receptor.

106 ding site similar to the binding site in the asialoglycoprotein receptor.

107 lin 1 structures had no asialoorosomucoid or asialoglycoprotein receptor.

108 sfer into HuH-7 human hepatoma cells via the asialoglycoprotein receptor.

109 se, making it a good functional mimic of the asialoglycoprotein receptor.

110 the gene coding for the major subunit of the asialoglycoprotein receptor.

111 i.v., and targeted to the hepatocyte via the asialoglycoprotein receptor.

112 or inhibition of in vitro translation of the asialoglycoprotein receptor.

113 efficiency in targeting hepatocytes via the asialoglycoprotein receptor.

114 al N-acetylgalactosamine binding site of the asialoglycoprotein receptor.

115 The asialoglycoprotein-receptor (ASGP-R) located on liver pa

116 terminal galactosylation leading to reduced asialoglycoprotein-receptor binding and to improved phar

117 cells can be enriched and recovered based on asialoglycoprotein-receptor expression and potentially c

118 tocytes were isolated by sorting for surface asialoglycoprotein-receptor expression.

119 Functional rat or human asialoglycoprotein receptors (ASGP-Rs) are hetero-oligom

120 actosamine = GalNAc) for hepatocyte-specific asialoglycoprotein receptors (ASGPR) to enhance uptake t

121 The asialoglycoprotein receptors and many other C-type (Ca2+

122 ity; zinc-treated cells accumulated inactive asialoglycoprotein receptors intracellularly, whereas co

123 Asialoglycoprotein receptors on hepatocytes lose endocyt

124 ns, and N-acetylgalactosamine, which targets asialoglycoprotein receptors on hepatocytes, were synthe

125 the endocytic and ligand binding activity of asialoglycoprotein receptors on isolated rat hepatocytes

126 Asialoglycoprotein receptors on the surfaces of both hep

127 sting a decrease in the number of functional asialoglycoprotein receptors with concomitant increase i

128 ticular, there is a striking loss of State 2 asialoglycoprotein receptors.

129 sed activity, but retain the ability to bind asialoglycoprotein substrates.

130 e have previously shown decreased binding of asialoglycoproteins to this receptor after as early as 1