ライフサイエンスコーパス: asparagine synthetase

1 espectively), which both likely evolved from asparagine synthetase.

2 e inhibitor of the ammonia-dependent E. coli asparagine synthetase A (AS-A) can be regarded as such a

3 One is the ammonia-utilizing asparagine synthetase A (AsnA), and the other is asparag

4 . possess asparagine-tRNA synthetase paralog asparagine synthetase A (LdASNA) that is ammonia-depende

5 However, all known bacteria that contain asparagine synthetase A form Asn-tRNA(Asn) by direct acy

6 Transcription from the asparagine synthetase (A.S.) gene is increased in respon

7 acid is also a partial substrate for E. coli asparagine synthetase, acting as a nucleophile to form t

8 sulting mutant enzymes possess no detectable asparagine synthetase activity.

9 ndent asparagine formation in this bacterial asparagine synthetase and (ii) ammonia in bulk solution

10 (p-eIF2) leading to increased mRNA levels of asparagine synthetase and CCAAT/enhancer-binding protein

11 Importantly, increased expression of asparagine synthetase and CHOP does not require eIF2 pho

12 p-eIF2, p-ERK1/2, p-Akt, and mRNA levels of asparagine synthetase and CHOP in liver.

13 ion of the amino acid stress response genes, asparagine synthetase and CHOP/GADD153, increased as a r

14 We report the transactivation of two genes, asparagine synthetase and human telomerase reverse trans

15 ns genome of genes encoding tRNA-independent asparagine synthetase and the lack of this enzyme in D.

16 dolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase.

17 ative pentose pathway, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase; and

18 and also down-regulated the transcription of asparagine synthetase as compared with WT-EcA.

19 o and in vitro characterizations of FdmV, an asparagine synthetase (AS) B-like protein, as an amide s

20 Transcription from the human asparagine synthetase (AS) gene is increased in response

21 The human asparagine synthetase (AS) gene is transcriptionally reg

22 The human asparagine synthetase (AS) gene responds to depletion of

23 nd trans-factors affecting the expression of asparagine synthetase (AS) genes whose transcription is

24 ene for the amino acid biosynthetic activity asparagine synthetase (AS) is induced by both amino acid

25 omology to the nitrogen-assimilating enzyme, asparagine synthetase (AS).

26 f this family of ATP/Mg2+-dependent enzymes, asparagine synthetase (AS-B), catalyzes intermolecular,

27 AS1 and SAS2) encoding different isoforms of asparagine synthetase (AS; EC 6.3.5.4) were isolated.

28 ct in many plant species, is synthesized via asparagine synthetase (AS; EC 6.3.5.4).

29 clones, LJAS1 and LJAS2, encoding different asparagine synthetases (AS) have been identified and seq

30 n of a gene that is down-regulated by light, asparagine synthetase (AS1).

31 genes such as glutamine synthetase (GLN) and asparagine synthetase (ASN) are modulated by carbon and

32 get genes involved in nitrogen assimilation: asparagine synthetase (ASN1 and ASN2) and glutamine synt

33 Genes encoding the ammonia-dependent asparagine synthetase (asnA) and asparaginyl-tRNA synthe

34 of ATF4 significantly reduced the levels of asparagine synthetase (ASNS) and overexpression of ASNS

35 Asparagine synthetase (ASNS) converts aspartate and glut

36 Because of their low asparagine synthetase (ASNS) expression and asparagine b

37 Among them, asparagine synthetase (ASNS) expression was reduced in s

38 P suppressed the induction of the endogenous asparagine synthetase (ASNS) gene and inhibited transcri

39 ted analysis of these data revealed that the asparagine synthetase (ASNS) gene showed a gain in copy

40 In particular, baseline expression of asparagine synthetase (ASNS) was not predictive of respo

41 Silencing of asparagine synthetase (ASNS), an amidotransferase that c

42 ntigen 1 (FOSL1), transglutaminase 2 (TGM2), asparagine synthetase (ASNS), PLAB, PAOh1 and ELF3, whil

43 Expression of human asparagine synthetase (ASNS), which catalyzes asparagine

44 regulation of the enzyme glutamine-dependent asparagine synthetase (ASNS).

45 against cancer cells that express measurable asparagine synthetase (ASNS).

46 While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-de

47 ave examined the methylation profiles of the asparagine synthetase (ASY) promoter in a number of huma

48 mall-molecule inhibitors of Escherichia coli asparagine synthetase B (AS-B) as a model system for the

49 Escherichia coli asparagine synthetase B (AS-B) catalyzes the synthesis o

50 Escherichia coli asparagine synthetase B (AS-B) catalyzes the synthesis o

51 e aspartate binding site of Escherichia coli asparagine synthetase B (AS-B) using a number of stereoc

52 Incubation of Escherichia coli asparagine synthetase B (AS-B) with [14C]-L-glutamine gi

53 evolutionarily linked to a common ancestor, asparagine synthetase B (AS-B).

54 trate its use in studies of Escherichia coli asparagine synthetase B (AS-B).

55 n the reaction mechanism of Escherichia coli asparagine synthetase B (AS-B).

56 ine-dependent activities of Escherichia coli asparagine synthetase B (AS-B).

57 ragine synthetase A (AsnA), and the other is asparagine synthetase B (AsnB) that uses glutamine or am

58 osine (5'-FSBA) inactivates Escherichia coli asparagine synthetase B activity following pseudo-first-

59 Asparagine synthetase B catalyzes the assembly of aspara

60 in the synthetase active site of the enzyme asparagine synthetase B from Escherichia coli (AS-B).

61 l-tRNA synthetase genes and a duplication of asparagine synthetase B genes.

62 nal architecture of the N-terminal domain of asparagine synthetase B is similar to that observed for

63 s of the homologous primary metabolic enzyme asparagine synthetase B, and a chemical mechanism is pro

64 constitute a clinically useful inhibitor of asparagine synthetase B, these results suggested that re

65 ent amidotransferase much like the unrelated asparagine synthetase B.

66 is actually involved in aspartate binding in asparagine synthetase B.

67 Asparagine synthetase catalyzes the ATP-dependent format

68 other glutamine amidotransferases including asparagine synthetase, cytidine 5'-triphosphate (CTP) sy

69 NS gene have been clinically associated with asparagine synthetase deficiency (ASD).

70 rans and Thermus thermophilus do not possess asparagine synthetase (encoded by asnA or asnB), the enz

71 mology protein (Chop) genes, but not for the asparagine synthetase gene.

72 Transcription from the ASNS (asparagine synthetase) gene is increased in response to

73 subfamily of amidotransferases that includes asparagine synthetase, glucosamine 6-phosphate synthase,

74 horibosylpyrophosphate amidotransferase, and asparagine synthetase have revealed the relative locatio

75 agine is formed by two structurally distinct asparagine synthetases in prokaryotes.

76 Through asparagine synthetase knockdown and altering of media as

77 Novel inhibitors of asparagine synthetase, that will lower circulating level

78 synthesis was suppressed, and expression of asparagine synthetase was statistically correlated with

79 ASNS encodes asparagine synthetase, which catalyzes the synthesis of