ライフサイエンスコーパス: aspartase

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1 f death diverge at the level of the cysteine aspartase.

2 inate lyase, delta-crystallin, fumarase, and aspartase.

3 m in the apoptotic pathway compared with the aspartase activation.

4 Mean aspartase aminotransferase increased from 23 (baseline)

5 tenuated, whereas an SR-11 DeltaaspA mutant (aspartase) and an SR-11 DeltafrdABCD mutant (fumarate re

6 An aspartase (aspA) mutant (unable to utilize any amino aci

7 itor, blocked the activity/activation of the aspartase at concentrations about one order of magnitude

8 eviously that general inhibitors of cysteine aspartases block apoptosis of PC12 cells and sympathetic

9 a caspase recruitment domain (ASC), cysteine aspartase (caspase)-1, and interleukin (IL)-1beta from i

10 Activation of cysteine aspartases (caspases) seems to be a required element of

11 In addition to the previously described aspartase-cleavable biosensors, we report development of

12 ed their responses to inhibitors of cysteine aspartases, elements of apoptotic pathways.

13 We find additionally that the cysteine aspartase family protease inhibitor zVAD-fmk inhibits ap

14 mediated by distinct members of the cysteine aspartase family.

15 mology comparisons with other members of the aspartase-fumarase enzyme family, and the necessity for

16 The active site of aspartase has been located in a region that contains sid

17 her, our data highlight the dual function of aspartase in C. jejuni and suggest a role during growth

18 In living cells, zVAD-FMK, a pseudosubstrate aspartase inhibitor, blocked the activity/activation of

19 In contrast, the cysteine aspartase inhibitory peptide zVAD-fmk conferred protecti

20 raising the possibility that the CPP32-like aspartase is not the main death effector in this model.

21 e that diminished expression of the cysteine aspartase Nedd2 in PC12 cells and sympathetic neurons in

22 enzyme (ICE) and a related group of cysteine aspartases of the ICE/ced-3 family inhibit cell death in

23 and BAF, two peptide inhibitors of cysteine aspartases, protected neurons in all three death paradig

24 Aspartase was shown by activity and proteomic analyses t

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