ライフサイエンスコーパス: aspartic

1 ds in alginate and alginate-arginine-glycine-aspartic acid (-RGD) microgel was demonstrated, with enh

2 le crystals containing glycine (0-7 mol%) or aspartic acid (0-4 mol%), we elucidate the origin of the

3 t-poly(ethylene glycol)-S-S-arginine-glycine-aspartic acid (Alg-g-RGD).

4 ations including methionine (Met) oxidation, aspartic acid (Asp) isomerization, and asparagine (Asn)

5 Aspartic acid (Asp), wool, parchment, and rabbit skin gl

6 transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown t

7 Specifically, a conserved aspartic acid (Asp53) of the LytR response regulator was

8 unctionalized with a cyclic arginine-glycine-aspartic acid (cRGD) tripeptide for targeting integrin a

9 from other herpesviruses revealed conserved aspartic acid (D) and glutamic acid (E) residues.

10 dditionally, ICl of the mutant containing an aspartic acid (D) to asparagine (N) substitution at posi

11 acting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modu

12 48), Ser(226), and Ser(227) were replaced by aspartic acid (designated as D-Tg) or alanines (designat

13 iable gene segments encoding a glutamic acid-aspartic acid (ED) motif for K169 recognition.

14 ddition to the already known indole-3-acetyl-aspartic acid (IA-Asp) and indole-3-acetyl-glutamic acid

15 in the conjugated forms indole-3-acetic acid aspartic acid (IAA-Asp) and indole-3-acetic acid glutami

16 previous reports; brain volume and N-acetyl aspartic acid (NAA) decreased steadily, but no published

17 ppocampal neurons, treatment with N-methyl-D-aspartic acid (NMDA) (10 muM) for 48 hours reduced the s

18 e sensitive conductances, such as N-methyl-D-aspartic acid (NMDA) channels can be more easily activat

19 ynaptic vesicles was dependent on N-methyl-D-aspartic acid (NMDA) receptor activation during LTP.

20 hetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely util

21 subunits required for assembly of N-methyl-d-aspartic acid (NMDA) receptors (NMDA-Rs), alpha-amino-3-

22 Blockade of N-methyl-D-aspartic acid (NMDA) receptors by intra-CA3 infusion of

23 is accompanied by the increase of N-Methyl-D-aspartic acid (NMDA) receptors in the hippocampus follow

24 st common targets and mechanisms: N-methyl-d-aspartic acid (NMDA) receptors, voltage gated calcium ch

25 < 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p < 0.001) without affecting cell integri

26 Mutation of tyrosine 89 to aspartic acid (PrimPolY89D) has been identified in a num

27 esive through exhibition of arginine-glycine-aspartic acid (RGD) adhesion peptides under stretching.

28 ty and accessibility of the arginine-glycine-aspartic acid (RGD) binding site in FN, which, in turn,

29 Cyclic arginine-glycine-aspartic acid (RGD) containing peptides are known to mim

30 with acetylenic bombesin or arginine-glycine-aspartic acid (RGD) derivatives, either in solution or o

31 x protein, has a functional arginine-glycine-aspartic acid (RGD) domain for binding to integrin.

32 lphavbeta6, via a conserved arginine-glycine-aspartic acid (RGD) motif in the exposed, antigenic, GH

33 ing a ketone-functionalized arginine-glycine-aspartic acid (RGD) peptide to modify the O-hydroxylamin

34 eta5/beta3 integrins and an arginine-glycine-aspartic acid (RGD) sequence in the first extracellular

35 old electrode surface using arginine-glycine-aspartic acid (RGD) tripeptide was electrochemically con

36 Arginine-glycine-aspartic acid (RGD)-based imaging tracers allow specific

37 ith hydrogels modified with arginine-glycine-aspartic acid (RGD)-containing peptides.

38 Arginine-glycine-aspartic acid (RGD)-mimetic platelet inhibitors act by o

39 o either alanine (S225A; phosphoablatant) or aspartic acid (S225D; phosphomimetic) in the context of

40 whereas replacing S47 with phospho-mimicking aspartic acid (S47D) abolished the antisenescent, growth

41 utation by substituting the S936-TRP site to aspartic acid (trp(S936D) ) set the frequency response o

42 In both cases, we identify aspartic acid 137 as the caspase cleavage site and demon

43 Cleavage of JunB at aspartic acid 137 separates the N-terminal transactivati

44 mus), with the latter being reprotonated by aspartic acid 156 (t(1/2) = 2 ms).

45 ion of a fibril-specific salt bridge between aspartic acid 23 and lysine 28.

46 he N276 glycan, loop D, and V5, but not with aspartic acid 368, similarly to HJ16 and 179NC75.

47 ich is demonstrated to then be protonated by aspartic acid 396 to the neutral radical within 3.5 mus.

48 vibration of two non-natural amino acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methy

49 vitro phosphorylation that histidine 245 and aspartic acid 536 are conserved sites of phosphorylation

50 that contributed to flavour (glutamic acid, aspartic acid and alanine) were present and the most abu

51 o catalyze the hydrolysis of asparagine into aspartic acid and ammonia has been recently put into que

52 he first time that a glycopeptide containing aspartic acid and an O-sulfated glycan was synthesized.

53 , are conserved, but the salt bridge between aspartic acid and arginine is lost.

54 (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growt

55 d proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cysteine.

56 lysine, leucine, alanine, arginine, glycine, aspartic acid and glutamic acid residues represented the

57 equired for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the

58 88 to lysine) and Nav1.6 (asparagine 1768 to aspartic acid and leucine 1331 to valine) by obtaining w

59 , followed by N-[4'-hydroxy-(E)-cinnamoyl]-l-aspartic acid and N-[3',4'-dihydroxy-(E)-cinnamoyl]-3-hy

60 c acid is a nitrogen acceptor while alanine, aspartic acid and proline are nitrogen donors in cancero

61 ticed in the case of glutamic acid, alanine, aspartic acid and proline between cancer and healthy cel

62 The major phosphoprotein in dentin is the aspartic acid and serine-rich protein called dentin phos

63 linear relationship between the d/l ratio of aspartic acid and the age of the specimens.

64 how that when gas-phase mixtures of D- and L-aspartic acid are exposed to an achiral Cu(111) surface,

65 y on the PHR domain, that replacement of the aspartic acid Asp-396 with cysteine prevents proton tran

66 ction from PBC, and its sequence includes an aspartic acid at beta57.

67 The formation of an external aldimine with aspartic acid at pH 9 also produces the ketoenamine form

68 in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is asso

69 hown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233.

70 en ablated by deletion of a highly conserved aspartic acid at position 385, which, for HIV-1, plays a

71 3 of ERalpha, resulting in a substitution of aspartic acid at position 538 to glycine (D538G), was id

72 The mutation substituting the aspartic acid at position 838 (equivalent to the human a

73 The replacement of tyrosine by aspartic acid at position M210 in the photosynthetic rea

74 The phosphomimetic aspartic acid can restore activity at the two serine sit

75 oxylacylcarnitine metabolites and asparagine/aspartic acid could serve as biomarkers associated with

76 suggests that ATP-binding shifts the pKa of aspartic acid D396, the putative proton donor to FAD.(-)

77 The most potent congeners were a l-aspartic acid diisoamyl ester phenoxy prodrug and a l-ph

78 In contrast, mutations to aspartic acid drastically destabilize the protein and re

79 observe changes in the protonation state of aspartic acid during folding that have not been captured

80 The dynamics of the aspartic acid follow the dynamics of the intermediate ph

81 Substituting aspartic acid for hydrophobic interface residues dramati

82 The D/L ratio of aspartic acid for these specimens ranged from 2.4% to ~1

83 Free glutamic acid and free aspartic acid found in the PPI hydrolysate likely increa

84 fy the presence of D-serine, D-alanine, or D-aspartic acid in eight biologically relevant peptides.

85 chondrial import, whereas the presence of an aspartic acid in over 95% of all avian influenza viruses

86 The pK(a) value of aspartic acid in the catalytic triad of serine proteases

87 pled to protein folding; the apparent pKa of aspartic acid in the folded protein is 6.4.

88 The conversion of homoserine to aspartic acid in the glycopeptide was successfully accom

89 A motif of histidine, proline, and aspartic acid in the J domain of DNAJB6a was required fo

90 One compound with an aspartic acid in the P2 position (compound 16) displayed

91 tides, one challenge is the incorporation of aspartic acid in the peptide backbone and acid sensitive

92 Substitution of the surface-exposed Y1544 to aspartic acid is able to stabilize the domain in the abs

93 The negative charge of aspartic acid is believed to be able to mimic the phosph

94 The protonation state of aspartic acid is coupled to protein folding; the apparen

95 FFD-NH2) and a second novel one in which the aspartic acid is substituted by an asparagine (Ac-LPFFN-

96 Aspartic acid isomerization rates can be predicted from

97 ifications such as asparagine deamidation or aspartic acid isomerization.

98 ict the effect of mutating each glutamic and aspartic acid located in MTBD domain to alanine.

99 use of asparaginase to convert asparagine to aspartic acid may provide a means to reduce acrylamide f

100 vivo MRI studies in mice; however, only the aspartic acid modified chelates produced an amide proton

101 n o-boronato-phosphonium amino ester with an aspartic acid moiety.

102 A phosphomimetic Ser-500 to aspartic acid mutation (eEF-2K S500D) enhances the rate

103 The aspartic acid mutation of beta4 T1736 impaired hemidesmo

104 mHTT gene within a BAC to express either an aspartic acid or an alanine at position 421, mimicking t

105 For example, isomerization of aspartic acid or epimerization of any chiral residue wit

106 Furthermore, we showed that a serine 120 to aspartic acid phospho-mimetic mutant of Rpt6 (S120D) inc

107 ected mutagenesis of predicted histidine and aspartic acid phosphoacceptor residues.

108 idases exhibit a monoglutamase activity when aspartic acid precedes a single glutamate, which, togeth

109 mical design relies on the modification of l-aspartic acid precursor to controllably combine, through

110 egy was developed utilizing homoserine as an aspartic acid precursor.

111 ening that binds to a specific pocket of the aspartic acid protease, beta-secretase (BACE-1).

112 In addition, the aspartic acid racemization ratio of this specimen was al

113 to LRP1, we demonstrate that the N-methyl-D-aspartic acid receptor (NMDA-R) is expressed by macropha

114 K-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurr

115 Because N-methyl-D-aspartic acid receptor (NMDAR) dysregulation has been st

116 By measuring N-methyl-d-aspartic acid receptor (NMDAR)-driven calcium responses

117 (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA)

118 beta2* activation did not enhance N-methyl-D-aspartic acid receptor function.

119 The N-methyl-d-aspartic acid receptor hypofunction model of schizophren

120 chizophrenia, as predicted by the N-methyl-d-aspartic acid receptor hypofunction model.

121 ent, we found abnormally enhanced N-methyl-d-aspartic acid receptor-dependent long-term depression in

122 ed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term pot

123 panoic acid receptor-mediated and N-methyl-D-aspartic acid receptor-mediated synaptic currents in lam

124 asing glutamatergic excitation at N-methyl-D-aspartic acid receptors, alters both the amplitude and f

125 titution of the N-terminal position S27 with aspartic acid rescued this loss of upregulation.

126 ity was shown to be dependent on a conserved aspartic acid residue (Asp(666)), identified as the cata

127 Previous studies have suggested that the aspartic acid residue (D) at the third position is criti

128 p) CX(5)R and the loop containing a critical aspartic acid residue (D-loop), required for the catalyt

129 ymes share a consensus sequence harboring an aspartic acid residue as a catalytic nucleophile.

130 polymorphism, causing the replacement of the aspartic acid residue at position 398 with an asparagine

131 cid at position 838 (equivalent to the human aspartic acid residue at position 835) with a tyrosine (

132 al metalloenzyme in which a glutamic acid or aspartic acid residue engineered into streptavidin acts

133 analysis of isomaltase predicts that another aspartic acid residue functions as a proton donor in hyd

134 reported previously for other proteins, the aspartic acid residue in Kremen1 is not critical.

135 In a previous report, a conserved aspartic acid residue in the NqrB subunit at position 39

136 with a non-histidine zinc ligand, having an aspartic acid residue instead.

137 A nearby aspartic acid residue side-chain transiently stores prot

138 e carboxyl function at the side chain of the aspartic acid residue, which was selected on the basis o

139 absolute specificity of hydrolysis after an aspartic acid residue.

140 the L-selectin tail as well as a doublet of aspartic acid residues ((369)DD(370)) in the membrane-di

141 length LRPIV variants with glycine replacing aspartic acid residues 3394, 3556, and 3674 in the calci

142 nduced two-proton transfer between catalytic aspartic acid residues and the hydroxy group of the boun

143 alogues show that, like GH31 hydrolases, the aspartic acid residues Asp(553) and Asp(665) are the cat

144 neutral, despite harboring the two conserved aspartic acid residues found in NapA and other bacterial

145 egration activity of PGBD5 requires distinct aspartic acid residues in its transposase domain, and sp

146 ked homodimers that contain a pair of acidic aspartic acid residues in their transmembrane (TM) domai

147 Focusing on the two key aspartic acid residues of NhaA, D163 and D164, shows tha

148 By mutating two aspartic acid residues predicted to be responsible for t

149 Mutation of the aspartic acid residues to alanine in the C-terminal doma

150 Essential aspartic acid residues, in the predicted S1 binding pock

151 bonds formed via catalytic glutamic acid or aspartic acid residues.

152 inner Odelta1 oxygen atoms of the catalytic aspartic acid residues.

153 y, substitution with the sulfinic acid mimic aspartic acid resulted in constitutive Hsf1 activation.

154 t peptides and small proteins containing the aspartic acid semialdehyde (Asa) side chain can be easil

155 lcium ion that is coordinated by a conserved aspartic acid side chain and is essential for catalytic

156 heets and beta-turns, and negatively charged aspartic acid side chain of FiP35 were measured independ

157 d type (WT) or with alanine or glutamic acid/aspartic acid substitutions at the phosphorylation sites

158 wild type (WT) sequences or with alanine or aspartic acid substitutions at the phosphorylation sites

159 Among all the substitutions screened, aspartic acid substitutions were generally well-tolerate

160 ect dog cells, a single mutation changing an aspartic acid to a glycine at capsid (VP2) position 300

161 Although an amino acid substitution from aspartic acid to alanine at position 168 (D168A) reduced

162 changing coat protein N-arm residue 14 from aspartic acid to alanine causes a lethal phenotype.

163 amino acid in the nAChR alpha5 subunit from aspartic acid to asparagine (D398N), with greater risk f

164 (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of A(H7N9)

165 ), which changes a conserved amino acid from aspartic acid to asparagine.

166 urthermore, we found that a single change of aspartic acid to glutamic acid in CW3 NS1/2 was sufficie

167 c.298G-->T) in LEP, leading to a change from aspartic acid to tyrosine at amino acid position 100 (p.

168 frequent kinase domain mutation, converting aspartic acid to tyrosine.

169 characteristic, with cyclic arginine-glycine-aspartic acid tripeptide (cRGD), a targeting ligand to i

170 ment to the high density of arginine-glycine-aspartic acid tripeptide present in DAPF.

171 ctures of the WoA variants in complex with L-aspartic acid versus L-glutamic acid provide insights in

172 technique based on the racemization rate of aspartic acid was applied to dating human bone, as well

173 li (E. coli) HCB33 to the chemoattractant dl-aspartic acid was quantified in terms of change in total

174 acterization of mutant enzymes in which this aspartic acid was substituted by other residues that cha

175 N-[3',4'-dihydroxy-(E)-cinnamoyl]-l-aspartic acid was the most abundant metabolite, followed

176 lices, and the residues in the beta-turn, by aspartic acid was used examine the importance of the con

177 rylcarnitine/malonylcarnitine and asparagine/aspartic acid were associated with worse clinical rank s

178 lanine, glutamine, glutamic acid, aspargine, aspartic acid were detected.

179 multiple phyla reveals a uniquely conserved aspartic acid within an FFXRX6RX12PXD motif, two uniquel

180 A point mutation neutralizing a conserved aspartic acid within the intracellular loop close to the

181 lytic zinc ion ligated by the histidines and aspartic acid within the motif (HEXXHXXGXXD).

182 RGD (arginine-glycine-aspartic acid) blocking peptides induced CNTF expression

183 a peptide-bound residue (like asparagine and aspartic acid) has not been demonstrated.

184 D1416 in the IHD motif (isoleucine-histidine-aspartic acid) in the NBARC domain cause effector-indepe

185 ic the tripeptide sequence (arginine-glycine-aspartic acid) of the natural ligands; however, the RGD-

186 report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified polylactic acid-co-glyco

187 n of CA2 synapses relies on NMDA (N-methyl-D-aspartic acid) receptor activation, calcium and calcium/

188 D-aas such as D-Asp (aspartic acid), D-Glu (glutamic acid), combined D-[Asp/G

189 made of cyanophycin [multi-L-arginyl-poly (L-aspartic acid)], which is synthesized by cyanophycin syn

190 cial model peptides containing protein-bound aspartic acid, alanine and methionine, respectively, at

191 jugate reactions targeting lysine, glutamine/aspartic acid, and cysteine residues.

192 netic code four amino acids-valine, alanine, aspartic acid, and glycine-were coded by GNC codons (N =

193 vels of amino acid racemization not only for aspartic acid, but also for phenylalanine and tyrosine,

194 of alanine, alpha-ketoglutarate, asparagine, aspartic acid, cystathionine, total cysteine, glutamic a

195 N-acetyl-l-aspartate (NAA) to acetate and l-aspartic acid, elevates brain NAA and causes "spongiform

196 traction of the C3 proton by the active site aspartic acid, forming Neu5Ac2en.

197 han in vegetable protein (alanine, arginine, aspartic acid, glycine, histidine, lysine, methionine, a

198 the DHHC (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the

199 beta-catenin, where serine 45 is mutated to aspartic acid, in mice resulted in improved liver regene

200 mologue of Garner's aldehyde, derived from l-aspartic acid, is reported.

201 Several carbon sources (L-Asparagine, L-Aspartic Acid, L- Glutamic Acid, m- Erythritol, D-Melezi

202 amino acids, such as L-serine, L-leucine, L-aspartic acid, L-glutamic acid, histamine, glycine.

203 f cMyBP-C were replaced by either alanine or aspartic acid, mimicking the fully nonphosphorylated and

204 esults imply that the racemization ratios of aspartic acid, phenylalanine, and tyrosine can be used a

205 form stabilized by interaction with a second aspartic acid, probably via a H-bond to the phenolic oxy

206 c acid residues are replaced by arginine and aspartic acid, respectively as refractive increment incr

207 atives which are prepared from L-serine or L-aspartic acid, respectively.

208 oxidised lipid was absent, cysteine, serine, aspartic acid, threonine, asparagine, tryptophan, tyrosi

209 ncluding 2-hydroxyglutaric acid and N-acetyl-aspartic acid, was also observed in the DESI mass spectr

210 lpha mutant, where serine 41 was replaced by aspartic acid, which mimics phosphorylation.

211 describe a method to characterize the human aspartic acid- and glutamic acid-ADP-ribosylated proteom

212 ving copper-catalyzed allylation of serine-, aspartic acid-, and glutamic acid-derived organozinc rea

213 raction of cathepsin Z with arginine-glycine-aspartic acid-binding integrins, specifically alphavbeta

214 (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), as a therapeutic candidat

215 Food restriction also enhanced aspartic acid-induced burst firing of dopamine neurons i

216 ks containing cell adhesive Arginine-Glycine-Aspartic acid-Serene (RGDS) peptide and/or nanocrystalli

217 ugation of one of the alkyl side chains with aspartic acid.

218 h alanine, present in higher plants, or with aspartic acid.

219 phan triad and proton transfer from a nearby aspartic acid.

220 served element of the I-Ak binding motif, an aspartic acid.

221 ecycle except when serine 312 was mutated to aspartic acid.

222 lpiece or their mutation to glutamic acid or aspartic acid.

223 d initiates the conversion of isoAsp back to aspartic acid.

224 ,2-oxazol-4-yl) propanoic acid or N-methyl-d-aspartic acid.

225 a water molecule coordinated by a catalytic aspartic acid.

226 Arg-Gly triplet is recognized by a conserved aspartic acid.

227 2-glutaric acid] and RGD is arginine-glycine-aspartic acid.) RESULTS: alphavbeta3 integrin is express

228 pitope could be engaged, despite the lack of aspartic acid/glutamic acid encoded in the mouse reperto

229 earing Vlambda rearrangements that expressed aspartic acid/glutamic acid in CDR L2.

230 d to identify a region of ~350A(2) involving aspartic acids 186, 228, and 246 in Gbetagamma where we

231 Glycine, glutamic and aspartic acids accounted for 40% of total amino acids.

232 fragments with all four serines replaced by aspartic acids confirmed that the motif did adopt a more

233 A phosphorylation or serine replacement with aspartic acids did not affect persistence length (0.43 +

234 Mg(2+), which neutralizes the Ca(2+)-binding aspartic acids that likely contribute to the C2B interfa

235 variability, which enables the two catalytic aspartic acids to be brought closer to each other.

236 ith cTn having cTnI serines 23/24 mutated to aspartic acids to mimic phosphorylation always shifted a

237 tamylases, with CCP3 being able to hydrolyze aspartic acids with similar efficiency.

238 nce of acidic amino acids (i.e. glutamic and aspartic acids).

239 d by the PPi dissociation from two catalytic aspartic acids, followed by a comparatively slow jump-fr

240 inine residue at a similar register to these aspartic acids, with the activating immunoreceptors.

241 ally catalytic residues, including essential aspartic acids.

242 that coding and non-coding regions explained aspartic and glutamic acid consumption differences, like

243 These peptides possess aspartic and glutamic acid residues at p4 and p7, respec

244 nd KIEs) of carboxylic groups of various key aspartic and glutamic acid residues by monitoring their

245 trategy was adopted to probe solvent-exposed aspartic and glutamic acid residues on the CP43 protein.

246 including the digestion motifs flanked with aspartic and glutamic acid.

247 contain proteins that are unusually rich in aspartic and glutamic acids [4-6], the role of these pro

248 to the polar serine, the negatively charged aspartic and glutamic acids, and the hydrophobic amino a

249 frequently observed when acidic amino acids, aspartic and glutamic acids, are present near the cleava

250 Inhibition of aspartic cathepsin D-like peptidases (APDs) has been oft

251 rotease inhibitors indicated the presence of aspartic, cysteine, serine and metallo proteases.

252 ydrolyzing sterile alpha motif and histidine aspartic domain containing protein 1 (SAMHD1) protein, w

253 (dNTPase) sterile alpha motif and histidine/aspartic domain-containing protein 1 (SAMHD1), previousl

254 acterized by a central tryptophan flanked by aspartic/glutamic acid residues (W-acidic).

255 Sterile alpha motif (SAM) and histidine-aspartic (HD) domains protein 1 (SAMHD1) was previously

256 w renal tricarbonyl radiotracer based on the aspartic-N-monoacetic acid (ASMA) ligand, (99m)Tc(CO)(3)

257 eptidases and were not hydrolyzed by serine, aspartic, or metallo peptidases.

258 Our results revealed an aspartic peptidase with molecular mass approximately 38k

259 and analysis of catalytic specificity of an aspartic peptidase.

260 , such as the (near) absence of cysteine and aspartic peptidases and peptidase inhibitors, whereas ot

261 struction through activation of the cysteine-aspartic protease (caspase) cascade.

262 One of these genes, coding for an aspartic protease (UNDEAD), may control the timing of ta

263 approach based on proteolysis with secreted aspartic protease 9, Sap9, for analysis of monoclonal an

264 he absence of ERG-28, SLO-1 channels undergo aspartic protease DDI-1-dependent degradation, resulting

265 61-entry fragment library for binding to the aspartic protease endothiapepsin by crystallography.

266 ening to map the protein-binding site of the aspartic protease endothiapepsin by individual soaking e

267 rent milk clotting enzymes, belonging to the aspartic protease family, were extracted from both artic

268 An aspartic protease from Salpichroa origanifolia fruits wa

269 entral statine-core unit, characteristic for aspartic protease inhibition.

270 he multistage antiplasmodial activity of the aspartic protease inhibitor hydroxyl-ethyl-amine-based s

271 yethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible

272 erefore, we have investigated the effects of aspartic protease inhibitors on both enzymes and compara

273 cted by proteasome, caspase-3, or serine and aspartic protease inhibitors.

274 C. albicans secreted aspartic protease Sap6 is important for virulence during

275 Our findings showed that the alpine thistle aspartic protease was successfully immobilized at pH 7.0

276 BACE1 is an aspartic protease which functions in the first step of t

277 HTLV-1 protease (HTLV-1 PR) is an aspartic protease which represents a promising drug targ

278 cathepsin E is a nonlysosomal intracellular aspartic protease whose function has been described only

279 ling proteins such as receptor-like kinases, aspartic protease, a putative lipid-binding START domain

280 E reactivity with 60% of the sera, lysosomal aspartic protease, and "AAEL006070-PA" (Uniprot: Q177P3)

281 in 2/2', plasmepsin II, plasmepsin IV, histo aspartic protease, and heme detoxification protein.

282 particular cleavage specificity of the cocoa aspartic protease, which cannot be substituted by pepsin

283 peptide N-glycanase, and DDI-1, a conserved aspartic protease.

284 olecule, and cathepsin D (CTSD), a lysosomal aspartic protease.

285 ucosal surfaces, facilitated by the secreted aspartic proteases (Saps) 4, 5, and 6.

286 f Pepstatin A (PA), a selective inhibitor of aspartic proteases (Saps).

287 Aspartic proteases appear to be the main enzymes involve

288 The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involve

289 Carnivorous plants primarily use aspartic proteases during digestion of captured prey.

290 In contrast to most aspartic proteases from other origins, basic amino acid

291 recombinant nepenthesin I (one of two known aspartic proteases in the fluid) revealed a partial clea

292 Plasmepsins (Plms) are aspartic proteases involved in the degradation of human

293 recognition motifs for the catalytic dyad of aspartic proteases was generated by in silico similarity

294 Caspases (cysteine-aspartic proteases) are induced early in the apoptotic p

295 otent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity.

296 nd NB-ARC, and five additional families: the Aspartic proteases, BTB/POZ proteins (BTB), Glutaredoxin

297 ationships with respect to BACE1 and related aspartic proteases, cathepsins D and E.

298 enzyme and may apply more generally to other aspartic proteases.

299 Aspartic proteinases, which include HIV-1 proteinase, fu

300 The first cleavage occurs at aspartic residue 332, located between the kinase domain