ライフサイエンスコーパス: aspartic acid

1 nce of acidic amino acids (i.e. glutamic and aspartic acids).

2 phan triad and proton transfer from a nearby aspartic acid.

3 served element of the I-Ak binding motif, an aspartic acid.

4 ecycle except when serine 312 was mutated to aspartic acid.

5 lpiece or their mutation to glutamic acid or aspartic acid.

6 d initiates the conversion of isoAsp back to aspartic acid.

7 ,2-oxazol-4-yl) propanoic acid or N-methyl-d-aspartic acid.

8 a water molecule coordinated by a catalytic aspartic acid.

9 Arg-Gly triplet is recognized by a conserved aspartic acid.

10 gamma-iodo NHBoc-amino ester, derived from L-aspartic acid.

11 entage of asparagine was found hydrolyzed to aspartic acid.

12 h alanine, present in higher plants, or with aspartic acid.

13 ugation of one of the alkyl side chains with aspartic acid.

14 ally catalytic residues, including essential aspartic acids.

15 le crystals containing glycine (0-7 mol%) or aspartic acid (0-4 mol%), we elucidate the origin of the

16 In both cases, we identify aspartic acid 137 as the caspase cleavage site and demon

17 Cleavage of JunB at aspartic acid 137 separates the N-terminal transactivati

18 apparent, however, that an important role of aspartic acid 151 in the activity of NA may be to restri

19 mus), with the latter being reprotonated by aspartic acid 156 (t(1/2) = 2 ms).

20 d to identify a region of ~350A(2) involving aspartic acids 186, 228, and 246 in Gbetagamma where we

21 ion of a fibril-specific salt bridge between aspartic acid 23 and lysine 28.

22 he N276 glycan, loop D, and V5, but not with aspartic acid 368, similarly to HJ16 and 179NC75.

23 ich is demonstrated to then be protonated by aspartic acid 396 to the neutral radical within 3.5 mus.

24 vibration of two non-natural amino acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methy

25 vitro phosphorylation that histidine 245 and aspartic acid 536 are conserved sites of phosphorylation

26 plicate the intermolecular charge pairing of aspartic acid 777 (VE-Cad) and arginine 609 (par3-PDZ3)

27 Glycine, glutamic and aspartic acids accounted for 40% of total amino acids.

28 iation to a histidine (basic amino acid) for aspartic acid (acidic amino acid) substitution in the en

29 Arginine-glycine-aspartic acid affinity chromatography of proteins from t

30 cial model peptides containing protein-bound aspartic acid, alanine and methionine, respectively, at

31 t-poly(ethylene glycol)-S-S-arginine-glycine-aspartic acid (Alg-g-RGD).

32 that contributed to flavour (glutamic acid, aspartic acid and alanine) were present and the most abu

33 o catalyze the hydrolysis of asparagine into aspartic acid and ammonia has been recently put into que

34 catalyzes the hydrolysis of L-asparagine to aspartic acid and ammonia.

35 he first time that a glycopeptide containing aspartic acid and an O-sulfated glycan was synthesized.

36 , are conserved, but the salt bridge between aspartic acid and arginine is lost.

37 (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growt

38 d proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cysteine.

39 Conserved aspartic acid and cysteine residues play important catal

40 , cysteine-class proteases that cleave after aspartic acid and deconstruct the cell.

41 lysine, leucine, alanine, arginine, glycine, aspartic acid and glutamic acid residues represented the

42 equired for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the

43 88 to lysine) and Nav1.6 (asparagine 1768 to aspartic acid and leucine 1331 to valine) by obtaining w

44 , followed by N-[4'-hydroxy-(E)-cinnamoyl]-l-aspartic acid and N-[3',4'-dihydroxy-(E)-cinnamoyl]-3-hy

45 c acid is a nitrogen acceptor while alanine, aspartic acid and proline are nitrogen donors in cancero

46 ticed in the case of glutamic acid, alanine, aspartic acid and proline between cancer and healthy cel

47 The major phosphoprotein in dentin is the aspartic acid and serine-rich protein called dentin phos

48 linear relationship between the d/l ratio of aspartic acid and the age of the specimens.

49 jugate reactions targeting lysine, glutamine/aspartic acid, and cysteine residues.

50 netic code four amino acids-valine, alanine, aspartic acid, and glycine-were coded by GNC codons (N =

51 describe a method to characterize the human aspartic acid- and glutamic acid-ADP-ribosylated proteom

52 ving copper-catalyzed allylation of serine-, aspartic acid-, and glutamic acid-derived organozinc rea

53 how that when gas-phase mixtures of D- and L-aspartic acid are exposed to an achiral Cu(111) surface,

54 fMSP8) contains an N-terminal asparagine and aspartic acid (Asn/Asp)-rich domain whose function is un

55 y on the PHR domain, that replacement of the aspartic acid Asp-396 with cysteine prevents proton tran

56 tes membrane insertion is the protonation of aspartic acid (Asp) and/or glutamic acid (Glu) residues,

57 Arising from spontaneous aspartic acid (Asp) isomerization or asparagine (Asn) de

58 ations including methionine (Met) oxidation, aspartic acid (Asp) isomerization, and asparagine (Asn)

59 ic acid (isoAsp) is a common modification of aspartic acid (Asp) or asparagine (Asn) residue in prote

60 Aspartic acid (Asp), wool, parchment, and rabbit skin gl

61 transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown t

62 Specifically, a conserved aspartic acid (Asp53) of the LytR response regulator was

63 on the extent of protein degradation, using aspartic acid/asparagine (Asx), glutamic acid/glutamine

64 ction from PBC, and its sequence includes an aspartic acid at beta57.

65 The formation of an external aldimine with aspartic acid at pH 9 also produces the ketoenamine form

66 in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is asso

67 hown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233.

68 en ablated by deletion of a highly conserved aspartic acid at position 385, which, for HIV-1, plays a

69 3 of ERalpha, resulting in a substitution of aspartic acid at position 538 to glycine (D538G), was id

70 The mutation substituting the aspartic acid at position 838 (equivalent to the human a

71 The replacement of tyrosine by aspartic acid at position M210 in the photosynthetic rea

72 raction of cathepsin Z with arginine-glycine-aspartic acid-binding integrins, specifically alphavbeta

73 RGD (arginine-glycine-aspartic acid) blocking peptides induced CNTF expression

74 vels of amino acid racemization not only for aspartic acid, but also for phenylalanine and tyrosine,

75 The phosphomimetic aspartic acid can restore activity at the two serine sit

76 fragments with all four serines replaced by aspartic acids confirmed that the motif did adopt a more

77 he previously characterized arginine-glycine-aspartic acid-containing peptide.

78 oxylacylcarnitine metabolites and asparagine/aspartic acid could serve as biomarkers associated with

79 unctionalized with a cyclic arginine-glycine-aspartic acid (cRGD) tripeptide for targeting integrin a

80 of alanine, alpha-ketoglutarate, asparagine, aspartic acid, cystathionine, total cysteine, glutamic a

81 complementarity-determining region 2 (HCDR2) aspartic acid (D(H54)) or an HCDR2 asparagine (N(H54)) r

82 from other herpesviruses revealed conserved aspartic acid (D) and glutamic acid (E) residues.

83 dditionally, ICl of the mutant containing an aspartic acid (D) to asparagine (N) substitution at posi

84 acting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modu

85 d them to either lysine (K), alanine (A), or aspartic acid (D).

86 D-aas such as D-Asp (aspartic acid), D-Glu (glutamic acid), combined D-[Asp/G

87 suggests that ATP-binding shifts the pKa of aspartic acid D396, the putative proton donor to FAD.(-)

88 48), Ser(226), and Ser(227) were replaced by aspartic acid (designated as D-Tg) or alanines (designat

89 A phosphorylation or serine replacement with aspartic acids did not affect persistence length (0.43 +

90 The most potent congeners were a l-aspartic acid diisoamyl ester phenoxy prodrug and a l-ph

91 In contrast, mutations to aspartic acid drastically destabilize the protein and re

92 observe changes in the protonation state of aspartic acid during folding that have not been captured

93 iable gene segments encoding a glutamic acid-aspartic acid (ED) motif for K169 recognition.

94 N-acetyl-l-aspartate (NAA) to acetate and l-aspartic acid, elevates brain NAA and causes "spongiform

95 The dynamics of the aspartic acid follow the dynamics of the intermediate ph

96 d by the PPi dissociation from two catalytic aspartic acids, followed by a comparatively slow jump-fr

97 Substituting aspartic acid for hydrophobic interface residues dramati

98 The D/L ratio of aspartic acid for these specimens ranged from 2.4% to ~1

99 traction of the C3 proton by the active site aspartic acid, forming Neu5Ac2en.

100 Free glutamic acid and free aspartic acid found in the PPI hydrolysate likely increa

101 pitope could be engaged, despite the lack of aspartic acid/glutamic acid encoded in the mouse reperto

102 earing Vlambda rearrangements that expressed aspartic acid/glutamic acid in CDR L2.

103 han in vegetable protein (alanine, arginine, aspartic acid, glycine, histidine, lysine, methionine, a

104 (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), as a therapeutic candidat

105 a peptide-bound residue (like asparagine and aspartic acid) has not been demonstrated.

106 the DHHC (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the

107 ine (hLigI51A) to prevent phosphorylation or aspartic acid (hLigI51D) to mimic phosphorylation.

108 ddition to the already known indole-3-acetyl-aspartic acid (IA-Asp) and indole-3-acetyl-glutamic acid

109 in the conjugated forms indole-3-acetic acid aspartic acid (IAA-Asp) and indole-3-acetic acid glutami

110 A), a dithiol that can be synthesized from l-aspartic acid in a few high-yielding steps that are amen

111 , a phosphomimetic mutation of serine 216 to aspartic acid in Abi1 was sufficient to attenuate Bcr-Ab

112 fy the presence of D-serine, D-alanine, or D-aspartic acid in eight biologically relevant peptides.

113 chondrial import, whereas the presence of an aspartic acid in over 95% of all avian influenza viruses

114 The pK(a) value of aspartic acid in the catalytic triad of serine proteases

115 pled to protein folding; the apparent pKa of aspartic acid in the folded protein is 6.4.

116 The conversion of homoserine to aspartic acid in the glycopeptide was successfully accom

117 A motif of histidine, proline, and aspartic acid in the J domain of DNAJB6a was required fo

118 One compound with an aspartic acid in the P2 position (compound 16) displayed

119 tides, one challenge is the incorporation of aspartic acid in the peptide backbone and acid sensitive

120 D1416 in the IHD motif (isoleucine-histidine-aspartic acid) in the NBARC domain cause effector-indepe

121 beta-catenin, where serine 45 is mutated to aspartic acid, in mice resulted in improved liver regene

122 Food restriction also enhanced aspartic acid-induced burst firing of dopamine neurons i

123 A key aspartic acid involved in de-N-acetylation, normally see

124 Substitution of the surface-exposed Y1544 to aspartic acid is able to stabilize the domain in the abs

125 The negative charge of aspartic acid is believed to be able to mimic the phosph

126 The protonation state of aspartic acid is coupled to protein folding; the apparen

127 FFD-NH2) and a second novel one in which the aspartic acid is substituted by an asparagine (Ac-LPFFN-

128 mologue of Garner's aldehyde, derived from l-aspartic acid, is reported.

129 Aspartic acid isomerization rates can be predicted from

130 ifications such as asparagine deamidation or aspartic acid isomerization.

131 Several carbon sources (L-Asparagine, L-Aspartic Acid, L- Glutamic Acid, m- Erythritol, D-Melezi

132 amino acids, such as L-serine, L-leucine, L-aspartic acid, L-glutamic acid, histamine, glycine.

133 ict the effect of mutating each glutamic and aspartic acid located in MTBD domain to alanine.

134 use of asparaginase to convert asparagine to aspartic acid may provide a means to reduce acrylamide f

135 f cMyBP-C were replaced by either alanine or aspartic acid, mimicking the fully nonphosphorylated and

136 vivo MRI studies in mice; however, only the aspartic acid modified chelates produced an amide proton

137 n o-boronato-phosphonium amino ester with an aspartic acid moiety.

138 minal domains, but not the histidine-proline-aspartic acid motif, are critical for TopJ localization

139 Phosphorylation of the aspartic acid mutant with PAK resulted in the slow phosp

140 A phosphomimetic Ser-500 to aspartic acid mutation (eEF-2K S500D) enhances the rate

141 The aspartic acid mutation of beta4 T1736 impaired hemidesmo

142 previous reports; brain volume and N-acetyl aspartic acid (NAA) decreased steadily, but no published

143 ppocampal neurons, treatment with N-methyl-D-aspartic acid (NMDA) (10 muM) for 48 hours reduced the s

144 e sensitive conductances, such as N-methyl-D-aspartic acid (NMDA) channels can be more easily activat

145 ynaptic vesicles was dependent on N-methyl-D-aspartic acid (NMDA) receptor activation during LTP.

146 hetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely util

147 subunits required for assembly of N-methyl-d-aspartic acid (NMDA) receptors (NMDA-Rs), alpha-amino-3-

148 e excitation at central synapses: N-methyl-D-aspartic acid (NMDA) receptors and non-NMDA receptors.

149 Blockade of N-methyl-D-aspartic acid (NMDA) receptors by intra-CA3 infusion of

150 rectly required for clustering of N-methyl-D-aspartic acid (NMDA) receptors in PSDs early in developm

151 is accompanied by the increase of N-Methyl-D-aspartic acid (NMDA) receptors in the hippocampus follow

152 st common targets and mechanisms: N-methyl-d-aspartic acid (NMDA) receptors, voltage gated calcium ch

153 ic the tripeptide sequence (arginine-glycine-aspartic acid) of the natural ligands; however, the RGD-

154 is SNP determines if the protein contains an aspartic acid or a glycine residue at position 103 and m

155 mHTT gene within a BAC to express either an aspartic acid or an alanine at position 421, mimicking t

156 For example, isomerization of aspartic acid or epimerization of any chiral residue wit

157 nd to adhesion ligand (e.g. arginine-glycine-aspartic acid or RGD containing peptides) on extracellul

158 < 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p < 0.001) without affecting cell integri

159 functionalized with cyclic arginine-glycine-aspartic acid peptide ligands and radioiodine, exhibited

160 Application of arginine-glycine-aspartic acid peptide loops prevented the formation of a

161 report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified polylactic acid-co-glyco

162 esults imply that the racemization ratios of aspartic acid, phenylalanine, and tyrosine can be used a

163 Furthermore, we showed that a serine 120 to aspartic acid phospho-mimetic mutant of Rpt6 (S120D) inc

164 ected mutagenesis of predicted histidine and aspartic acid phosphoacceptor residues.

165 Stable expression of aspartic acid phosphomimetic (S490D) results in centroso

166 econd, the mutant methionine is converted to aspartic acid post-translationally, probably through oxi

167 idases exhibit a monoglutamase activity when aspartic acid precedes a single glutamate, which, togeth

168 mical design relies on the modification of l-aspartic acid precursor to controllably combine, through

169 egy was developed utilizing homoserine as an aspartic acid precursor.

170 Mutation of tyrosine 89 to aspartic acid (PrimPolY89D) has been identified in a num

171 form stabilized by interaction with a second aspartic acid, probably via a H-bond to the phenolic oxy

172 ening that binds to a specific pocket of the aspartic acid protease, beta-secretase (BACE-1).

173 lectivity over the physiologically important aspartic acid proteases.

174 In addition, the aspartic acid racemization ratio of this specimen was al

175 to LRP1, we demonstrate that the N-methyl-D-aspartic acid receptor (NMDA-R) is expressed by macropha

176 K-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurr

177 Because N-methyl-D-aspartic acid receptor (NMDAR) dysregulation has been st

178 By measuring N-methyl-d-aspartic acid receptor (NMDAR)-driven calcium responses

179 their free radical-generating and N-methyl-d-aspartic acid receptor agonist activities.

180 (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA)

181 ice were treated with the partial N-methyl-d-aspartic acid receptor antagonist memantine.

182 beta2* activation did not enhance N-methyl-D-aspartic acid receptor function.

183 The N-methyl-d-aspartic acid receptor hypofunction model of schizophren

184 chizophrenia, as predicted by the N-methyl-d-aspartic acid receptor hypofunction model.

185 te-binding GluN2A subunits of the N-methyl D-aspartic acid receptor upon binding agonists of varying

186 N-methyl-D-aspartic acid receptor-dependent long term potentiation

187 ent, we found abnormally enhanced N-methyl-d-aspartic acid receptor-dependent long-term depression in

188 ed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term pot

189 panoic acid receptor-mediated and N-methyl-D-aspartic acid receptor-mediated synaptic currents in lam

190 n of CA2 synapses relies on NMDA (N-methyl-D-aspartic acid) receptor activation, calcium and calcium/

191 asing glutamatergic excitation at N-methyl-D-aspartic acid receptors, alters both the amplitude and f

192 -isoxazole-propionate (AMPA), and N-methyl-d-aspartic acid receptors.

193 The combination of DNase and anionic poly(aspartic acid) reduced the PA biofilms formed in the pre

194 n binds directly and specifically to leucine-aspartic acid repeat (LD) motifs in paxillin via its C-t

195 treatment, we generated a knockin mouse with aspartic acid replacing serine 2808 (mice are referred t

196 titution of the N-terminal position S27 with aspartic acid rescued this loss of upregulation.

197 ity was shown to be dependent on a conserved aspartic acid residue (Asp(666)), identified as the cata

198 Previous studies have suggested that the aspartic acid residue (D) at the third position is criti

199 p) CX(5)R and the loop containing a critical aspartic acid residue (D-loop), required for the catalyt

200 Neutralization of an aspartic acid residue (D641) in the extracellular pore l

201 s revealed the near universal presence of an aspartic acid residue (D99) at the V-D junction, irrespe

202 capsid proteins were specifically cleaved at aspartic acid residue 420 (D420) during virus infection,

203 ymes share a consensus sequence harboring an aspartic acid residue as a catalytic nucleophile.

204 polymorphism, causing the replacement of the aspartic acid residue at position 398 with an asparagine

205 cid at position 838 (equivalent to the human aspartic acid residue at position 835) with a tyrosine (

206 a beta4 mutant containing a phosphomimicking aspartic acid residue at T1736 in the C-tail suggests th

207 al metalloenzyme in which a glutamic acid or aspartic acid residue engineered into streptavidin acts

208 analysis of isomaltase predicts that another aspartic acid residue functions as a proton donor in hyd

209 reported previously for other proteins, the aspartic acid residue in Kremen1 is not critical.

210 In a previous report, a conserved aspartic acid residue in the NqrB subunit at position 39

211 with a non-histidine zinc ligand, having an aspartic acid residue instead.

212 A nearby aspartic acid residue side-chain transiently stores prot

213 e carboxyl function at the side chain of the aspartic acid residue, which was selected on the basis o

214 absolute specificity of hydrolysis after an aspartic acid residue.

215 the L-selectin tail as well as a doublet of aspartic acid residues ((369)DD(370)) in the membrane-di

216 length LRPIV variants with glycine replacing aspartic acid residues 3394, 3556, and 3674 in the calci

217 nduced two-proton transfer between catalytic aspartic acid residues and the hydroxy group of the boun

218 alogues show that, like GH31 hydrolases, the aspartic acid residues Asp(553) and Asp(665) are the cat

219 neutral, despite harboring the two conserved aspartic acid residues found in NapA and other bacterial

220 egration activity of PGBD5 requires distinct aspartic acid residues in its transposase domain, and sp

221 ugates of chlorin e(6), containing lysine or aspartic acid residues in positions 17(3), 15(2), or 13(

222 hanism for translocation, where glutamic and aspartic acid residues in the substrate are the "molecul

223 ked homodimers that contain a pair of acidic aspartic acid residues in their transmembrane (TM) domai

224 Focusing on the two key aspartic acid residues of NhaA, D163 and D164, shows tha

225 By mutating two aspartic acid residues predicted to be responsible for t

226 that a mutation to glycine of two conserved aspartic acid residues that are important for nucleotide

227 Mutation of the aspartic acid residues to alanine in the C-terminal doma

228 Essential aspartic acid residues, in the predicted S1 binding pock

229 e is defined by samarium coordinated by four aspartic acid residues, whereas calcium binding itself i

230 bonds formed via catalytic glutamic acid or aspartic acid residues.

231 inner Odelta1 oxygen atoms of the catalytic aspartic acid residues.

232 c acid residues are replaced by arginine and aspartic acid, respectively as refractive increment incr

233 atives which are prepared from L-serine or L-aspartic acid, respectively.

234 y, substitution with the sulfinic acid mimic aspartic acid resulted in constitutive Hsf1 activation.

235 no acid residue (E115) that, when mutated to aspartic acid, resulted in a 14-fold decrease in the k(c

236 2-glutaric acid] and RGD is arginine-glycine-aspartic acid.) RESULTS: alphavbeta3 integrin is express

237 esive through exhibition of arginine-glycine-aspartic acid (RGD) adhesion peptides under stretching.

238 ty and accessibility of the arginine-glycine-aspartic acid (RGD) binding site in FN, which, in turn,

239 Cyclic arginine-glycine-aspartic acid (RGD) containing peptides are known to mim

240 with acetylenic bombesin or arginine-glycine-aspartic acid (RGD) derivatives, either in solution or o

241 x protein, has a functional arginine-glycine-aspartic acid (RGD) domain for binding to integrin.

242 lphavbeta6, via a conserved arginine-glycine-aspartic acid (RGD) motif in the exposed, antigenic, GH

243 ing a ketone-functionalized arginine-glycine-aspartic acid (RGD) peptide to modify the O-hydroxylamin

244 lphaVbeta3-specific, cyclic arginine-glycine-aspartic acid (RGD) peptides, will bind to dental pulp c

245 eta5/beta3 integrins and an arginine-glycine-aspartic acid (RGD) sequence in the first extracellular

246 old electrode surface using arginine-glycine-aspartic acid (RGD) tripeptide was electrochemically con

247 Arginine-glycine-aspartic acid (RGD)-based imaging tracers allow specific

248 n integrin-receptor-binding arginine-glycine-aspartic acid (RGD)-containing peptide at early healing

249 ith hydrogels modified with arginine-glycine-aspartic acid (RGD)-containing peptides.

250 Arginine-glycine-aspartic acid (RGD)-mimetic platelet inhibitors act by o

251 ally functionalized with an arginine-glycine-aspartic acid (RGD)-terminated thiol.

252 ds in alginate and alginate-arginine-glycine-aspartic acid (-RGD) microgel was demonstrated, with enh

253 o either alanine (S225A; phosphoablatant) or aspartic acid (S225D; phosphomimetic) in the context of

254 whereas replacing S47 with phospho-mimicking aspartic acid (S47D) abolished the antisenescent, growth

255 on resonance, the substitution of serine for aspartic acid (S77D) in the PDZ I domain decreased the b

256 t peptides and small proteins containing the aspartic acid semialdehyde (Asa) side chain can be easil

257 ks containing cell adhesive Arginine-Glycine-Aspartic acid-Serene (RGDS) peptide and/or nanocrystalli

258 lcium ion that is coordinated by a conserved aspartic acid side chain and is essential for catalytic

259 heets and beta-turns, and negatively charged aspartic acid side chain of FiP35 were measured independ

260 ucture of a GRASP phosphomimic containing an aspartic acid substitution for a serine residue (Ser-189

261 d type (WT) or with alanine or glutamic acid/aspartic acid substitutions at the phosphorylation sites

262 wild type (WT) sequences or with alanine or aspartic acid substitutions at the phosphorylation sites

263 Among all the substitutions screened, aspartic acid substitutions were generally well-tolerate

264 Mutation of T286 to alanine (T286A), aspartic acid (T286D), or glutamic acid (T286E) reduced

265 Mg(2+), which neutralizes the Ca(2+)-binding aspartic acids that likely contribute to the C2B interfa

266 half-life of ~2500 years for silk (B. mori) aspartic acid, the technique is capable of dating silk t

267 oxidised lipid was absent, cysteine, serine, aspartic acid, threonine, asparagine, tryptophan, tyrosi

268 ect dog cells, a single mutation changing an aspartic acid to a glycine at capsid (VP2) position 300

269 Although an amino acid substitution from aspartic acid to alanine at position 168 (D168A) reduced

270 changing coat protein N-arm residue 14 from aspartic acid to alanine causes a lethal phenotype.

271 amino acid in the nAChR alpha5 subunit from aspartic acid to asparagine (D398N), with greater risk f

272 (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of A(H7N9)

273 ), which changes a conserved amino acid from aspartic acid to asparagine.

274 urthermore, we found that a single change of aspartic acid to glutamic acid in CW3 NS1/2 was sufficie

275 c.298G-->T) in LEP, leading to a change from aspartic acid to tyrosine at amino acid position 100 (p.

276 frequent kinase domain mutation, converting aspartic acid to tyrosine.

277 variability, which enables the two catalytic aspartic acids to be brought closer to each other.

278 ith cTn having cTnI serines 23/24 mutated to aspartic acids to mimic phosphorylation always shifted a

279 One of these SNPs leads to an aspartic acid-to-asparagine substitution in the nicotini

280 characteristic, with cyclic arginine-glycine-aspartic acid tripeptide (cRGD), a targeting ligand to i

281 ment to the high density of arginine-glycine-aspartic acid tripeptide present in DAPF.

282 utation by substituting the S936-TRP site to aspartic acid (trp(S936D) ) set the frequency response o

283 The rate of [(3)H]-d-aspartic acid uptake in WM tissue was also decreased at

284 ctures of the WoA variants in complex with L-aspartic acid versus L-glutamic acid provide insights in

285 technique based on the racemization rate of aspartic acid was applied to dating human bone, as well

286 li (E. coli) HCB33 to the chemoattractant dl-aspartic acid was quantified in terms of change in total

287 acterization of mutant enzymes in which this aspartic acid was substituted by other residues that cha

288 N-[3',4'-dihydroxy-(E)-cinnamoyl]-l-aspartic acid was the most abundant metabolite, followed

289 lices, and the residues in the beta-turn, by aspartic acid was used examine the importance of the con

290 A d-isomer of poly(aspartic acid) was used alone and with DNase to reduce b

291 ncluding 2-hydroxyglutaric acid and N-acetyl-aspartic acid, was also observed in the DESI mass spectr

292 rylcarnitine/malonylcarnitine and asparagine/aspartic acid were associated with worse clinical rank s

293 lanine, glutamine, glutamic acid, aspargine, aspartic acid were detected.

294 made of cyanophycin [multi-L-arginyl-poly (L-aspartic acid)], which is synthesized by cyanophycin syn

295 lpha mutant, where serine 41 was replaced by aspartic acid, which mimics phosphorylation.

296 tamylases, with CCP3 being able to hydrolyze aspartic acids with similar efficiency.

297 inine residue at a similar register to these aspartic acids, with the activating immunoreceptors.

298 multiple phyla reveals a uniquely conserved aspartic acid within an FFXRX6RX12PXD motif, two uniquel

299 A point mutation neutralizing a conserved aspartic acid within the intracellular loop close to the

300 lytic zinc ion ligated by the histidines and aspartic acid within the motif (HEXXHXXGXXD).