ライフサイエンスコーパス: aspartyl

1 logue that mimics the loop structure bearing aspartyl 88 of the S12 ribosomal protein from E. coli.

2 ructurally characterized with a covalent Cys-aspartyl adduct, a malonyl/succinyl group can be reliabl

3 ocin C7 (McC7) consists of a nonhydrolyzable aspartyl-adenylate conjugated to a hexapeptide carrier t

4 the product of processing, a nonhydrolyzable aspartyl-adenylate, inhibits translation by preventing a

5 to release a toxic warhead-a nonhydrolyzable aspartyl-adenylate, which inhibits aspartyl-tRNA synthet

6 essed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthet

7 HSA having lost its amino terminal dipeptide aspartyl alanyl (HSA-DA) were correlated.

8 Mass spectrometry analysis of aspartyl-alanyl diketopiperazine (DA-DKP) content of HSA

9 ified to give a novel amino acid side chain, aspartyl aldehyde.

10 Aspartyl aminopeptidase (DNPEP) has been implicated in t

11 analysis of an evolutionary highly conserved aspartyl aminopeptidase called DNPEP.

12 ied in the active fractions, and recombinant aspartyl aminopeptidase recapitulated the cleavage patte

13 mass spectrometry identified the protease as aspartyl aminopeptidase.

14 We find that formation of the beta-aspartyl-AMP intermediate, and therefore the eventual pr

15 de intermediate to form a varying mixture of aspartyl and isoaspartyl residues.

16 rboxyl side of Asn and leads to formation of aspartyl and isoaspartyl residues.

17 otease mechanistic classes-serine, cysteine, aspartyl, and metallo-proteases-and develop a discrimina

18 the absence or presence of serine, cysteine, aspartyl, and metalloprotease inhibitors.

19 In addition, we show that addition of aspartyl- and gamma-secretase specific protease inhibito

20 red with existing methods that use synthetic aspartyl- and isoaspartyl-containing peptide standards.

21 isomer-specific mass tags were introduced to aspartyl- and isoaspartyl-containing peptides, which cou

22 cin identify the nitrogen-rich molecule beta-aspartyl-arginine as a nitrogen vehicle in the unique mu

23 These observations imply that beta-aspartyl-arginine produced from cyanophycin in the heter

24 action of cyanophycinase (that releases beta-aspartyl-arginine) and isoaspartyl dipeptidase (that pro

25 The mutant accumulated cyanophycin and beta-aspartyl-arginine, and was impaired specifically in diaz

26 rocysts released substantial amounts of beta-aspartyl-arginine.

27 Aspartyl-(asparaginyl)-beta-hydroxylase (ASPH) is a cell

28 -II, proliferating cell nuclear antigen, and aspartyl-(asparaginyl)-beta-hydroxylase, a gene associat

29 ASPH encodes aspartyl/asparaginyl beta-hydroxylase (ASPH), which has

30 Aspartyl-(asparagyl)-beta-hydroxylase (AAH) is overexpre

31 BeF3-trehalose complex structure captures an aspartyl-BeF3 covalent adduct, which closely mimics the

32 the core catalytic interaction group or the aspartyl binding motif (ABM).

33 As anticipated, the aspartyl carboxylate replaces the serine hydroxyl at the

34 at the BcpA variant Asp(312) Ala, lacking an aspartyl catalyst, did not generate the isopeptide bond

35 Of note, the aspartyl cathepsin Cth3p plays a key role in mucocyst-ba

36 hepatoma 1c1c7 cultures presensitized with N-aspartyl chlorin e6 (NPe6) caused lysosomal disruption a

37 retase complex imply that these two putative aspartyl class proteases may contribute to different bio

38 of IAA, PAA, SA, and BA and their respective aspartyl conjugates were determined in wild-type and ove

39 terica serovar Typhimurium strain contain an aspartyl dipeptidase activity that is dependent on Mn(2+

40 inetic parameters for the hydrolysis of beta-aspartyl dipeptides were obtained at pH 8.1.

41 nd catalyzes the hydrolytic cleavage of beta-aspartyl dipeptides.

42 d Mn(2+)-dependent peptidase activity toward aspartyl dipeptides.

43 DapE was found to be specific for N-terminal aspartyl dipeptides: no N-terminal Glu, Met, or Leu pept

44 titratable residues in BACE-1 including its aspartyl dyad are computed and compared between apo and

45 requires water-mediated proton transfer from aspartyl dyad to the substrate, as well as structural fl

46 in neurons treated with camptothecin and Boc-aspartyl-fluoromethylketone.

47 N-acetyl-aspartyl glutamate (NAAG), a prevalent neuropeptide in t

48 N-acetyl-aspartyl glutamate (NAAG), a prevalent neuropeptide in t

49 Ratios of N-acetyl-aspartate plus N-acetyl-aspartyl-glutamate (NAA) to creatine (Cr) and choline co

50 Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) a

51 of two methods for the analysis of N-acetyl-aspartyl-glutamate (NAAG) in biological fluids.

52 Remarkably, N-acetyl-aspartyl-glutamate (NAAG), a common dipeptide in brain,

53 CP II is an enzyme that metabolizes N-acetyl-aspartyl-glutamate (NAAG), which is the only known speci

54 ked by the mGluR3-selective agonist N-acetyl-aspartyl-glutamate (NAAG, 200-500 microM).

55 ysis of its two natural substrates, N-acetyl-aspartyl-glutamate and folyl-poly-gamma-glutamates, resp

56 phapeptide analogs of folyl-gamma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate, refine

57 the neurotransmitters glutamate and N-acetyl-aspartyl-glutamic acid (NAAG) and their precursor glutam

58 l ketone (a pan-caspase inhibitor) or acetyl-aspartyl-glutamyl-valyl-aspart-1-aldehyde (a relatively

59 agents are the same except for the valyl and aspartyl groups which provide a distinctive chemical fea

60 -defined amphoteric carriers, glutamic acid, aspartyl-histidine (Asp-His), cycloserine (cSer), and ar

61 romic form of ectopia lentis and the role of aspartyl hydroxylation in human development.

62 erotetrameric core complex that includes the aspartyl intramembrane protease presenilin (PS).

63 this assay we show that (i) SPP is the first aspartyl intramembrane-cleaving protease whose activity

64 d was designed for unambiguous assignment of aspartyl/isoaspartyl products produced by Asn deamidatio

65 spartyl residues (isoAsp or isoD) via either aspartyl isomerization or asparaginyl deamidation alters

66 NMR studies of two compounds, l-Aspartyl-l-boroProline (Asp-boroPro) and l-Histidyl-l-bo

67 xypeptidase II (GCPII) hydrolyzes N-acetyl-L-aspartyl-L-glutamate (NAAG) to liberate N-acetylaspartat

68 olyzes the abundant neuropeptide, N-acetyl-L-aspartyl-L-glutamate (NAAG), to produce N-acetylaspartat

69 N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 (NAALADL2) is a me

70 ibitors and the natural substrate N-acetyl-l-aspartyl-l-glutamate.

71 ethotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate.

72 atment of silicotic rats with N-acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) inhibits myofibroblast

73 g the anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile

74 s of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP).

75 blockade of the hydrolysis of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP).

76 CE), such as the tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), play a significant role

77 o-angiogenic cleavage product N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP).

78 26) phosphorylation is partially mimicked by aspartyl mutation.

79 These proteins use an aspartyl nucleophile as their common catalytic strategy

80 Although the protein-l-isoaspartyl (d-aspartyl) O-methyltransferase (EC 2.1.1.77) can initiate

81 with organisms with protein-l-isoaspartyl (d-aspartyl) O-methyltransferase, suggesting a novel regula

82 caspase inhibitor carbobenzoxyl-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone before the combin

83 Here, we report that NGF-deprived, boc-aspartyl-(OMe)-fluoromethylketone-saved neurons rely hea

84 e of a broad-spectrum caspase inhibitor, boc-aspartyl-(OMe)-fluoromethylketone.

85 the replacement of asparginyl residues with aspartyl or isoaspartyl residues.

86 present evidence that hASRGL1 exhibits beta-aspartyl peptidase activity consistent with enzymes desi

87 d a 3,200-fold elevation of Mn(2+)-dependent aspartyl peptidase activity relative to the MPD dapE(+)

88 Crude extracts of this strain showed no aspartyl peptidase activity, and the strain failed to ut

89 Mutagenesis studies identify LspA as an aspartyl peptidase.

90 ase Asp-N (EC 3.4.24.33) selectively cleaves aspartyl peptides but not the isoaspartyl counterparts.

91 rypsin and driven by hydrolysis of dipeptide aspartyl-phenylalanine-methyl ester (the sweetener aspar

92 as phosphatase regulators (Phr) of receptor aspartyl phosphatases (Raps).

93 n of the genes rapE and rapK, coding for two aspartyl phosphatases that negatively modulate the flow

94 also of minimizing unproductive catalysis of aspartyl phosphate hydrolysis.

95 gglesworthia glossinidia) or all of the beta-aspartyl phosphate pathway (Sodalis glossinidius).

96 threonine from aspartate occurs via the beta-aspartyl phosphate pathway in plants, bacteria and fungi

97 ate the system, while two response regulator aspartyl phosphate phosphatases of the Rap family negati

98 h the action of histidine sensor kinases and aspartyl phosphate phosphatases.

99 lytic glutamate to dephosphorylate the Spo0F aspartyl phosphate, and the implications of the RapP cat

100 t a water molecule for in-line attack of the aspartyl phosphate.

101 dence a significant stabilization of betaPGM aspartyl phosphate.

102 smic domains that prevents hydrolysis of the aspartyl phosphate.

103 nt adduct, which closely mimics the proposed aspartyl-phosphate intermediate of the phosphatase catal

104 Aspartyl-phosphate phosphatases underlie the rapid respo

105 MccF only hydrolyzes the naturally occurring aspartyl phosphoramidate McC7 and synthetic peptidyl sul

106 The EnvZ/OmpR histidyl-aspartyl phosphorelay (HAP) system in Escherichia coli r

107 e studies provide new insights into histidyl-aspartyl phosphoryl transfers in two-component systems a

108 al molecular event of GSR activation entails aspartyl phosphorylation of PhyR, which promotes its bin

109 Aspartyl phosphorylation of the PhyR receiver in respons

110 r crescentus and characterized the effect of aspartyl phosphorylation on PhyR structure by molecular

111 thodology based on disuccinimidyl-succinamyl-aspartyl-proline (SuDP), disuccinimidyl-succinamyl-valyl

112 with a C2 GRAM domain protein (BAGP1) and an aspartyl protease (APCB1), both of which are required fo

113 ases, plasmepsin I, II, and IV and the histo-aspartyl protease (HAP), have been identified in the foo

114 ase is a multiprotein intramembrane cleaving aspartyl protease (I-CLiP) that catalyzes the final clea

115 Coinfection with a secreted aspartyl protease (sap) mutant sap2456 and S. oralis inc

116 quently named it Malassezia globosa Secreted Aspartyl Protease 1 (MgSAP1).

117 Here we establish that Toxoplasma gondii aspartyl protease 3 (ASP3) resides in the endosomal-like

118 ort pathway that requires the Golgi-resident aspartyl protease 5 (ASP5).

119 Inhibitors of the HIV aspartyl protease [HIV protease inhibitors (HIV-PIs)] ar

120 cterized mechanism-based inactivators for an aspartyl protease and show promise as novel antimalarial

121 The active site of this transmembrane aspartyl protease apparently lies at the interface betwe

122 Identification of an aspartyl protease as the beta-secretase (beta-site APP c

123 +)-regulated calpain protease TRA-3, and the aspartyl protease ASP-4.

124 by sequential proteolysis, catalysed by the aspartyl protease BACE, followed by presenilin-dependent

125 The aspartyl protease BACE1 cleaves the amyloid precursor pr

126 cleavage of amyloid precursor protein by the aspartyl protease BACE1.

127 hough not selective over the closely related aspartyl protease BACE2, verubecestat has high selectivi

128 rotein (APP) cleaving enzyme 1 (BACE1) is an aspartyl protease best known for its role in generating

129 ge of amyloid precursor protein (APP) by the aspartyl protease beta-secretase and the presenilin-depe

130 The aspartyl protease beta-secretase, or BACE, has been demo

131 The aspartyl protease beta-site amyloid precursor protein cl

132 The membrane-anchored aspartyl protease beta-site APP-cleaving enzyme (BACE) e

133 obtained, validating the molecular design as aspartyl protease catalytic site inhibitors.

134 selectivity against the structurally related aspartyl protease cathepsin D.

135 Gamma-secretase is an intramembrane aspartyl protease complex that cleaves type I integral m

136 HIV protease, an aspartyl protease crucial to the life cycle of HIV, is t

137 ficiency virus 1 (HIV-1) protease (PR) is an aspartyl protease essential for HIV-1 viral infectivity.

138 BACE1 is a type 1 transmembrane aspartyl protease expressed predominantly in neurons of

139 c functions for members of the intramembrane aspartyl protease family.

140 also efficiently inhibited Sap9p, a secreted aspartyl protease from the human pathogen, Candida albic

141 ive catalytic component of the intramembrane aspartyl protease gamma-secretase complex.

142 senilin-1 (PS1) is the catalytic core of the aspartyl protease gamma-secretase.

143 s in an unprecedented manner in the field of aspartyl protease inhibition.

144 ealed a novel spiropiperidine iminohydantoin aspartyl protease inhibitor template.

145 As aspartyl protease inhibitors, these compounds all posses

146 teases and gamma-secretase, an intramembrane aspartyl protease involved in Alzheimer's disease, cleav

147 peptidase (SPP) is an intramembrane cleaving aspartyl protease involved in release of leader peptide

148 Renin is an aspartyl protease involved in the production of angioten

149 This unique intramembrane-cleaving aspartyl protease is required for the normal processing

150 The gamma-secretase aspartyl protease is responsible for the cleavage of num

151 the first cleavage event is a transmembrane aspartyl protease known as beta-site amyloid precursor p

152 tor motif that has not been described in the aspartyl protease literature and may serve as a starting

153 cursor protein (APP) by an integral membrane aspartyl protease named the beta-site APP-cleaving enzym

154 opportunity to examine the role this unique aspartyl protease plays in altering Abeta metabolism and

155 ts associated with strong inhibition of this aspartyl protease raised serious concerns regarding this

156 A second integral membrane aspartyl protease related to BACE1, referred to as beta-

157 The aspartyl protease renin was first isolated from the kidn

158 tanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of A

159 Gamma-secretase is an intramembrane-cleaving aspartyl protease required for the normal development of

160 ase enzyme 1 (BACE1), a type I transmembrane aspartyl protease required to cleave amyloid precursor p

161 aving enzyme 1 (BACE1), an integral membrane aspartyl protease responsible for cleavage of amyloid pr

162 BACE1 is an aspartyl protease responsible for cleaving amyloid precu

163 Thus, human SPPL3 is the first GxGD-type aspartyl protease shown to be capable of acting like a s

164 cally cleavage by the intramembrane-cleaving aspartyl protease signal peptide peptidase (SPP), is inv

165 A transmembrane aspartyl protease termed beta-site APP cleavage enzyme 1

166 ion of a gene encoding a chloroplast-located aspartyl protease that alters its pattern of expression.

167 effected by Presenilin, an unusual polytopic aspartyl protease that apparently cleaves Notch and nume

168 cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease that catalyzes the proteolytic process

169 BACE1 is a type I transmembrane aspartyl protease that cleaves amyloid precursor protein

170 gamma-secretase complex is an intramembrane aspartyl protease that cleaves its substrates along thei

171 peptide peptidase (SPP) is an intramembrane aspartyl protease that cleaves remnant signal peptides a

172 gamma-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor pro

173 Cathepsin D is an aspartyl protease that plays a crucial role in normal ce

174 BACE1 is a membrane-bound aspartyl protease that specifically cleaves amyloid prec

175 Both proteases are inhibited by the same aspartyl protease transition-state analogue inhibitors,

176 Aspartyl protease upregulation occurred and may represen

177 cleaving enzyme 1 (BACE1), the transmembrane aspartyl protease which initiates Abeta production, is a

178 results identify a mechanism that couples an aspartyl protease with a molecular cochaperone to trigge

179 gamma-Secretase is an unusual and ubiquitous aspartyl protease with an intramembrane catalytic site t

180 racellular inhibitory domain of Msb2p by the aspartyl protease Yps1p generated the active form of the

181 Inhibitors of gamma-secretase, an aspartyl protease, also prevented the appearance of the

182 The genes encoding AED1, a predicted aspartyl protease, and another AED, LEGUME LECTIN-LIKE P

183 BACE is an aspartyl protease, and there is significant effort in th

184 gene for presenilin 1, a multi-transmembrane aspartyl protease, are known to cause familial Alzheimer

185 A type I transmembrane aspartyl protease, BACE (beta-site APP cleaving enzyme),

186 eta-secretase (BACE), a type-I transmembrane aspartyl protease, cleaves APP first to generate a 99-am

187 of XRN4 and VCS in seeds (PECTIN LYASE-LIKE, ASPARTYL PROTEASE, DWD-HYPERSENSITIVE-TO-ABA3, and YELLO

188 Unlike beta-secretase, which is a monomeric aspartyl protease, gamma-secretase activity resides as p

189 estigate the role of SPPL3, an intramembrane aspartyl protease, in murine NK cell biology.

190 Gamma-secretase, a unique aspartyl protease, is required for the regulated intrame

191 Within lysosomes, cathepsin D (CtsD), an aspartyl protease, is suggested to be the main protease

192 The beta-secretase is membrane-bound aspartyl protease, most commonly known as BACE1.

193 Here we show that an inhibitor of the HIV aspartyl protease, Nelfinavir, triggers inflammasome for

194 Export is dependent on the activity of the aspartyl protease, plasmepsin V (PMV), which cleaves pro

195 protease inhibitors (HIV-PIs) target the HIV aspartyl protease, which cleaves the HIV gag-pol polypro

196 Cysteine aspartyl protease-3 (caspase-3) is a mediator of apoptos

197 nes a functional domain for an intramembrane aspartyl protease.

198 butes one aspartate to the active site of an aspartyl protease.

199 (Spp) that encodes a multipass transmembrane aspartyl protease.

200 2, but not by cathepsin D, a closely related aspartyl protease.

201 rary of inhibitors of cathepsin D (CatD), an aspartyl protease.

202 ysis within autolysosomes with cysteine- and aspartyl-protease inhibitors caused a marked accumulatio

203 ive diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execut

204 II) is the most extensively studied of these aspartyl proteases and catalyzes the initial step in the

205 ey have a direct bearing on the mechanism of aspartyl proteases and efforts to model beta-secretase.

206 eptide peptidase (SPP)-related intramembrane aspartyl proteases are a homologous group of polytopic m

207 lectivity for the other structurally related aspartyl proteases BACE2, cathepsin D, renin, and pepsin

208 lectivity for the other structurally related aspartyl proteases BACE2, cathepsinD, renin, and pepsin.

209 uration and expand the role of intramembrane aspartyl proteases in innate immunity.

210 Four aspartyl proteases known as plasmepsins are involved in

211 An analysis of the diversity of the aspartyl proteases of Plasmodium falciparum, known as pl

212 ecretase complex, are intramembrane-cleaving aspartyl proteases of the GxGD type.

213 bers of the family of intramembrane-cleaving aspartyl proteases of the GXGD-type.

214 no inhibition of other proteases such as the aspartyl proteases porcine pepsin, human cathepsin D, pl

215 The GxGD aspartyl proteases SPPL2a and, to a lesser extent, SPPL2

216 The assay has also been applied to related aspartyl proteases such as cathepsin D (Cat D) and BACE-

217 Caspases are a family of cysteine-aspartyl proteases that are well recognized for their es

218 (SPP) and gamma-secretase are intramembrane aspartyl proteases that bear similar active site motifs

219 lin 2 (PS2) are proposed to be transmembrane aspartyl proteases that cleave amyloid precursor protein

220 se is a founding member of membrane-embedded aspartyl proteases that cleave substrates within transme

221 de peptidase (SPP) are related transmembrane aspartyl proteases that cleave transmembrane substrates.

222 (BACE1) is a membrane-tethered member of the aspartyl proteases that has been identified as beta-secr

223 hromatography on pepstatin-A agarose bed the aspartyl proteases were purified and concentrated over 2

224 d hydrolases (e.g., lipases, phospholipases, aspartyl proteases, and acid sphingomyelinases) was foun

225 zyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of beta

226 as high selectivity for BACE1 over other key aspartyl proteases, notably cathepsin D, and profoundly

227 y that results in the activation of cysteine-aspartyl proteases, or caspases.

228 igen, which is homologous to secreted fungal aspartyl proteases, protected mice against pulmonary inf

229 Increasing evidence suggests that serine-aspartyl proteases-caspases are activated in the AD brai

230 0 nM, and >100-fold selectivity over related aspartyl proteases.

231 -embedded enzyme in the presenilin family of aspartyl proteases.

232 cellular glycosylphosphatidylinositol-linked aspartyl proteases.

233 homologs are related intramembrane-cleaving aspartyl proteases.

234 t disturbing the functions of other cellular aspartyl proteases.

235 ectivity against other biologically relevant aspartyl proteases.

236 the catalytic mechanism of BACE and related aspartyl proteases.

237 omplex and its similarity to other polytopic aspartyl proteases.

238 rger family of polytopic membrane-associated aspartyl proteases.

239 ecursor Gag (Pr55(Gag)) operated by cellular aspartyl proteases.

240 eleterious conversion of l-asparaginyl and l-aspartyl protein residues to l-iso-Asp or d-Asp occurs a

241 he prototype for a novel class of eukaryotic aspartyl protein tyrosine phosphatases.

242 ony appearances, mating competency, secreted aspartyl proteinase (Sap) activities, and virulence.

243 vivo expression of Candida albicans secreted aspartyl proteinase (SAP1-SAP8) and phospholipase B (PLB

244 It is an aspartyl proteinase able to specifically cleave fibronec

245 llmark of tumor invasion and metastasis, and aspartyl proteinase cathepsin D is implicated as a major

246 lytic gene expression, we compared secretory aspartyl proteinase gene (SAP) and phospholipase B gene

247 ed the role of Candida parapsilosis-secreted aspartyl proteinase isoenzyme 1 (SAPP1) in virulence.

248 ene of C. albicans encodes a unique secreted aspartyl proteinase that contributes to corneal pathogen

249 us mutants deficient in one or more secreted aspartyl proteinases encoded by SAP genes or in transcri

250 The secreted aspartyl proteinases of Candida albicans have long been

251 phal-specific virulence factors, such as the aspartyl proteinases Sap4 and Sap5 and the proposed inva

252 combination of a prolyl residue at P4 and an aspartyl residue at P2 was totally selective for PR3.

253 site, (2). replacing the negatively charged aspartyl residue at P4 with neutral groups, and (3). usi

254 bring the GXGD motif and a second essential aspartyl residue from transmembrane helix 1 into close p

255 on of ATP includes autophosphorylation of an aspartyl residue serving as ATPase catalytic intermediat

256 c receiver domain, which lacks the conserved aspartyl residue that serves as a phosphoryl acceptor in

257 horylates a response regulator protein on an aspartyl residue, resulting in activation.

258 oxyl group and the side chain of a conserved aspartyl residue, two residues to the N-terminal side of

259 e 3 pro-R or 3 pro-S positions of the target aspartyl residue, we show that RimO from Bacteroides the

260 s has been localized to two highly conserved aspartyl residues (Asp157), each in a 2-fold-symmetry-re

261 ased on the unique coordination chemistry of aspartyl residues and a model for the translocation path

262 Homology modeling revealed glutamyl and aspartyl residues in close proximity (less than 5 A) to

263 te the repair of l-isoaspartyl residues to l-aspartyl residues in most organisms, no gene homolog or

264 (mutants with substitutions of the catalytic aspartyl residues retain the activity).

265 eavages at the NH2-terminal peptide bonds of aspartyl residues suggests that a single proteinase is i

266 e spontaneous degradation of asparaginyl and aspartyl residues to isoaspartyl residues is a common ty

267 is the case in the spontaneous conversion of aspartyl residues to isoaspartyl residues, a modificatio

268 Cleavage at aspartyl residues was found to be efficient and specific

269 through the beta-carbonyl of asparaginyl or aspartyl residues, thereby adding an extra carbon to the

270 e-spanning substrates that require a pair of aspartyl residues.

271 re also detected, indicating the presence of aspartyl residues.

272 in spontaneously damaged proteins to normal aspartyl residues.

273 s no mass difference between isoaspartyl and aspartyl species, sensitive and specific detection of is

274 Whereas cysteine aspartyl-specific proteases (caspases) mediate apoptosis

275 and accurate quantification of site-specific aspartyl succinimide (Asu) formation in complex protein

276 The aspartyl tRNA synthetase "Trojan horse" inhibitor microc

277 Aspartyl-tRNA synthetase (AspRS) occurs in two types: th

278 ecies is synthesized by a non-discriminating aspartyl-tRNA synthetase (AspRS) that acylates both tRNA

279 tterns distinguish the two distinct forms of aspartyl-tRNA synthetase (AspRS) that exist in different

280 by preventing aminoacylation of tRNA(Asp) by aspartyl-tRNA synthetase (AspRS).

281 a similar manner using a non-discriminating aspartyl-tRNA synthetase (ND-AspRS) and the heterotrimer

282 -step indirect pathway, a non-discriminating aspartyl-tRNA synthetase (ND-AspRS) attaches Asp to tRNA

283 an entire transamidation pathway composed of aspartyl-tRNA synthetase and one set of GatCAB genes is

284 7 (McC) acts as a bacteriocide by inhibiting aspartyl-tRNA synthetase and stalling the protein transl

285 They also comprise the identification of aspartyl-tRNA synthetase as a receptor of the priming ac

286 Two types of aspartyl-tRNA synthetase exist: the discriminating enzym

287 ransferase genes, there is a triplication of aspartyl-tRNA synthetase genes and a duplication of aspa

288 of Asp-tRNA(Asn) from the non-discriminating aspartyl-tRNA synthetase to AdT, where it is converted i

289 ; this complex contains a non-discriminating aspartyl-tRNA synthetase, AdT, and Hp0100 but does not r

290 cytosines are biologically active and target aspartyl-tRNA synthetase, and that the carboxymethyl gro

291 se evolved from glutamyl-tRNA synthetase and aspartyl-tRNA synthetase, respectively, after the split

292 -nucleotide Trojan horse antibiotic, targets aspartyl-tRNA synthetase.

293 rolyzable aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

294 zable aspartamidyl-adenylate, which inhibits aspartyl-tRNA synthetase.

295 peptide-nucleotide antibiotic that inhibits aspartyl-tRNA synthetase.

296 analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

297 e mischarged species, glutamyl-tRNA(Gln) and aspartyl-tRNA(Asn), by tRNA-dependent amidotransferases,

298 scharged tRNA species, glutamyl-tRNA(Gln) or aspartyl-tRNA(Asn).

299 2, 3, and 7 because benzyloxycarbonyl-valyl-aspartyl-valyl-alanyl-aspartic acid fluoromethyl ketone

300 raginyl-Xaa bonds or direct isomerization of aspartyl-Xaa bonds is a major contributor to spontaneous