ライフサイエンスコーパス: astacin

1 ucture and primary sequence only in nematode astacins.

2 this hypothesis of zymogen activation of the astacins.

3 with a Glu residue that is conserved in all astacins.

4 Astacin, a crustacean digestive enzyme, has been propose

5 It is proposed that prosequence removal of astacins allows the formation of hydrogen bonds involvin

6 tency maintenance in the otherwise unrelated astacin and fragilysin metallopeptidase families.

7 te the metal-centered mechanism proposed for astacin and the role of the coordinated Tyr.

8 s with thrombospondin domains (ADAM-TS), and Astacins are now recognized as key signaling "scissors"

9 Mature, active astacins are produced by proteolytic removal of an activ

10 lpha and beta protease domains, based on the astacin crystal structure, revealed active site differen

11 gen activation mechanism of meprin and other astacins differs from that of the trypsin family of enzy

12 Therefore, BMP-1 was a member of the "astacin families" of zinc-requiring endopeptidases.

13 ylated, secreted zinc metalloprotease of the astacin family and metzincin superfamily.

14 Metalloendopeptidases of the astacin family contain a homologous protease domain of a

15 ers, have extended this correlation to other astacin family members from different organisms.

16 vastacin is an oocyte-specific member of the astacin family of metalloendoproteases.

17 mbryogenesis, which has been assigned to the astacin family of zinc-dependent endopeptidases.

18 tween gene and protein structures within the astacin family provide novel information on the evolutio

19 these, SpAN, which encodes a protease in the astacin family related to Drosophila tolloid and vertebr

20 ly related to astacin, the prototype of the "astacin family" of metalloproteases.

21 Meprins, metalloendopeptidases of the astacin family, are composed of alpha and/or beta subuni

22 s a zinc binding motif characteristic of the astacin family.

23 Many astacins have been shown to play critical roles in embry

24 sion of key gene families--families encoding astacin-like and SCP/TAPS proteins--is associated with t

25 1 (BMP-1), which is a tolloid member of the astacin-like family of zinc metalloproteinases, is a hig

26 P3), a trypsin like protein (Lltryp2) and an astacin-like metalloprotease (LuloAstacin).

27 dog hookworm Ancylostoma caninum secretes an astacin-like metalloprotease, Ac-MTP-1, upon activation

28 Mammalian Tolloid-like 1 (mTLL-1) is an astacin-like metalloprotease, highly similar in domain s

29 ), a selective inhibitor of a small group of astacin-like metalloproteinases, which includes bone mor

30 NA sequences encoding the active site of the astacin-like protease domain common to all splice varian

31 ed protein domain structure: an NH2-terminal astacin-like protease domain, followed by a fixed order

32 ino terminal signal peptides, prodomains and astacin-like protease domains.

33 alt bridge is required for the activation of astacin-like proteases.

34 ha(2)-macroglobulin is unable to inhibit the astacin-like proteinases meprin alpha and meprin beta, w

35 etic protein1 (Bmp1) gene encodes a secreted astacin metalloprotease that cleaves the COOH-propeptide

36 Here we present an astacin metalloprotease, dubbed patristacin, which has b

37 The newly emerging astacin metalloproteinase family comprises multiple memb

38 Several members of the newly emerging astacin metalloproteinase family have been shown to func

39 ese results suggest that HMP-1 is a secreted astacin metalloproteinase that has an important role in

40 for the substrate specificity differences of astacin metalloproteinases.

41 ely resembles that of meprins, a subgroup of astacin metalloproteinases.

42 roles in other systems-BMP-1/TLD (tolloid) (astacins), MMPs (matrix metalloproteases) and the ADAMs

43 cessed HMP-1 is composed of a characteristic astacin proteinase domain and a unique Cys-rich C-termin

44 The mature HMP2 starts with an astacin proteinase domain that contains a zinc binding m

45 inase 1 (HMP-1), a developmentally important astacin proteinase that functions in head regeneration a

46 We have characterized a new astacin proteinase, hydra metalloproteinase 2 (HMP2) fro

47 ain structure, HMP-1 represents an ancestral astacin proteinase.

48 tase mu) that is only present in meprin-like astacin proteinases; and a unique C-terminal domain (TH

49 The astacin-related metalloproteases Bone Morphogenetic Prot

50 sed on the crystal structure of the crayfish astacin, showed electrostatic differences within the mep

51 ion of patristacin and found conservation of astacin-specific motifs but also several positively sele

52 ith protease domains structurally related to astacin, the prototype of the "astacin family" of metall

53 conserved structural motifs consistent with astacin, tolloid, and bone morphogenetic protein 1.

54 of the more structurally complex members of astacin-type enzymes in deuterostomes, which can add sup

55 We found that CG11864, a predicted astacin-type metalloprotease in seminal fluid, is necess

56 Meprinalpha, an astacin-type metalloprotease is overexpressed in colorec