ライフサイエンスコーパス: astroglia

1 a1 (microglia), COX-1 (microglia), and GFAP (astroglia).

2 r dense perisynaptic expression primarily on astroglia.

3 were purely via contact between T cells and astroglia.

4 e role of N-SMase in the activation of human astroglia.

5 d generation of proinflammatory molecules in astroglia.

6 nuclear factor-kappaB in Abeta1-42-activated astroglia.

7 hat the phenotype may be cell autonomous for astroglia.

8 the end feet and radial processes of Muller astroglia.

9 ion in primary microglia, but not in primary astroglia.

10 d NFkappaB were associated with this site in astroglia.

11 ructural characteristics of both neurons and astroglia.

12 ld, suggesting AQP4-dependent K(+) uptake by astroglia.

13 dendrocytes, whereas BCATm is the isoform in astroglia.

14 in human U373MG astroglial cells and primary astroglia.

15 mal models to be metabolized specifically in astroglia.

16 nduced the production of NO in human primary astroglia.

17 hat Tat is secreted from RSV-tat-transfected astroglia.

18 stochemistry for microglia, macrophages, and astroglia.

19 to the multitude of adaptive roles played by astroglia.

20 hat monensin also raises intracellular pH in astroglia.

21 (ADNF), a protein secreted by VIP-stimulated astroglia.

22 stributed glial fibrillary acidic protein-ir astroglia.

23 ynthesis by mobilizing [Ca2+]i in developing astroglia.

24 xamined, including fibroblasts, myeloma, and astroglia.

25 ivity in these cells indicates that they are astroglia.

26 ed abnormal gene expression profiles from DS astroglia.

27 synthase, and thrombospondins 1 and 2 in DS astroglia.

28 urce and metabolic function are regulated by astroglia.

29 rminals accumulate d-aspartate as quickly as astroglia.

30 nction of interneurons, oligodendrocytes and astroglia.

31 exity of calcium signaling mechanisms in CNS astroglia.

32 th the bacterial lipopolysaccharide (LPS) in astroglia.

33 ession of inducible NO synthase in activated astroglia.

34 ve intranuclear inclusions in neurons and in astroglia.

35 he substantia nigra but in the microglia and astroglia.

36 ting the selective uptake of angiogenin into astroglia.

37 n contributed to activation of microglia and astroglia.

38 nthase (CerS) 6 in monocytes/macrophages and astroglia.

39 nd resulted in fewer activated microglia and astroglia.

40 ls in the VZ/SVZ region are neurons, 30% are astroglia, 15% are nestin+ cells, with other cell types

41 fferent percentages of microglia (10-20%) or astroglia (40-50%) back to the neuron-enriched cultures

42 strocyte preparations indicate that cortical astroglia account for approximately one-third of the tot

43 regulation and in correlation with prominent astroglia activation.

44 of fluorescently labeled AQP4+/+ and AQP4-/- astroglia after implantation into mouse brains in which

45 nd characterize an inhibitory role played by astroglia after neuronal transplantation.

46 low input resistance of electrically passive astroglia allows extracellular currents to pass through

47 n the human brain, SVZ cells including local astroglia also express EZH2, correlating with postnatal

48 hic GFAP(+)/vimentin(+)/nestin(+) "reactive" astroglia and also the plasticities and lineage relation

49 t targets: a neurotrophic effect mediated by astroglia and an anti-inflammatory effect mediated by th

50 nd post-synaptic compartments of neurons and astroglia and are a unique model for studying the synapt

51 water-selective channel that is expressed in astroglia and basolateral plasma membranes of epithelia

52 Non-neurogenic cell types, such as cortical astroglia and fibroblasts, can be directly converted int

53 s, especially mGluR5) in developing cortical astroglia and found that developmental arborization of a

54 pecified during mid-embryogenesis to produce astroglia and interneurons, switch their fate and genera

55 phagocytic cells (e.g. activated microglia, astroglia and macrophages) for the efficient removal of

56 nally secreted factor that is endocytosed by astroglia and mediates neuroprotection in paracrine.

57 resent experiments, we studied activation of astroglia and microglia after intraocular scrapie infect

58 xpression of Socs3 mRNA and protein in mouse astroglia and microglia in both a time- and dose-depende

59 e in the activation of brain-derived primary astroglia and microglia in prion disease and perhaps oth

60 To study the roles of astroglia and microglia in these cytokine responses, pri

61 onneuronal pathology in neocortex (activated astroglia and microglia) is consistent with findings in

62 pha was observed only in neurons, but not in astroglia and microglia, and it was contingent on the ac

63 s contained micro-opioid receptor-expressing astroglia and microglia, and since glia are the principa

64 hanges in the number and activation of brain astroglia and microglia, particularly in the region of t

65 ts induced strong COX-2 expression mainly in astroglia and microglia, whereas COX-1 expression was pr

66 progenitor cells (GPCs), which give rise to astroglia and myelin-producing oligodendrocytes.

67 ise precursors displaying traits of juvenile astroglia and neural stem cell markers.

68 ate/glutamine neurotransmitter cycle between astroglia and neurons (0.32 +/- 0.07 micromol x gm(-1) x

69 tmentalization of glucose metabolism between astroglia and neurons but indicate that the compartmenta

70 Rapid signal exchange between astroglia and neurons has emerged as a key player in neu

71 Rapid signal exchange between astroglia and neurons has emerged as an essential elemen

72 ies and functional disorders, affecting both astroglia and neurons with a pathogenesis that is only m

73 gical features of intranuclear inclusions in astroglia and neurons.

74 mma was unique in inducing Shh expression in astroglia and NSCs, while paradoxically suppressing Gli1

75 roglia) or neuroepithelial progenitor cells (astroglia and oligodendrocytes).

76 but each progenitor compartment produces new astroglia and oligodendroglia; the latter expand 10- to

77 but not A-SMase, decreased the activation of astroglia and protected neurons from fibrillar Abeta tox

78 ndings demonstrate heterogeneity of reactive astroglia and show that scar borders are formed by newly

79 awareness that synaptic plasticity involves astroglia and the extracellular matrix is revealing new

80 opriate targets, whereas Pax2(+) optic nerve astroglia and Vim(+) radial glia may aid in early axonal

81 the extrinsic factors (such as perisynaptic astroglia) and the intrinsic factors (such as core subce

82 neurons survived longer than either NPCs or astroglia, and a small proportion were alive until at le

83 es showed marked activation of microglia and astroglia, and cytokine profiling indicated that macroph

84 in vivo include immature and mature neurons, astroglia, and endothelial cells.

85 active sites in hippocampal pyramidal cells, astroglia, and in microglia within 72 h after a period o

86 rillary acidic proteins (GFAPs), a marker of astroglia, and interleukin-1beta (IL-1beta), a prototype

87 lectively named endozepines, are secreted by astroglia, and ODN is a potent anorexigenic factor.

88 entiate into three neural lineages (neurons, astroglia, and oligodendrocytes) when cultured in differ

89 rebellum give rise to cortical interneurons, astroglia, and oligodendroglia.

90 etained the size and pleomorphism of hominid astroglia, and propagated Ca2+ signals 3-fold faster tha

91 neurons, giant neuroglial cells, dysplastic astroglia, and reactive astrocytes.

92 dentity of cells induced from Ink4a/Arf-null astroglia, and short hairpin RNA-mediated acute knockdow

93 eful for studying the heterogeneity of human astroglia, and the unique Olig2PC-Astros may constitute

94 molecules, such as NO, IL-1beta, and IL-6 in astroglia, and these responses were purely via contact b

95 ttern recognition receptors on microglia and astroglia, and trigger an innate immune response charact

96 Astroglia are a principal target of long-term mu antipro

97 Astroglia are heterogeneous, and not all astroglia are equivalent in promoting neural repair.

98 Astroglia are heterogeneous, and not all astroglia are e

99 Double null mutant astroglia are hyper-responsive to stimulation with epide

100 Astroglia are interposed between the cerebral vasculatur

101 Activated microglia and astroglia are known to be involved in a variety of neuro

102 These data suggest that astroglia are not involved in the generation or migratio

103 ical evidence strongly suggests that resting astroglia are potential sources of nitric oxide--a power

104 Because astroglia are the predominant cell type contacting LHRH-

105 ese results indicate that some microglia and astroglia arise from a precursor that is a normal consti

106 troglia, but the utilization of hPSC-derived astroglia as cell therapy for neurological diseases has

107 expression of mSOD1(G93A) in motoneurons and astroglia, as well as microglia, was required to produce

108 SCI, cell processes deriving from different astroglia associated into overlapping bundles that quant

109 yte precursor-correlated proneural toward an astroglia-associated gene expression pattern, manifest i

110 ssage in vitro, wild-type postnatal cortical astroglia become progressively resistant to Dlx2-induced

111 (14)C]lactate oxidation to (14)CO(2) only in astroglia but not in neurons, indicating a kinetic prefe

112 ibrillary acidic protein immunoreactivity in astroglia, but it was not colocalized with markers for o

113 3-HM was neurotrophic after the addition of astroglia, but not microglia.

114 t to volume regulation is provided by Muller astroglia, but the identity of their osmosensor is unkno

115 em cells (hPSCs) have been differentiated to astroglia, but the utilization of hPSC-derived astroglia

116 , it is apparent that both the activation of astroglia by Abeta and that the cytotoxicity of activate

117 neurons from cytotoxic effects of activated astroglia by antisense knockdown of N-SMase, but not aci

118 y corrects the pathological phenotypes of DS astroglia by specifically modulating the expression of S

119 owever, increases in Ca(2+) concentration in astroglia can also release other signalling molecules, m

120 These results demonstrate that astroglia can play a causal role in regulating the synch

121 ceptors (NMDARs), and it has been shown that astroglia can regulate their activation through Ca(2+)-d

122 lay of Glu and GABA transporters of adjacent astroglia can result in shortened seizures.

123 trocyte-conditioned medium collected from DS astroglia causes toxicity to neurons, and fails to promo

124 licated in dorsal telencephalic neuronal and astroglia cell fate decisions.

125 -dependent chemotactic activity of OPN in C6 astroglia cells and normal human astrocytes.

126 Similar results were observed in human astroglia cells, where endogenous CXCR4 was rapidly phos

127 optic tract and tectum, radial glia and free astroglia coexist.

128 Thus, neuron-astroglia communication via NRG-erbB4/2 receptor signali

129 e in cytokine response between microglia and astroglia correlated with 20-fold-higher levels of PrP e

130 that shape both short- and long-range neuro-astroglia coupling, as these are manifest in epilepsy ph

131 We reported previously that astroglia cultured from aquaporin-4-deficient (AQP4-/-)

132 Immunostaining of astroglia cultured from rat neonatal SON-VGL confirmed t

133 es, motoneuron-like NSC34 cells, and primary astroglia cultures as model systems, we here demonstrate

134 es but not in enriched neuron, microglia, or astroglia cultures nor in mixed neuron-astroglia culture

135 a, or astroglia cultures nor in mixed neuron-astroglia cultures.

136 rected production of interleukin-6 (IL-6) by astroglia decreased overall neurogenesis by 63% in the h

137 Astroglia demonstrate morphological and molecular change

138 he effect of kappa-agonists on the growth of astroglia derived from 1-2-day-old mouse cerebra was exa

139 Furthermore, 3-HM-treated astroglia-derived conditioned media exerted a significan

140 ause we have reported that IL-1 can regulate astroglia-derived dopaminergic neurotrophic factors, it

141 ese Olig2PC-Astros differ substantially from astroglia differentiated from Olig2-negative hESC-derive

142 is a critical strategy for cytokine-induced astroglia differentiation and lineage-characteristic gen

143 Transplantation studies show that DS astroglia do not promote neurogenesis of endogenous neur

144 at morphological activation of microglia and astroglia does not predict glial function, and that the

145 ulates the functional maturation of cortical astroglia during development.

146 mplementary and often contradictory roles of astroglia during neuronal integration.

147 [Ca(2+)] inside neuronal dendrites or inside astroglia dye-filled via gap junctions.

148 These findings remind us that astroglia exert positive and negative influences on neur

149 DS astroglia exhibit higher levels of reactive oxygen speci

150 The activated astroglia exhibited hypertrophy and an increased level o

151 harvested from N-PPARgamma-KO mice, but not astroglia, exposed to ischemia in vitro demonstrated mor

152 found that rat Per1::luc and mouse Per2::luc astroglia express circadian rhythms with a genetically d

153 plastic neurons, giant cells, and dysplastic astroglia express high levels of pS6 and demonstrate alt

154 its DNA synthesis and proliferation in human astroglia expressing IL-4 receptors.

155 segregated clusters, whereas STAT3-deficient astroglia failed to do so.

156 sly absent, suggesting that the emergence of astroglia from CN occurred only with passage.

157 We generated functional astroglia from human induced pluripotent stem cells carr

158 ifferentiation and maintenance of functional astroglia from human pluripotent stem cells in a chemica

159 thed by processes from individual developing astroglia from postnatal day (P) 14 to P26, when astrogl

160 fluence of ethanol on proliferation of human astroglia from the gray and white matter of adult tempor

161 ot express markers characteristic for mature astroglia (GFAP), oligodendroglia (CNPase), or neurons (

162 was carried out for 21 days to obtain either astroglia (>95% GFAP(+)) or a 1:5 mixed neuron/astroglia

163 Although it has been suggested that astroglia guide pioneering axons during development, the

164 s regulating the early fate specification of astroglia have been characterized, mechanisms regulating

165 Astroglia have long been thought to play merely a suppor

166 sis that matrix proteins generated by mature astroglia impose temporal and spatial limitations on axo

167 proliferation of both gray and white matter astroglia in a dose and duration dependent manner.

168 dly upregulated by reactive and perivascular astroglia in areas of injury in MS lesions and during EA

169 trigeminal sensory neurons and activation of astroglia in brainstem trigeminal sensory nuclei.

170 al function and injury leads to dysregulated astroglia in CNS disease.

171 by phenotypic transformation of protoplasmic astroglia in gray matter.

172 on, probably occurring almost exclusively in astroglia in response to glutamate stimulation, followed

173 find that Syt IV is located in processes of astroglia in situ.

174 oach could potentially enlighten the role of astroglia in supporting brain glutamatergic activity and

175 leads to long-term changes in the density of astroglia in the brain regions involved in stress respon

176 Midline astroglia in the cerebral cortex develop earlier than ot

177 control of the production of neurons versus astroglia in the developing hippocampus.Finally, we conf

178 of GLT1 in the cortex, but has no effect on astroglia in the hypothalamus, where non-VGluT1(+) synap

179 These findings support a role for astroglia in the hypoxic induction of VEGF expression an

180 tly, pioneer RGC axons run among the Pax2(+) astroglia in the optic nerve and reach the superficial o

181 ion and phenotypic transformation of fibrous astroglia in white matter, and solely by phenotypic tran

182 jor cell types, neural precursors (nestin+), astroglia including radial glia (GFAP+, vimentin+), and

183 CO(2) and reduced lactate release mainly in astroglia, indicating that limitations in glucose and la

184 oducts released from activated primary human astroglia induced the activation of neutral sphingomyeli

185 Astroglia interact with cerebral endothelia to maintain

186 Finally, we show that reprogramming of astroglia into neurons is dependent on the presence of S

187 ably disrupted the organization of elongated astroglia into scar borders, and caused a failure of ast

188 The communication medium of astroglia involves intracellular [Ca(2+)] waves, which u

189 flammation involving activated microglia and astroglia is becoming a hallmark of many human diseases,

190 neurogenic competence of Ink4a/Arf-deficient astroglia is both greatly increased and does not diminis

191 Functional maturation of astroglia is characterized by the development of a uniqu

192 Activation of microglia and astroglia is seen in many neurodegenerative diseases inc

193 hat soluble products released from activated astroglia kill neurons via N-SMase but not A-SMase.

194 renewal and spontaneous differentiation into astroglia-like cells.

195 vestigated how these T cells interacted with astroglia, major resident glial cells of the CNS.

196 tem; however, the specific contribution that astroglia make to neurodegeneration in human disease sta

197 itations in glucose and lactate oxidation by astroglia may be due to a greater balance of PDH toward

198 These observations indicate that astroglia may contribute strongly to the abnormal cholin

199 Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat n

200 First, astroglia mediated the 3-HM-induced neurotrophic effect

201 suggesting that high-level PrP expression on astroglia might be important for induction of certain cy

202 In transwell assays, AQP4+/+ astroglia migrated faster than AQP4-/- cells in a manner

203 AQP4+/+ astroglia moved on average 1.5 mm toward the stab compar

204 dysfunctional crosstalk between neurons and astroglia, neurons and innate immune system cells, as we

205 We subsequently demonstrated that it was the astroglia, not the microglia, that contributed to the ne

206 Cholinergic neurons and cerebral cortical astroglia, obtained separately from Ts16 mouse fetuses a

207 kI expression was found in testis, heart and astroglia of the qk(v)/qk(v) mice, suggesting that the r

208 rate a subtype of previously uncharacterized astroglia (Olig2PC-Astros).

209 maturation of affected cell types, including astroglia, oligodendroglia and neurons.

210 concept that non-neuronal cells (microglia, astroglia, oligodendroglia) participate in the degenerat

211 deletion of Dicer selectively from postnatal astroglia on brain development.

212 Abeta and that the cytotoxicity of activated astroglia on neurons depend on N-SMase.

213 loid-beta 1-42 (Abeta1-42) peptide-activated astroglia on neurons.

214 ned medium (ACM) to examine the influence of astroglia on the regulation of GABAA receptor/Cl- channe

215 eir low proliferative rate, nor give rise to astroglia or OPCs.

216 Astroglia outside the subventricular zone niche can supp

217 While astroglia play positive roles in the life of the neuron,

218 troglia (>95% GFAP(+)) or a 1:5 mixed neuron/astroglia population (beta-tubulin III(+)/GFAP(+)).

219 a produced only IL-12p40 and CXCL10, whereas astroglia produced these cytokines plus CCL2, CCL3, CCL5

220 onin may represent a mechanism through which astroglia provide these polyunsaturated fatty acids to n

221 Selective deletion of STAT3 from astroglia quantifiably disrupted the organization of elo

222 Astroglia regulate synaptic glutamate, via neurotransmit

223 echanisms regulating postnatal maturation of astroglia remain essentially unknown.

224 Angiogenin uptake into astroglia requires heparan sulfate proteoglycans, and en

225 conditions on hippocampal neurogenesis from astroglia, resulting in a robust increase in the number

226 Astroglia secrete factors that promote synapse formation

227 Dystrophic neurites and astroglia showed no M-CSFR labeling in the transgenic an

228 ems, we demonstrated that microglia, but not astroglia, significantly enhanced the progression of MPT

229 pattern of cytokine release by microglia and astroglia similar to that induced by scrapie-infected br

230 We show that a small population of Gfap+ astroglia spans the midline of the zebrafish forebrain i

231 In cocultures, wild-type astroglia spontaneously corralled inflammatory or fibrom

232 ast, phosphacan message was detected only in astroglia, such as the Golgi epithelial cells of the cer

233 ypertrophic, vimentin(+)/nestin(+), reactive astroglia that accumulated in spinal cord in this multip

234 2 in mice with conditional MeCP2 deletion in astroglia, these data support the hypothesis of an impor

235 By contrast, long-range activation of astroglia through gap junctions may promote recurrent se

236 nuclear inclusions were found in neurons and astroglia throughout the brain in cortical and subcortic

237 To specifically measure the contribution of astroglia to brain energy metabolism in humans, we used

238 ut the cortex; furthermore, the targeting of astroglia to dorsolateral cortex requires FGFr2 signalin

239 a into scar borders, and caused a failure of astroglia to surround inflammatory cells, resulting in i

240 t mice, suggesting that precise targeting of astroglia to the cortex has unexpected roles in axon gui

241 oglia from postnatal day (P) 14 to P26, when astroglia undergo dramatic postnatal maturation.

242 After hypoxia, immature cortical astroglia underwent a shift toward neuronal fate and gen

243 h 20-fold-higher levels of PrP expression in astroglia versus microglia, suggesting that high-level P

244 t proinflammatory molecules in microglia and astroglia via cell-to-cell contact.

245 ial processes are abnormal and GFAP-positive astroglia were aberrantly present on the pial surface.

246 idermal growth factor (EGF)-stimulated human astroglia were arrested in G1 phase by IL-4, even though

247 Activated astroglia were detected in the cortex and hippocampus fo

248 sessing the morphological characteristics of astroglia were weakly immunoreactive for the endothelial

249 ein was expressed primarily in microglia and astroglia, whereas DR5 co-localized with neurons and OPC

250 fibrillary acidic protein-positive (GFAP(+)) astroglia, which also express immunoreactive nestin and

251 lutamate receptor 5 (mGluR5) signaling in S1 astroglia, which elicits spontaneous somatic Ca2+ transi

252 d the release of neurotrophic factor(s) from astroglia, which in turn was responsible for the neurotr

253 are formed by newly proliferated, elongated astroglia, which organize via STAT3-dependent mechanisms

254 ained in the adult, defining the optic nerve astroglia, which wrap the left and right nerves separate

255 s unidirectionally to induce RNA cleavage in astroglia, while the ALS-associated K40I mutant is also

256 CI consisted primarily of newly proliferated astroglia with elongated cell processes that surrounded

257 human glia were gap-junction-coupled to host astroglia, yet retained the size and pleomorphism of hom